RING-CH-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-variant domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFD1_LEIBR

TriTrypDb:

LbrM.27.0130 , LBRM2903_270006500

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 2
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HFD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD1

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	351	353	PF00675	0.372
CLV_PCSK_FUR_1	349	353	PF00082	0.376
CLV_PCSK_KEX2_1	349	351	PF00082	0.371
CLV_PCSK_SKI1_1	190	194	PF00082	0.638
CLV_PCSK_SKI1_1	209	213	PF00082	0.446
CLV_PCSK_SKI1_1	267	271	PF00082	0.341
CLV_PCSK_SKI1_1	322	326	PF00082	0.395
CLV_PCSK_SKI1_1	365	369	PF00082	0.435
CLV_PCSK_SKI1_1	419	423	PF00082	0.284
CLV_PCSK_SKI1_1	487	491	PF00082	0.602
CLV_PCSK_SKI1_1	61	65	PF00082	0.722
DEG_APCC_DBOX_1	266	274	PF00400	0.393
DEG_APCC_DBOX_1	3	11	PF00400	0.389
DOC_CYCLIN_RxL_1	463	475	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.351
DOC_MAPK_MEF2A_6	114	122	PF00069	0.287
DOC_MAPK_MEF2A_6	237	246	PF00069	0.234
DOC_MAPK_MEF2A_6	267	275	PF00069	0.393
DOC_MAPK_MEF2A_6	31	38	PF00069	0.311
DOC_MAPK_MEF2A_6	67	76	PF00069	0.425
DOC_PP1_RVXF_1	485	491	PF00149	0.329
DOC_PP2B_LxvP_1	397	400	PF13499	0.484
DOC_PP2B_LxvP_1	96	99	PF13499	0.347
DOC_USP7_MATH_1	29	33	PF00917	0.346
DOC_USP7_MATH_1	70	74	PF00917	0.384
DOC_USP7_MATH_1	84	88	PF00917	0.419
DOC_WW_Pin1_4	219	224	PF00397	0.252
DOC_WW_Pin1_4	351	356	PF00397	0.615
DOC_WW_Pin1_4	387	392	PF00397	0.433
DOC_WW_Pin1_4	433	438	PF00397	0.503
LIG_14-3-3_CanoR_1	190	195	PF00244	0.422
LIG_14-3-3_CanoR_1	227	233	PF00244	0.359
LIG_14-3-3_CanoR_1	294	304	PF00244	0.565
LIG_14-3-3_CanoR_1	349	355	PF00244	0.591
LIG_14-3-3_CanoR_1	4	8	PF00244	0.433
LIG_14-3-3_CanoR_1	61	70	PF00244	0.363
LIG_Actin_WH2_2	473	489	PF00022	0.341
LIG_AP2alpha_2	315	317	PF02296	0.522
LIG_BRCT_BRCA1_1	17	21	PF00533	0.386
LIG_BRCT_BRCA1_1	405	409	PF00533	0.488
LIG_BRCT_BRCA1_1	546	550	PF00533	0.482
LIG_BRCT_BRCA1_1	563	567	PF00533	0.319
LIG_Clathr_ClatBox_1	548	552	PF01394	0.382
LIG_EH1_1	542	550	PF00400	0.199
LIG_eIF4E_1	206	212	PF01652	0.396
LIG_eIF4E_1	557	563	PF01652	0.284
LIG_FHA_1	168	174	PF00498	0.512
LIG_FHA_1	33	39	PF00498	0.333
LIG_FHA_1	451	457	PF00498	0.613
LIG_FHA_1	50	56	PF00498	0.354
LIG_FHA_1	557	563	PF00498	0.359
LIG_FHA_1	570	576	PF00498	0.419
LIG_FHA_1	582	588	PF00498	0.290
LIG_FHA_2	176	182	PF00498	0.442
LIG_FHA_2	236	242	PF00498	0.348
LIG_FHA_2	352	358	PF00498	0.587
LIG_FHA_2	372	378	PF00498	0.559
LIG_FHA_2	492	498	PF00498	0.341
LIG_GBD_Chelix_1	11	19	PF00786	0.509
LIG_LIR_Apic_2	135	140	PF02991	0.240
LIG_LIR_Apic_2	22	28	PF02991	0.425
LIG_LIR_Gen_1	278	288	PF02991	0.392
LIG_LIR_Gen_1	314	324	PF02991	0.573
LIG_LIR_Gen_1	436	446	PF02991	0.529
LIG_LIR_Gen_1	537	546	PF02991	0.472
LIG_LIR_Gen_1	547	558	PF02991	0.396
LIG_LIR_Gen_1	564	575	PF02991	0.351
LIG_LIR_Gen_1	592	600	PF02991	0.613
LIG_LIR_Gen_1	90	100	PF02991	0.419
LIG_LIR_Nem_3	195	201	PF02991	0.395
LIG_LIR_Nem_3	278	284	PF02991	0.377
LIG_LIR_Nem_3	314	320	PF02991	0.576
LIG_LIR_Nem_3	436	441	PF02991	0.510
LIG_LIR_Nem_3	537	541	PF02991	0.472
LIG_LIR_Nem_3	547	553	PF02991	0.396
LIG_LIR_Nem_3	564	570	PF02991	0.345
LIG_LIR_Nem_3	592	596	PF02991	0.606
LIG_LIR_Nem_3	90	96	PF02991	0.372
LIG_LIR_Nem_3	97	103	PF02991	0.304
LIG_LYPXL_SIV_4	514	522	PF13949	0.341
LIG_Pex14_1	573	577	PF04695	0.325
LIG_Pex14_2	567	571	PF04695	0.466
LIG_Pex14_2	64	68	PF04695	0.318
LIG_PTB_Apo_2	181	188	PF02174	0.329
LIG_PTB_Phospho_1	181	187	PF10480	0.329
LIG_Rb_pABgroove_1	490	498	PF01858	0.331
LIG_REV1ctd_RIR_1	317	326	PF16727	0.527
LIG_SH2_CRK	100	104	PF00017	0.236
LIG_SH2_CRK	438	442	PF00017	0.537
LIG_SH2_NCK_1	25	29	PF00017	0.527
LIG_SH2_SRC	25	28	PF00017	0.433
LIG_SH2_STAP1	128	132	PF00017	0.356
LIG_SH2_STAP1	194	198	PF00017	0.417
LIG_SH2_STAP1	206	210	PF00017	0.333
LIG_SH2_STAP1	334	338	PF00017	0.558
LIG_SH2_STAP1	557	561	PF00017	0.385
LIG_SH2_STAT5	100	103	PF00017	0.298
LIG_SH2_STAT5	119	122	PF00017	0.240
LIG_SH2_STAT5	187	190	PF00017	0.408
LIG_SH2_STAT5	194	197	PF00017	0.383
LIG_SH2_STAT5	206	209	PF00017	0.247
LIG_SH2_STAT5	218	221	PF00017	0.376
LIG_SH2_STAT5	337	340	PF00017	0.668
LIG_SH2_STAT5	438	441	PF00017	0.529
LIG_SH2_STAT5	484	487	PF00017	0.273
LIG_SH2_STAT5	515	518	PF00017	0.312
LIG_SH2_STAT5	569	572	PF00017	0.364
LIG_SH3_3	159	165	PF00018	0.370
LIG_SH3_3	298	304	PF00018	0.749
LIG_SH3_3	440	446	PF00018	0.559
LIG_SUMO_SIM_anti_2	238	244	PF11976	0.283
LIG_SUMO_SIM_par_1	13	18	PF11976	0.532
LIG_SUMO_SIM_par_1	241	247	PF11976	0.271
LIG_SUMO_SIM_par_1	269	274	PF11976	0.341
LIG_SUMO_SIM_par_1	34	40	PF11976	0.396
LIG_SUMO_SIM_par_1	559	566	PF11976	0.358
LIG_TRAF2_1	149	152	PF00917	0.253
LIG_TRAF2_1	376	379	PF00917	0.705
LIG_TYR_ITIM	98	103	PF00017	0.319
LIG_TYR_ITSM	434	441	PF00017	0.510
LIG_UBA3_1	211	216	PF00899	0.398
LIG_WRC_WIRS_1	276	281	PF05994	0.306
LIG_WRC_WIRS_1	372	377	PF05994	0.558
LIG_WRC_WIRS_1	590	595	PF05994	0.594
MOD_CDK_SPxxK_3	387	394	PF00069	0.386
MOD_CK1_1	175	181	PF00069	0.335
MOD_CK1_1	204	210	PF00069	0.361
MOD_CK1_1	32	38	PF00069	0.370
MOD_CK1_1	373	379	PF00069	0.664
MOD_CK1_1	50	56	PF00069	0.294
MOD_CK1_1	556	562	PF00069	0.329
MOD_CK1_1	594	600	PF00069	0.542
MOD_CK1_1	62	68	PF00069	0.368
MOD_CK1_1	75	81	PF00069	0.394
MOD_CK1_1	87	93	PF00069	0.304
MOD_CK2_1	194	200	PF00069	0.416
MOD_CK2_1	371	377	PF00069	0.695
MOD_CK2_1	522	528	PF00069	0.341
MOD_CK2_1	599	605	PF00069	0.591
MOD_CK2_1	63	69	PF00069	0.478
MOD_GlcNHglycan	104	107	PF01048	0.595
MOD_GlcNHglycan	108	111	PF01048	0.536
MOD_GlcNHglycan	143	146	PF01048	0.522
MOD_GlcNHglycan	174	178	PF01048	0.593
MOD_GlcNHglycan	377	383	PF01048	0.399
MOD_GlcNHglycan	459	462	PF01048	0.377
MOD_GlcNHglycan	49	52	PF01048	0.532
MOD_GlcNHglycan	559	562	PF01048	0.619
