Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFC7_LEIBR

TriTrypDb:

LbrM.27.0090 , LBRM2903_270006100

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.430
CLV_C14_Caspase3-7	70	74	PF00656	0.498
CLV_NRD_NRD_1	20	22	PF00675	0.471
CLV_NRD_NRD_1	262	264	PF00675	0.525
CLV_NRD_NRD_1	275	277	PF00675	0.493
CLV_NRD_NRD_1	284	286	PF00675	0.498
CLV_NRD_NRD_1	288	290	PF00675	0.512
CLV_NRD_NRD_1	64	66	PF00675	0.552
CLV_PCSK_KEX2_1	262	264	PF00082	0.537
CLV_PCSK_KEX2_1	274	276	PF00082	0.410
CLV_PCSK_KEX2_1	284	286	PF00082	0.486
CLV_PCSK_KEX2_1	340	342	PF00082	0.440
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.591
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.440
CLV_PCSK_SKI1_1	224	228	PF00082	0.378
CLV_PCSK_SKI1_1	30	34	PF00082	0.343
DEG_APCC_DBOX_1	135	143	PF00400	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.566
DEG_SCF_FBW7_1	109	114	PF00400	0.438
DEG_SPOP_SBC_1	143	147	PF00917	0.541
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.406
DOC_MAPK_DCC_7	134	144	PF00069	0.477
DOC_MAPK_gen_1	136	144	PF00069	0.485
DOC_MAPK_gen_1	21	29	PF00069	0.399
DOC_MAPK_gen_1	289	295	PF00069	0.512
DOC_MAPK_MEF2A_6	136	144	PF00069	0.496
DOC_MAPK_MEF2A_6	177	184	PF00069	0.246
DOC_PP4_FxxP_1	87	90	PF00568	0.453
DOC_USP7_MATH_1	143	147	PF00917	0.603
DOC_USP7_MATH_1	247	251	PF00917	0.377
DOC_WW_Pin1_4	1	6	PF00397	0.433
DOC_WW_Pin1_4	105	110	PF00397	0.643
DOC_WW_Pin1_4	147	152	PF00397	0.463
DOC_WW_Pin1_4	212	217	PF00397	0.434
DOC_WW_Pin1_4	51	56	PF00397	0.581
DOC_WW_Pin1_4	71	76	PF00397	0.464
LIG_14-3-3_CanoR_1	165	169	PF00244	0.367
LIG_14-3-3_CanoR_1	230	238	PF00244	0.460
LIG_14-3-3_CanoR_1	284	292	PF00244	0.584
LIG_14-3-3_CanoR_1	341	347	PF00244	0.617
LIG_BRCT_BRCA1_1	87	91	PF00533	0.455
LIG_Clathr_ClatBox_1	179	183	PF01394	0.282
LIG_eIF4E_1	193	199	PF01652	0.359
LIG_FHA_1	108	114	PF00498	0.368
LIG_FHA_1	115	121	PF00498	0.402
LIG_FHA_1	96	102	PF00498	0.404
LIG_FHA_2	201	207	PF00498	0.347
LIG_GBD_Chelix_1	11	19	PF00786	0.280
LIG_IBAR_NPY_1	281	283	PF08397	0.530
LIG_LIR_Apic_2	169	174	PF02991	0.443
LIG_LIR_Gen_1	98	105	PF02991	0.380
LIG_LIR_Nem_3	166	171	PF02991	0.341
LIG_LIR_Nem_3	327	333	PF02991	0.516
LIG_LIR_Nem_3	98	103	PF02991	0.359
LIG_NRBOX	15	21	PF00104	0.460
LIG_Pex14_2	87	91	PF04695	0.455
LIG_SH2_CRK	171	175	PF00017	0.389
LIG_SH2_CRK	344	348	PF00017	0.511
LIG_SH2_STAT5	171	174	PF00017	0.438
LIG_SH2_STAT5	193	196	PF00017	0.460
