J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF97_LEIBR

TriTrypDb:

LbrM.26.2460 , LBRM2903_260030400

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.465
CLV_NRD_NRD_1	279	281	PF00675	0.393
CLV_NRD_NRD_1	322	324	PF00675	0.415
CLV_NRD_NRD_1	40	42	PF00675	0.392
CLV_NRD_NRD_1	443	445	PF00675	0.601
CLV_NRD_NRD_1	447	449	PF00675	0.585
CLV_NRD_NRD_1	81	83	PF00675	0.399
CLV_PCSK_FUR_1	320	324	PF00082	0.412
CLV_PCSK_FUR_1	444	448	PF00082	0.534
CLV_PCSK_KEX2_1	132	134	PF00082	0.574
CLV_PCSK_KEX2_1	322	324	PF00082	0.461
CLV_PCSK_KEX2_1	357	359	PF00082	0.487
CLV_PCSK_KEX2_1	40	42	PF00082	0.392
CLV_PCSK_KEX2_1	409	411	PF00082	0.521
CLV_PCSK_KEX2_1	443	445	PF00082	0.616
CLV_PCSK_KEX2_1	446	448	PF00082	0.624
CLV_PCSK_KEX2_1	83	85	PF00082	0.499
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.574
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.487
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.521
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.663
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.499
CLV_PCSK_PC7_1	318	324	PF00082	0.414
CLV_PCSK_SKI1_1	357	361	PF00082	0.496
CLV_PCSK_SKI1_1	384	388	PF00082	0.655
CLV_PCSK_SKI1_1	398	402	PF00082	0.652
CLV_PCSK_SKI1_1	406	410	PF00082	0.686
CLV_PCSK_SKI1_1	8	12	PF00082	0.495
CLV_PCSK_SKI1_1	91	95	PF00082	0.417
DEG_MDM2_SWIB_1	230	238	PF02201	0.405
DEG_Nend_UBRbox_2	1	3	PF02207	0.398
DEG_SCF_FBW7_1	29	35	PF00400	0.310
DEG_SPOP_SBC_1	112	116	PF00917	0.618
DOC_ANK_TNKS_1	322	329	PF00023	0.448
DOC_ANK_TNKS_1	363	370	PF00023	0.339
DOC_CKS1_1	29	34	PF01111	0.452
DOC_CKS1_1	425	430	PF01111	0.517
DOC_MAPK_FxFP_2	283	286	PF00069	0.330
DOC_MAPK_gen_1	236	244	PF00069	0.409
DOC_MAPK_gen_1	40	46	PF00069	0.387
DOC_MAPK_RevD_3	28	41	PF00069	0.317
DOC_PP4_FxxP_1	283	286	PF00568	0.330
DOC_PP4_FxxP_1	76	79	PF00568	0.435
DOC_USP7_MATH_1	120	124	PF00917	0.743
DOC_USP7_MATH_1	187	191	PF00917	0.434
DOC_USP7_MATH_1	32	36	PF00917	0.598
DOC_USP7_MATH_1	39	43	PF00917	0.424
DOC_USP7_MATH_1	430	434	PF00917	0.550
DOC_USP7_MATH_1	85	89	PF00917	0.329
DOC_USP7_UBL2_3	128	132	PF12436	0.605
DOC_USP7_UBL2_3	135	139	PF12436	0.568
DOC_USP7_UBL2_3	409	413	PF12436	0.748
DOC_WW_Pin1_4	191	196	PF00397	0.548
DOC_WW_Pin1_4	28	33	PF00397	0.443
DOC_WW_Pin1_4	388	393	PF00397	0.700
DOC_WW_Pin1_4	424	429	PF00397	0.555
LIG_14-3-3_CanoR_1	224	230	PF00244	0.490
LIG_14-3-3_CanoR_1	40	44	PF00244	0.596
LIG_14-3-3_CanoR_1	54	60	PF00244	0.381
LIG_14-3-3_CanoR_1	91	99	PF00244	0.456
LIG_BIR_III_2	222	226	PF00653	0.305
LIG_FHA_1	32	38	PF00498	0.325
LIG_FHA_1	413	419	PF00498	0.650
LIG_FHA_1	93	99	PF00498	0.366
LIG_FHA_2	153	159	PF00498	0.627
LIG_FHA_2	160	166	PF00498	0.576
LIG_FHA_2	462	468	PF00498	0.546
LIG_Integrin_RGD_1	448	450	PF01839	0.575
LIG_LIR_Apic_2	74	79	PF02991	0.437
LIG_LIR_Gen_1	42	50	PF02991	0.436
LIG_LIR_Gen_1	63	73	PF02991	0.346
LIG_LIR_Nem_3	268	273	PF02991	0.421
LIG_LIR_Nem_3	42	46	PF02991	0.439
LIG_LIR_Nem_3	63	69	PF02991	0.346
LIG_LYPXL_SIV_4	286	294	PF13949	0.326
LIG_PCNA_PIPBox_1	198	207	PF02747	0.377
LIG_PCNA_yPIPBox_3	193	205	PF02747	0.396
LIG_Pex14_2	230	234	PF04695	0.411
LIG_SH2_CRK	270	274	PF00017	0.438
LIG_SH2_CRK	43	47	PF00017	0.410
LIG_SH2_NCK_1	270	274	PF00017	0.409
LIG_SH2_SRC	470	473	PF00017	0.591
LIG_SH2_STAP1	227	231	PF00017	0.337
LIG_SH2_STAP1	265	269	PF00017	0.348
LIG_SH2_STAT5	293	296	PF00017	0.259
LIG_SH3_3	143	149	PF00018	0.549
LIG_SH3_3	207	213	PF00018	0.352
LIG_SH3_3	26	32	PF00018	0.412
LIG_SH3_3	283	289	PF00018	0.306
LIG_SH3_3	422	428	PF00018	0.721
LIG_TRAF2_1	155	158	PF00917	0.585
LIG_TRAF2_1	172	175	PF00917	0.538
LIG_TRAF2_1	299	302	PF00917	0.419
LIG_TRAF2_1	333	336	PF00917	0.455
LIG_TRAF2_1	453	456	PF00917	0.618
MOD_CDK_SPK_2	424	429	PF00069	0.517
MOD_CK1_1	115	121	PF00069	0.593
MOD_CK1_1	167	173	PF00069	0.551
MOD_CK1_1	272	278	PF00069	0.280
MOD_CK1_1	451	457	PF00069	0.626
MOD_CK1_1	460	466	PF00069	0.458
MOD_CK2_1	152	158	PF00069	0.661
MOD_CK2_1	214	220	PF00069	0.492
MOD_CK2_1	310	316	PF00069	0.547
MOD_CK2_1	32	38	PF00069	0.325
MOD_CK2_1	330	336	PF00069	0.359
MOD_CK2_1	362	368	PF00069	0.322
MOD_CK2_1	449	455	PF00069	0.582
MOD_Cter_Amidation	234	237	PF01082	0.349
MOD_Cter_Amidation	434	437	PF01082	0.706
MOD_GlcNHglycan	117	120	PF01048	0.692
MOD_GlcNHglycan	332	335	PF01048	0.393
MOD_GlcNHglycan	421	424	PF01048	0.764
MOD_GlcNHglycan	87	90	PF01048	0.367
MOD_GSK3_1	111	118	PF00069	0.720
MOD_GSK3_1	187	194	PF00069	0.472
MOD_GSK3_1	265	272	PF00069	0.380
MOD_GSK3_1	28	35	PF00069	0.365
MOD_GSK3_1	326	333	PF00069	0.548
MOD_GSK3_1	358	365	PF00069	0.418
MOD_GSK3_1	412	419	PF00069	0.642
MOD_GSK3_1	457	464	PF00069	0.680
MOD_LATS_1	356	362	PF00433	0.471
MOD_N-GLC_1	191	196	PF02516	0.610
MOD_N-GLC_1	430	435	PF02516	0.503
MOD_NEK2_1	269	274	PF00069	0.437
MOD_NEK2_1	342	347	PF00069	0.441
MOD_NEK2_1	378	383	PF00069	0.520
MOD_NEK2_1	6	11	PF00069	0.277
MOD_NEK2_2	225	230	PF00069	0.436
MOD_NEK2_2	265	270	PF00069	0.341
MOD_PIKK_1	120	126	PF00454	0.623
MOD_PK_1	436	442	PF00069	0.507
MOD_PKA_1	436	442	PF00069	0.662
MOD_PKA_2	39	45	PF00069	0.451
MOD_PKB_1	446	454	PF00069	0.629
MOD_Plk_1	167	173	PF00069	0.554
MOD_Plk_1	265	271	PF00069	0.345
MOD_Plk_1	32	38	PF00069	0.376
MOD_Plk_1	461	467	PF00069	0.687
MOD_Plk_4	225	231	PF00069	0.349
MOD_Plk_4	265	271	PF00069	0.345
MOD_Plk_4	32	38	PF00069	0.325
MOD_Plk_4	436	442	PF00069	0.507
MOD_Plk_4	6	12	PF00069	0.385
MOD_ProDKin_1	191	197	PF00069	0.546
MOD_ProDKin_1	28	34	PF00069	0.438
MOD_ProDKin_1	388	394	PF00069	0.701
MOD_ProDKin_1	424	430	PF00069	0.556
MOD_SUMO_for_1	127	130	PF00179	0.511
MOD_SUMO_for_1	93	96	PF00179	0.384
MOD_SUMO_rev_2	368	378	PF00179	0.428
MOD_SUMO_rev_2	74	81	PF00179	0.465
TRG_DiLeu_BaEn_1	337	342	PF01217	0.399
TRG_DiLeu_BaEn_4	349	355	PF01217	0.413
TRG_ENDOCYTIC_2	227	230	PF00928	0.335
TRG_ENDOCYTIC_2	270	273	PF00928	0.418
TRG_ENDOCYTIC_2	287	290	PF00928	0.228
TRG_ENDOCYTIC_2	43	46	PF00928	0.382
TRG_ER_diArg_1	103	106	PF00400	0.446
TRG_ER_diArg_1	320	323	PF00400	0.425
TRG_ER_diArg_1	444	447	PF00400	0.549
TRG_NLS_Bipartite_1	131	151	PF00514	0.568
TRG_NLS_MonoCore_2	146	151	PF00514	0.608
TRG_NLS_MonoCore_2	442	447	PF00514	0.629
TRG_NLS_MonoExtC_3	442	447	PF00514	0.636
TRG_NLS_MonoExtN_4	144	151	PF00514	0.691
TRG_NLS_MonoExtN_4	443	449	PF00514	0.653
TRG_NLS_MonoExtN_4	79	86	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P789	Trypanosomatidae	42%	100%
A0A3R7KYR3	Trypanosoma rangeli	45%	100%
A0A3S7X087	Leishmania donovani	70%	97%
A4I2I9	Leishmania infantum	70%	97%
C9ZX14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AYN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	97%
Q4Q8T9	Leishmania major	70%	100%