MOD_GSK3_1	102	109	PF00069	0.349
MOD_GSK3_1	15	22	PF00069	0.523
MOD_GSK3_1	186	193	PF00069	0.368
MOD_GSK3_1	244	251	PF00069	0.369
MOD_GSK3_1	271	278	PF00069	0.418
MOD_GSK3_1	41	48	PF00069	0.329
MOD_GSK3_1	491	498	PF00069	0.370
MOD_GSK3_1	50	57	PF00069	0.379
MOD_GSK3_1	553	560	PF00069	0.510
MOD_GSK3_1	569	576	PF00069	0.316
MOD_GSK3_1	59	66	PF00069	0.353
MOD_LATS_1	125	131	PF00433	0.269
MOD_LATS_1	225	231	PF00433	0.248
MOD_N-GLC_1	157	162	PF02516	0.532
MOD_N-GLC_1	370	375	PF02516	0.417
MOD_N-GLC_1	403	408	PF02516	0.383
MOD_N-GLC_1	41	46	PF02516	0.559
MOD_N-GLC_1	522	527	PF02516	0.341
MOD_N-GLC_1	594	599	PF02516	0.302
MOD_N-GLC_2	184	186	PF02516	0.518
MOD_N-GLC_2	43	45	PF02516	0.464
MOD_NEK2_1	143	148	PF00069	0.392
MOD_NEK2_1	19	24	PF00069	0.515
MOD_NEK2_1	228	233	PF00069	0.299
MOD_NEK2_1	244	249	PF00069	0.309
MOD_NEK2_1	271	276	PF00069	0.389
MOD_NEK2_1	370	375	PF00069	0.694
MOD_NEK2_1	46	51	PF00069	0.359
MOD_NEK2_1	472	477	PF00069	0.489
MOD_NEK2_1	490	495	PF00069	0.292
MOD_NEK2_1	522	527	PF00069	0.409
MOD_NEK2_1	581	586	PF00069	0.276
MOD_NEK2_1	589	594	PF00069	0.525
MOD_NEK2_1	63	68	PF00069	0.381
MOD_NEK2_2	59	64	PF00069	0.425
MOD_NEK2_2	77	82	PF00069	0.234
MOD_PIKK_1	201	207	PF00454	0.350
MOD_PKA_1	350	356	PF00069	0.563
MOD_PKA_2	228	234	PF00069	0.311
MOD_PKA_2	295	301	PF00069	0.562
MOD_PKA_2	3	9	PF00069	0.515
MOD_PKA_2	350	356	PF00069	0.645
MOD_PKB_1	417	425	PF00069	0.438
MOD_Plk_1	365	371	PF00069	0.654
MOD_Plk_1	41	47	PF00069	0.358
MOD_Plk_1	522	528	PF00069	0.449
MOD_Plk_1	573	579	PF00069	0.259
MOD_Plk_1	84	90	PF00069	0.393
MOD_Plk_2-3	235	241	PF00069	0.343
MOD_Plk_2-3	601	607	PF00069	0.609
MOD_Plk_4	271	277	PF00069	0.360
MOD_Plk_4	302	308	PF00069	0.646
MOD_Plk_4	436	442	PF00069	0.559
MOD_Plk_4	452	458	PF00069	0.617
MOD_Plk_4	491	497	PF00069	0.478
MOD_Plk_4	522	528	PF00069	0.360
MOD_Plk_4	534	540	PF00069	0.606
MOD_Plk_4	544	550	PF00069	0.306
MOD_Plk_4	77	83	PF00069	0.459
MOD_ProDKin_1	219	225	PF00069	0.252
MOD_ProDKin_1	351	357	PF00069	0.614
MOD_ProDKin_1	387	393	PF00069	0.433
MOD_ProDKin_1	433	439	PF00069	0.507
MOD_SUMO_rev_2	151	155	PF00179	0.276
TRG_ENDOCYTIC_2	100	103	PF00928	0.323
TRG_ENDOCYTIC_2	119	122	PF00928	0.293
TRG_ENDOCYTIC_2	198	201	PF00928	0.424
TRG_ENDOCYTIC_2	438	441	PF00928	0.512
TRG_ENDOCYTIC_2	508	511	PF00928	0.276
TRG_ENDOCYTIC_2	515	518	PF00928	0.276
TRG_ER_diArg_1	226	229	PF00400	0.388
TRG_ER_diArg_1	293	296	PF00400	0.638
TRG_ER_diArg_1	348	351	PF00400	0.614
TRG_NES_CRM1_1	540	552	PF08389	0.342
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS2	Leptomonas seymouri	53%	97%
A0A3Q8IHD5	Leishmania donovani	75%	98%
A0A3R7MRQ1	Trypanosoma rangeli	32%	95%
A4I364	Leishmania infantum	75%	98%
C9ZKV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	85%
E9ACY9	Leishmania major	74%	100%
E9AYR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
V5BGA4	Trypanosoma cruzi	33%	91%