Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP92

Species:

Leishmania braziliensis

UniProt:

A4HFB0_LEIBR

TriTrypDb:

LbrM.26.2590 , LBRM2903_260032100

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005643	nuclear pore	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005816	spindle pole body	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0044615	nuclear pore nuclear basket	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HFB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFB0

Function

Biological processes
Term	Name	Level	Count
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.531
CLV_C14_Caspase3-7	284	288	PF00656	0.504
CLV_C14_Caspase3-7	506	510	PF00656	0.436
CLV_NRD_NRD_1	423	425	PF00675	0.550
CLV_NRD_NRD_1	531	533	PF00675	0.594
CLV_NRD_NRD_1	571	573	PF00675	0.592
CLV_NRD_NRD_1	617	619	PF00675	0.533
CLV_PCSK_KEX2_1	124	126	PF00082	0.566
CLV_PCSK_KEX2_1	201	203	PF00082	0.488
CLV_PCSK_KEX2_1	213	215	PF00082	0.540
CLV_PCSK_KEX2_1	423	425	PF00082	0.507
CLV_PCSK_KEX2_1	571	573	PF00082	0.549
CLV_PCSK_KEX2_1	617	619	PF00082	0.569
CLV_PCSK_KEX2_1	665	667	PF00082	0.673
CLV_PCSK_KEX2_1	766	768	PF00082	0.480
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.566
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.488
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.577
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.673
CLV_PCSK_PC1ET2_1	766	768	PF00082	0.480
CLV_PCSK_SKI1_1	11	15	PF00082	0.726
CLV_PCSK_SKI1_1	125	129	PF00082	0.605
CLV_PCSK_SKI1_1	264	268	PF00082	0.539
CLV_PCSK_SKI1_1	373	377	PF00082	0.571
CLV_PCSK_SKI1_1	384	388	PF00082	0.511
CLV_PCSK_SKI1_1	391	395	PF00082	0.438
CLV_PCSK_SKI1_1	491	495	PF00082	0.556
CLV_PCSK_SKI1_1	508	512	PF00082	0.446
CLV_PCSK_SKI1_1	590	594	PF00082	0.494
CLV_PCSK_SKI1_1	722	726	PF00082	0.355
CLV_PCSK_SKI1_1	76	80	PF00082	0.720
CLV_PCSK_SKI1_1	767	771	PF00082	0.476
CLV_PCSK_SKI1_1	812	816	PF00082	0.409
DEG_APCC_DBOX_1	390	398	PF00400	0.596
DEG_APCC_DBOX_1	766	774	PF00400	0.294
DEG_SPOP_SBC_1	38	42	PF00917	0.522
DOC_CYCLIN_RxL_1	119	132	PF00134	0.601
DOC_MAPK_DCC_7	822	832	PF00069	0.414
DOC_MAPK_gen_1	124	130	PF00069	0.606
DOC_MAPK_gen_1	174	182	PF00069	0.552
DOC_MAPK_gen_1	511	519	PF00069	0.496
DOC_MAPK_gen_1	588	596	PF00069	0.364
DOC_MAPK_MEF2A_6	513	521	PF00069	0.358
DOC_MAPK_MEF2A_6	590	598	PF00069	0.362
DOC_MAPK_MEF2A_6	690	697	PF00069	0.570
DOC_PP1_RVXF_1	133	140	PF00149	0.516
DOC_USP7_MATH_1	178	182	PF00917	0.584
DOC_USP7_MATH_1	184	188	PF00917	0.604
DOC_USP7_MATH_1	277	281	PF00917	0.480
DOC_USP7_MATH_1	38	42	PF00917	0.788
DOC_USP7_MATH_1	408	412	PF00917	0.712
DOC_USP7_MATH_1	427	431	PF00917	0.587
DOC_USP7_MATH_1	628	632	PF00917	0.563
DOC_USP7_MATH_1	705	709	PF00917	0.480
DOC_USP7_UBL2_3	252	256	PF12436	0.386
DOC_USP7_UBL2_3	348	352	PF12436	0.593
DOC_USP7_UBL2_3	533	537	PF12436	0.593
DOC_USP7_UBL2_3	815	819	PF12436	0.323
DOC_WW_Pin1_4	624	629	PF00397	0.622
LIG_14-3-3_CanoR_1	117	127	PF00244	0.604
LIG_14-3-3_CanoR_1	179	183	PF00244	0.501
LIG_14-3-3_CanoR_1	229	234	PF00244	0.565
LIG_14-3-3_CanoR_1	309	315	PF00244	0.548
LIG_14-3-3_CanoR_1	350	358	PF00244	0.563
LIG_14-3-3_CanoR_1	373	380	PF00244	0.650
LIG_14-3-3_CanoR_1	384	392	PF00244	0.524
LIG_14-3-3_CanoR_1	513	518	PF00244	0.556
LIG_14-3-3_CanoR_1	550	557	PF00244	0.470
LIG_14-3-3_CanoR_1	604	612	PF00244	0.457
LIG_14-3-3_CanoR_1	648	656	PF00244	0.646
LIG_14-3-3_CanoR_1	666	675	PF00244	0.460
LIG_14-3-3_CanoR_1	767	775	PF00244	0.420
LIG_14-3-3_CanoR_1	86	90	PF00244	0.664
LIG_14-3-3_CanoR_1	99	108	PF00244	0.539
LIG_Actin_WH2_2	70	88	PF00022	0.761
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_CaM_IQ_9	337	352	PF13499	0.421
LIG_CaM_IQ_9	365	381	PF13499	0.638
LIG_eIF4E_1	780	786	PF01652	0.413
LIG_FHA_1	186	192	PF00498	0.552
LIG_FHA_1	34	40	PF00498	0.689
LIG_FHA_1	514	520	PF00498	0.615
LIG_FHA_1	544	550	PF00498	0.564
LIG_FHA_1	551	557	PF00498	0.567
LIG_FHA_1	591	597	PF00498	0.517
LIG_FHA_1	636	642	PF00498	0.529
LIG_FHA_1	709	715	PF00498	0.414
LIG_FHA_1	718	724	PF00498	0.402
LIG_FHA_1	73	79	PF00498	0.693
LIG_FHA_1	780	786	PF00498	0.393
LIG_FHA_2	12	18	PF00498	0.703
LIG_FHA_2	190	196	PF00498	0.594
LIG_FHA_2	266	272	PF00498	0.612
LIG_FHA_2	311	317	PF00498	0.517
LIG_FHA_2	351	357	PF00498	0.582
LIG_FHA_2	411	417	PF00498	0.651
LIG_FHA_2	46	52	PF00498	0.806
LIG_FHA_2	604	610	PF00498	0.522
LIG_FHA_2	805	811	PF00498	0.428
LIG_LIR_Gen_1	112	120	PF02991	0.522
LIG_LIR_Gen_1	136	144	PF02991	0.579
LIG_LIR_Nem_3	112	116	PF02991	0.523
LIG_LIR_Nem_3	136	142	PF02991	0.580
LIG_MYND_1	31	35	PF01753	0.764
LIG_RPA_C_Fungi	253	265	PF08784	0.631
LIG_RPA_C_Fungi	357	369	PF08784	0.670
LIG_SH2_NCK_1	780	784	PF00017	0.472
LIG_SH2_STAP1	168	172	PF00017	0.600
LIG_SH2_STAT3	754	757	PF00017	0.547
LIG_SH2_STAT5	120	123	PF00017	0.380
LIG_SH2_STAT5	314	317	PF00017	0.626
LIG_SH2_STAT5	738	741	PF00017	0.388
LIG_SH3_3	29	35	PF00018	0.769
LIG_SH3_3	54	60	PF00018	0.787
LIG_SH3_3	86	92	PF00018	0.665
LIG_SUMO_SIM_anti_2	518	524	PF11976	0.353
LIG_SUMO_SIM_par_1	30	37	PF11976	0.513
LIG_SUMO_SIM_par_1	515	520	PF11976	0.540
LIG_SUMO_SIM_par_1	592	597	PF11976	0.367
LIG_TRAF2_1	109	112	PF00917	0.564
LIG_TRAF2_1	147	150	PF00917	0.469
LIG_TRAF2_1	240	243	PF00917	0.616
LIG_TRAF2_1	354	357	PF00917	0.591
LIG_TRAF2_1	414	417	PF00917	0.563
LIG_TRAF2_1	450	453	PF00917	0.621
LIG_TRAF2_1	48	51	PF00917	0.553
LIG_TRAF2_1	481	484	PF00917	0.560
LIG_UBA3_1	826	831	PF00899	0.536
MOD_CK1_1	332	338	PF00069	0.574
MOD_CK1_1	41	47	PF00069	0.776
MOD_CK1_1	411	417	PF00069	0.697
MOD_CK1_1	431	437	PF00069	0.287
MOD_CK1_1	631	637	PF00069	0.621
MOD_CK1_1	649	655	PF00069	0.623
MOD_CK1_1	708	714	PF00069	0.451
MOD_CK1_1	781	787	PF00069	0.533
MOD_CK2_1	106	112	PF00069	0.551
MOD_CK2_1	144	150	PF00069	0.486
MOD_CK2_1	189	195	PF00069	0.594
MOD_CK2_1	229	235	PF00069	0.527
MOD_CK2_1	272	278	PF00069	0.553
MOD_CK2_1	310	316	PF00069	0.496
MOD_CK2_1	350	356	PF00069	0.581
MOD_CK2_1	410	416	PF00069	0.572
MOD_CK2_1	45	51	PF00069	0.754
MOD_CK2_1	521	527	PF00069	0.484
MOD_CK2_1	603	609	PF00069	0.479
MOD_CK2_1	739	745	PF00069	0.495
MOD_CK2_1	804	810	PF00069	0.416
MOD_GlcNHglycan	104	107	PF01048	0.564
MOD_GlcNHglycan	108	111	PF01048	0.595
MOD_GlcNHglycan	356	361	PF01048	0.567
MOD_GlcNHglycan	537	540	PF01048	0.481
MOD_GlcNHglycan	597	601	PF01048	0.520
MOD_GlcNHglycan	651	654	PF01048	0.644
MOD_GlcNHglycan	677	680	PF01048	0.412
MOD_GSK3_1	185	192	PF00069	0.442
MOD_GSK3_1	260	267	PF00069	0.612
MOD_GSK3_1	277	284	PF00069	0.520
MOD_GSK3_1	33	40	PF00069	0.641
MOD_GSK3_1	41	48	PF00069	0.720
MOD_GSK3_1	427	434	PF00069	0.492
MOD_GSK3_1	513	520	PF00069	0.527
MOD_GSK3_1	586	593	PF00069	0.579
MOD_GSK3_1	618	625	PF00069	0.634
MOD_GSK3_1	631	638	PF00069	0.613
MOD_GSK3_1	648	655	PF00069	0.672
MOD_GSK3_1	656	663	PF00069	0.635
MOD_GSK3_1	708	715	PF00069	0.446
MOD_GSK3_1	98	105	PF00069	0.679
MOD_LATS_1	644	650	PF00433	0.796
MOD_N-GLC_1	310	315	PF02516	0.519
MOD_N-GLC_1	634	639	PF02516	0.732
MOD_N-GLC_1	646	651	PF02516	0.579
MOD_N-GLC_1	708	713	PF02516	0.456
MOD_N-GLC_1	97	102	PF02516	0.666
MOD_NEK2_1	142	147	PF00069	0.531
MOD_NEK2_1	154	159	PF00069	0.502
MOD_NEK2_1	260	265	PF00069	0.624
MOD_NEK2_1	272	277	PF00069	0.556
MOD_NEK2_1	310	315	PF00069	0.527
MOD_NEK2_1	517	522	PF00069	0.558
MOD_NEK2_1	675	680	PF00069	0.474
MOD_NEK2_1	72	77	PF00069	0.649
MOD_NEK2_1	773	778	PF00069	0.328
MOD_NEK2_1	79	84	PF00069	0.657
MOD_NEK2_1	85	90	PF00069	0.663
MOD_NEK2_1	9	14	PF00069	0.634
MOD_NEK2_2	628	633	PF00069	0.779
MOD_NEK2_2	660	665	PF00069	0.782
MOD_NEK2_2	717	722	PF00069	0.418
MOD_PIKK_1	118	124	PF00454	0.524
MOD_PIKK_1	144	150	PF00454	0.505
MOD_PIKK_1	46	52	PF00454	0.712
MOD_PIKK_1	55	61	PF00454	0.744
MOD_PIKK_1	618	624	PF00454	0.669
MOD_PK_1	646	652	PF00069	0.739
MOD_PKA_2	118	124	PF00069	0.305
MOD_PKA_2	154	160	PF00069	0.573
MOD_PKA_2	178	184	PF00069	0.506
MOD_PKA_2	408	414	PF00069	0.621
MOD_PKA_2	603	609	PF00069	0.451
MOD_PKA_2	85	91	PF00069	0.672
MOD_PKA_2	98	104	PF00069	0.545
MOD_Plk_1	242	248	PF00069	0.379
MOD_Plk_1	310	316	PF00069	0.521
MOD_Plk_1	431	437	PF00069	0.540
MOD_Plk_1	517	523	PF00069	0.522
MOD_Plk_1	558	564	PF00069	0.629
MOD_Plk_1	646	652	PF00069	0.742
MOD_Plk_1	708	714	PF00069	0.448
MOD_Plk_1	744	750	PF00069	0.521
MOD_Plk_1	79	85	PF00069	0.738
MOD_Plk_1	97	103	PF00069	0.535
MOD_Plk_4	3	9	PF00069	0.538
MOD_Plk_4	310	316	PF00069	0.579
MOD_Plk_4	517	523	PF00069	0.534
MOD_Plk_4	734	740	PF00069	0.487
MOD_Plk_4	744	750	PF00069	0.462
MOD_Plk_4	781	787	PF00069	0.498
MOD_Plk_4	80	86	PF00069	0.723
MOD_ProDKin_1	624	630	PF00069	0.625
MOD_SUMO_for_1	123	126	PF00179	0.566
MOD_SUMO_for_1	448	451	PF00179	0.615
MOD_SUMO_for_1	610	613	PF00179	0.607
MOD_SUMO_rev_2	147	154	PF00179	0.551
MOD_SUMO_rev_2	173	178	PF00179	0.531
MOD_SUMO_rev_2	181	187	PF00179	0.565
MOD_SUMO_rev_2	259	266	PF00179	0.596
MOD_SUMO_rev_2	316	321	PF00179	0.625
MOD_SUMO_rev_2	58	67	PF00179	0.672
MOD_SUMO_rev_2	603	612	PF00179	0.538
TRG_AP2beta_CARGO_1	136	146	PF09066	0.578
TRG_DiLeu_BaEn_1	149	154	PF01217	0.594
TRG_DiLeu_BaEn_2	194	200	PF01217	0.582
TRG_DiLeu_BaEn_4	149	155	PF01217	0.597
TRG_DiLeu_BaEn_4	195	201	PF01217	0.581
TRG_DiLeu_BaEn_4	242	248	PF01217	0.550
TRG_DiLeu_BaEn_4	316	322	PF01217	0.625
TRG_DiLeu_BaEn_4	417	423	PF01217	0.514
TRG_DiLeu_BaEn_4	558	564	PF01217	0.629
TRG_DiLeu_BaEn_4	759	765	PF01217	0.517
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.497
TRG_DiLeu_LyEn_5	759	764	PF01217	0.514
TRG_ENDOCYTIC_2	113	116	PF00928	0.606
TRG_ER_diArg_1	116	119	PF00400	0.494
TRG_ER_diArg_1	283	286	PF00400	0.360
TRG_ER_diArg_1	422	424	PF00400	0.555
TRG_ER_diArg_1	571	573	PF00400	0.605
TRG_ER_diArg_1	580	583	PF00400	0.565
TRG_ER_diArg_1	617	619	PF00400	0.550
TRG_NLS_MonoExtC_3	664	670	PF00514	0.694
TRG_NLS_MonoExtN_4	762	769	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9T1	Leptomonas seymouri	68%	100%
A0A1X0P756	Trypanosomatidae	39%	100%
A0A3Q8IE13	Leishmania donovani	83%	100%
A0A3S5IQG3	Trypanosoma rangeli	38%	100%
A4I2J2	Leishmania infantum	83%	100%
C9ZWZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AYP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q8S5	Leishmania major	83%	100%
V5BGQ7	Trypanosoma cruzi	38%	100%