LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HFA1_LEIBR
TriTrypDb:
LbrM.26.2500 , LBRM2903_260031100
Length:
433

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFA1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFA1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 15
GO:0006793 phosphorus metabolic process 3 15
GO:0006796 phosphate-containing compound metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009987 cellular process 1 15
GO:0016310 phosphorylation 5 15
GO:0019538 protein metabolic process 3 15
GO:0036211 protein modification process 4 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043412 macromolecule modification 4 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 15
GO:0003824 catalytic activity 1 15
GO:0004672 protein kinase activity 3 15
GO:0004674 protein serine/threonine kinase activity 4 11
GO:0005488 binding 1 15
GO:0005524 ATP binding 5 15
GO:0016301 kinase activity 4 15
GO:0016740 transferase activity 2 15
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 15
GO:0017076 purine nucleotide binding 4 15
GO:0030554 adenyl nucleotide binding 5 15
GO:0032553 ribonucleotide binding 3 15
GO:0032555 purine ribonucleotide binding 4 15
GO:0032559 adenyl ribonucleotide binding 5 15
GO:0035639 purine ribonucleoside triphosphate binding 4 15
GO:0036094 small molecule binding 2 15
GO:0043167 ion binding 2 15
GO:0043168 anion binding 3 15
GO:0097159 organic cyclic compound binding 2 15
GO:0097367 carbohydrate derivative binding 2 15
GO:0140096 catalytic activity, acting on a protein 2 15
GO:1901265 nucleoside phosphate binding 3 15
GO:1901363 heterocyclic compound binding 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 342 346 PF00656 0.529
CLV_MEL_PAP_1 195 201 PF00089 0.432
CLV_NRD_NRD_1 152 154 PF00675 0.307
CLV_NRD_NRD_1 428 430 PF00675 0.316
CLV_NRD_NRD_1 58 60 PF00675 0.355
CLV_PCSK_KEX2_1 152 154 PF00082 0.424
CLV_PCSK_KEX2_1 240 242 PF00082 0.409
CLV_PCSK_KEX2_1 58 60 PF00082 0.383
CLV_PCSK_PC1ET2_1 240 242 PF00082 0.438
CLV_PCSK_PC7_1 236 242 PF00082 0.307
CLV_PCSK_SKI1_1 157 161 PF00082 0.313
CLV_PCSK_SKI1_1 241 245 PF00082 0.366
CLV_PCSK_SKI1_1 250 254 PF00082 0.378
CLV_PCSK_SKI1_1 317 321 PF00082 0.550
CLV_PCSK_SKI1_1 357 361 PF00082 0.544
CLV_PCSK_SKI1_1 37 41 PF00082 0.307
DEG_APCC_DBOX_1 351 359 PF00400 0.605
DOC_CKS1_1 199 204 PF01111 0.315
DOC_CYCLIN_RxL_1 10 19 PF00134 0.482
DOC_CYCLIN_yCln2_LP_2 298 304 PF00134 0.447
DOC_MAPK_DCC_7 125 134 PF00069 0.307
DOC_MAPK_FxFP_2 46 49 PF00069 0.261
DOC_MAPK_gen_1 125 134 PF00069 0.307
DOC_MAPK_gen_1 157 166 PF00069 0.315
DOC_MAPK_gen_1 352 360 PF00069 0.508
DOC_MAPK_MEF2A_6 125 134 PF00069 0.390
DOC_MAPK_MEF2A_6 160 168 PF00069 0.307
DOC_PP4_FxxP_1 46 49 PF00568 0.248
DOC_USP7_MATH_1 263 267 PF00917 0.459
DOC_USP7_MATH_1 329 333 PF00917 0.723
DOC_USP7_MATH_1 390 394 PF00917 0.475
DOC_WW_Pin1_4 198 203 PF00397 0.315
DOC_WW_Pin1_4 297 302 PF00397 0.495
DOC_WW_Pin1_4 322 327 PF00397 0.605
LIG_14-3-3_CanoR_1 241 249 PF00244 0.361
LIG_14-3-3_CanoR_1 262 269 PF00244 0.444
LIG_14-3-3_CanoR_1 288 296 PF00244 0.375
LIG_14-3-3_CanoR_1 297 301 PF00244 0.337
LIG_14-3-3_CanoR_1 373 382 PF00244 0.594
LIG_14-3-3_CanoR_1 59 67 PF00244 0.470
LIG_APCC_ABBA_1 311 316 PF00400 0.495
LIG_APCC_ABBAyCdc20_2 152 158 PF00400 0.436
LIG_APCC_ABBAyCdc20_2 250 256 PF00400 0.404
LIG_BIR_II_1 1 5 PF00653 0.670
LIG_BIR_III_1 1 5 PF00653 0.570
LIG_BIR_III_3 1 5 PF00653 0.570
LIG_BRCT_BRCA1_1 23 27 PF00533 0.357
LIG_deltaCOP1_diTrp_1 405 410 PF00928 0.433
LIG_EH1_1 382 390 PF00400 0.424
LIG_FHA_1 189 195 PF00498 0.276
LIG_FHA_1 263 269 PF00498 0.354
LIG_FHA_1 297 303 PF00498 0.379
LIG_FHA_1 370 376 PF00498 0.444
LIG_FHA_1 394 400 PF00498 0.578
LIG_FHA_1 7 13 PF00498 0.334
LIG_FHA_2 215 221 PF00498 0.315
LIG_FHA_2 280 286 PF00498 0.316
LIG_FHA_2 288 294 PF00498 0.241
LIG_FHA_2 340 346 PF00498 0.439
LIG_FHA_2 61 67 PF00498 0.307
LIG_GBD_Chelix_1 273 281 PF00786 0.307
LIG_HCF-1_HBM_1 81 84 PF13415 0.307
LIG_LIR_Apic_2 201 207 PF02991 0.315
LIG_LIR_Apic_2 405 411 PF02991 0.441
LIG_LIR_Apic_2 81 87 PF02991 0.194
LIG_LIR_Gen_1 226 237 PF02991 0.277
LIG_LIR_Gen_1 29 39 PF02991 0.420
LIG_LIR_Gen_1 290 298 PF02991 0.261
LIG_LIR_Gen_1 414 425 PF02991 0.419
LIG_LIR_Nem_3 181 185 PF02991 0.399
LIG_LIR_Nem_3 226 232 PF02991 0.277
LIG_LIR_Nem_3 24 30 PF02991 0.442
LIG_LIR_Nem_3 290 295 PF02991 0.261
LIG_LIR_Nem_3 414 420 PF02991 0.436
LIG_LIR_Nem_3 427 431 PF02991 0.341
LIG_NRBOX 370 376 PF00104 0.416
LIG_NRBOX 402 408 PF00104 0.421
LIG_Pex14_2 119 123 PF04695 0.173
LIG_SH2_CRK 182 186 PF00017 0.307
LIG_SH2_CRK 292 296 PF00017 0.320
LIG_SH2_CRK 309 313 PF00017 0.222
LIG_SH2_CRK 428 432 PF00017 0.470
LIG_SH2_PTP2 204 207 PF00017 0.404
LIG_SH2_PTP2 84 87 PF00017 0.194
LIG_SH2_SRC 309 312 PF00017 0.402
LIG_SH2_STAP1 264 268 PF00017 0.352
LIG_SH2_STAP1 292 296 PF00017 0.320
LIG_SH2_STAT5 104 107 PF00017 0.132
LIG_SH2_STAT5 110 113 PF00017 0.364
LIG_SH2_STAT5 204 207 PF00017 0.309
LIG_SH2_STAT5 264 267 PF00017 0.430
LIG_SH2_STAT5 305 308 PF00017 0.347
LIG_SH2_STAT5 31 34 PF00017 0.372
LIG_SH2_STAT5 84 87 PF00017 0.325
LIG_SH2_STAT5 88 91 PF00017 0.266
LIG_SH3_1 309 315 PF00018 0.524
LIG_SH3_2 312 317 PF14604 0.424
LIG_SH3_3 196 202 PF00018 0.315
LIG_SH3_3 2 8 PF00018 0.554
LIG_SH3_3 309 315 PF00018 0.536
LIG_SH3_3 323 329 PF00018 0.573
LIG_SUMO_SIM_anti_2 419 425 PF11976 0.398
LIG_TRAF2_1 416 419 PF00917 0.438
LIG_UBA3_1 358 363 PF00899 0.383
MOD_CK1_1 216 222 PF00069 0.341
MOD_CK1_1 223 229 PF00069 0.359
MOD_CK1_1 287 293 PF00069 0.397
MOD_CK1_1 300 306 PF00069 0.301
MOD_CK1_1 337 343 PF00069 0.576
MOD_CK1_1 393 399 PF00069 0.453
MOD_CK2_1 279 285 PF00069 0.353
MOD_DYRK1A_RPxSP_1 198 202 PF00069 0.315
MOD_GlcNHglycan 143 146 PF01048 0.261
MOD_GlcNHglycan 170 173 PF01048 0.382
MOD_GlcNHglycan 222 225 PF01048 0.268
MOD_GlcNHglycan 23 26 PF01048 0.276
MOD_GlcNHglycan 265 268 PF01048 0.309
MOD_GSK3_1 164 171 PF00069 0.358
MOD_GSK3_1 184 191 PF00069 0.338
MOD_GSK3_1 194 201 PF00069 0.295
MOD_GSK3_1 216 223 PF00069 0.265
MOD_GSK3_1 296 303 PF00069 0.362
MOD_GSK3_1 318 325 PF00069 0.691
MOD_GSK3_1 33 40 PF00069 0.341
MOD_GSK3_1 369 376 PF00069 0.433
MOD_N-GLC_1 146 151 PF02516 0.276
MOD_N-GLC_1 44 49 PF02516 0.463
MOD_NEK2_1 146 151 PF00069 0.276
MOD_NEK2_1 168 173 PF00069 0.438
MOD_NEK2_1 188 193 PF00069 0.307
MOD_NEK2_1 194 199 PF00069 0.247
MOD_NEK2_1 21 26 PF00069 0.291
MOD_NEK2_2 347 352 PF00069 0.387
MOD_PKA_2 287 293 PF00069 0.277
MOD_PKA_2 296 302 PF00069 0.369
MOD_PKA_2 369 375 PF00069 0.432
MOD_Plk_1 44 50 PF00069 0.463
MOD_Plk_4 200 206 PF00069 0.401
MOD_Plk_4 223 229 PF00069 0.280
MOD_ProDKin_1 198 204 PF00069 0.315
MOD_ProDKin_1 297 303 PF00069 0.489
MOD_ProDKin_1 322 328 PF00069 0.605
TRG_DiLeu_BaEn_1 356 361 PF01217 0.512
TRG_DiLeu_BaEn_1 419 424 PF01217 0.400
TRG_DiLeu_BaLyEn_6 150 155 PF01217 0.307
TRG_DiLeu_BaLyEn_6 17 22 PF01217 0.307
TRG_DiLeu_BaLyEn_6 370 375 PF01217 0.477
TRG_ENDOCYTIC_2 182 185 PF00928 0.442
TRG_ENDOCYTIC_2 229 232 PF00928 0.436
TRG_ENDOCYTIC_2 292 295 PF00928 0.276
TRG_ENDOCYTIC_2 31 34 PF00928 0.392
TRG_ENDOCYTIC_2 428 431 PF00928 0.464
TRG_ER_diArg_1 152 154 PF00400 0.430
TRG_ER_diArg_1 351 354 PF00400 0.673
TRG_ER_diArg_1 57 59 PF00400 0.367
TRG_Pf-PMV_PEXEL_1 14 19 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 429 433 PF00026 0.445
TRG_Pf-PMV_PEXEL_1 59 64 PF00026 0.307

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8X6 Leptomonas seymouri 29% 100%
A0A0N1HT76 Leptomonas seymouri 28% 97%
A0A0N1HZW6 Leptomonas seymouri 50% 98%
A0A0N1I9A0 Leptomonas seymouri 25% 67%
A0A0N1IM47 Leptomonas seymouri 27% 100%
A0A0S4J3Y5 Bodo saltans 25% 100%
A0A0S4J6L4 Bodo saltans 27% 100%
A0A0S4JNA1 Bodo saltans 28% 87%
A0A0S4JP91 Bodo saltans 30% 72%
A0A0S4KN74 Bodo saltans 24% 100%
A0A1X0NIA0 Trypanosomatidae 28% 100%
A0A1X0NJV4 Trypanosomatidae 24% 84%
A0A1X0NRZ9 Trypanosomatidae 29% 100%
A0A1X0NVR3 Trypanosomatidae 24% 100%
A0A1X0NWR7 Trypanosomatidae 23% 84%
A0A1X0P150 Trypanosomatidae 27% 70%
A0A1X0P1A2 Trypanosomatidae 25% 94%
A0A1X0P765 Trypanosomatidae 44% 80%
A0A1X0P919 Trypanosomatidae 27% 100%
A0A1X0P994 Trypanosomatidae 29% 87%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 27% 83%
A0A3Q8IAQ1 Leishmania donovani 28% 100%
A0A3Q8ICW9 Leishmania donovani 25% 72%
A0A3Q8IIG1 Leishmania donovani 32% 100%
A0A3Q8IPJ5 Leishmania donovani 92% 100%
A0A3R7M848 Trypanosoma rangeli 39% 93%
A0A3R7NLI6 Trypanosoma rangeli 29% 100%
A0A3S5H4Z4 Leishmania donovani 26% 82%
A0A3S7X7Y2 Leishmania donovani 26% 100%
A0A422NUF0 Trypanosoma rangeli 27% 100%
A0A509AHB6 Plasmodium berghei (strain Anka) 27% 83%
A2ZMH2 Oryza sativa subsp. indica 28% 73%
A4H3C7 Leishmania braziliensis 26% 100%
A4HCE6 Leishmania braziliensis 26% 100%
A4HDJ5 Leishmania braziliensis 26% 80%
A4HH03 Leishmania braziliensis 31% 100%
A4HNI1 Leishmania braziliensis 27% 91%
A4HNU6 Leishmania braziliensis 30% 82%
A4HRM6 Leishmania infantum 26% 82%
A4HZW8 Leishmania infantum 28% 100%
A4I0Y4 Leishmania infantum 25% 72%
A4I2H8 Leishmania infantum 92% 100%
A4I435 Leishmania infantum 32% 100%
A4I9Y5 Leishmania infantum 26% 100%
A4IDC1 Leishmania infantum 26% 85%
C9ZIN1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 87%
C9ZN29 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 89%
C9ZX04 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 93%
C9ZX09 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 93%
D0A8X3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D3ZBE5 Rattus norvegicus 30% 100%
E9ACA4 Leishmania major 26% 100%
E9AJJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 80%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 85%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AWZ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 72%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AYN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
G5EFM9 Caenorhabditis elegans 28% 100%
O00141 Homo sapiens 25% 100%
O00506 Homo sapiens 29% 100%
O61122 Dictyostelium discoideum 27% 91%
O80673 Arabidopsis thaliana 27% 75%
P08458 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 88%
P22209 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P54739 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 31% 80%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 27% 83%
P62344 Plasmodium falciparum (isolate 3D7) 27% 83%
P62345 Plasmodium berghei (strain Anka) 30% 82%
Q06226 Rattus norvegicus 26% 100%
Q0JI49 Oryza sativa subsp. japonica 27% 86%
Q10GB1 Oryza sativa subsp. japonica 30% 72%
Q13188 Homo sapiens 26% 88%
Q2QM77 Oryza sativa subsp. japonica 29% 89%
Q2QMH1 Oryza sativa subsp. japonica 28% 73%
Q3SWY6 Bos taurus 29% 100%
Q4Q1S4 Leishmania major 27% 100%
Q4Q1Z0 Leishmania major 29% 84%
Q4Q2Z2 Leishmania major 26% 100%
Q4Q7W2 Leishmania major 32% 100%
Q4Q8T4 Leishmania major 92% 100%
Q4QAI6 Leishmania major 26% 72%
Q4QBQ2 Leishmania major 28% 100%
Q4QCR2 Leishmania major 26% 100%
Q4R633 Macaca fascicularis 25% 100%
Q54EY4 Dictyostelium discoideum 28% 77%
Q54QD5 Dictyostelium discoideum 26% 89%
Q5Q0U5 Fundulus heteroclitus 25% 100%
Q5QNM6 Oryza sativa subsp. japonica 29% 85%
Q6F3A6 Oryza sativa subsp. japonica 27% 72%
Q6IP06 Xenopus laevis 26% 88%
Q6ZEZ5 Oryza sativa subsp. japonica 29% 74%
Q7RAH3 Plasmodium yoelii yoelii 27% 81%
Q7RJG2 Plasmodium yoelii yoelii 30% 82%
Q8C0Q4 Mus musculus 28% 69%
Q8RX66 Arabidopsis thaliana 31% 76%
Q8TDX7 Homo sapiens 30% 100%
Q94A06 Arabidopsis thaliana 27% 100%
Q99JT2 Mus musculus 26% 100%
Q9ES70 Mus musculus 28% 100%
Q9ES74 Mus musculus 30% 100%
Q9HBY8 Homo sapiens 26% 100%
Q9LET1 Arabidopsis thaliana 27% 75%
Q9LHI7 Arabidopsis thaliana 27% 76%
Q9P289 Homo sapiens 26% 100%
Q9WVC6 Mus musculus 26% 100%
Q9Z2W1 Mus musculus 29% 100%
Q9ZV15 Arabidopsis thaliana 28% 74%
V5B8E0 Trypanosoma cruzi 25% 100%
V5BCH2 Trypanosoma cruzi 24% 100%
V5CI11 Trypanosoma cruzi 46% 90%
V5D179 Trypanosoma cruzi 25% 71%
V5D9M1 Trypanosoma cruzi 31% 100%
V5DC40 Trypanosoma cruzi 25% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS