LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
serine/threonine protein phosphatase, putative
Species:
Leishmania braziliensis
UniProt:
A4HF98_LEIBR
TriTrypDb:
LbrM.26.2470 , LBRM2903_260030500
Length:
546

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005955 calcineurin complex 3 1
GO:0008287 protein serine/threonine phosphatase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1903293 phosphatase complex 3 1

Expansion

Sequence features

A4HF98
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF98

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 12
GO:0009987 cellular process 1 12
GO:0019722 calcium-mediated signaling 5 12
GO:0019932 second-messenger-mediated signaling 4 12
GO:0035556 intracellular signal transduction 3 12
GO:0050789 regulation of biological process 2 12
GO:0050794 regulation of cellular process 3 12
GO:0065007 biological regulation 1 12
GO:0097720 calcineurin-mediated signaling 6 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004721 phosphoprotein phosphatase activity 3 12
GO:0004722 protein serine/threonine phosphatase activity 4 12
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5 12
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0005516 calmodulin binding 3 11
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0016791 phosphatase activity 5 12
GO:0017018 myosin phosphatase activity 5 12
GO:0033192 calmodulin-dependent protein phosphatase activity 6 12
GO:0042578 phosphoric ester hydrolase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 447 449 PF00675 0.366
CLV_NRD_NRD_1 87 89 PF00675 0.313
CLV_PCSK_KEX2_1 199 201 PF00082 0.314
CLV_PCSK_KEX2_1 243 245 PF00082 0.366
CLV_PCSK_KEX2_1 87 89 PF00082 0.235
CLV_PCSK_PC1ET2_1 199 201 PF00082 0.314
CLV_PCSK_PC1ET2_1 243 245 PF00082 0.366
CLV_PCSK_PC7_1 83 89 PF00082 0.226
CLV_PCSK_SKI1_1 103 107 PF00082 0.275
CLV_PCSK_SKI1_1 148 152 PF00082 0.337
CLV_PCSK_SKI1_1 190 194 PF00082 0.259
CLV_PCSK_SKI1_1 200 204 PF00082 0.235
CLV_PCSK_SKI1_1 449 453 PF00082 0.369
CLV_PCSK_SKI1_1 46 50 PF00082 0.400
CLV_Separin_Metazoa 80 84 PF03568 0.236
DOC_CYCLIN_RxL_1 40 51 PF00134 0.374
DOC_CYCLIN_yCln2_LP_2 117 123 PF00134 0.174
DOC_MAPK_gen_1 359 367 PF00069 0.367
DOC_MAPK_MEF2A_6 158 167 PF00069 0.279
DOC_PP2B_LxvP_1 284 287 PF13499 0.279
DOC_PP4_FxxP_1 254 257 PF00568 0.253
DOC_PP4_FxxP_1 342 345 PF00568 0.231
DOC_USP7_MATH_1 213 217 PF00917 0.366
DOC_USP7_MATH_1 432 436 PF00917 0.579
DOC_USP7_MATH_1 483 487 PF00917 0.423
DOC_USP7_MATH_1 64 68 PF00917 0.436
DOC_WW_Pin1_4 236 241 PF00397 0.234
DOC_WW_Pin1_4 370 375 PF00397 0.349
DOC_WW_Pin1_4 478 483 PF00397 0.575
DOC_WW_Pin1_4 509 514 PF00397 0.470
LIG_14-3-3_CanoR_1 190 198 PF00244 0.270
LIG_14-3-3_CanoR_1 244 251 PF00244 0.279
LIG_14-3-3_CanoR_1 291 296 PF00244 0.228
LIG_14-3-3_CanoR_1 459 465 PF00244 0.591
LIG_14-3-3_CanoR_1 46 55 PF00244 0.409
LIG_Actin_WH2_2 227 245 PF00022 0.366
LIG_BIR_II_1 1 5 PF00653 0.482
LIG_BRCT_BRCA1_1 388 392 PF00533 0.315
LIG_BRCT_BRCA1_1 457 461 PF00533 0.580
LIG_BRCT_BRCA1_1 67 71 PF00533 0.369
LIG_CSL_BTD_1 543 546 PF09270 0.455
LIG_EH1_1 160 168 PF00400 0.366
LIG_FHA_1 122 128 PF00498 0.153
LIG_FHA_1 16 22 PF00498 0.428
LIG_FHA_1 2 8 PF00498 0.458
LIG_FHA_1 385 391 PF00498 0.390
