Zinc finger protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania braziliensis

UniProt:

A4HFD2_LEIBR

TriTrypDb:

LbrM.27.0140 , LBRM2903_270006600

Length:

115

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HFD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	18
GO:0043167	ion binding	2	18
GO:0043169	cation binding	3	18
GO:0046872	metal ion binding	4	18
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	90	94	PF00082	0.284
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DOC_MAPK_gen_1	68	77	PF00069	0.478
DOC_PP4_MxPP_1	11	14	PF00568	0.441
DOC_USP7_MATH_1	44	48	PF00917	0.505
DOC_USP7_UBL2_3	70	74	PF12436	0.446
LIG_14-3-3_CanoR_1	101	107	PF00244	0.651
LIG_APCC_ABBA_1	75	80	PF00400	0.291
LIG_APCC_ABBAyCdc20_2	74	80	PF00400	0.291
LIG_FHA_2	41	47	PF00498	0.534
LIG_Integrin_isoDGR_2	51	53	PF01839	0.635
LIG_LIR_Apic_2	35	41	PF02991	0.304
LIG_LIR_Nem_3	43	48	PF02991	0.523
LIG_MYND_1	10	14	PF01753	0.293
LIG_Pex14_1	16	20	PF04695	0.318
LIG_SH2_GRB2like	48	51	PF00017	0.527
LIG_SH2_SRC	28	31	PF00017	0.334
LIG_SH2_STAP1	45	49	PF00017	0.403
LIG_SH2_STAT3	5	8	PF00017	0.520
LIG_SH2_STAT5	20	23	PF00017	0.326
LIG_SH2_STAT5	28	31	PF00017	0.292
LIG_SH2_STAT5	5	8	PF00017	0.546
LIG_SH3_3	7	13	PF00018	0.516
MOD_CK2_1	40	46	PF00069	0.527
MOD_GSK3_1	102	109	PF00069	0.635
MOD_GSK3_1	32	39	PF00069	0.366
MOD_GSK3_1	40	47	PF00069	0.532
MOD_GSK3_1	66	73	PF00069	0.534
MOD_PIKK_1	102	108	PF00454	0.602
MOD_Plk_4	44	50	PF00069	0.379
MOD_SUMO_rev_2	19	26	PF00179	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E5	Leptomonas seymouri	83%	98%
A0A0N0P975	Leptomonas seymouri	50%	90%
A0A0S4IT37	Bodo saltans	45%	80%
A0A1X0NLL7	Trypanosomatidae	57%	88%
A0A3R7NZE2	Trypanosoma rangeli	55%	80%
A0A3S7X0B7	Leishmania donovani	96%	76%
A0A3S7X5L3	Leishmania donovani	46%	89%
A4HKG1	Leishmania braziliensis	43%	91%
A4I363	Leishmania infantum	96%	76%
A4I7Y9	Leishmania infantum	46%	89%
C9ZKV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	88%
D0AA56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	83%
E9ACZ0	Leishmania major	94%	100%
E9AYR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B2V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	89%
Q4Q5A6	Leishmania major	48%	100%