BPI2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HFB2_LEIBR

TriTrypDb:

LbrM.26.2610 , LBRM2903_260032300

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.405
CLV_C14_Caspase3-7	32	36	PF00656	0.473
CLV_C14_Caspase3-7	339	343	PF00656	0.417
CLV_C14_Caspase3-7	80	84	PF00656	0.509
CLV_NRD_NRD_1	202	204	PF00675	0.476
CLV_PCSK_SKI1_1	204	208	PF00082	0.525
DEG_APCC_DBOX_1	181	189	PF00400	0.338
DEG_APCC_KENBOX_2	280	284	PF00400	0.409
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.482
DOC_MAPK_gen_1	112	120	PF00069	0.428
DOC_MAPK_gen_1	203	211	PF00069	0.437
DOC_MAPK_gen_1	243	250	PF00069	0.560
DOC_MAPK_gen_1	253	262	PF00069	0.548
DOC_MAPK_MEF2A_6	203	211	PF00069	0.437
DOC_MAPK_MEF2A_6	243	250	PF00069	0.487
DOC_MAPK_MEF2A_6	253	262	PF00069	0.555
DOC_PP2B_LxvP_1	155	158	PF13499	0.359
DOC_PP2B_LxvP_1	258	261	PF13499	0.440
DOC_USP7_MATH_1	210	214	PF00917	0.490
DOC_WW_Pin1_4	102	107	PF00397	0.403
DOC_WW_Pin1_4	34	39	PF00397	0.535
DOC_WW_Pin1_4	42	47	PF00397	0.455
DOC_WW_Pin1_4	81	86	PF00397	0.466
LIG_14-3-3_CanoR_1	112	117	PF00244	0.473
LIG_14-3-3_CanoR_1	253	259	PF00244	0.448
LIG_14-3-3_CanoR_1	294	299	PF00244	0.511
LIG_Actin_WH2_2	202	218	PF00022	0.340
LIG_Actin_WH2_2	346	364	PF00022	0.330
LIG_APCC_ABBA_1	23	28	PF00400	0.444
LIG_BIR_III_4	233	237	PF00653	0.402
LIG_BRCT_BRCA1_1	217	221	PF00533	0.458
LIG_FHA_1	176	182	PF00498	0.571
LIG_FHA_1	215	221	PF00498	0.595
LIG_FHA_1	255	261	PF00498	0.614
LIG_FHA_1	35	41	PF00498	0.605
LIG_FHA_1	356	362	PF00498	0.394
LIG_FHA_2	103	109	PF00498	0.422
LIG_FHA_2	30	36	PF00498	0.521
LIG_FHA_2	337	343	PF00498	0.417
LIG_FHA_2	57	63	PF00498	0.480
LIG_FHA_2	78	84	PF00498	0.495
LIG_LIR_Gen_1	119	127	PF02991	0.459
LIG_LIR_Gen_1	297	307	PF02991	0.433
LIG_LIR_Gen_1	310	320	PF02991	0.382
LIG_LIR_Gen_1	60	71	PF02991	0.377
LIG_LIR_Nem_3	163	167	PF02991	0.400
LIG_LIR_Nem_3	297	303	PF02991	0.555
LIG_LIR_Nem_3	310	315	PF02991	0.413
LIG_LIR_Nem_3	4	9	PF02991	0.369
LIG_LIR_Nem_3	60	66	PF02991	0.383
LIG_LIR_Nem_3	95	100	PF02991	0.459
LIG_LYPXL_yS_3	164	167	PF13949	0.477
LIG_Pex14_2	116	120	PF04695	0.365
LIG_Pex14_2	307	311	PF04695	0.323
LIG_PTB_Apo_2	325	332	PF02174	0.387
LIG_SH2_CRK	183	187	PF00017	0.488
LIG_SH2_CRK	300	304	PF00017	0.532
LIG_SH2_SRC	373	376	PF00017	0.398
LIG_SH2_STAP1	225	229	PF00017	0.537
LIG_SH2_STAP1	300	304	PF00017	0.405
LIG_SH2_STAT5	179	182	PF00017	0.429
LIG_SH2_STAT5	373	376	PF00017	0.398
LIG_SH2_STAT5	7	10	PF00017	0.645
LIG_SH3_3	264	270	PF00018	0.479
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.517
LIG_SUMO_SIM_par_1	7	14	PF11976	0.365
LIG_TRAF2_1	59	62	PF00917	0.412
LIG_TYR_ITIM	162	167	PF00017	0.489
LIG_TYR_ITIM	181	186	PF00017	0.364
LIG_TYR_ITIM	298	303	PF00017	0.418
LIG_WRC_WIRS_1	211	216	PF05994	0.491
MOD_CK1_1	190	196	PF00069	0.528
MOD_CK1_1	21	27	PF00069	0.511
MOD_CK1_1	329	335	PF00069	0.345
MOD_CK1_1	52	58	PF00069	0.453
MOD_CK2_1	55	61	PF00069	0.544
MOD_GlcNHglycan	126	130	PF01048	0.358
MOD_GlcNHglycan	345	348	PF01048	0.513
MOD_GSK3_1	10	17	PF00069	0.501
MOD_GSK3_1	210	217	PF00069	0.515
MOD_GSK3_1	30	37	PF00069	0.350
MOD_GSK3_1	307	314	PF00069	0.435
MOD_GSK3_1	341	348	PF00069	0.489
MOD_GSK3_1	351	358	PF00069	0.365
MOD_GSK3_1	48	55	PF00069	0.486
MOD_GSK3_1	77	84	PF00069	0.508
MOD_N-GLC_1	100	105	PF02516	0.416
MOD_N-GLC_1	21	26	PF02516	0.517
MOD_N-GLC_1	246	251	PF02516	0.521
MOD_N-GLC_1	253	258	PF02516	0.516
MOD_N-GLC_1	354	359	PF02516	0.565
MOD_N-GLC_1	42	47	PF02516	0.516
MOD_N-GLC_1	92	97	PF02516	0.430
MOD_NEK2_1	100	105	PF00069	0.496
MOD_NEK2_1	11	16	PF00069	0.431
MOD_NEK2_1	125	130	PF00069	0.496
MOD_NEK2_1	214	219	PF00069	0.515
MOD_NEK2_1	220	225	PF00069	0.482
MOD_NEK2_1	307	312	PF00069	0.449
MOD_NEK2_1	341	346	PF00069	0.417
MOD_NEK2_1	54	59	PF00069	0.472
MOD_NEK2_2	284	289	PF00069	0.494
MOD_PIKK_1	146	152	PF00454	0.437
MOD_PIKK_1	236	242	PF00454	0.399
MOD_PKA_2	215	221	PF00069	0.589
MOD_PKA_2	254	260	PF00069	0.442
MOD_PKA_2	329	335	PF00069	0.345
MOD_Plk_1	21	27	PF00069	0.508
MOD_Plk_1	221	227	PF00069	0.401
MOD_Plk_1	246	252	PF00069	0.507
MOD_Plk_1	253	259	PF00069	0.535
MOD_Plk_1	341	347	PF00069	0.420
MOD_Plk_1	354	360	PF00069	0.457
MOD_Plk_1	92	98	PF00069	0.480
MOD_Plk_2-3	336	342	PF00069	0.415
MOD_Plk_4	112	118	PF00069	0.667
MOD_Plk_4	175	181	PF00069	0.415
MOD_Plk_4	21	27	PF00069	0.557
MOD_Plk_4	210	216	PF00069	0.640
MOD_Plk_4	307	313	PF00069	0.342
MOD_Plk_4	336	342	PF00069	0.453
MOD_Plk_4	92	98	PF00069	0.614
MOD_ProDKin_1	102	108	PF00069	0.404
MOD_ProDKin_1	34	40	PF00069	0.532
MOD_ProDKin_1	42	48	PF00069	0.460
MOD_ProDKin_1	81	87	PF00069	0.462
TRG_DiLeu_BaEn_1	4	9	PF01217	0.370
TRG_ENDOCYTIC_2	124	127	PF00928	0.624
TRG_ENDOCYTIC_2	164	167	PF00928	0.477
TRG_ENDOCYTIC_2	183	186	PF00928	0.482
TRG_ENDOCYTIC_2	300	303	PF00928	0.533
TRG_ENDOCYTIC_2	373	376	PF00928	0.398
TRG_ENDOCYTIC_2	97	100	PF00928	0.587
TRG_ER_diArg_1	252	255	PF00400	0.476
TRG_ER_diArg_1	288	291	PF00400	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM7	Leptomonas seymouri	39%	100%
A0A3Q8IHC1	Leishmania donovani	74%	100%
A4I2J4	Leishmania infantum	74%	100%
E9AYP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q8S3	Leishmania major	73%	100%