Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFC6_LEIBR

TriTrypDb:

LbrM.27.0080 , LBRM2903_270006000

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HFC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.583
CLV_NRD_NRD_1	210	212	PF00675	0.680
CLV_NRD_NRD_1	241	243	PF00675	0.580
CLV_PCSK_KEX2_1	115	117	PF00082	0.583
CLV_PCSK_KEX2_1	162	164	PF00082	0.583
CLV_PCSK_KEX2_1	205	207	PF00082	0.613
CLV_PCSK_KEX2_1	209	211	PF00082	0.659
CLV_PCSK_KEX2_1	241	243	PF00082	0.580
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.583
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.659
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.700
CLV_PCSK_PC7_1	206	212	PF00082	0.684
CLV_PCSK_SKI1_1	185	189	PF00082	0.662
CLV_PCSK_SKI1_1	276	280	PF00082	0.560
DEG_APCC_DBOX_1	45	53	PF00400	0.280
DOC_CDC14_PxL_1	44	52	PF14671	0.285
DOC_CYCLIN_RxL_1	18	28	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.399
DOC_MAPK_gen_1	167	177	PF00069	0.380
DOC_PP2B_LxvP_1	157	160	PF13499	0.432
DOC_PP2B_LxvP_1	23	26	PF13499	0.412
DOC_USP7_MATH_1	220	224	PF00917	0.483
DOC_USP7_UBL2_3	205	209	PF12436	0.540
DOC_USP7_UBL2_3	94	98	PF12436	0.308
LIG_14-3-3_CanoR_1	211	217	PF00244	0.570
LIG_14-3-3_CanoR_1	241	249	PF00244	0.499
LIG_14-3-3_CanoR_1	252	259	PF00244	0.375
LIG_14-3-3_CanoR_1	267	273	PF00244	0.549
LIG_14-3-3_CanoR_1	76	83	PF00244	0.498
LIG_14-3-3_CterR_2	276	280	PF00244	0.573
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BRCT_BRCA1_1	255	259	PF00533	0.306
LIG_BRCT_BRCA1_1	3	7	PF00533	0.556
LIG_EH1_1	175	183	PF00400	0.354
LIG_EH1_1	6	14	PF00400	0.427
LIG_eIF4E_1	253	259	PF01652	0.362
LIG_FHA_1	149	155	PF00498	0.488
LIG_FHA_1	182	188	PF00498	0.452
LIG_FHA_1	253	259	PF00498	0.439
LIG_FHA_1	263	269	PF00498	0.405
LIG_FHA_1	56	62	PF00498	0.413
LIG_FHA_2	17	23	PF00498	0.587
LIG_LIR_Gen_1	256	266	PF02991	0.428
LIG_LIR_Gen_1	4	13	PF02991	0.423
LIG_LIR_Nem_3	130	134	PF02991	0.310
LIG_LIR_Nem_3	256	262	PF02991	0.440
LIG_LIR_Nem_3	265	269	PF02991	0.479
LIG_LIR_Nem_3	4	8	PF02991	0.513
LIG_Pex14_1	249	253	PF04695	0.503
LIG_Pex14_2	259	263	PF04695	0.519
LIG_REV1ctd_RIR_1	270	280	PF16727	0.546
LIG_SH2_CRK	131	135	PF00017	0.414
LIG_SH2_CRK	254	258	PF00017	0.453
LIG_SH2_CRK	266	270	PF00017	0.379
LIG_SH2_GRB2like	30	33	PF00017	0.351
LIG_SH2_NCK_1	30	34	PF00017	0.431
LIG_SH2_SRC	30	33	PF00017	0.416
LIG_SH2_STAP1	254	258	PF00017	0.334
LIG_SH2_STAP1	30	34	PF00017	0.431
LIG_SH2_STAT5	110	113	PF00017	0.442
LIG_SH2_STAT5	176	179	PF00017	0.316
LIG_SH2_STAT5	254	257	PF00017	0.428
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.635
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.417
LIG_SUMO_SIM_par_1	10	16	PF11976	0.539
LIG_TRAF2_1	63	66	PF00917	0.322
LIG_TYR_ITIM	264	269	PF00017	0.306
LIG_UBA3_1	49	56	PF00899	0.282
LIG_WRC_WIRS_1	269	274	PF05994	0.593
LIG_WRC_WIRS_1	52	57	PF05994	0.295
MOD_CK1_1	139	145	PF00069	0.534
MOD_CK1_1	148	154	PF00069	0.467
MOD_CK1_1	271	277	PF00069	0.630
MOD_CK1_1	75	81	PF00069	0.483
MOD_CK2_1	135	141	PF00069	0.367
MOD_CK2_1	143	149	PF00069	0.405
MOD_CK2_1	16	22	PF00069	0.610
MOD_GlcNHglycan	131	134	PF01048	0.689
MOD_GlcNHglycan	218	221	PF01048	0.696
MOD_GlcNHglycan	273	276	PF01048	0.477
MOD_GlcNHglycan	85	88	PF01048	0.553
MOD_GSK3_1	123	130	PF00069	0.383
MOD_GSK3_1	135	142	PF00069	0.429
MOD_GSK3_1	212	219	PF00069	0.546
MOD_GSK3_1	258	265	PF00069	0.446
MOD_GSK3_1	51	58	PF00069	0.336
MOD_GSK3_1	72	79	PF00069	0.443
MOD_N-GLC_1	56	61	PF02516	0.624
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_1	111	116	PF00069	0.477
MOD_NEK2_1	123	128	PF00069	0.411
MOD_NEK2_1	161	166	PF00069	0.388
MOD_NEK2_1	171	176	PF00069	0.302
MOD_NEK2_1	216	221	PF00069	0.566
MOD_NEK2_1	258	263	PF00069	0.509
MOD_NEK2_1	55	60	PF00069	0.399
MOD_NEK2_1	7	12	PF00069	0.541
MOD_NEK2_1	72	77	PF00069	0.436
MOD_NEK2_1	83	88	PF00069	0.462
MOD_NEK2_2	233	238	PF00069	0.433
MOD_NEK2_2	51	56	PF00069	0.403
MOD_PIKK_1	103	109	PF00454	0.461
MOD_PKA_1	204	210	PF00069	0.452
MOD_PKA_2	136	142	PF00069	0.475
MOD_PKA_2	240	246	PF00069	0.455
MOD_PKA_2	72	78	PF00069	0.437
MOD_Plk_1	148	154	PF00069	0.459
MOD_Plk_1	35	41	PF00069	0.429
MOD_Plk_1	56	62	PF00069	0.452
MOD_Plk_4	123	129	PF00069	0.466
MOD_Plk_4	171	177	PF00069	0.306
MOD_Plk_4	253	259	PF00069	0.405
MOD_Plk_4	268	274	PF00069	0.519
MOD_Plk_4	7	13	PF00069	0.660
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.427
TRG_ENDOCYTIC_2	131	134	PF00928	0.393
TRG_ENDOCYTIC_2	254	257	PF00928	0.453
TRG_ENDOCYTIC_2	266	269	PF00928	0.379
TRG_ER_diArg_1	115	117	PF00400	0.383
TRG_ER_diArg_1	240	242	PF00400	0.386
TRG_NLS_MonoExtN_4	160	166	PF00514	0.371
TRG_NLS_MonoExtN_4	206	213	PF00514	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD93	Leptomonas seymouri	50%	98%
A0A1X0NLP1	Trypanosomatidae	32%	96%
A0A3R7RDJ4	Trypanosoma rangeli	27%	100%
A0A3S7X0B8	Leishmania donovani	72%	89%
A4I2K3	Leishmania infantum	72%	89%
C9ZKU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
E9ACY4	Leishmania major	72%	100%
E9AYQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	89%
V5BKS2	Trypanosoma cruzi	27%	100%