LIG_FHA_1 524 530 PF00498 0.566
LIG_FHA_2 75 81 PF00498 0.231
LIG_Integrin_RGD_1 52 54 PF01839 0.412
LIG_LIR_Apic_2 265 271 PF02991 0.229
LIG_LIR_Apic_2 387 391 PF02991 0.382
LIG_LIR_Gen_1 146 156 PF02991 0.149
LIG_LIR_Gen_1 216 226 PF02991 0.300
LIG_LIR_Gen_1 458 466 PF02991 0.588
LIG_LIR_Nem_3 146 152 PF02991 0.149
LIG_LIR_Nem_3 193 198 PF02991 0.250
LIG_LIR_Nem_3 323 328 PF02991 0.302
LIG_LIR_Nem_3 458 464 PF02991 0.514
LIG_NRBOX 133 139 PF00104 0.244
LIG_Pex14_1 388 392 PF04695 0.315
LIG_Pex14_2 382 386 PF04695 0.308
LIG_PTB_Apo_2 225 232 PF02174 0.253
LIG_SH2_GRB2like 195 198 PF00017 0.235
LIG_SH2_GRB2like 297 300 PF00017 0.279
LIG_SH2_PTP2 149 152 PF00017 0.279
LIG_SH2_SRC 295 298 PF00017 0.366
LIG_SH2_STAP1 206 210 PF00017 0.239
LIG_SH2_STAP1 297 301 PF00017 0.308
LIG_SH2_STAT5 149 152 PF00017 0.233
LIG_SH2_STAT5 155 158 PF00017 0.242
LIG_SH2_STAT5 195 198 PF00017 0.235
LIG_SH2_STAT5 295 298 PF00017 0.303
LIG_SH2_STAT5 347 350 PF00017 0.337
LIG_SH2_STAT5 378 381 PF00017 0.327
LIG_SH3_1 52 58 PF00018 0.558
LIG_SH3_3 276 282 PF00018 0.244
LIG_SH3_3 507 513 PF00018 0.436
LIG_SH3_3 52 58 PF00018 0.415
LIG_SUMO_SIM_anti_2 164 170 PF11976 0.253
LIG_SUMO_SIM_anti_2 310 316 PF11976 0.390
LIG_SUMO_SIM_anti_2 96 102 PF11976 0.270
LIG_SUMO_SIM_par_1 118 124 PF11976 0.184
LIG_UBA3_1 166 173 PF00899 0.285
LIG_UBA3_1 460 468 PF00899 0.451
MOD_CDK_SPxxK_3 236 243 PF00069 0.235
MOD_CK1_1 246 252 PF00069 0.173
MOD_CK1_1 310 316 PF00069 0.235
MOD_CK1_1 35 41 PF00069 0.406
MOD_CK1_1 435 441 PF00069 0.688
MOD_CK2_1 435 441 PF00069 0.506
MOD_CK2_1 509 515 PF00069 0.578
MOD_CK2_1 74 80 PF00069 0.239
MOD_CK2_1 9 15 PF00069 0.493
MOD_GlcNHglycan 11 14 PF01048 0.493
MOD_GlcNHglycan 18 21 PF01048 0.471
MOD_GlcNHglycan 215 218 PF01048 0.314
MOD_GlcNHglycan 247 251 PF01048 0.257
MOD_GlcNHglycan 259 262 PF01048 0.224
MOD_GlcNHglycan 342 345 PF01048 0.248
MOD_GlcNHglycan 436 440 PF01048 0.642
MOD_GlcNHglycan 67 70 PF01048 0.465
MOD_GSK3_1 186 193 PF00069 0.263
MOD_GSK3_1 287 294 PF00069 0.350
MOD_GSK3_1 431 438 PF00069 0.582
MOD_GSK3_1 538 545 PF00069 0.674
MOD_N-GLC_1 287 292 PF02516 0.366
MOD_N-GLC_1 370 375 PF02516 0.324
MOD_N-GLC_2 346 348 PF02516 0.259
MOD_NEK2_1 1 6 PF00069 0.493
MOD_NEK2_1 386 391 PF00069 0.309
MOD_NEK2_1 460 465 PF00069 0.479
MOD_NEK2_1 65 70 PF00069 0.455
MOD_PKA_1 243 249 PF00069 0.279
MOD_PKA_1 455 461 PF00069 0.324
MOD_PKA_2 243 249 PF00069 0.279
MOD_Plk_1 246 252 PF00069 0.404
MOD_Plk_1 307 313 PF00069 0.235
MOD_Plk_4 176 182 PF00069 0.326
MOD_Plk_4 291 297 PF00069 0.253
MOD_Plk_4 307 313 PF00069 0.174
MOD_ProDKin_1 236 242 PF00069 0.234
MOD_ProDKin_1 370 376 PF00069 0.347
MOD_ProDKin_1 478 484 PF00069 0.578
MOD_ProDKin_1 509 515 PF00069 0.481
MOD_SUMO_for_1 198 201 PF00179 0.279
MOD_SUMO_rev_2 143 150 PF00179 0.139
MOD_SUMO_rev_2 239 245 PF00179 0.279
MOD_SUMO_rev_2 389 398 PF00179 0.375
MOD_SUMO_rev_2 413 423 PF00179 0.387
TRG_DiLeu_BaEn_1 164 169 PF01217 0.279
TRG_DiLeu_BaEn_3 27 33 PF01217 0.437
TRG_ENDOCYTIC_2 149 152 PF00928 0.294
TRG_ENDOCYTIC_2 195 198 PF00928 0.245
TRG_ENDOCYTIC_2 211 214 PF00928 0.165
TRG_ER_diArg_1 86 88 PF00400 0.384
TRG_NLS_MonoExtC_3 447 453 PF00514 0.327
TRG_Pf-PMV_PEXEL_1 304 308 PF00026 0.139
TRG_Pf-PMV_PEXEL_1 46 51 PF00026 0.421

