LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HFC9_LEIBR
TriTrypDb:
LbrM.27.0110 , LBRM2903_270006300
Length:
659

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HFC9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFC9

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 5
GO:0004707 MAP kinase activity 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 374 378 PF00656 0.596
CLV_C14_Caspase3-7 81 85 PF00656 0.311
CLV_NRD_NRD_1 147 149 PF00675 0.333
CLV_NRD_NRD_1 366 368 PF00675 0.632
CLV_NRD_NRD_1 512 514 PF00675 0.685
CLV_NRD_NRD_1 55 57 PF00675 0.333
CLV_NRD_NRD_1 592 594 PF00675 0.649
CLV_NRD_NRD_1 617 619 PF00675 0.651
CLV_PCSK_KEX2_1 132 134 PF00082 0.333
CLV_PCSK_KEX2_1 326 328 PF00082 0.546
CLV_PCSK_KEX2_1 436 438 PF00082 0.647
CLV_PCSK_KEX2_1 512 514 PF00082 0.641
CLV_PCSK_KEX2_1 532 534 PF00082 0.434
CLV_PCSK_KEX2_1 55 57 PF00082 0.283
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.333
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.546
CLV_PCSK_PC1ET2_1 436 438 PF00082 0.647
CLV_PCSK_PC1ET2_1 532 534 PF00082 0.504
CLV_PCSK_SKI1_1 121 125 PF00082 0.379
CLV_PCSK_SKI1_1 138 142 PF00082 0.422
CLV_PCSK_SKI1_1 215 219 PF00082 0.387
CLV_PCSK_SKI1_1 247 251 PF00082 0.333
CLV_PCSK_SKI1_1 281 285 PF00082 0.373
CLV_PCSK_SKI1_1 326 330 PF00082 0.560
CLV_PCSK_SKI1_1 33 37 PF00082 0.408
CLV_PCSK_SKI1_1 436 440 PF00082 0.640
CLV_PCSK_SKI1_1 455 459 PF00082 0.518
CLV_PCSK_SKI1_1 645 649 PF00082 0.575
CLV_PCSK_SKI1_1 92 96 PF00082 0.333
DEG_APCC_DBOX_1 120 128 PF00400 0.333
DEG_Nend_UBRbox_2 1 3 PF02207 0.418
DEG_SPOP_SBC_1 388 392 PF00917 0.624
DEG_SPOP_SBC_1 519 523 PF00917 0.670
DOC_AGCK_PIF_2 77 82 PF00069 0.333
DOC_CYCLIN_RxL_1 212 221 PF00134 0.333
DOC_CYCLIN_RxL_1 433 442 PF00134 0.512
DOC_CYCLIN_yClb1_LxF_4 73 79 PF00134 0.333
DOC_CYCLIN_yCln2_LP_2 464 470 PF00134 0.483
DOC_MAPK_gen_1 138 147 PF00069 0.387
DOC_MAPK_gen_1 181 190 PF00069 0.387
DOC_MAPK_gen_1 24 32 PF00069 0.387
DOC_MAPK_gen_1 491 500 PF00069 0.504
DOC_MAPK_gen_1 650 658 PF00069 0.593
DOC_MAPK_HePTP_8 178 190 PF00069 0.387
DOC_MAPK_JIP1_4 141 147 PF00069 0.387
DOC_MAPK_MEF2A_6 181 190 PF00069 0.387
DOC_PP2B_LxvP_1 464 467 PF13499 0.476
DOC_USP7_MATH_1 100 104 PF00917 0.202
DOC_USP7_MATH_1 353 357 PF00917 0.630
DOC_USP7_MATH_1 425 429 PF00917 0.764
DOC_USP7_MATH_1 443 447 PF00917 0.636
DOC_USP7_MATH_1 471 475 PF00917 0.685
