CAAX prenyl protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo- peptidase, Clan M- Family M48

Species:

Leishmania braziliensis

UniProt:

A4HFC3_LEIBR

TriTrypDb:

LbrM.27.0050 , LBRM2903_270005600

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A4HFC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFC3

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016485	protein processing	5	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071586	CAAX-box protein processing	6	11
GO:0071704	organic substance metabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	173	179	PF00089	0.265
CLV_NRD_NRD_1	175	177	PF00675	0.405
CLV_NRD_NRD_1	245	247	PF00675	0.208
CLV_NRD_NRD_1	31	33	PF00675	0.353
CLV_NRD_NRD_1	362	364	PF00675	0.301
CLV_PCSK_FUR_1	29	33	PF00082	0.335
CLV_PCSK_KEX2_1	135	137	PF00082	0.148
CLV_PCSK_KEX2_1	175	177	PF00082	0.405
CLV_PCSK_KEX2_1	245	247	PF00082	0.205
CLV_PCSK_KEX2_1	261	263	PF00082	0.170

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC87	Leptomonas seymouri	59%	100%
A0A0S4J5R2	Bodo saltans	46%	100%
A0A1X0P508	Trypanosomatidae	45%	100%
A0A3S7X0A9	Leishmania donovani	76%	100%
A4I2K0	Leishmania infantum	76%	100%
C9ZYC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ACY1	Leishmania major	77%	100%
E9AYQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
O75844	Homo sapiens	33%	90%
P40769	Bacillus subtilis (strain 168)	25%	100%

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