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Y2 Leptomonas seymouri 70% 100%
A0A0S4IIW0 Bodo saltans 43% 100%
A0A0S4JDD1 Bodo saltans 52% 100%
A0A0S4JKZ6 Bodo saltans 56% 100%
A0A1X0P7H9 Trypanosomatidae 55% 100%
A0A1X0P7Q5 Trypanosomatidae 44% 100%
A0A3Q8I8M6 Leishmania donovani 31% 100%
A0A3Q8ID20 Leishmania donovani 78% 100%
A0A3Q8II54 Leishmania donovani 29% 93%
A0A3R7MBA3 Trypanosoma rangeli 53% 100%
A0A3S5H6K2 Leishmania donovani 25% 100%
A0A3S5H6T9 Leishmania donovani 35% 100%
A0A3S5H7Q6 Leishmania donovani 36% 100%
A0A3S7XAY3 Leishmania donovani 37% 100%
A0A422N1U7 Trypanosoma rangeli 27% 91%
A0A422N9D5 Trypanosoma rangeli 46% 100%
A4H6S0 Leishmania braziliensis 24% 100%
A4H7Z3 Leishmania braziliensis 35% 100%
A4HJQ1 Leishmania braziliensis 36% 100%
A4HP65 Leishmania braziliensis 37% 100%
A4HV49 Leishmania infantum 25% 100%
A4HVT0 Leishmania infantum 31% 100%
A4HVT6 Leishmania infantum 29% 93%
A4HWC1 Leishmania infantum 35% 100%
A4I2J0 Leishmania infantum 78% 100%
A4I768 Leishmania infantum 36% 100%
A4IDH0 Leishmania infantum 37% 100%
D0A358 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A366 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 86%
E9ANT1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9APH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AQ21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9ASX3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AYN4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9B262 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
O42773 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) 44% 85%
P14747 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 90%
P16298 Homo sapiens 44% 100%
P20651 Rattus norvegicus 44% 100%
P23287 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 99%
P48452 Bos taurus 45% 100%
P48453 Mus musculus 44% 100%
P48454 Homo sapiens 45% 100%
P48455 Mus musculus 44% 100%
P48456 Drosophila melanogaster 45% 88%
P48457 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 45% 99%
P63328 Mus musculus 45% 100%
P63329 Rattus norvegicus 45% 100%
Q05681 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 47% 98%
Q08209 Homo sapiens 45% 100%
Q0G819 Caenorhabditis elegans 46% 100%
Q12705 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 99%
Q27889 Drosophila melanogaster 48% 96%
Q4Q1M5 Leishmania major 36% 100%
Q4Q5Z8 Leishmania major 37% 100%
Q4Q8T8 Leishmania major 77% 100%
Q4QFG0 Leishmania major 35% 100%
Q4QG03 Leishmania major 29% 100%
Q4QGT8 Leishmania major 27% 100%
Q4WUR1 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 45% 100%
Q7YSW8 Dictyostelium discoideum 45% 88%
Q9VXF1 Drosophila melanogaster 47% 93%
V5B3V2 Trypanosoma cruzi 53% 100%
V5BBR3 Trypanosoma cruzi 46% 100%
V5BBS3 Trypanosoma cruzi 26% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS