CAAX prenyl protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo- peptidase, Clan M- Family M48

Species:

Leishmania braziliensis

UniProt:

A4HFC3_LEIBR

TriTrypDb:

LbrM.27.0050 , LBRM2903_270005600

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HFC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFC3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016485	protein processing	5	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071586	CAAX-box protein processing	6	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	173	179	PF00089	0.265
CLV_NRD_NRD_1	175	177	PF00675	0.405
CLV_NRD_NRD_1	245	247	PF00675	0.208
CLV_NRD_NRD_1	31	33	PF00675	0.353
CLV_NRD_NRD_1	362	364	PF00675	0.301
CLV_PCSK_FUR_1	29	33	PF00082	0.335
CLV_PCSK_KEX2_1	135	137	PF00082	0.148
CLV_PCSK_KEX2_1	175	177	PF00082	0.405
CLV_PCSK_KEX2_1	245	247	PF00082	0.205
CLV_PCSK_KEX2_1	261	263	PF00082	0.170
CLV_PCSK_KEX2_1	31	33	PF00082	0.353
CLV_PCSK_KEX2_1	321	323	PF00082	0.491
CLV_PCSK_KEX2_1	362	364	PF00082	0.356
CLV_PCSK_KEX2_1	382	384	PF00082	0.148
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.148
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.208
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.491
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.148
CLV_PCSK_SKI1_1	149	153	PF00082	0.199
CLV_PCSK_SKI1_1	236	240	PF00082	0.283
CLV_PCSK_SKI1_1	262	266	PF00082	0.208
CLV_PCSK_SKI1_1	315	319	PF00082	0.413
CLV_PCSK_SKI1_1	382	386	PF00082	0.261
CLV_PCSK_SKI1_1	45	49	PF00082	0.313
DEG_APCC_KENBOX_2	389	393	PF00400	0.450
DEG_Nend_Nbox_1	1	3	PF02207	0.385
DOC_CYCLIN_RxL_1	149	160	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.300
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.358
DOC_MAPK_MEF2A_6	153	161	PF00069	0.408
DOC_MAPK_MEF2A_6	77	85	PF00069	0.353
DOC_PP1_RVXF_1	313	320	PF00149	0.265
DOC_PP1_RVXF_1	360	367	PF00149	0.405
DOC_PP2B_LxvP_1	121	124	PF13499	0.300
DOC_PP2B_LxvP_1	198	201	PF13499	0.403
DOC_PP2B_LxvP_1	83	86	PF13499	0.302
DOC_PP4_FxxP_1	341	344	PF00568	0.339
DOC_SPAK_OSR1_1	370	374	PF12202	0.491
DOC_USP7_MATH_1	57	61	PF00917	0.414
DOC_USP7_MATH_1	93	97	PF00917	0.184
DOC_USP7_UBL2_3	149	153	PF12436	0.411
DOC_WW_Pin1_4	209	214	PF00397	0.435
LIG_14-3-3_CanoR_1	158	162	PF00244	0.300
LIG_14-3-3_CanoR_1	245	253	PF00244	0.425
LIG_14-3-3_CanoR_1	347	353	PF00244	0.157
LIG_14-3-3_CanoR_1	393	402	PF00244	0.425
LIG_14-3-3_CanoR_1	62	68	PF00244	0.440
LIG_Actin_WH2_2	144	160	PF00022	0.441
LIG_Actin_WH2_2	220	238	PF00022	0.450
LIG_APCC_ABBA_1	338	343	PF00400	0.375
LIG_BRCT_BRCA1_1	349	353	PF00533	0.237
LIG_BRCT_BRCA1_1	95	99	PF00533	0.217
LIG_Clathr_ClatBox_1	316	320	PF01394	0.266
LIG_EH1_1	296	304	PF00400	0.157
LIG_eIF4E_1	297	303	PF01652	0.157
LIG_eIF4E_1	407	413	PF01652	0.405
LIG_FHA_1	143	149	PF00498	0.506
LIG_FHA_1	214	220	PF00498	0.405
LIG_FHA_1	298	304	PF00498	0.270
LIG_FHA_1	9	15	PF00498	0.158
LIG_FHA_2	117	123	PF00498	0.172
LIG_FHA_2	141	147	PF00498	0.408
LIG_FHA_2	210	216	PF00498	0.572
LIG_FHA_2	266	272	PF00498	0.425
LIG_FHA_2	46	52	PF00498	0.460
LIG_KLC1_Yacidic_2	129	134	PF13176	0.428
LIG_LIR_Apic_2	339	344	PF02991	0.185
LIG_LIR_Gen_1	115	125	PF02991	0.236
LIG_LIR_Gen_1	126	133	PF02991	0.427
LIG_LIR_Gen_1	154	164	PF02991	0.279
LIG_LIR_Gen_1	23	33	PF02991	0.408
LIG_LIR_Gen_1	399	410	PF02991	0.408
LIG_LIR_Gen_1	64	71	PF02991	0.451
LIG_LIR_Nem_3	115	121	PF02991	0.227
LIG_LIR_Nem_3	122	128	PF02991	0.237
LIG_LIR_Nem_3	154	159	PF02991	0.218
LIG_LIR_Nem_3	179	184	PF02991	0.207
LIG_LIR_Nem_3	20	25	PF02991	0.242
LIG_LIR_Nem_3	343	349	PF02991	0.319
LIG_LIR_Nem_3	399	405	PF02991	0.450
LIG_LIR_Nem_3	64	68	PF02991	0.428
LIG_PCNA_yPIPBox_3	166	180	PF02747	0.266
LIG_Pex14_2	177	181	PF04695	0.196
LIG_Pex14_2	341	345	PF04695	0.265
LIG_Pex14_2	353	357	PF04695	0.197
LIG_SH2_CRK	221	225	PF00017	0.384
LIG_SH2_CRK	266	270	PF00017	0.396
LIG_SH2_CRK	346	350	PF00017	0.157
LIG_SH2_CRK	402	406	PF00017	0.425
LIG_SH2_GRB2like	128	131	PF00017	0.425
LIG_SH2_NCK_1	407	411	PF00017	0.408
LIG_SH2_STAP1	108	112	PF00017	0.304
LIG_SH2_STAP1	128	132	PF00017	0.324
LIG_SH2_STAP1	266	270	PF00017	0.396
LIG_SH2_STAT3	163	166	PF00017	0.266
LIG_SH2_STAT5	132	135	PF00017	0.428
LIG_SH2_STAT5	184	187	PF00017	0.225
LIG_SH2_STAT5	25	28	PF00017	0.268
LIG_SH2_STAT5	253	256	PF00017	0.423
LIG_SH2_STAT5	407	410	PF00017	0.450
LIG_SH2_STAT5	42	45	PF00017	0.396
LIG_SH2_STAT5	46	49	PF00017	0.468
LIG_SH2_STAT5	91	94	PF00017	0.358
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.266
LIG_TRAF2_1	48	51	PF00917	0.460
LIG_TYR_ITIM	219	224	PF00017	0.348
LIG_TYR_ITIM	264	269	PF00017	0.396
LIG_UBA3_1	203	210	PF00899	0.372
LIG_UBA3_1	269	274	PF00899	0.466
LIG_UBA3_1	385	390	PF00899	0.429
MOD_CK1_1	100	106	PF00069	0.243
MOD_CK1_1	187	193	PF00069	0.255
MOD_CK1_1	244	250	PF00069	0.396
MOD_CK2_1	123	129	PF00069	0.290
MOD_CK2_1	140	146	PF00069	0.338
MOD_CK2_1	265	271	PF00069	0.474
MOD_CK2_1	45	51	PF00069	0.433
MOD_GlcNHglycan	186	189	PF01048	0.157
MOD_GlcNHglycan	402	405	PF01048	0.225
