Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFA2_LEIBR

TriTrypDb:

LbrM.26.2510 , LBRM2903_260031200

Length:

151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.676
CLV_NRD_NRD_1	142	144	PF00675	0.637
CLV_NRD_NRD_1	33	35	PF00675	0.511
CLV_NRD_NRD_1	96	98	PF00675	0.692
CLV_PCSK_FUR_1	143	147	PF00082	0.686
CLV_PCSK_KEX2_1	131	133	PF00082	0.650
CLV_PCSK_KEX2_1	142	144	PF00082	0.606
CLV_PCSK_KEX2_1	145	147	PF00082	0.595
CLV_PCSK_KEX2_1	149	151	PF00082	0.563
CLV_PCSK_KEX2_1	33	35	PF00082	0.511
CLV_PCSK_KEX2_1	70	72	PF00082	0.488
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.724
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.767
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.416
CLV_PCSK_SKI1_1	18	22	PF00082	0.550
CLV_PCSK_SKI1_1	70	74	PF00082	0.475
DEG_Nend_Nbox_1	1	3	PF02207	0.429
DOC_MAPK_gen_1	33	39	PF00069	0.392
DOC_PP1_RVXF_1	23	30	PF00149	0.372
DOC_PP2B_LxvP_1	19	22	PF13499	0.492
DOC_USP7_MATH_1	119	123	PF00917	0.722
DOC_USP7_UBL2_3	145	149	PF12436	0.704
DOC_WW_Pin1_4	57	62	PF00397	0.611
LIG_14-3-3_CanoR_1	118	124	PF00244	0.590
LIG_14-3-3_CanoR_1	131	137	PF00244	0.610
LIG_14-3-3_CanoR_1	25	30	PF00244	0.515
LIG_14-3-3_CanoR_1	45	54	PF00244	0.642
LIG_14-3-3_CanoR_1	97	103	PF00244	0.641
LIG_APCC_ABBA_1	37	42	PF00400	0.398
LIG_FHA_1	49	55	PF00498	0.610
LIG_Integrin_isoDGR_2	80	82	PF01839	0.402
LIG_PCNA_yPIPBox_3	45	54	PF02747	0.447
LIG_SH2_GRB2like	91	94	PF00017	0.595
LIG_SH2_STAP1	91	95	PF00017	0.564
LIG_SH3_3	113	119	PF00018	0.668
LIG_SUMO_SIM_par_1	51	58	PF11976	0.659
LIG_SUMO_SIM_par_1	60	67	PF11976	0.519
LIG_TRAF2_1	28	31	PF00917	0.457
LIG_UBA3_1	1	7	PF00899	0.393
LIG_UBA3_1	72	78	PF00899	0.525
MOD_CK1_1	122	128	PF00069	0.679
MOD_CK1_1	48	54	PF00069	0.648
MOD_CK2_1	25	31	PF00069	0.457
MOD_Cter_Amidation	147	150	PF01082	0.786
MOD_Cter_Amidation	31	34	PF01082	0.495
MOD_GlcNHglycan	98	101	PF01048	0.613
MOD_GSK3_1	118	125	PF00069	0.677
MOD_NEK2_1	123	128	PF00069	0.617
MOD_NEK2_1	64	69	PF00069	0.539
MOD_PKA_2	117	123	PF00069	0.679
MOD_PKA_2	141	147	PF00069	0.656
MOD_PKA_2	96	102	PF00069	0.700
MOD_Plk_1	48	54	PF00069	0.586
MOD_ProDKin_1	57	63	PF00069	0.607
MOD_SUMO_rev_2	49	59	PF00179	0.644
TRG_DiLeu_BaEn_1	49	54	PF01217	0.653
TRG_DiLeu_BaEn_4	30	36	PF01217	0.476
TRG_ER_diArg_1	131	134	PF00400	0.673
TRG_ER_diArg_1	33	35	PF00400	0.511
TRG_NLS_MonoExtC_3	138	143	PF00514	0.687
TRG_NLS_MonoExtN_4	137	143	PF00514	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC7	Leptomonas seymouri	75%	100%
A0A1X0NEM8	Trypanosomatidae	50%	100%
A0A3R7R8R4	Trypanosoma rangeli	50%	100%
A0A3S7X093	Leishmania donovani	83%	100%
C9ZX03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	97%
E9AYN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q8T3	Leishmania major	83%	100%