Protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HF96_LEIBR

TriTrypDb:

LbrM.26.2450 , LBRM2903_260030300

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF96

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.190
CLV_NRD_NRD_1	228	230	PF00675	0.353
CLV_NRD_NRD_1	29	31	PF00675	0.344
CLV_NRD_NRD_1	33	35	PF00675	0.342
CLV_NRD_NRD_1	370	372	PF00675	0.341
CLV_NRD_NRD_1	68	70	PF00675	0.267
CLV_PCSK_KEX2_1	165	167	PF00082	0.306
CLV_PCSK_KEX2_1	175	177	PF00082	0.328
CLV_PCSK_KEX2_1	228	230	PF00082	0.346
CLV_PCSK_KEX2_1	29	31	PF00082	0.380
CLV_PCSK_KEX2_1	33	35	PF00082	0.387
CLV_PCSK_KEX2_1	370	372	PF00082	0.344
CLV_PCSK_KEX2_1	59	61	PF00082	0.431
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.257
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.289
CLV_PCSK_PC7_1	29	35	PF00082	0.400
CLV_PCSK_SKI1_1	106	110	PF00082	0.462
CLV_PCSK_SKI1_1	160	164	PF00082	0.269
CLV_PCSK_SKI1_1	167	171	PF00082	0.263
CLV_PCSK_SKI1_1	269	273	PF00082	0.249
CLV_PCSK_SKI1_1	431	435	PF00082	0.582
DEG_APCC_DBOX_1	166	174	PF00400	0.278
DEG_APCC_DBOX_1	211	219	PF00400	0.400
DEG_APCC_KENBOX_2	408	412	PF00400	0.330
DEG_Nend_UBRbox_2	1	3	PF02207	0.666
DEG_SPOP_SBC_1	465	469	PF00917	0.376
DOC_CKS1_1	10	15	PF01111	0.530
DOC_CKS1_1	102	107	PF01111	0.513
DOC_CKS1_1	282	287	PF01111	0.400
DOC_MAPK_gen_1	269	278	PF00069	0.249
DOC_MAPK_MEF2A_6	212	219	PF00069	0.400
DOC_USP7_MATH_1	356	360	PF00917	0.330
DOC_USP7_UBL2_3	171	175	PF12436	0.252
DOC_WW_Pin1_4	101	106	PF00397	0.531
DOC_WW_Pin1_4	281	286	PF00397	0.400
DOC_WW_Pin1_4	395	400	PF00397	0.202
DOC_WW_Pin1_4	415	420	PF00397	0.235
DOC_WW_Pin1_4	9	14	PF00397	0.539
LIG_14-3-3_CanoR_1	160	169	PF00244	0.452
LIG_14-3-3_CanoR_1	176	182	PF00244	0.259
LIG_14-3-3_CanoR_1	81	85	PF00244	0.554
LIG_14-3-3_CterR_2	482	485	PF00244	0.419
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.249
LIG_BRCT_BRCA1_1	358	362	PF00533	0.330
LIG_BRCT_BRCA1_2	358	364	PF00533	0.330
LIG_FHA_1	107	113	PF00498	0.496
LIG_FHA_1	180	186	PF00498	0.309
LIG_FHA_1	19	25	PF00498	0.318
LIG_FHA_1	244	250	PF00498	0.286
LIG_FHA_1	282	288	PF00498	0.357
LIG_FHA_1	416	422	PF00498	0.411
LIG_FHA_1	5	11	PF00498	0.683
LIG_FHA_2	159	165	PF00498	0.167
LIG_FHA_2	209	215	PF00498	0.331
LIG_FHA_2	437	443	PF00498	0.644
LIG_LIR_Apic_2	279	285	PF02991	0.400
LIG_LIR_Apic_2	309	315	PF02991	0.249
LIG_LIR_Gen_1	114	124	PF02991	0.339
LIG_LIR_Gen_1	359	369	PF02991	0.331
LIG_LIR_Gen_1	404	413	PF02991	0.437
LIG_LIR_Gen_1	442	451	PF02991	0.518
LIG_LIR_Nem_3	150	154	PF02991	0.410
LIG_LIR_Nem_3	300	306	PF02991	0.420
LIG_LIR_Nem_3	404	408	PF02991	0.437
LIG_LIR_Nem_3	442	446	PF02991	0.501
LIG_MAD2	192	200	PF02301	0.317
LIG_Pex14_1	472	476	PF04695	0.613
LIG_Pex14_2	151	155	PF04695	0.330
LIG_Pex14_2	35	39	PF04695	0.322
LIG_Pex14_2	80	84	PF04695	0.512
LIG_SH2_CRK	130	134	PF00017	0.477
LIG_SH2_CRK	282	286	PF00017	0.368
LIG_SH2_CRK	405	409	PF00017	0.330
LIG_SH2_NCK_1	312	316	PF00017	0.355
LIG_SH2_NCK_1	397	401	PF00017	0.330
LIG_SH2_STAP1	181	185	PF00017	0.442
LIG_SH2_STAT3	63	66	PF00017	0.330
LIG_SH2_STAT5	102	105	PF00017	0.535
LIG_SH2_STAT5	116	119	PF00017	0.371
LIG_SH2_STAT5	181	184	PF00017	0.420
LIG_SH2_STAT5	259	262	PF00017	0.249
LIG_SH2_STAT5	304	307	PF00017	0.298
LIG_SH2_STAT5	349	352	PF00017	0.359
LIG_SH2_STAT5	476	479	PF00017	0.625
LIG_SH2_STAT5	52	55	PF00017	0.390
LIG_SH3_3	194	200	PF00018	0.330
LIG_SH3_3	459	465	PF00018	0.667
LIG_SUMO_SIM_anti_2	213	220	PF11976	0.322
LIG_SUMO_SIM_par_1	213	220	PF11976	0.265
LIG_TRAF2_2	399	404	PF00917	0.330
LIG_TYR_ITIM	346	351	PF00017	0.262
LIG_UBA3_1	169	175	PF00899	0.330
LIG_WRC_WIRS_1	137	142	PF05994	0.382
MOD_CDK_SPK_2	101	106	PF00069	0.520
MOD_CDK_SPxxK_3	395	402	PF00069	0.292
MOD_CDK_SPxxK_3	415	422	PF00069	0.234
MOD_CK1_1	114	120	PF00069	0.349
MOD_CK1_1	174	180	PF00069	0.292
MOD_CK1_1	3	9	PF00069	0.482
MOD_CK2_1	436	442	PF00069	0.609
MOD_Cter_Amidation	27	30	PF01082	0.400
MOD_Cter_Amidation	31	34	PF01082	0.400
MOD_GlcNHglycan	278	281	PF01048	0.400
MOD_GlcNHglycan	351	354	PF01048	0.298
MOD_GSK3_1	239	246	PF00069	0.167
MOD_GSK3_1	276	283	PF00069	0.278
MOD_GSK3_1	442	449	PF00069	0.651
MOD_GSK3_1	478	485	PF00069	0.622
MOD_N-GLC_1	177	182	PF02516	0.400
MOD_N-GLC_2	72	74	PF02516	0.262
MOD_NEK2_1	1	6	PF00069	0.718
MOD_NEK2_1	111	116	PF00069	0.444
MOD_NEK2_1	129	134	PF00069	0.382
MOD_NEK2_1	179	184	PF00069	0.331
MOD_NEK2_1	466	471	PF00069	0.493
MOD_NEK2_1	80	85	PF00069	0.540
MOD_NEK2_2	331	336	PF00069	0.400
MOD_PIKK_1	466	472	PF00454	0.381
MOD_PKA_2	147	153	PF00069	0.400
MOD_PKA_2	4	10	PF00069	0.436
MOD_PKA_2	478	484	PF00069	0.670
MOD_PKA_2	80	86	PF00069	0.585
MOD_Plk_1	177	183	PF00069	0.395
MOD_Plk_1	18	24	PF00069	0.173
MOD_Plk_2-3	442	448	PF00069	0.592
MOD_Plk_4	114	120	PF00069	0.533
MOD_Plk_4	136	142	PF00069	0.329
MOD_Plk_4	150	156	PF00069	0.249
MOD_ProDKin_1	101	107	PF00069	0.529
MOD_ProDKin_1	281	287	PF00069	0.400
MOD_ProDKin_1	395	401	PF00069	0.202
MOD_ProDKin_1	415	421	PF00069	0.229
MOD_ProDKin_1	9	15	PF00069	0.530
MOD_SUMO_for_1	155	158	PF00179	0.330
TRG_DiLeu_BaEn_1	20	25	PF01217	0.167
TRG_DiLeu_BaEn_1	459	464	PF01217	0.555
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.556
TRG_ENDOCYTIC_2	116	119	PF00928	0.435
TRG_ENDOCYTIC_2	130	133	PF00928	0.341
TRG_ENDOCYTIC_2	348	351	PF00928	0.278
TRG_ENDOCYTIC_2	405	408	PF00928	0.330
TRG_ER_diArg_1	165	167	PF00400	0.184
TRG_ER_diArg_1	33	35	PF00400	0.411
TRG_ER_diArg_1	369	371	PF00400	0.343
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J7	Leptomonas seymouri	23%	100%
A0A0N0P7K3	Leptomonas seymouri	65%	100%
A0A0S4IQ75	Bodo saltans	26%	96%
A0A0S4IRU8	Bodo saltans	24%	100%
A0A0S4J4B3	Bodo saltans	24%	100%
A0A0S4JH92	Bodo saltans	40%	98%
A0A0S4JQP0	Bodo saltans	41%	99%
A0A0S4KKJ1	Bodo saltans	23%	77%
A0A1X0P5U3	Trypanosomatidae	26%	95%
A0A1X0P834	Trypanosomatidae	45%	100%
A0A3Q8IHA5	Leishmania donovani	89%	100%
A0A3R7MPF2	Trypanosoma rangeli	26%	75%
A0A3R7RIN5	Trypanosoma rangeli	29%	97%
A0A3S5H5G0	Leishmania donovani	29%	100%
A0A422N3U8	Trypanosoma rangeli	27%	67%
A0A422P3P9	Trypanosoma rangeli	48%	98%
A4H459	Leishmania braziliensis	29%	100%
A4HCE6	Leishmania braziliensis	24%	100%
A4HSE2	Leishmania infantum	29%	100%
A4I2I8	Leishmania infantum	89%	100%
C9ZUU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	74%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AYN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P28867	Mus musculus	26%	72%
P31749	Homo sapiens	28%	100%
Q0VD22	Bos taurus	29%	100%
Q4Q8U0	Leishmania major	90%	100%
Q4QJJ0	Leishmania major	28%	100%
Q60823	Mus musculus	27%	100%
Q6IP76	Xenopus laevis	28%	100%
Q7ZX15	Xenopus laevis	28%	100%
Q8INB9	Drosophila melanogaster	28%	79%
Q9FZ36	Arabidopsis thaliana	24%	75%
Q9SN43	Arabidopsis thaliana	28%	99%
Q9ZSA2	Arabidopsis thaliana	27%	91%
V5BC57	Trypanosoma cruzi	47%	98%
V5C224	Trypanosoma cruzi	28%	97%