MOD_GlcNHglycan	99	102	PF01048	0.387
MOD_GSK3_1	209	216	PF00069	0.601
MOD_GSK3_1	391	398	PF00069	0.527
MOD_GSK3_1	57	64	PF00069	0.401
MOD_GSK3_1	8	15	PF00069	0.204
MOD_GSK3_1	93	100	PF00069	0.279
MOD_N-GLC_1	391	396	PF02516	0.158
MOD_N-GLC_1	77	82	PF02516	0.270
MOD_NEK2_1	1	6	PF00069	0.317
MOD_NEK2_1	157	162	PF00069	0.292
MOD_NEK2_1	265	270	PF00069	0.400
MOD_NEK2_1	308	313	PF00069	0.328
MOD_NEK2_1	345	350	PF00069	0.157
MOD_NEK2_1	405	410	PF00069	0.433
MOD_NEK2_1	52	57	PF00069	0.363
MOD_NEK2_1	8	13	PF00069	0.234
MOD_NEK2_1	94	99	PF00069	0.221
MOD_PK_1	77	83	PF00069	0.157
MOD_PKA_2	157	163	PF00069	0.300
MOD_PKA_2	244	250	PF00069	0.408
MOD_PKA_2	61	67	PF00069	0.372
MOD_Plk_1	276	282	PF00069	0.384
MOD_Plk_1	77	83	PF00069	0.257
MOD_Plk_4	151	157	PF00069	0.431
MOD_Plk_4	187	193	PF00069	0.271
MOD_Plk_4	199	205	PF00069	0.180
MOD_Plk_4	265	271	PF00069	0.396
MOD_Plk_4	276	282	PF00069	0.403
MOD_Plk_4	336	342	PF00069	0.182
MOD_Plk_4	348	354	PF00069	0.337
MOD_Plk_4	77	83	PF00069	0.203
MOD_Plk_4	9	15	PF00069	0.169
MOD_ProDKin_1	209	215	PF00069	0.437
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.348
TRG_ENDOCYTIC_2	128	131	PF00928	0.408
TRG_ENDOCYTIC_2	221	224	PF00928	0.468
TRG_ENDOCYTIC_2	25	28	PF00928	0.402
TRG_ENDOCYTIC_2	266	269	PF00928	0.402
TRG_ENDOCYTIC_2	324	327	PF00928	0.208
TRG_ENDOCYTIC_2	346	349	PF00928	0.266
TRG_ENDOCYTIC_2	402	405	PF00928	0.450
TRG_ENDOCYTIC_2	91	94	PF00928	0.301
TRG_ER_diArg_1	174	176	PF00400	0.205
TRG_ER_diArg_1	28	31	PF00400	0.515
TRG_ER_diArg_1	362	364	PF00400	0.479
TRG_ER_diLys_1	424	427	PF00400	0.510
TRG_NES_CRM1_1	230	242	PF08389	0.425
TRG_NES_CRM1_1	331	343	PF08389	0.148

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC87	Leptomonas seymouri	59%	100%
A0A0S4J5R2	Bodo saltans	46%	100%
A0A1X0P508	Trypanosomatidae	45%	100%
A0A3S7X0A9	Leishmania donovani	76%	100%
A4I2K0	Leishmania infantum	76%	100%
C9ZYC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ACY1	Leishmania major	77%	100%
E9AYQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
O75844	Homo sapiens	33%	90%
P40769	Bacillus subtilis (strain 168)	25%	100%
P47154	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
Q10071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	90%
Q3Y6B8	Taenia solium	33%	90%
Q54FH7	Dictyostelium discoideum	34%	100%
Q6EPN8	Oryza sativa subsp. japonica	38%	100%
Q80W54	Mus musculus	33%	90%
Q8RX88	Arabidopsis thaliana	39%	100%
Q9XVE5	Caenorhabditis elegans	32%	97%
V5DQF4	Trypanosoma cruzi	48%	100%