Pentatricopeptide repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF99_LEIBR

TriTrypDb:

LbrM.26.2480 , LBRM2903_260030600

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.365
CLV_C14_Caspase3-7	322	326	PF00656	0.228
CLV_MEL_PAP_1	356	362	PF00089	0.287
CLV_NRD_NRD_1	104	106	PF00675	0.622
CLV_NRD_NRD_1	15	17	PF00675	0.479
CLV_NRD_NRD_1	193	195	PF00675	0.533
CLV_NRD_NRD_1	228	230	PF00675	0.396
CLV_NRD_NRD_1	530	532	PF00675	0.433
CLV_NRD_NRD_1	614	616	PF00675	0.307
CLV_NRD_NRD_1	773	775	PF00675	0.620
CLV_PCSK_FUR_1	771	775	PF00082	0.527
CLV_PCSK_KEX2_1	104	106	PF00082	0.558
CLV_PCSK_KEX2_1	15	17	PF00082	0.480
CLV_PCSK_KEX2_1	193	195	PF00082	0.533
CLV_PCSK_KEX2_1	614	616	PF00082	0.308
CLV_PCSK_KEX2_1	773	775	PF00082	0.651
CLV_PCSK_PC7_1	610	616	PF00082	0.416
CLV_PCSK_PC7_1	769	775	PF00082	0.628
CLV_PCSK_SKI1_1	105	109	PF00082	0.428
CLV_PCSK_SKI1_1	263	267	PF00082	0.531
CLV_PCSK_SKI1_1	631	635	PF00082	0.331
DEG_APCC_DBOX_1	569	577	PF00400	0.404
DEG_APCC_DBOX_1	613	621	PF00400	0.323
DEG_SPOP_SBC_1	232	236	PF00917	0.402
DEG_SPOP_SBC_1	64	68	PF00917	0.659
DEG_SPOP_SBC_1	70	74	PF00917	0.660
DOC_MAPK_gen_1	666	675	PF00069	0.558
DOC_MAPK_gen_1	709	718	PF00069	0.565
DOC_MAPK_MEF2A_6	296	304	PF00069	0.489
DOC_MAPK_MEF2A_6	486	495	PF00069	0.390
DOC_MAPK_MEF2A_6	619	627	PF00069	0.501
DOC_PP1_RVXF_1	666	673	PF00149	0.421
DOC_PP2B_LxvP_1	408	411	PF13499	0.451
DOC_PP2B_LxvP_1	623	626	PF13499	0.377
DOC_PP2B_LxvP_1	705	708	PF13499	0.388
DOC_USP7_MATH_1	233	237	PF00917	0.552
DOC_USP7_MATH_1	319	323	PF00917	0.323
DOC_USP7_MATH_1	402	406	PF00917	0.607
DOC_USP7_MATH_1	430	434	PF00917	0.344
DOC_USP7_MATH_1	548	552	PF00917	0.498
DOC_USP7_MATH_1	64	68	PF00917	0.591
DOC_USP7_MATH_1	70	74	PF00917	0.538
DOC_USP7_MATH_1	96	100	PF00917	0.557
DOC_USP7_MATH_2	6	12	PF00917	0.525
DOC_USP7_UBL2_3	504	508	PF12436	0.469
DOC_WW_Pin1_4	132	137	PF00397	0.420
DOC_WW_Pin1_4	171	176	PF00397	0.647
DOC_WW_Pin1_4	339	344	PF00397	0.564
DOC_WW_Pin1_4	553	558	PF00397	0.559
DOC_WW_Pin1_4	730	735	PF00397	0.547
DOC_WW_Pin1_4	97	102	PF00397	0.471
LIG_14-3-3_CanoR_1	111	120	PF00244	0.321
LIG_14-3-3_CanoR_1	359	365	PF00244	0.563
LIG_14-3-3_CanoR_1	372	378	PF00244	0.384
LIG_14-3-3_CanoR_1	510	516	PF00244	0.403
LIG_14-3-3_CanoR_1	619	627	PF00244	0.568
LIG_14-3-3_CanoR_1	666	671	PF00244	0.564
LIG_Actin_WH2_2	613	630	PF00022	0.305
