Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFA9_LEIBR

TriTrypDb:

LbrM.26.2580 , LBRM2903_260032000

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.604
CLV_C14_Caspase3-7	383	387	PF00656	0.568
CLV_NRD_NRD_1	252	254	PF00675	0.525
CLV_NRD_NRD_1	27	29	PF00675	0.517
CLV_NRD_NRD_1	366	368	PF00675	0.643
CLV_NRD_NRD_1	433	435	PF00675	0.534
CLV_NRD_NRD_1	546	548	PF00675	0.657
CLV_PCSK_KEX2_1	157	159	PF00082	0.671
CLV_PCSK_KEX2_1	252	254	PF00082	0.702
CLV_PCSK_KEX2_1	27	29	PF00082	0.577
CLV_PCSK_KEX2_1	366	368	PF00082	0.610
CLV_PCSK_KEX2_1	546	548	PF00082	0.657
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.671
CLV_PCSK_SKI1_1	211	215	PF00082	0.599
CLV_PCSK_SKI1_1	238	242	PF00082	0.688
CLV_PCSK_SKI1_1	482	486	PF00082	0.482
DEG_APCC_DBOX_1	546	554	PF00400	0.609
DEG_SPOP_SBC_1	316	320	PF00917	0.512
DEG_SPOP_SBC_1	464	468	PF00917	0.402
DEG_SPOP_SBC_1	539	543	PF00917	0.393
DEG_SPOP_SBC_1	56	60	PF00917	0.664
DOC_CYCLIN_yCln2_LP_2	240	243	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.742
DOC_CYCLIN_yCln2_LP_2	458	464	PF00134	0.446
DOC_MAPK_gen_1	157	164	PF00069	0.534
DOC_MAPK_MEF2A_6	77	84	PF00069	0.511
DOC_PP2B_LxvP_1	240	243	PF13499	0.531
DOC_PP2B_LxvP_1	458	461	PF13499	0.666
DOC_PP4_FxxP_1	276	279	PF00568	0.505
DOC_PP4_FxxP_1	382	385	PF00568	0.424
DOC_PP4_FxxP_1	531	534	PF00568	0.389
DOC_PP4_MxPP_1	133	136	PF00568	0.524
DOC_USP7_MATH_1	127	131	PF00917	0.742
DOC_USP7_MATH_1	183	187	PF00917	0.363
DOC_USP7_MATH_1	233	237	PF00917	0.707
DOC_USP7_MATH_1	269	273	PF00917	0.714
DOC_USP7_MATH_1	464	468	PF00917	0.642
DOC_USP7_MATH_1	501	505	PF00917	0.607
DOC_USP7_MATH_1	56	60	PF00917	0.592
DOC_USP7_MATH_1	7	11	PF00917	0.453
DOC_WW_Pin1_4	136	141	PF00397	0.636
DOC_WW_Pin1_4	145	150	PF00397	0.695
DOC_WW_Pin1_4	295	300	PF00397	0.589
DOC_WW_Pin1_4	305	310	PF00397	0.593
DOC_WW_Pin1_4	369	374	PF00397	0.370
DOC_WW_Pin1_4	447	452	PF00397	0.526
DOC_WW_Pin1_4	61	66	PF00397	0.538
LIG_14-3-3_CanoR_1	193	199	PF00244	0.347
LIG_14-3-3_CanoR_1	429	434	PF00244	0.633
LIG_14-3-3_CanoR_1	503	510	PF00244	0.567
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_FHA_1	105	111	PF00498	0.625
LIG_FHA_1	121	127	PF00498	0.450
LIG_FHA_1	246	252	PF00498	0.797
LIG_FHA_1	273	279	PF00498	0.736
LIG_FHA_1	301	307	PF00498	0.477
LIG_FHA_1	316	322	PF00498	0.739
LIG_FHA_1	35	41	PF00498	0.606
LIG_FHA_1	379	385	PF00498	0.438
LIG_FHA_1	428	434	PF00498	0.630
LIG_FHA_1	464	470	PF00498	0.553
LIG_FHA_1	492	498	PF00498	0.588
LIG_FHA_1	528	534	PF00498	0.393
LIG_FHA_2	154	160	PF00498	0.760
LIG_FHA_2	540	546	PF00498	0.517
LIG_Integrin_isoDGR_2	209	211	PF01839	0.608
LIG_IRF3_LxIS_1	74	81	PF10401	0.546
LIG_LIR_Apic_2	275	279	PF02991	0.705
LIG_LIR_Apic_2	381	385	PF02991	0.425
LIG_LIR_Apic_2	530	534	PF02991	0.389
LIG_LIR_Gen_1	409	418	PF02991	0.482
LIG_LIR_Gen_1	504	514	PF02991	0.427
LIG_LIR_Gen_1	565	574	PF02991	0.327
LIG_LIR_Nem_3	170	176	PF02991	0.493
LIG_LIR_Nem_3	20	26	PF02991	0.599
LIG_LIR_Nem_3	218	223	PF02991	0.517
LIG_LIR_Nem_3	294	300	PF02991	0.615
LIG_LIR_Nem_3	409	413	PF02991	0.449
LIG_LIR_Nem_3	467	473	PF02991	0.532
LIG_LIR_Nem_3	504	510	PF02991	0.518
LIG_LIR_Nem_3	565	571	PF02991	0.333
LIG_LYPXL_yS_3	578	581	PF13949	0.589
LIG_PCNA_yPIPBox_3	193	207	PF02747	0.567
LIG_REV1ctd_RIR_1	170	178	PF16727	0.495
LIG_SH2_CRK	297	301	PF00017	0.483
LIG_SH2_STAT5	100	103	PF00017	0.563
LIG_SH2_STAT5	223	226	PF00017	0.470
LIG_SH2_STAT5	470	473	PF00017	0.583
LIG_SH2_STAT5	483	486	PF00017	0.542
LIG_SH2_STAT5	498	501	PF00017	0.318
LIG_SH3_1	440	446	PF00018	0.439
LIG_SH3_3	129	135	PF00018	0.803
LIG_SH3_3	138	144	PF00018	0.696
LIG_SH3_3	146	152	PF00018	0.809
LIG_SH3_3	193	199	PF00018	0.464
LIG_SH3_3	318	324	PF00018	0.674
LIG_SH3_3	367	373	PF00018	0.486
LIG_SH3_3	440	446	PF00018	0.561
LIG_SH3_3	558	564	PF00018	0.535
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.371
LIG_SUMO_SIM_par_1	36	41	PF11976	0.377
LIG_TRAF2_1	202	205	PF00917	0.504
LIG_TRAF2_1	542	545	PF00917	0.512
LIG_TRAF2_2	561	566	PF00917	0.493
LIG_TYR_ITSM	293	300	PF00017	0.476
LIG_WRC_WIRS_1	355	360	PF05994	0.625
MOD_CDK_SPxxK_3	305	312	PF00069	0.742
MOD_CDK_SPxxK_3	61	68	PF00069	0.622
MOD_CK1_1	111	117	PF00069	0.531
MOD_CK1_1	139	145	PF00069	0.705
MOD_CK1_1	244	250	PF00069	0.696
MOD_CK1_1	272	278	PF00069	0.689
MOD_CK1_1	308	314	PF00069	0.579
MOD_CK1_1	34	40	PF00069	0.616
MOD_CK1_1	452	458	PF00069	0.646
MOD_CK1_1	465	471	PF00069	0.611
MOD_CK1_1	532	538	PF00069	0.468
MOD_CK1_1	59	65	PF00069	0.564
MOD_CK2_1	153	159	PF00069	0.687
MOD_CK2_1	532	538	PF00069	0.452
MOD_CK2_1	539	545	PF00069	0.468
MOD_CK2_1	61	67	PF00069	0.501
MOD_GlcNHglycan	113	116	PF01048	0.626
MOD_GlcNHglycan	129	132	PF01048	0.697
MOD_GlcNHglycan	141	144	PF01048	0.665
MOD_GlcNHglycan	271	274	PF01048	0.655
MOD_GlcNHglycan	33	36	PF01048	0.667
MOD_GlcNHglycan	333	336	PF01048	0.678
MOD_GlcNHglycan	423	426	PF01048	0.699
MOD_GlcNHglycan	499	502	PF01048	0.586
MOD_GlcNHglycan	51	55	PF01048	0.477
MOD_GlcNHglycan	521	524	PF01048	0.428
MOD_GlcNHglycan	547	550	PF01048	0.605
MOD_GlcNHglycan	556	559	PF01048	0.563
MOD_GlcNHglycan	69	74	PF01048	0.566
MOD_GlcNHglycan	9	12	PF01048	0.510
MOD_GSK3_1	104	111	PF00069	0.532
MOD_GSK3_1	158	165	PF00069	0.784
MOD_GSK3_1	241	248	PF00069	0.676
MOD_GSK3_1	291	298	PF00069	0.618
MOD_GSK3_1	338	345	PF00069	0.781
MOD_GSK3_1	34	41	PF00069	0.615
MOD_GSK3_1	497	504	PF00069	0.447
MOD_GSK3_1	529	536	PF00069	0.512
MOD_GSK3_1	55	62	PF00069	0.611
MOD_N-GLC_2	118	120	PF02516	0.736
MOD_NEK2_1	105	110	PF00069	0.545
MOD_NEK2_1	338	343	PF00069	0.530
MOD_NEK2_1	378	383	PF00069	0.460
MOD_NEK2_1	497	502	PF00069	0.589
MOD_NEK2_1	55	60	PF00069	0.594
MOD_NEK2_1	78	83	PF00069	0.483
MOD_PIKK_1	108	114	PF00454	0.691
MOD_PIKK_1	162	168	PF00454	0.659
MOD_PIKK_1	233	239	PF00454	0.753
MOD_PK_1	158	164	PF00069	0.627
MOD_PK_1	429	435	PF00069	0.523
MOD_PKA_2	108	114	PF00069	0.548
MOD_PKA_2	183	189	PF00069	0.369
MOD_PKA_2	291	297	PF00069	0.686
MOD_PKA_2	339	345	PF00069	0.767
MOD_PKA_2	502	508	PF00069	0.605
MOD_PKA_2	545	551	PF00069	0.607
MOD_Plk_1	158	164	PF00069	0.665
MOD_Plk_1	292	298	PF00069	0.693
MOD_Plk_1	353	359	PF00069	0.627
MOD_Plk_1	38	44	PF00069	0.478
MOD_Plk_1	50	56	PF00069	0.497
MOD_Plk_1	69	75	PF00069	0.578
MOD_Plk_2-3	354	360	PF00069	0.637
MOD_Plk_2-3	506	512	PF00069	0.565
MOD_Plk_4	158	164	PF00069	0.651
MOD_Plk_4	292	298	PF00069	0.656
MOD_Plk_4	317	323	PF00069	0.725
MOD_Plk_4	38	44	PF00069	0.499
MOD_Plk_4	465	471	PF00069	0.523
MOD_Plk_4	93	99	PF00069	0.476
MOD_ProDKin_1	136	142	PF00069	0.641
MOD_ProDKin_1	145	151	PF00069	0.692
MOD_ProDKin_1	295	301	PF00069	0.589
MOD_ProDKin_1	305	311	PF00069	0.595
MOD_ProDKin_1	369	375	PF00069	0.363
MOD_ProDKin_1	447	453	PF00069	0.526
MOD_ProDKin_1	61	67	PF00069	0.531
MOD_SUMO_rev_2	511	519	PF00179	0.550
TRG_AP2beta_CARGO_1	565	575	PF09066	0.329
TRG_DiLeu_BaEn_1	409	414	PF01217	0.443
TRG_DiLeu_BaEn_1	70	75	PF01217	0.530
TRG_DiLeu_LyEn_5	409	414	PF01217	0.463
TRG_ENDOCYTIC_2	217	220	PF00928	0.443
TRG_ENDOCYTIC_2	297	300	PF00928	0.700
TRG_ENDOCYTIC_2	507	510	PF00928	0.510
TRG_ENDOCYTIC_2	578	581	PF00928	0.589
TRG_ER_diArg_1	251	253	PF00400	0.772
TRG_ER_diArg_1	26	28	PF00400	0.538
TRG_ER_diArg_1	365	367	PF00400	0.614
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I848	Leptomonas seymouri	54%	100%
A0A1X0P7D0	Trypanosomatidae	33%	100%
A0A3R7MCE3	Trypanosoma rangeli	34%	100%
A0A3S7X099	Leishmania donovani	79%	100%
A4I2J1	Leishmania infantum	79%	100%
C9ZWZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AYP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q8S6	Leishmania major	79%	100%
V5B7P2	Trypanosoma cruzi	34%	100%