SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-ala D-ala ligase C-terminus/SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFA0_LEIBR

TriTrypDb:

LbrM.26.2490 , LBRM2903_260030900

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFA0

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0008716	D-alanine-D-alanine ligase activity	5	16
GO:0016740	transferase activity	2	15
GO:0016874	ligase activity	2	16
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	16
GO:0016881	acid-amino acid ligase activity	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0008168	methyltransferase activity	4	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.495
CLV_C14_Caspase3-7	488	492	PF00656	0.671
CLV_NRD_NRD_1	349	351	PF00675	0.511
CLV_NRD_NRD_1	439	441	PF00675	0.309
CLV_PCSK_KEX2_1	269	271	PF00082	0.361
CLV_PCSK_KEX2_1	349	351	PF00082	0.482
CLV_PCSK_KEX2_1	439	441	PF00082	0.300
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.361
CLV_PCSK_PC7_1	265	271	PF00082	0.361
CLV_PCSK_SKI1_1	265	269	PF00082	0.293
CLV_PCSK_SKI1_1	291	295	PF00082	0.353
CLV_PCSK_SKI1_1	334	338	PF00082	0.332
CLV_PCSK_SKI1_1	55	59	PF00082	0.440
DEG_APCC_DBOX_1	341	349	PF00400	0.388
DEG_APCC_DBOX_1	438	446	PF00400	0.385
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.519
DOC_MAPK_gen_1	286	295	PF00069	0.467
DOC_MAPK_gen_1	339	348	PF00069	0.404
DOC_MAPK_gen_1	439	447	PF00069	0.385
DOC_MAPK_MEF2A_6	217	226	PF00069	0.489
DOC_MAPK_MEF2A_6	288	297	PF00069	0.542
DOC_PP1_RVXF_1	289	295	PF00149	0.521
DOC_PP4_FxxP_1	99	102	PF00568	0.438
DOC_USP7_MATH_1	432	436	PF00917	0.535
DOC_USP7_MATH_1	438	442	PF00917	0.489
DOC_USP7_MATH_1	505	509	PF00917	0.719
DOC_USP7_MATH_2	392	398	PF00917	0.385
DOC_USP7_UBL2_3	115	119	PF12436	0.387
DOC_WW_Pin1_4	32	37	PF00397	0.427
DOC_WW_Pin1_4	482	487	PF00397	0.502
DOC_WW_Pin1_4	489	494	PF00397	0.566
DOC_WW_Pin1_4	496	501	PF00397	0.621
LIG_14-3-3_CanoR_1	439	443	PF00244	0.474
LIG_BRCT_BRCA1_1	68	72	PF00533	0.473
LIG_EH1_1	171	179	PF00400	0.561
LIG_eIF4E_1	172	178	PF01652	0.460
LIG_FHA_1	102	108	PF00498	0.422
LIG_FHA_1	492	498	PF00498	0.630
LIG_FHA_2	209	215	PF00498	0.537
LIG_FHA_2	223	229	PF00498	0.489
LIG_LIR_Apic_2	481	486	PF02991	0.541
LIG_LIR_Apic_2	98	102	PF02991	0.447
LIG_LIR_Gen_1	129	137	PF02991	0.350
LIG_LIR_Gen_1	158	165	PF02991	0.477
LIG_LIR_Gen_1	187	197	PF02991	0.561
LIG_LIR_Gen_1	327	336	PF02991	0.385
LIG_LIR_Gen_1	394	403	PF02991	0.512
LIG_LIR_Gen_1	69	76	PF02991	0.404
LIG_LIR_Nem_3	129	135	PF02991	0.350
LIG_LIR_Nem_3	149	153	PF02991	0.402
LIG_LIR_Nem_3	158	163	PF02991	0.454
LIG_LIR_Nem_3	187	193	PF02991	0.574
LIG_LIR_Nem_3	230	235	PF02991	0.475
LIG_LIR_Nem_3	327	331	PF02991	0.381
LIG_LIR_Nem_3	394	399	PF02991	0.497
LIG_LIR_Nem_3	409	415	PF02991	0.466
LIG_LIR_Nem_3	457	463	PF02991	0.474
LIG_LIR_Nem_3	58	63	PF02991	0.391
LIG_LIR_Nem_3	69	75	PF02991	0.390
LIG_MAD2	291	299	PF02301	0.535
LIG_PCNA_PIPBox_1	118	127	PF02747	0.387
LIG_Pex14_2	235	239	PF04695	0.474
LIG_SH2_CRK	160	164	PF00017	0.474
LIG_SH2_CRK	60	64	PF00017	0.419
LIG_SH2_GRB2like	124	127	PF00017	0.494
LIG_SH2_NCK_1	160	164	PF00017	0.482
LIG_SH2_NCK_1	172	176	PF00017	0.482
LIG_SH2_PTP2	483	486	PF00017	0.316
LIG_SH2_STAP1	47	51	PF00017	0.435
LIG_SH2_STAT5	347	350	PF00017	0.434
LIG_SH2_STAT5	39	42	PF00017	0.469
LIG_SH2_STAT5	483	486	PF00017	0.540
LIG_SH3_3	131	137	PF00018	0.531
LIG_SH3_3	215	221	PF00018	0.475
LIG_SH3_4	115	122	PF00018	0.409
LIG_SH3_5	392	396	PF00018	0.385
LIG_TYR_ITIM	275	280	PF00017	0.490
LIG_TYR_ITSM	56	63	PF00017	0.435
LIG_UBA3_1	316	321	PF00899	0.427
MOD_CDK_SPxxK_3	489	496	PF00069	0.607
MOD_CK1_1	158	164	PF00069	0.501
MOD_CK1_1	366	372	PF00069	0.519
MOD_CK1_1	485	491	PF00069	0.582
MOD_CK1_1	499	505	PF00069	0.624
MOD_CK2_1	13	19	PF00069	0.403
MOD_CK2_1	195	201	PF00069	0.493
MOD_CK2_1	208	214	PF00069	0.555
MOD_CK2_1	222	228	PF00069	0.470
MOD_GlcNHglycan	157	160	PF01048	0.268
MOD_GlcNHglycan	197	200	PF01048	0.320
MOD_GlcNHglycan	265	268	PF01048	0.356
MOD_GlcNHglycan	310	314	PF01048	0.385
MOD_GlcNHglycan	41	44	PF01048	0.533
MOD_GlcNHglycan	68	71	PF01048	0.477
MOD_GSK3_1	14	21	PF00069	0.417
MOD_GSK3_1	155	162	PF00069	0.472
MOD_GSK3_1	259	266	PF00069	0.454
MOD_GSK3_1	363	370	PF00069	0.446
MOD_GSK3_1	485	492	PF00069	0.573
MOD_N-GLC_1	426	431	PF02516	0.299
MOD_N-GLC_1	432	437	PF02516	0.361
MOD_N-GLC_2	208	210	PF02516	0.185
MOD_N-GLC_2	77	79	PF02516	0.371
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	165	170	PF00069	0.494
MOD_NEK2_1	426	431	PF00069	0.464
MOD_NEK2_1	463	468	PF00069	0.457
MOD_NEK2_1	66	71	PF00069	0.457
MOD_PIKK_1	208	214	PF00454	0.486
MOD_PIKK_1	30	36	PF00454	0.509
MOD_PKA_1	55	61	PF00069	0.446
MOD_PKA_2	179	185	PF00069	0.530
MOD_PKA_2	438	444	PF00069	0.385
MOD_Plk_1	200	206	PF00069	0.489
MOD_Plk_1	363	369	PF00069	0.535
MOD_Plk_1	432	438	PF00069	0.561
MOD_Plk_1	454	460	PF00069	0.462
MOD_Plk_1	464	470	PF00069	0.418
MOD_Plk_2-3	454	460	PF00069	0.462
MOD_Plk_4	200	206	PF00069	0.474
MOD_Plk_4	367	373	PF00069	0.488
MOD_ProDKin_1	32	38	PF00069	0.427
MOD_ProDKin_1	482	488	PF00069	0.508
MOD_ProDKin_1	489	495	PF00069	0.559
MOD_ProDKin_1	496	502	PF00069	0.628
MOD_SUMO_for_1	451	454	PF00179	0.525
MOD_SUMO_for_1	495	498	PF00179	0.425
MOD_SUMO_for_1	82	85	PF00179	0.551
MOD_SUMO_rev_2	112	121	PF00179	0.403
MOD_SUMO_rev_2	228	235	PF00179	0.484
MOD_SUMO_rev_2	94	102	PF00179	0.481
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.538
TRG_ENDOCYTIC_2	110	113	PF00928	0.428
TRG_ENDOCYTIC_2	124	127	PF00928	0.405
TRG_ENDOCYTIC_2	132	135	PF00928	0.470
TRG_ENDOCYTIC_2	160	163	PF00928	0.478
TRG_ENDOCYTIC_2	242	245	PF00928	0.496
TRG_ENDOCYTIC_2	277	280	PF00928	0.489
TRG_ENDOCYTIC_2	396	399	PF00928	0.493
TRG_ENDOCYTIC_2	412	415	PF00928	0.451
TRG_ENDOCYTIC_2	460	463	PF00928	0.428
TRG_ENDOCYTIC_2	60	63	PF00928	0.397
TRG_ER_diArg_1	348	350	PF00400	0.494
TRG_ER_diArg_1	438	440	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV0	Leptomonas seymouri	79%	100%
A0A0S4JLQ2	Bodo saltans	60%	100%
A0A0S4JPH7	Bodo saltans	36%	80%
A0A1X0P879	Trypanosomatidae	66%	100%
A0A1X0P8J8	Trypanosomatidae	28%	100%
A0A3Q8ID63	Leishmania donovani	87%	100%
A0A3R7MWC4	Trypanosoma rangeli	63%	100%
A0A3R7P2U3	Trypanosoma rangeli	28%	100%
A4I1M6	Leishmania infantum	38%	98%
A4I2H5	Leishmania infantum	87%	100%
C9ZK70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	67%
C9ZX10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AYN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8T5	Leishmania major	88%	100%
V5B7P8	Trypanosoma cruzi	65%	100%
V5BHW2	Trypanosoma cruzi	37%	100%