6-phosphogluconolactonase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphogluconolactonase

Species:

Leishmania braziliensis

UniProt:

A4HFB4_LEIBR

TriTrypDb:

LbrM.26.2660 , LBRM2903_260032500

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFB4

PDB structure(s): 3ch7_A , 3css_A

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006098	pentose-phosphate shunt	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006739	NADP metabolic process	7	12
GO:0006740	NADPH regeneration	4	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0019362	pyridine nucleotide metabolic process	5	12
GO:0019637	organophosphate metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046496	nicotinamide nucleotide metabolic process	6	12
GO:0051156	glucose 6-phosphate metabolic process	4	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072524	pyridine-containing compound metabolic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009051	pentose-phosphate shunt, oxidative branch	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0017057	6-phosphogluconolactonase activity	5	12
GO:0052689	carboxylic ester hydrolase activity	4	12
GO:0016853	isomerase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.277
CLV_PCSK_KEX2_1	109	111	PF00082	0.277
CLV_PCSK_KEX2_1	50	52	PF00082	0.484
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.484
CLV_PCSK_SKI1_1	110	114	PF00082	0.334
CLV_PCSK_SKI1_1	229	233	PF00082	0.394
CLV_PCSK_SKI1_1	93	97	PF00082	0.366
DOC_CYCLIN_RxL_1	90	98	PF00134	0.476
DOC_MAPK_gen_1	247	257	PF00069	0.468
DOC_MAPK_gen_1	32	41	PF00069	0.444
DOC_MAPK_HePTP_8	29	41	PF00069	0.277
DOC_MAPK_MEF2A_6	151	160	PF00069	0.277
DOC_MAPK_MEF2A_6	250	257	PF00069	0.329
DOC_MAPK_MEF2A_6	32	41	PF00069	0.383
DOC_PP4_FxxP_1	190	193	PF00568	0.376
DOC_WW_Pin1_4	189	194	PF00397	0.435
DOC_WW_Pin1_4	232	237	PF00397	0.355
DOC_WW_Pin1_4	45	50	PF00397	0.346
LIG_14-3-3_CanoR_1	201	205	PF00244	0.369
LIG_14-3-3_CanoR_1	229	239	PF00244	0.277
LIG_14-3-3_CanoR_1	250	256	PF00244	0.504
LIG_BRCT_BRCA1_1	186	190	PF00533	0.390
LIG_FHA_1	167	173	PF00498	0.355
LIG_FHA_1	235	241	PF00498	0.364
LIG_FHA_1	252	258	PF00498	0.416
LIG_FHA_1	5	11	PF00498	0.425
LIG_FHA_1	90	96	PF00498	0.450
LIG_FHA_2	113	119	PF00498	0.436
LIG_FHA_2	178	184	PF00498	0.417
LIG_LIR_Apic_2	187	193	PF02991	0.378
LIG_PCNA_yPIPBox_3	222	232	PF02747	0.476
LIG_PDZ_Class_2	262	267	PF00595	0.547
LIG_SH2_STAP1	133	137	PF00017	0.390
LIG_SH3_3	185	191	PF00018	0.382
LIG_SH3_3	233	239	PF00018	0.504
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.357
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.323
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.471
LIG_SUMO_SIM_par_1	101	108	PF11976	0.412
LIG_SUMO_SIM_par_1	180	189	PF11976	0.482
LIG_SUMO_SIM_par_1	252	258	PF11976	0.323
LIG_SUMO_SIM_par_1	39	44	PF11976	0.476
LIG_TRAF2_1	180	183	PF00917	0.277
LIG_UBA3_1	137	144	PF00899	0.373
LIG_WRC_WIRS_1	1	6	PF05994	0.638
MOD_CDK_SPK_2	193	198	PF00069	0.351
MOD_CDK_SPK_2	45	50	PF00069	0.355
MOD_CDK_SPxK_1	45	51	PF00069	0.476
MOD_CK1_1	15	21	PF00069	0.473
MOD_CK1_1	189	195	PF00069	0.461
MOD_CK1_1	44	50	PF00069	0.397
MOD_CK1_1	86	92	PF00069	0.450
MOD_CK2_1	113	119	PF00069	0.436
MOD_CK2_1	177	183	PF00069	0.335
MOD_GlcNHglycan	43	46	PF01048	0.313
MOD_GSK3_1	162	169	PF00069	0.330
MOD_GSK3_1	173	180	PF00069	0.420
MOD_GSK3_1	189	196	PF00069	0.293
MOD_GSK3_1	200	207	PF00069	0.441
MOD_GSK3_1	230	237	PF00069	0.409
MOD_GSK3_1	41	48	PF00069	0.382
MOD_GSK3_1	99	106	PF00069	0.391
MOD_N-GLC_1	12	17	PF02516	0.348
MOD_N-GLC_1	146	151	PF02516	0.482
MOD_N-GLC_1	86	91	PF02516	0.504
MOD_NEK2_1	204	209	PF00069	0.488
MOD_NEK2_1	41	46	PF00069	0.401
MOD_PIKK_1	12	18	PF00454	0.513
MOD_PKA_2	200	206	PF00069	0.355
MOD_PKA_2	249	255	PF00069	0.535
MOD_Plk_1	12	18	PF00069	0.450
MOD_Plk_1	33	39	PF00069	0.401
MOD_Plk_1	86	92	PF00069	0.504
MOD_Plk_2-3	103	109	PF00069	0.277
MOD_Plk_4	168	174	PF00069	0.355
MOD_Plk_4	204	210	PF00069	0.393
MOD_Plk_4	251	257	PF00069	0.413
MOD_ProDKin_1	189	195	PF00069	0.435
MOD_ProDKin_1	232	238	PF00069	0.355
MOD_ProDKin_1	45	51	PF00069	0.346
MOD_SUMO_rev_2	132	138	PF00179	0.511
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.409
TRG_ENDOCYTIC_2	53	56	PF00928	0.355
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Y4	Leptomonas seymouri	68%	98%
A0A0S4J8H1	Bodo saltans	37%	100%
A0A1X0NX24	Trypanosomatidae	46%	100%
A0A3Q8IG46	Leishmania donovani	83%	100%
A0A3R7NAW7	Trypanosoma rangeli	47%	100%
A2XI04	Oryza sativa subsp. indica	25%	90%
A2YNH4	Oryza sativa subsp. indica	25%	95%
A2YXS5	Oryza sativa subsp. indica	27%	82%
A2Z3C4	Oryza sativa subsp. indica	29%	82%
A6ZT71	Saccharomyces cerevisiae (strain YJM789)	27%	100%
B3LSS7	Saccharomyces cerevisiae (strain RM11-1a)	27%	100%
B5VK90	Saccharomyces cerevisiae (strain AWRI1631)	27%	100%
D0A7E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AHB9	Leishmania infantum	83%	100%
E9AYQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O18229	Caenorhabditis elegans	29%	99%
O51240	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	23%	100%
O74455	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O83490	Treponema pallidum (strain Nichols)	31%	100%
O84189	Chlamydia trachomatis (strain D/UW-3/Cx)	27%	100%
O95336	Homo sapiens	28%	100%
P37262	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	85%
P38858	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P46016	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	30%	100%
P50278	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	83%
P53315	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P63339	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	100%
P74618	Synechocystis sp. (strain PCC 6803 / Kazusa)	31%	100%
P85971	Rattus norvegicus	31%	100%
P9WQP4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WQP5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
Q2TBQ8	Bos taurus	29%	100%
Q49700	Mycobacterium leprae (strain TN)	27%	100%
Q4Q8S1	Leishmania major	84%	100%
Q57039	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
Q69NG5	Oryza sativa subsp. japonica	29%	82%
Q6Z4H0	Oryza sativa subsp. japonica	25%	95%
Q6Z9C3	Oryza sativa subsp. japonica	27%	82%
Q75IV7	Oryza sativa subsp. japonica	25%	90%
Q84WW2	Arabidopsis thaliana	28%	82%
Q87EG7	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	28%	100%
Q8LG70	Arabidopsis thaliana	29%	100%
Q989A3	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	27%	100%
Q9CQ60	Mus musculus	30%	100%
Q9EV79	Pseudomonas putida	25%	100%
Q9LMX8	Arabidopsis thaliana	25%	100%
Q9PEG5	Xylella fastidiosa (strain 9a5c)	29%	100%
Q9VZ64	Drosophila melanogaster	28%	100%
Q9X2N2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	28%	100%
Q9Z3S1	Rhizobium meliloti (strain 1021)	24%	100%
Q9Z8U5	Chlamydia pneumoniae	27%	100%
Q9ZKB1	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
V5D050	Trypanosoma cruzi	45%	100%