LIG_Actin_WH2_2	79	95	PF00022	0.574
LIG_BIR_III_4	166	170	PF00653	0.447
LIG_BRCT_BRCA1_1	414	418	PF00533	0.365
LIG_BRCT_BRCA1_1	73	77	PF00533	0.478
LIG_Clathr_ClatBox_1	248	252	PF01394	0.323
LIG_deltaCOP1_diTrp_1	325	334	PF00928	0.362
LIG_FHA_1	2	8	PF00498	0.585
LIG_FHA_1	276	282	PF00498	0.342
LIG_FHA_1	288	294	PF00498	0.442
LIG_FHA_1	372	378	PF00498	0.458
LIG_FHA_1	388	394	PF00498	0.463
LIG_FHA_1	501	507	PF00498	0.357
LIG_FHA_1	66	72	PF00498	0.636
LIG_FHA_1	688	694	PF00498	0.473
LIG_FHA_1	731	737	PF00498	0.500
LIG_FHA_2	127	133	PF00498	0.572
LIG_FHA_2	136	142	PF00498	0.531
LIG_FHA_2	242	248	PF00498	0.395
LIG_FHA_2	267	273	PF00498	0.539
LIG_FHA_2	342	348	PF00498	0.463
LIG_FHA_2	43	49	PF00498	0.649
LIG_FHA_2	60	66	PF00498	0.499
LIG_FHA_2	677	683	PF00498	0.448
LIG_IRF3_LxIS_1	248	254	PF10401	0.340
LIG_LIR_Apic_2	311	316	PF02991	0.508
LIG_LIR_Gen_1	303	313	PF02991	0.427
LIG_LIR_Gen_1	332	341	PF02991	0.386
LIG_LIR_Gen_1	347	356	PF02991	0.504
LIG_LIR_Gen_1	433	443	PF02991	0.399
LIG_LIR_Gen_1	669	680	PF02991	0.389
LIG_LIR_Nem_3	121	126	PF02991	0.484
LIG_LIR_Nem_3	173	179	PF02991	0.510
LIG_LIR_Nem_3	303	308	PF02991	0.411
LIG_LIR_Nem_3	332	337	PF02991	0.373
LIG_LIR_Nem_3	347	353	PF02991	0.507
LIG_LIR_Nem_3	433	439	PF02991	0.370
LIG_LIR_Nem_3	590	596	PF02991	0.445
LIG_LIR_Nem_3	669	675	PF02991	0.553
LIG_LIR_Nem_3	74	80	PF02991	0.626
LIG_OCRL_FandH_1	333	345	PF00620	0.337
LIG_PCNA_PIPBox_1	103	112	PF02747	0.547
LIG_PCNA_yPIPBox_3	103	116	PF02747	0.519
LIG_PTAP_UEV_1	29	34	PF05743	0.495
LIG_Rb_pABgroove_1	513	521	PF01858	0.402
LIG_SH2_CRK	305	309	PF00017	0.503
LIG_SH2_CRK	313	317	PF00017	0.464
LIG_SH2_CRK	593	597	PF00017	0.454
LIG_SH2_STAP1	160	164	PF00017	0.521
LIG_SH2_STAP1	264	268	PF00017	0.490
LIG_SH2_STAP1	305	309	PF00017	0.372
LIG_SH2_STAT3	608	611	PF00017	0.534
LIG_SH2_STAT5	109	112	PF00017	0.482
LIG_SH2_STAT5	443	446	PF00017	0.384
LIG_SH2_STAT5	456	459	PF00017	0.353
LIG_SH2_STAT5	572	575	PF00017	0.496
LIG_SH3_3	268	274	PF00018	0.469
LIG_SH3_3	27	33	PF00018	0.644
LIG_SH3_3	522	528	PF00018	0.436
LIG_SH3_3	610	616	PF00018	0.342
LIG_Sin3_3	697	704	PF02671	0.397
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.362
LIG_SUMO_SIM_par_1	219	225	PF11976	0.436
LIG_SUMO_SIM_par_1	735	741	PF11976	0.320
LIG_TRAF2_1	129	132	PF00917	0.452
LIG_UBA3_1	281	289	PF00899	0.389
LIG_WRC_WIRS_1	436	441	PF05994	0.435
MOD_CDK_SPK_2	730	735	PF00069	0.547
MOD_CDK_SPxxK_3	339	346	PF00069	0.478
MOD_CDK_SPxxK_3	97	104	PF00069	0.408
MOD_CK1_1	135	141	PF00069	0.543
MOD_CK1_1	241	247	PF00069	0.368
MOD_CK1_1	254	260	PF00069	0.416
MOD_CK1_1	422	428	PF00069	0.506
MOD_CK1_1	59	65	PF00069	0.555
MOD_CK1_1	594	600	PF00069	0.479
MOD_CK1_1	66	72	PF00069	0.540
MOD_CK1_1	730	736	PF00069	0.404
MOD_CK2_1	112	118	PF00069	0.567
MOD_CK2_1	126	132	PF00069	0.454
MOD_CK2_1	201	207	PF00069	0.544
MOD_CK2_1	241	247	PF00069	0.278
MOD_CK2_1	59	65	PF00069	0.501
MOD_CK2_1	676	682	PF00069	0.479
MOD_CK2_1	742	748	PF00069	0.382
MOD_GlcNHglycan	235	238	PF01048	0.555
MOD_GlcNHglycan	30	33	PF01048	0.586
MOD_GlcNHglycan	310	313	PF01048	0.377
MOD_GlcNHglycan	321	324	PF01048	0.305
MOD_GlcNHglycan	432	435	PF01048	0.410
MOD_GlcNHglycan	446	449	PF01048	0.420
MOD_GlcNHglycan	466	469	PF01048	0.258
MOD_GlcNHglycan	62	65	PF01048	0.568
MOD_GlcNHglycan	68	71	PF01048	0.539
MOD_GlcNHglycan	729	732	PF01048	0.397
MOD_GlcNHglycan	757	761	PF01048	0.570
MOD_GlcNHglycan	777	780	PF01048	0.596
MOD_GSK3_1	112	119	PF00069	0.428
MOD_GSK3_1	24	31	PF00069	0.515
MOD_GSK3_1	283	290	PF00069	0.385
MOD_GSK3_1	32	39	PF00069	0.530
MOD_GSK3_1	337	344	PF00069	0.477
MOD_GSK3_1	397	404	PF00069	0.503
MOD_GSK3_1	412	419	PF00069	0.308
MOD_GSK3_1	452	459	PF00069	0.315
MOD_GSK3_1	553	560	PF00069	0.659
MOD_GSK3_1	56	63	PF00069	0.559
MOD_GSK3_1	587	594	PF00069	0.435
MOD_GSK3_1	65	72	PF00069	0.469
MOD_GSK3_1	687	694	PF00069	0.406
MOD_GSK3_1	738	745	PF00069	0.338
MOD_GSK3_1	92	99	PF00069	0.619
MOD_NEK2_1	110	115	PF00069	0.497
MOD_NEK2_1	142	147	PF00069	0.398
MOD_NEK2_1	251	256	PF00069	0.361
MOD_NEK2_1	308	313	PF00069	0.433
MOD_NEK2_1	337	342	PF00069	0.434
MOD_NEK2_1	397	402	PF00069	0.491
MOD_NEK2_1	416	421	PF00069	0.318
MOD_NEK2_1	435	440	PF00069	0.354
MOD_NEK2_1	495	500	PF00069	0.349
MOD_NEK2_1	518	523	PF00069	0.553
MOD_NEK2_1	56	61	PF00069	0.694
MOD_NEK2_1	595	600	PF00069	0.442
MOD_NEK2_1	634	639	PF00069	0.383
MOD_NEK2_1	71	76	PF00069	0.550
MOD_NEK2_1	80	85	PF00069	0.448
MOD_NEK2_1	92	97	PF00069	0.508
MOD_NEK2_2	441	446	PF00069	0.401
MOD_NEK2_2	456	461	PF00069	0.463
MOD_NEK2_2	572	577	PF00069	0.421
MOD_PIKK_1	495	501	PF00454	0.472
MOD_PIKK_1	595	601	PF00454	0.400
MOD_PIKK_1	738	744	PF00454	0.326
MOD_PIKK_1	80	86	PF00454	0.693
MOD_PK_1	116	122	PF00069	0.276
MOD_PKA_2	110	116	PF00069	0.477
MOD_PKA_2	24	30	PF00069	0.560
MOD_PKA_2	358	364	PF00069	0.569
MOD_PKA_2	371	377	PF00069	0.389
MOD_PKA_2	42	48	PF00069	0.669
MOD_PKA_2	578	584	PF00069	0.459
MOD_PKA_2	618	624	PF00069	0.546
MOD_PKA_2	639	645	PF00069	0.482
MOD_PKA_2	775	781	PF00069	0.570
MOD_PKA_2	92	98	PF00069	0.476
MOD_Plk_1	251	257	PF00069	0.339
MOD_Plk_1	266	272	PF00069	0.398
MOD_Plk_1	387	393	PF00069	0.455
MOD_Plk_1	397	403	PF00069	0.500
MOD_Plk_1	47	53	PF00069	0.515
MOD_Plk_4	142	148	PF00069	0.381
MOD_Plk_4	241	247	PF00069	0.278
MOD_Plk_4	330	336	PF00069	0.471
MOD_Plk_4	412	418	PF00069	0.353
MOD_Plk_4	452	458	PF00069	0.260
MOD_Plk_4	511	517	PF00069	0.315
MOD_Plk_4	534	540	PF00069	0.326
MOD_Plk_4	572	578	PF00069	0.479
MOD_Plk_4	591	597	PF00069	0.345
MOD_Plk_4	634	640	PF00069	0.405
MOD_Plk_4	691	697	PF00069	0.520
MOD_Plk_4	750	756	PF00069	0.568
MOD_ProDKin_1	132	138	PF00069	0.417
MOD_ProDKin_1	171	177	PF00069	0.644
MOD_ProDKin_1	339	345	PF00069	0.559
MOD_ProDKin_1	553	559	PF00069	0.557
MOD_ProDKin_1	730	736	PF00069	0.538
MOD_ProDKin_1	97	103	PF00069	0.459
MOD_SUMO_rev_2	551	556	PF00179	0.613
TRG_AP2beta_CARGO_1	437	446	PF09066	0.432
TRG_DiLeu_BaEn_1	121	126	PF01217	0.454
TRG_DiLeu_BaEn_1	591	596	PF01217	0.461
TRG_DiLeu_BaEn_2	182	188	PF01217	0.289
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.571
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.510
TRG_DiLeu_BaLyEn_6	561	566	PF01217	0.328
TRG_DiLeu_BaLyEn_6	732	737	PF01217	0.428
TRG_ENDOCYTIC_2	305	308	PF00928	0.473
TRG_ENDOCYTIC_2	436	439	PF00928	0.418
TRG_ENDOCYTIC_2	593	596	PF00928	0.481
TRG_ER_diArg_1	104	106	PF00400	0.605
TRG_ER_diArg_1	14	16	PF00400	0.482
TRG_ER_diArg_1	193	195	PF00400	0.581
TRG_ER_diArg_1	354	357	PF00400	0.466
TRG_ER_diArg_1	613	615	PF00400	0.403
TRG_ER_diArg_1	708	711	PF00400	0.609
TRG_ER_diArg_1	771	774	PF00400	0.610
TRG_NES_CRM1_1	469	480	PF08389	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K6	Leptomonas seymouri	64%	100%
A0A0S4JKX7	Bodo saltans	24%	95%
A0A1X0P8M4	Trypanosomatidae	37%	100%
A0A3Q8IG37	Leishmania donovani	84%	100%
A0A3S5ISN2	Trypanosoma rangeli	41%	100%
A4I2H6	Leishmania infantum	83%	100%
C9ZX12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AYN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q8T7	Leishmania major	83%	100%
V5AS65	Trypanosoma cruzi	40%	100%