DOC_USP7_MATH_1 492 496 PF00917 0.594
DOC_USP7_MATH_1 560 564 PF00917 0.521
DOC_USP7_MATH_1 592 596 PF00917 0.516
DOC_USP7_UBL2_3 20 24 PF12436 0.333
DOC_USP7_UBL2_3 34 38 PF12436 0.333
DOC_WW_Pin1_4 233 238 PF00397 0.438
DOC_WW_Pin1_4 338 343 PF00397 0.621
DOC_WW_Pin1_4 362 367 PF00397 0.604
DOC_WW_Pin1_4 389 394 PF00397 0.709
DOC_WW_Pin1_4 401 406 PF00397 0.665
DOC_WW_Pin1_4 410 415 PF00397 0.598
DOC_WW_Pin1_4 475 480 PF00397 0.700
DOC_WW_Pin1_4 505 510 PF00397 0.798
DOC_WW_Pin1_4 520 525 PF00397 0.538
DOC_WW_Pin1_4 633 638 PF00397 0.653
LIG_14-3-3_CanoR_1 253 257 PF00244 0.362
LIG_14-3-3_CanoR_1 291 298 PF00244 0.479
LIG_14-3-3_CanoR_1 354 361 PF00244 0.613
LIG_14-3-3_CanoR_1 493 498 PF00244 0.504
LIG_eIF4E_1 183 189 PF01652 0.333
LIG_eIF4E_1 82 88 PF01652 0.333
LIG_FHA_1 173 179 PF00498 0.387
LIG_FHA_1 219 225 PF00498 0.398
LIG_FHA_1 236 242 PF00498 0.214
LIG_FHA_1 24 30 PF00498 0.333
LIG_FHA_1 610 616 PF00498 0.660
LIG_FHA_2 149 155 PF00498 0.202
LIG_FHA_2 372 378 PF00498 0.596
LIG_FHA_2 39 45 PF00498 0.372
LIG_LIR_Apic_2 180 186 PF02991 0.387
LIG_LIR_Gen_1 2 10 PF02991 0.333
LIG_LIR_Nem_3 12 18 PF02991 0.339
LIG_LIR_Nem_3 161 165 PF02991 0.333
LIG_LIR_Nem_3 2 7 PF02991 0.333
LIG_LIR_Nem_3 255 259 PF02991 0.362
LIG_LIR_Nem_3 381 385 PF02991 0.522
LIG_LIR_Nem_3 75 80 PF02991 0.387
LIG_LYPXL_yS_3 113 116 PF13949 0.333
LIG_NRBOX 643 649 PF00104 0.579
LIG_PTB_Apo_2 585 592 PF02174 0.635
LIG_PTB_Apo_2 597 604 PF02174 0.536
LIG_PTB_Phospho_1 585 591 PF10480 0.637
LIG_REV1ctd_RIR_1 300 308 PF16727 0.330
LIG_SH2_CRK 254 258 PF00017 0.321
LIG_SH2_NCK_1 468 472 PF00017 0.704
LIG_SH2_STAP1 4 8 PF00017 0.372
LIG_SH2_STAP1 468 472 PF00017 0.497
LIG_SH2_STAT3 119 122 PF00017 0.333
LIG_SH2_STAT5 129 132 PF00017 0.499
LIG_SH2_STAT5 135 138 PF00017 0.381
LIG_SH2_STAT5 177 180 PF00017 0.387
LIG_SH2_STAT5 254 257 PF00017 0.333
LIG_SH2_STAT5 40 43 PF00017 0.333
LIG_SH2_STAT5 468 471 PF00017 0.496
LIG_SH3_3 106 112 PF00018 0.333
LIG_SH3_3 282 288 PF00018 0.333
LIG_SH3_3 377 383 PF00018 0.631
LIG_SH3_3 43 49 PF00018 0.333
LIG_SH3_3 484 490 PF00018 0.515
LIG_SH3_5 173 177 PF00018 0.333
LIG_SUMO_SIM_anti_2 319 325 PF11976 0.510
LIG_SUMO_SIM_anti_2 50 55 PF11976 0.333
LIG_SUMO_SIM_anti_2 86 92 PF11976 0.202
LIG_TRAF2_1 237 240 PF00917 0.333
LIG_TRAF2_1 41 44 PF00917 0.333
LIG_TYR_ITIM 111 116 PF00017 0.369
LIG_UBA3_1 123 132 PF00899 0.379
LIG_UBA3_1 87 95 PF00899 0.369
MOD_CDC14_SPxK_1 365 368 PF00782 0.464
MOD_CDC14_SPxK_1 404 407 PF00782 0.624
MOD_CDK_SPK_2 362 367 PF00069 0.618
MOD_CDK_SPK_2 633 638 PF00069 0.515
MOD_CDK_SPxK_1 362 368 PF00069 0.481
MOD_CDK_SPxK_1 401 407 PF00069 0.626
MOD_CDK_SPxxK_3 505 512 PF00069 0.531
MOD_CK1_1 103 109 PF00069 0.278
MOD_CK1_1 23 29 PF00069 0.333
MOD_CK1_1 362 368 PF00069 0.686
MOD_CK1_1 378 384 PF00069 0.569
MOD_CK1_1 392 398 PF00069 0.632
MOD_CK1_1 428 434 PF00069 0.688
MOD_CK1_1 546 552 PF00069 0.580
MOD_CK1_1 570 576 PF00069 0.579
MOD_CK2_1 233 239 PF00069 0.450
MOD_CK2_1 303 309 PF00069 0.425
MOD_CK2_1 38 44 PF00069 0.372
MOD_Cter_Amidation 434 437 PF01082 0.654
MOD_GlcNHglycan 100 103 PF01048 0.475
MOD_GlcNHglycan 105 108 PF01048 0.298
MOD_GlcNHglycan 150 154 PF01048 0.337
MOD_GlcNHglycan 261 264 PF01048 0.377
MOD_GlcNHglycan 314 317 PF01048 0.548
MOD_GlcNHglycan 361 364 PF01048 0.566
MOD_GlcNHglycan 377 380 PF01048 0.462
MOD_GlcNHglycan 473 476 PF01048 0.732
MOD_GlcNHglycan 479 482 PF01048 0.631
MOD_GlcNHglycan 487 490 PF01048 0.621
MOD_GlcNHglycan 527 530 PF01048 0.658
MOD_GlcNHglycan 562 565 PF01048 0.609
MOD_GlcNHglycan 574 577 PF01048 0.517
MOD_GlcNHglycan 653 656 PF01048 0.462
MOD_GSK3_1 172 179 PF00069 0.317
MOD_GSK3_1 229 236 PF00069 0.471
MOD_GSK3_1 353 360 PF00069 0.621
MOD_GSK3_1 371 378 PF00069 0.748
MOD_GSK3_1 388 395 PF00069 0.610
MOD_GSK3_1 397 404 PF00069 0.792
MOD_GSK3_1 439 446 PF00069 0.647
MOD_GSK3_1 462 469 PF00069 0.724
MOD_GSK3_1 471 478 PF00069 0.700
MOD_GSK3_1 518 525 PF00069 0.674
MOD_GSK3_1 592 599 PF00069 0.571
MOD_GSK3_1 629 636 PF00069 0.559
MOD_N-GLC_1 567 572 PF02516 0.522
MOD_N-GLC_1 586 591 PF02516 0.692
MOD_NEK2_1 361 366 PF00069 0.644
MOD_NEK2_1 375 380 PF00069 0.487
MOD_NEK2_1 439 444 PF00069 0.555
MOD_NEK2_1 485 490 PF00069 0.633
MOD_NEK2_1 586 591 PF00069 0.642
MOD_NEK2_1 603 608 PF00069 0.526
MOD_PIKK_1 570 576 PF00454 0.645
MOD_PK_1 229 235 PF00069 0.333
MOD_PKA_1 148 154 PF00069 0.202
MOD_PKA_2 103 109 PF00069 0.202
MOD_PKA_2 252 258 PF00069 0.362
MOD_PKA_2 290 296 PF00069 0.387
MOD_PKA_2 353 359 PF00069 0.656
MOD_PKA_2 425 431 PF00069 0.671
MOD_PKA_2 492 498 PF00069 0.617
MOD_PKA_2 503 509 PF00069 0.558
MOD_PKA_2 592 598 PF00069 0.647
MOD_PKA_2 609 615 PF00069 0.650
MOD_Plk_1 357 363 PF00069 0.607
MOD_Plk_1 546 552 PF00069 0.650
