Putative CAAX prenyl protease 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidase with unknown catalytic mechanism (family U48)

Species:

Leishmania braziliensis

UniProt:

A4HFB3_LEIBR

TriTrypDb:

LbrM.26.2620 , LBRM2903_260032400

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFB3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0016485	protein processing	5	10
GO:0019538	protein metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071586	CAAX-box protein processing	6	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004222	metalloendopeptidase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0008237	metallopeptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.278
CLV_NRD_NRD_1	180	182	PF00675	0.201
CLV_NRD_NRD_1	188	190	PF00675	0.180
CLV_NRD_NRD_1	24	26	PF00675	0.236
CLV_NRD_NRD_1	55	57	PF00675	0.233
CLV_PCSK_FUR_1	22	26	PF00082	0.235
CLV_PCSK_KEX2_1	149	151	PF00082	0.261
CLV_PCSK_KEX2_1	180	182	PF00082	0.201
CLV_PCSK_KEX2_1	24	26	PF00082	0.246
CLV_PCSK_KEX2_1	54	56	PF00082	0.235
CLV_PCSK_SKI1_1	140	144	PF00082	0.316
CLV_PCSK_SKI1_1	93	97	PF00082	0.276
DEG_APCC_DBOX_1	139	147	PF00400	0.461
DEG_APCC_DBOX_1	92	100	PF00400	0.220
DEG_Nend_UBRbox_2	1	3	PF02207	0.224
DOC_CYCLIN_RxL_1	89	98	PF00134	0.201
DOC_MAPK_gen_1	149	156	PF00069	0.504
DOC_MAPK_gen_1	54	62	PF00069	0.405
DOC_MAPK_HePTP_8	146	158	PF00069	0.401
DOC_MAPK_MEF2A_6	149	158	PF00069	0.481
DOC_MAPK_MEF2A_6	54	62	PF00069	0.461
DOC_MAPK_NFAT4_5	55	63	PF00069	0.401
DOC_PP1_RVXF_1	138	145	PF00149	0.563
DOC_PP4_FxxP_1	102	105	PF00568	0.396
DOC_PP4_FxxP_1	115	118	PF00568	0.607
DOC_USP7_MATH_1	7	11	PF00917	0.335
LIG_14-3-3_CanoR_1	149	158	PF00244	0.457
LIG_14-3-3_CanoR_1	24	34	PF00244	0.555
LIG_14-3-3_CanoR_1	47	53	PF00244	0.499
LIG_14-3-3_CanoR_1	55	61	PF00244	0.417
LIG_14-3-3_CanoR_1	83	88	PF00244	0.426
LIG_14-3-3_CanoR_1	93	102	PF00244	0.328
LIG_Actin_RPEL_3	143	162	PF02755	0.405
LIG_Actin_WH2_2	239	257	PF00022	0.278
LIG_BRCT_BRCA1_1	58	62	PF00533	0.348
LIG_BRCT_BRCA1_1	9	13	PF00533	0.304
LIG_CtBP_PxDLS_1	248	252	PF00389	0.457
LIG_FHA_1	14	20	PF00498	0.304
LIG_FHA_1	267	273	PF00498	0.251
LIG_FHA_1	279	285	PF00498	0.208
LIG_FHA_1	40	46	PF00498	0.503
LIG_FHA_1	55	61	PF00498	0.387
LIG_FHA_1	96	102	PF00498	0.317
LIG_FHA_2	258	264	PF00498	0.609
LIG_LIR_Apic_2	114	118	PF02991	0.609
LIG_LIR_Apic_2	15	21	PF02991	0.253
LIG_LIR_Apic_2	85	90	PF02991	0.422
LIG_LIR_Gen_1	257	266	PF02991	0.537
LIG_LIR_Gen_1	59	70	PF02991	0.337
LIG_LIR_Nem_3	136	142	PF02991	0.475
LIG_LIR_Nem_3	214	220	PF02991	0.373
LIG_LIR_Nem_3	257	262	PF02991	0.563
LIG_LIR_Nem_3	59	65	PF02991	0.337
LIG_LIR_Nem_3	67	73	PF02991	0.349
LIG_NRBOX	142	148	PF00104	0.488
LIG_NRBOX	215	221	PF00104	0.396
LIG_NRBOX	95	101	PF00104	0.220
LIG_Pex14_2	13	17	PF04695	0.250
LIG_Pex14_2	213	217	PF04695	0.353
LIG_SH2_CRK	139	143	PF00017	0.563
LIG_SH2_PTP2	18	21	PF00017	0.284
LIG_SH2_SRC	225	228	PF00017	0.327
LIG_SH2_STAT5	111	114	PF00017	0.604
LIG_SH2_STAT5	128	131	PF00017	0.525
LIG_SH2_STAT5	18	21	PF00017	0.313
LIG_SH2_STAT5	271	274	PF00017	0.339
LIG_SH2_STAT5	44	47	PF00017	0.470
LIG_SH2_STAT5	70	73	PF00017	0.353
LIG_SH3_3	126	132	PF00018	0.520
LIG_SUMO_SIM_anti_2	250	255	PF11976	0.602
LIG_SUMO_SIM_par_1	170	177	PF11976	0.401
LIG_TYR_ITIM	137	142	PF00017	0.563
LIG_WRC_WIRS_1	112	117	PF05994	0.554
LIG_WRC_WIRS_1	14	19	PF05994	0.250
MOD_CK1_1	173	179	PF00069	0.533
MOD_CK1_1	257	263	PF00069	0.545
MOD_CK1_1	30	36	PF00069	0.571
MOD_CK1_1	77	83	PF00069	0.405
MOD_CK1_1	94	100	PF00069	0.469
MOD_CK2_1	257	263	PF00069	0.556
MOD_GlcNHglycan	151	154	PF01048	0.353
MOD_GlcNHglycan	158	161	PF01048	0.335
MOD_GlcNHglycan	201	204	PF01048	0.399
MOD_GlcNHglycan	266	269	PF01048	0.331
MOD_GlcNHglycan	66	69	PF01048	0.384
MOD_GlcNHglycan	9	12	PF01048	0.263
MOD_GSK3_1	199	206	PF00069	0.420
MOD_GSK3_1	26	33	PF00069	0.544
MOD_GSK3_1	35	42	PF00069	0.479
MOD_GSK3_1	56	63	PF00069	0.425
MOD_GSK3_1	91	98	PF00069	0.335
MOD_N-GLC_1	184	189	PF02516	0.286
MOD_NEK2_1	13	18	PF00069	0.318
MOD_NEK2_1	163	168	PF00069	0.495
MOD_NEK2_1	211	216	PF00069	0.482
MOD_NEK2_1	254	259	PF00069	0.547
MOD_NEK2_1	26	31	PF00069	0.520
MOD_NEK2_1	60	65	PF00069	0.289
MOD_NEK2_1	95	100	PF00069	0.257
MOD_NEK2_2	266	271	PF00069	0.220
MOD_PIKK_1	254	260	PF00454	0.459
MOD_PKA_1	149	155	PF00069	0.457
MOD_PKA_1	54	60	PF00069	0.461
MOD_PKA_2	148	154	PF00069	0.506
MOD_PKA_2	254	260	PF00069	0.459
MOD_PKA_2	46	52	PF00069	0.478
MOD_PKA_2	54	60	PF00069	0.456
MOD_PKA_2	82	88	PF00069	0.465
MOD_PKB_1	54	62	PF00069	0.405
MOD_Plk_1	249	255	PF00069	0.566
MOD_Plk_2-3	46	52	PF00069	0.517
MOD_Plk_4	13	19	PF00069	0.269
MOD_Plk_4	212	218	PF00069	0.224
MOD_Plk_4	229	235	PF00069	0.239
MOD_Plk_4	249	255	PF00069	0.624
MOD_Plk_4	266	272	PF00069	0.393
MOD_Plk_4	39	45	PF00069	0.489
MOD_Plk_4	83	89	PF00069	0.477
MOD_Plk_4	95	101	PF00069	0.273
MOD_SUMO_rev_2	183	192	PF00179	0.501
TRG_ENDOCYTIC_2	139	142	PF00928	0.563
TRG_ENDOCYTIC_2	225	228	PF00928	0.281
TRG_ENDOCYTIC_2	70	73	PF00928	0.438
TRG_ER_diArg_1	179	181	PF00400	0.401
TRG_ER_diArg_1	24	26	PF00400	0.447
TRG_ER_diArg_1	53	56	PF00400	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS3	Leptomonas seymouri	50%	100%
A0A0S4JSY4	Bodo saltans	31%	91%
A0A1X0NYX6	Trypanosomatidae	31%	94%
A0A3S7X0B2	Leishmania donovani	75%	100%
A4I2J5	Leishmania infantum	75%	100%
C9ZK27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
E9AYQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q8S2	Leishmania major	70%	100%