TGT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

queuine tRNA-ribosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFC2_LEIBR

TriTrypDb:

LbrM.27.0040 , LBRM2903_270005500

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HFC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFC2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0101030	tRNA-guanine transglycosylation	7	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016763	pentosyltransferase activity	4	12
GO:0005488	binding	1	8
GO:0008479	queuine tRNA-ribosyltransferase activity	5	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140101	catalytic activity, acting on a tRNA	4	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.518
CLV_NRD_NRD_1	135	137	PF00675	0.217
CLV_PCSK_KEX2_1	13	15	PF00082	0.216
CLV_PCSK_KEX2_1	133	135	PF00082	0.217
CLV_PCSK_KEX2_1	280	282	PF00082	0.261
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.283
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.217
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.263
CLV_PCSK_SKI1_1	136	140	PF00082	0.253
CLV_PCSK_SKI1_1	242	246	PF00082	0.160
CLV_PCSK_SKI1_1	325	329	PF00082	0.395
CLV_PCSK_SKI1_1	67	71	PF00082	0.247
DEG_APCC_DBOX_1	283	291	PF00400	0.501
DEG_Nend_UBRbox_2	1	3	PF02207	0.624
DOC_MAPK_gen_1	198	204	PF00069	0.471
DOC_MAPK_gen_1	96	103	PF00069	0.466
DOC_MAPK_MEF2A_6	111	119	PF00069	0.453
DOC_MAPK_MEF2A_6	233	241	PF00069	0.483
DOC_PP2B_LxvP_1	237	240	PF13499	0.518
DOC_PP2B_LxvP_1	8	11	PF13499	0.427
DOC_PP2B_PxIxI_1	160	166	PF00149	0.441
DOC_PP4_FxxP_1	46	49	PF00568	0.483
DOC_PP4_FxxP_1	76	79	PF00568	0.360
DOC_USP7_MATH_1	214	218	PF00917	0.542
DOC_USP7_MATH_1	327	331	PF00917	0.470
DOC_USP7_MATH_1	79	83	PF00917	0.484
DOC_USP7_MATH_1	91	95	PF00917	0.501
DOC_USP7_MATH_1	99	103	PF00917	0.339
DOC_WW_Pin1_4	18	23	PF00397	0.427
DOC_WW_Pin1_4	193	198	PF00397	0.541
DOC_WW_Pin1_4	245	250	PF00397	0.423
LIG_14-3-3_CanoR_1	135	145	PF00244	0.439
LIG_14-3-3_CanoR_1	34	44	PF00244	0.416
LIG_14-3-3_CanoR_1	67	73	PF00244	0.450
LIG_14-3-3_CanoR_1	98	104	PF00244	0.445
LIG_BIR_III_2	175	179	PF00653	0.518
LIG_BRCT_BRCA1_1	182	186	PF00533	0.557
LIG_FHA_1	114	120	PF00498	0.512
LIG_FHA_1	199	205	PF00498	0.475
LIG_FHA_1	306	312	PF00498	0.378
LIG_FHA_2	138	144	PF00498	0.470
LIG_FHA_2	290	296	PF00498	0.427
LIG_LIR_Apic_2	45	49	PF02991	0.461
LIG_LIR_Apic_2	74	79	PF02991	0.360
LIG_LIR_Gen_1	181	192	PF02991	0.486
LIG_LIR_Gen_1	38	49	PF02991	0.464
LIG_LIR_LC3C_4	116	119	PF02991	0.360
LIG_LIR_Nem_3	104	109	PF02991	0.455
LIG_LIR_Nem_3	181	187	PF02991	0.501
LIG_LIR_Nem_3	38	44	PF02991	0.383
LIG_LIR_Nem_3	64	69	PF02991	0.431
LIG_MYND_1	18	22	PF01753	0.427
LIG_NRBOX	286	292	PF00104	0.501
LIG_PDZ_Class_1	331	336	PF00595	0.483
LIG_SH2_CRK	66	70	PF00017	0.475
LIG_SH2_SRC	173	176	PF00017	0.471
LIG_SH2_SRC	286	289	PF00017	0.418
LIG_SH2_STAT5	173	176	PF00017	0.456
LIG_SH2_STAT5	286	289	PF00017	0.440
LIG_SH2_STAT5	60	63	PF00017	0.471
LIG_SH3_3	203	209	PF00018	0.459
LIG_SH3_3	248	254	PF00018	0.490
LIG_SUMO_SIM_anti_2	116	124	PF11976	0.441
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.448
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.430
LIG_SUMO_SIM_par_1	116	124	PF11976	0.510
LIG_SUMO_SIM_par_1	254	260	PF11976	0.523
LIG_SUMO_SIM_par_1	289	295	PF11976	0.416
LIG_SUMO_SIM_par_1	68	75	PF11976	0.417
LIG_TRAF2_1	292	295	PF00917	0.421
LIG_WRC_WIRS_1	100	105	PF05994	0.471
MOD_CDC14_SPxK_1	196	199	PF00782	0.471
MOD_CDK_SPK_2	193	198	PF00069	0.471
MOD_CDK_SPxK_1	193	199	PF00069	0.471
MOD_CK1_1	217	223	PF00069	0.504
MOD_CK1_1	82	88	PF00069	0.503
