TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFC1_LEIBR

TriTrypDb:

LbrM.27.0020 , LBRM2903_270005000

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.396
CLV_NRD_NRD_1	366	368	PF00675	0.484
CLV_PCSK_KEX2_1	134	136	PF00082	0.584
CLV_PCSK_KEX2_1	200	202	PF00082	0.421
CLV_PCSK_KEX2_1	293	295	PF00082	0.390
CLV_PCSK_KEX2_1	35	37	PF00082	0.383
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.553
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.417
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.390
CLV_PCSK_PC7_1	289	295	PF00082	0.235
CLV_PCSK_SKI1_1	127	131	PF00082	0.629
CLV_PCSK_SKI1_1	163	167	PF00082	0.385
CLV_PCSK_SKI1_1	189	193	PF00082	0.444
CLV_PCSK_SKI1_1	273	277	PF00082	0.475
CLV_PCSK_SKI1_1	346	350	PF00082	0.388
CLV_PCSK_SKI1_1	35	39	PF00082	0.512
CLV_PCSK_SKI1_1	367	371	PF00082	0.420
DEG_APCC_DBOX_1	170	178	PF00400	0.270
DEG_APCC_DBOX_1	254	262	PF00400	0.316
DEG_APCC_DBOX_1	345	353	PF00400	0.233
DEG_APCC_KENBOX_2	325	329	PF00400	0.277
DEG_Nend_UBRbox_2	1	3	PF02207	0.475
DOC_CYCLIN_RxL_1	160	167	PF00134	0.460
DOC_CYCLIN_RxL_1	270	279	PF00134	0.477
DOC_MAPK_DCC_7	333	342	PF00069	0.301
DOC_MAPK_gen_1	333	342	PF00069	0.476
DOC_MAPK_gen_1	365	374	PF00069	0.529
DOC_MAPK_MEF2A_6	365	374	PF00069	0.593
DOC_MAPK_MEF2A_6	4	11	PF00069	0.341
DOC_MAPK_MEF2A_6	51	59	PF00069	0.307
DOC_MAPK_MEF2A_6	79	86	PF00069	0.241
DOC_PP1_RVXF_1	271	278	PF00149	0.475
DOC_PP1_RVXF_1	292	299	PF00149	0.428
DOC_PP4_FxxP_1	11	14	PF00568	0.333
DOC_USP7_MATH_1	149	153	PF00917	0.316
DOC_USP7_MATH_1	219	223	PF00917	0.424
DOC_USP7_UBL2_3	117	121	PF12436	0.495
DOC_WW_Pin1_4	189	194	PF00397	0.524
DOC_WW_Pin1_4	2	7	PF00397	0.316
DOC_WW_Pin1_4	340	345	PF00397	0.329
LIG_14-3-3_CanoR_1	171	175	PF00244	0.408
LIG_APCC_ABBAyCdc20_2	88	94	PF00400	0.378
LIG_Clathr_ClatBox_1	274	278	PF01394	0.475
LIG_FHA_1	190	196	PF00498	0.518
LIG_FHA_1	21	27	PF00498	0.345
LIG_LIR_Gen_1	128	137	PF02991	0.464
LIG_LIR_Gen_1	194	203	PF02991	0.388
LIG_LIR_Gen_1	268	277	PF02991	0.407
LIG_LIR_Gen_1	44	53	PF02991	0.389
LIG_LIR_Gen_1	5	14	PF02991	0.232
LIG_LIR_Nem_3	110	115	PF02991	0.413
LIG_LIR_Nem_3	128	133	PF02991	0.491
LIG_LIR_Nem_3	194	199	PF02991	0.377
LIG_LIR_Nem_3	268	274	PF02991	0.393
LIG_LIR_Nem_3	40	45	PF02991	0.411
LIG_LIR_Nem_3	5	11	PF02991	0.222
LIG_PDZ_Class_2	369	374	PF00595	0.503
LIG_PTB_Apo_2	86	93	PF02174	0.386
LIG_SH2_CRK	184	188	PF00017	0.408
LIG_SH2_CRK	271	275	PF00017	0.487
LIG_SH2_NCK_1	205	209	PF00017	0.395
LIG_SH2_SRC	299	302	PF00017	0.474
LIG_SH2_STAP1	22	26	PF00017	0.336
LIG_SH2_STAT3	115	118	PF00017	0.380
LIG_SH2_STAT5	10	13	PF00017	0.312
LIG_SH2_STAT5	22	25	PF00017	0.323
LIG_SH2_STAT5	299	302	PF00017	0.506
LIG_SH2_STAT5	85	88	PF00017	0.370
LIG_SH3_3	11	17	PF00018	0.355
LIG_SH3_3	237	243	PF00018	0.401
LIG_SH3_3	278	284	PF00018	0.474
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.375
LIG_SUMO_SIM_par_1	338	343	PF11976	0.285
LIG_TRAF2_1	116	119	PF00917	0.301
LIG_TRAF2_1	307	310	PF00917	0.440
LIG_UBA3_1	321	326	PF00899	0.322
MOD_CDK_SPxK_1	340	346	PF00069	0.324
MOD_CK2_1	117	123	PF00069	0.398
MOD_CK2_1	204	210	PF00069	0.467
MOD_CK2_1	245	251	PF00069	0.458
MOD_Cter_Amidation	365	368	PF01082	0.433
MOD_GlcNHglycan	206	209	PF01048	0.473
MOD_GSK3_1	117	124	PF00069	0.535
MOD_N-GLC_1	121	126	PF02516	0.450
MOD_PKA_2	170	176	PF00069	0.414
MOD_Plk_2-3	245	251	PF00069	0.270
MOD_Plk_4	142	148	PF00069	0.402
MOD_ProDKin_1	189	195	PF00069	0.517
MOD_ProDKin_1	2	8	PF00069	0.308
MOD_ProDKin_1	340	346	PF00069	0.324
MOD_SUMO_for_1	116	119	PF00179	0.438
MOD_SUMO_for_1	199	202	PF00179	0.403
TRG_DiLeu_BaEn_1	257	262	PF01217	0.332
TRG_DiLeu_BaEn_1	310	315	PF01217	0.299
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.459
TRG_DiLeu_LyEn_5	310	315	PF01217	0.316
TRG_ENDOCYTIC_2	10	13	PF00928	0.319
TRG_ENDOCYTIC_2	22	25	PF00928	0.360
TRG_ENDOCYTIC_2	271	274	PF00928	0.406
TRG_ENDOCYTIC_2	46	49	PF00928	0.378
TRG_ER_diArg_1	35	37	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	35	40	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I333	Leptomonas seymouri	74%	90%
A0A0S4IVD3	Bodo saltans	44%	81%
A0A1X0NPF3	Trypanosomatidae	61%	86%
A0A3Q8IPL3	Leishmania donovani	88%	100%
A4I2J7	Leishmania infantum	88%	100%
C9ZPM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	88%
E9ACX8	Leishmania major	89%	100%
E9AYQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BCK8	Trypanosoma cruzi	59%	88%