MOD_Plk_1 586 592 PF00069 0.720
MOD_Plk_4 229 235 PF00069 0.321
MOD_Plk_4 493 499 PF00069 0.516
MOD_Plk_4 581 587 PF00069 0.600
MOD_Plk_4 86 92 PF00069 0.202
MOD_ProDKin_1 233 239 PF00069 0.438
MOD_ProDKin_1 338 344 PF00069 0.619
MOD_ProDKin_1 362 368 PF00069 0.606
MOD_ProDKin_1 389 395 PF00069 0.711
MOD_ProDKin_1 401 407 PF00069 0.667
MOD_ProDKin_1 410 416 PF00069 0.596
MOD_ProDKin_1 475 481 PF00069 0.703
MOD_ProDKin_1 505 511 PF00069 0.803
MOD_ProDKin_1 520 526 PF00069 0.538
MOD_ProDKin_1 633 639 PF00069 0.649
MOD_SUMO_for_1 140 143 PF00179 0.333
MOD_SUMO_for_1 531 534 PF00179 0.618
TRG_DiLeu_BaEn_4 43 49 PF01217 0.333
TRG_DiLeu_BaLyEn_6 106 111 PF01217 0.333
TRG_DiLeu_BaLyEn_6 434 439 PF01217 0.515
TRG_ENDOCYTIC_2 113 116 PF00928 0.369
TRG_ENDOCYTIC_2 4 7 PF00928 0.362
TRG_ER_diArg_1 168 171 PF00400 0.278
TRG_ER_diArg_1 511 513 PF00400 0.651
TRG_ER_diArg_1 54 56 PF00400 0.333
TRG_NES_CRM1_1 296 309 PF08389 0.333
TRG_NLS_MonoExtN_4 247 254 PF00514 0.333
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 437 441 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4E3 Leptomonas seymouri 55% 98%
A0A3Q8IE25 Leishmania donovani 82% 100%
A0A3Q8IND3 Leishmania donovani 27% 100%
A0A3Q8IVR8 Leishmania donovani 34% 100%
A0A3S5H5U5 Leishmania donovani 24% 100%
A0A3S5H6C8 Leishmania donovani 27% 100%
A0A3S7WQK7 Leishmania donovani 27% 100%
A0A3S7X8Z8 Leishmania donovani 23% 100%
A4H4S9 Leishmania braziliensis 26% 100%
A4H5L7 Leishmania braziliensis 26% 100%
A4H7W1 Leishmania braziliensis 25% 100%
A4H9U7 Leishmania braziliensis 26% 100%
A4HEA1 Leishmania braziliensis 24% 100%
A4HFF3 Leishmania braziliensis 25% 100%
A4HNT2 Leishmania braziliensis 35% 100%
A4HNU6 Leishmania braziliensis 26% 100%
A4HTV4 Leishmania infantum 27% 100%
A4HTV5 Leishmania infantum 27% 100%
A4I2K6 Leishmania infantum 82% 100%
A4IB02 Leishmania infantum 23% 100%
A4ICP8 Leishmania infantum 27% 100%
A4ICR2 Leishmania infantum 34% 100%
E9ACY7 Leishmania major 82% 100%
E9AET0 Leishmania major 24% 100%
E9AG71 Leishmania infantum 24% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AYR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q4Q1Z0 Leishmania major 28% 100%
Q4QIV8 Leishmania major 24% 100%
Q4R7T5 Macaca fascicularis 31% 100%
Q5R754 Pongo abelii 32% 100%
Q92772 Homo sapiens 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS