Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HFA6_LEIBR

TriTrypDb:

LbrM.26.2550 , LBRM2903_260031600

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	100	104	PF00082	0.441
CLV_Separin_Metazoa	223	227	PF03568	0.467
DOC_CDC14_PxL_1	201	209	PF14671	0.385
DOC_MAPK_MEF2A_6	117	125	PF00069	0.538
DOC_USP7_MATH_1	171	175	PF00917	0.552
DOC_WW_Pin1_4	189	194	PF00397	0.548
DOC_WW_Pin1_4	81	86	PF00397	0.577
DOC_WW_Pin1_4	93	98	PF00397	0.492
LIG_14-3-3_CanoR_1	100	106	PF00244	0.443
LIG_14-3-3_CanoR_1	226	232	PF00244	0.453
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_Clathr_ClatBox_1	53	57	PF01394	0.580
LIG_EVH1_2	37	41	PF00568	0.466
LIG_FHA_1	118	124	PF00498	0.400
LIG_FHA_1	165	171	PF00498	0.637
LIG_FHA_1	175	181	PF00498	0.483
LIG_FHA_1	97	103	PF00498	0.429
LIG_FHA_2	244	250	PF00498	0.524
LIG_FHA_2	41	47	PF00498	0.573
LIG_FHA_2	65	71	PF00498	0.668
LIG_GBD_Chelix_1	160	168	PF00786	0.608
LIG_LIR_Gen_1	108	118	PF02991	0.508
LIG_LIR_Gen_1	195	204	PF02991	0.473
LIG_LIR_Gen_1	96	106	PF02991	0.448
LIG_LIR_Nem_3	108	114	PF02991	0.521
LIG_LIR_Nem_3	195	199	PF02991	0.459
LIG_LIR_Nem_3	96	101	PF02991	0.452
LIG_NRBOX	49	55	PF00104	0.488
LIG_Pex14_2	101	105	PF04695	0.434
LIG_Pex14_2	235	239	PF04695	0.542
LIG_Pex14_2	272	276	PF04695	0.470
LIG_SH2_CRK	111	115	PF00017	0.508
LIG_SH2_NCK_1	111	115	PF00017	0.508
LIG_SH2_SRC	196	199	PF00017	0.459
LIG_SH2_STAP1	106	110	PF00017	0.503
LIG_SH2_STAP1	98	102	PF00017	0.441
LIG_SH2_STAT3	186	189	PF00017	0.599
LIG_SH2_STAT3	206	209	PF00017	0.278
LIG_SH2_STAT5	196	199	PF00017	0.459
LIG_SH2_STAT5	206	209	PF00017	0.506
LIG_SH2_STAT5	63	66	PF00017	0.572
LIG_SH2_STAT5	98	101	PF00017	0.481
LIG_SH3_3	196	202	PF00018	0.572
LIG_SH3_3	222	228	PF00018	0.442
LIG_SH3_3	79	85	PF00018	0.354
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.460
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.208
LIG_SUMO_SIM_anti_2	246	255	PF11976	0.611
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.587
LIG_SUMO_SIM_par_1	52	57	PF11976	0.587
LIG_TRAF2_1	220	223	PF00917	0.467
LIG_TYR_ITIM	194	199	PF00017	0.454
LIG_TYR_ITSM	107	114	PF00017	0.615
LIG_UBA3_1	53	59	PF00899	0.587
LIG_WRC_WIRS_1	102	107	PF05994	0.454
MOD_CDK_SPxxK_3	93	100	PF00069	0.482
MOD_CK1_1	104	110	PF00069	0.256
MOD_CK1_1	174	180	PF00069	0.502
MOD_CK1_1	40	46	PF00069	0.562
MOD_CK1_1	84	90	PF00069	0.508
MOD_CK1_1	96	102	PF00069	0.445
MOD_CK2_1	145	151	PF00069	0.383
MOD_CK2_1	40	46	PF00069	0.540
MOD_CK2_1	70	76	PF00069	0.438
MOD_GSK3_1	101	108	PF00069	0.549
MOD_GSK3_1	113	120	PF00069	0.471
MOD_GSK3_1	37	44	PF00069	0.555
MOD_N-GLC_1	162	167	PF02516	0.607
MOD_NEK2_1	101	106	PF00069	0.390
MOD_NEK2_1	11	16	PF00069	0.616
MOD_NEK2_1	164	169	PF00069	0.554
MOD_NEK2_2	106	111	PF00069	0.603
MOD_PIKK_1	205	211	PF00454	0.499
MOD_PKA_2	174	180	PF00069	0.338
MOD_Plk_4	101	107	PF00069	0.404
MOD_Plk_4	212	218	PF00069	0.410
MOD_Plk_4	227	233	PF00069	0.442
MOD_Plk_4	37	43	PF00069	0.438
MOD_ProDKin_1	189	195	PF00069	0.549
MOD_ProDKin_1	81	87	PF00069	0.572
MOD_ProDKin_1	93	99	PF00069	0.483
TRG_DiLeu_BaEn_1	76	81	PF01217	0.411
TRG_ENDOCYTIC_2	111	114	PF00928	0.511
TRG_ENDOCYTIC_2	196	199	PF00928	0.459
TRG_ENDOCYTIC_2	98	101	PF00928	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K2	Leptomonas seymouri	61%	100%
A0A3S7X096	Leishmania donovani	86%	100%
A4I2I3	Leishmania infantum	86%	100%
E9AYP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8S9	Leishmania major	86%	100%