MOD_CK2_1	137	143	PF00069	0.486
MOD_CK2_1	217	223	PF00069	0.480
MOD_CK2_1	289	295	PF00069	0.416
MOD_CK2_1	36	42	PF00069	0.540
MOD_GlcNHglycan	170	173	PF01048	0.283
MOD_GlcNHglycan	333	336	PF01048	0.432
MOD_GlcNHglycan	57	60	PF01048	0.281
MOD_GlcNHglycan	63	66	PF01048	0.360
MOD_GlcNHglycan	81	84	PF01048	0.178
MOD_GSK3_1	146	153	PF00069	0.434
MOD_GSK3_1	155	162	PF00069	0.402
MOD_GSK3_1	327	334	PF00069	0.407
MOD_GSK3_1	61	68	PF00069	0.528
MOD_GSK3_1	79	86	PF00069	0.435
MOD_N-GLC_1	217	222	PF02516	0.318
MOD_N-GLC_1	305	310	PF02516	0.161
MOD_NEK2_1	155	160	PF00069	0.563
MOD_NEK2_1	186	191	PF00069	0.557
MOD_NEK2_1	313	318	PF00069	0.360
MOD_NEK2_1	36	41	PF00069	0.483
MOD_NEK2_1	72	77	PF00069	0.447
MOD_NEK2_2	275	280	PF00069	0.459
MOD_OFUCOSY	274	279	PF10250	0.216
MOD_PIKK_1	110	116	PF00454	0.537
MOD_PIKK_1	305	311	PF00454	0.400
MOD_PKA_1	198	204	PF00069	0.471
MOD_PKA_2	72	78	PF00069	0.518
MOD_PKB_1	134	142	PF00069	0.425
MOD_Plk_1	180	186	PF00069	0.430
MOD_Plk_1	217	223	PF00069	0.518
MOD_Plk_1	305	311	PF00069	0.361
MOD_Plk_1	86	92	PF00069	0.491
MOD_Plk_4	113	119	PF00069	0.393
MOD_Plk_4	155	161	PF00069	0.496
MOD_Plk_4	217	223	PF00069	0.438
MOD_Plk_4	36	42	PF00069	0.416
MOD_ProDKin_1	18	24	PF00069	0.427
MOD_ProDKin_1	193	199	PF00069	0.541
MOD_ProDKin_1	245	251	PF00069	0.423
MOD_SUMO_for_1	147	150	PF00179	0.501
TRG_DiLeu_BaEn_2	41	47	PF01217	0.471
TRG_DiLeu_BaEn_4	150	156	PF01217	0.471
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.535
TRG_ENDOCYTIC_2	184	187	PF00928	0.494
TRG_ENDOCYTIC_2	60	63	PF00928	0.562
TRG_ENDOCYTIC_2	66	69	PF00928	0.463
TRG_ER_diArg_1	134	136	PF00400	0.441
TRG_NES_CRM1_1	257	271	PF08389	0.360
TRG_NLS_MonoCore_2	132	137	PF00514	0.417
TRG_NLS_MonoExtN_4	130	137	PF00514	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE8	Leptomonas seymouri	62%	100%
A0A0S4IR14	Bodo saltans	37%	96%
A0A1X0NPI6	Trypanosomatidae	40%	100%
A0A3R7K861	Trypanosoma rangeli	41%	100%
A0A3S7X0A8	Leishmania donovani	83%	100%
A4I2J9	Leishmania infantum	83%	100%
B0WAN0	Culex quinquefasciatus	23%	78%
B2UC75	Ralstonia pickettii (strain 12J)	22%	88%
B2USB2	Helicobacter pylori (strain Shi470)	27%	91%
B3MA91	Drosophila ananassae	22%	81%
B3NCH1	Drosophila erecta	22%	80%
B3RNT0	Trichoplax adhaerens	23%	91%
B4H1X9	Drosophila persimilis	24%	81%
B4HL48	Drosophila sechellia	23%	80%
B4IXD3	Drosophila grimshawi	23%	80%
B4KXI8	Drosophila mojavensis	23%	81%
B4LFW2	Drosophila virilis	22%	81%
B4N549	Drosophila willistoni	22%	79%
B4PEV9	Drosophila yakuba	24%	80%
B5ZA47	Helicobacter pylori (strain G27)	26%	91%
B6JKL0	Helicobacter pylori (strain P12)	26%	91%
B8ZXI1	Mus musculus	23%	81%
C9ZPM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ACY0	Leishmania major	83%	100%
E9AYQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O08314	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	91%
Q16RF5	Aedes aegypti	22%	80%
Q17YB5	Helicobacter acinonychis (strain Sheeba)	27%	91%
Q1CUM2	Helicobacter pylori (strain HPAG1)	26%	91%
Q1GR26	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)	24%	90%
Q29EE9	Drosophila pseudoobscura pseudoobscura	25%	81%
Q2G639	Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)	28%	90%
Q3SH61	Thiobacillus denitrificans (strain ATCC 25259)	21%	92%
Q5SLI7	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	26%	87%
Q72H19	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	25%	87%
Q7Q727	Anopheles gambiae	23%	78%
Q9H974	Homo sapiens	24%	81%
Q9VSZ6	Drosophila melanogaster	22%	80%
Q9ZMF4	Helicobacter pylori (strain J99 / ATCC 700824)	26%	91%
V5BCL2	Trypanosoma cruzi	41%	100%