LIG_SH3_3	106	112	PF00018	0.569
LIG_SH3_3	115	121	PF00018	0.498
LIG_SH3_3	179	185	PF00018	0.312
LIG_SH3_3	210	216	PF00018	0.492
LIG_SH3_3	22	28	PF00018	0.375
LIG_SH3_3	66	72	PF00018	0.659
LIG_SUMO_SIM_anti_2	150	156	PF11976	0.468
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.321
LIG_SUMO_SIM_anti_2	208	215	PF11976	0.337
LIG_SUMO_SIM_par_1	150	156	PF11976	0.529
LIG_SUMO_SIM_par_1	208	215	PF11976	0.398
LIG_UBA3_1	14	23	PF00899	0.356
MOD_CDK_SPK_2	71	76	PF00069	0.575
MOD_CK1_1	114	120	PF00069	0.365
MOD_CK1_1	147	153	PF00069	0.623
MOD_CK1_1	215	221	PF00069	0.282
MOD_CK2_1	163	169	PF00069	0.482
MOD_CK2_1	200	206	PF00069	0.405
MOD_Cter_Amidation	272	275	PF01082	0.514
MOD_DYRK1A_RPxSP_1	107	111	PF00069	0.439
MOD_GlcNHglycan	219	222	PF01048	0.433
MOD_GlcNHglycan	249	252	PF01048	0.377
MOD_GlcNHglycan	306	309	PF01048	0.541
MOD_GSK3_1	10	17	PF00069	0.352
MOD_GSK3_1	101	108	PF00069	0.581
MOD_GSK3_1	138	145	PF00069	0.604
MOD_GSK3_1	159	166	PF00069	0.515
MOD_GSK3_1	247	254	PF00069	0.344
MOD_GSK3_1	57	64	PF00069	0.572
MOD_GSK3_1	67	74	PF00069	0.599
MOD_NEK2_1	14	19	PF00069	0.451
MOD_NEK2_1	142	147	PF00069	0.582
MOD_NEK2_1	231	236	PF00069	0.350
MOD_NEK2_1	291	296	PF00069	0.609
MOD_NEK2_1	304	309	PF00069	0.555
MOD_NEK2_1	33	38	PF00069	0.398
MOD_NEK2_2	57	62	PF00069	0.644
MOD_PIKK_1	231	237	PF00454	0.287
MOD_PIKK_1	302	308	PF00454	0.406
MOD_PIKK_1	34	40	PF00454	0.352
MOD_PIKK_1	67	73	PF00454	0.557
MOD_PIKK_1	95	101	PF00454	0.417
MOD_PKA_2	159	165	PF00069	0.396
MOD_PKA_2	283	289	PF00069	0.494
MOD_PKB_1	136	144	PF00069	0.574
MOD_Plk_1	114	120	PF00069	0.330
MOD_Plk_1	160	166	PF00069	0.537
MOD_Plk_1	186	192	PF00069	0.387
MOD_Plk_4	10	16	PF00069	0.458
MOD_Plk_4	200	206	PF00069	0.375
MOD_ProDKin_1	1	7	PF00069	0.424
MOD_ProDKin_1	105	111	PF00069	0.634
MOD_ProDKin_1	147	153	PF00069	0.459
MOD_ProDKin_1	212	218	PF00069	0.443
MOD_ProDKin_1	51	57	PF00069	0.588
MOD_ProDKin_1	71	77	PF00069	0.465
MOD_SUMO_rev_2	286	292	PF00179	0.485
TRG_DiLeu_BaEn_2	286	292	PF01217	0.511
TRG_ER_diArg_1	261	263	PF00400	0.493
TRG_ER_diArg_1	275	278	PF00400	0.495
TRG_ER_diArg_1	283	285	PF00400	0.530
TRG_NLS_Bipartite_1	262	278	PF00514	0.600
TRG_NLS_MonoExtC_3	273	278	PF00514	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUP8	Leptomonas seymouri	47%	100%
A0A1X0NLR8	Trypanosomatidae	25%	91%
A0A422N4S9	Trypanosoma rangeli	27%	91%
E9AYR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%