CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HF93_LEIBR

TriTrypDb:

LbrM.26.2410 , LBRM2903_260030000

Length:

226

Annotations

LeishMANIAdb annotations

A highly conserved Eukaryotic phosphatidylinositol biosynthesis enzyme. Potentially broadly distributed in membranes.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HF93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF93

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003881	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.589
CLV_C14_Caspase3-7	54	58	PF00656	0.256
CLV_PCSK_KEX2_1	148	150	PF00082	0.305
CLV_PCSK_KEX2_1	224	226	PF00082	0.353
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.231
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.353
DOC_MAPK_DCC_7	4	13	PF00069	0.499
DOC_MAPK_gen_1	148	154	PF00069	0.360
DOC_MAPK_HePTP_8	34	46	PF00069	0.386
DOC_MAPK_MEF2A_6	37	46	PF00069	0.324
DOC_USP7_MATH_1	168	172	PF00917	0.285
DOC_USP7_UBL2_3	128	132	PF12436	0.534
DOC_WW_Pin1_4	4	9	PF00397	0.542
LIG_14-3-3_CanoR_1	100	108	PF00244	0.368
LIG_14-3-3_CanoR_1	119	125	PF00244	0.375
LIG_14-3-3_CanoR_1	80	89	PF00244	0.256
LIG_APCC_ABBA_1	107	112	PF00400	0.300
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_Clathr_ClatBox_1	108	112	PF01394	0.256
LIG_Clathr_ClatBox_1	87	91	PF01394	0.386
LIG_eIF4E_1	39	45	PF01652	0.310
LIG_FHA_1	100	106	PF00498	0.368
LIG_GBD_Chelix_1	26	34	PF00786	0.344
LIG_LIR_Gen_1	115	125	PF02991	0.268
LIG_LIR_Gen_1	160	170	PF02991	0.256
LIG_LIR_Gen_1	171	178	PF02991	0.275
LIG_LIR_Gen_1	180	191	PF02991	0.184
LIG_LIR_Gen_1	83	94	PF02991	0.386
LIG_LIR_Nem_3	136	142	PF02991	0.487
LIG_LIR_Nem_3	160	166	PF02991	0.241
LIG_LIR_Nem_3	171	175	PF02991	0.270
LIG_LIR_Nem_3	180	186	PF02991	0.311
LIG_LIR_Nem_3	38	42	PF02991	0.246
LIG_LIR_Nem_3	83	89	PF02991	0.308
LIG_LYPXL_yS_3	39	42	PF13949	0.273
LIG_NRBOX	104	110	PF00104	0.273
LIG_NRBOX	41	47	PF00104	0.176
LIG_PCNA_PIPBox_1	202	211	PF02747	0.544
LIG_PCNA_yPIPBox_3	196	209	PF02747	0.444
LIG_Pex14_2	161	165	PF04695	0.422
LIG_Pex14_2	182	186	PF04695	0.399
LIG_SH2_CRK	121	125	PF00017	0.431
LIG_SH2_CRK	172	176	PF00017	0.372
LIG_SH2_NCK_1	121	125	PF00017	0.430
LIG_SH2_NCK_1	172	176	PF00017	0.363
LIG_SH2_PTP2	163	166	PF00017	0.335
LIG_SH2_STAP1	101	105	PF00017	0.386
LIG_SH2_STAP1	121	125	PF00017	0.320
LIG_SH2_STAP1	47	51	PF00017	0.288
LIG_SH2_STAT5	101	104	PF00017	0.386
LIG_SH2_STAT5	163	166	PF00017	0.256
LIG_SH2_STAT5	23	26	PF00017	0.217
LIG_SH2_STAT5	33	36	PF00017	0.363
LIG_SH2_STAT5	47	50	PF00017	0.198
LIG_SH3_3	2	8	PF00018	0.609
LIG_SH3_3	90	96	PF00018	0.275
LIG_SUMO_SIM_par_1	86	91	PF11976	0.306
LIG_TYR_ITIM	21	26	PF00017	0.289
MOD_CK1_1	127	133	PF00069	0.483
MOD_CK1_1	171	177	PF00069	0.286
MOD_CK2_1	171	177	PF00069	0.220
MOD_Cter_Amidation	222	225	PF01082	0.319
MOD_GSK3_1	120	127	PF00069	0.496
MOD_GSK3_1	173	180	PF00069	0.212
MOD_GSK3_1	65	72	PF00069	0.462
MOD_GSK3_1	75	82	PF00069	0.440
MOD_NEK2_1	120	125	PF00069	0.443
MOD_NEK2_1	204	209	PF00069	0.593
MOD_NEK2_1	45	50	PF00069	0.317
MOD_PKA_2	79	85	PF00069	0.300
MOD_PKA_2	99	105	PF00069	0.304
MOD_Plk_4	120	126	PF00069	0.426
MOD_Plk_4	134	140	PF00069	0.470
MOD_Plk_4	177	183	PF00069	0.210
MOD_Plk_4	204	210	PF00069	0.482
MOD_Plk_4	47	53	PF00069	0.335
MOD_Plk_4	69	75	PF00069	0.360
MOD_ProDKin_1	4	10	PF00069	0.537
MOD_SUMO_rev_2	54	61	PF00179	0.176
TRG_ENDOCYTIC_2	121	124	PF00928	0.361
TRG_ENDOCYTIC_2	163	166	PF00928	0.256
TRG_ENDOCYTIC_2	172	175	PF00928	0.276
TRG_ENDOCYTIC_2	23	26	PF00928	0.283
TRG_ENDOCYTIC_2	39	42	PF00928	0.289
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH3	Leptomonas seymouri	75%	100%
A0A0S4JGZ0	Bodo saltans	46%	100%
A0A1X0P7E9	Trypanosomatidae	50%	100%
A0A3Q8IE28	Leishmania donovani	79%	100%
A0A3R7N3Q1	Trypanosoma rangeli	54%	99%
C9ZX19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AHB8	Leishmania infantum	79%	100%
E9AYM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
O14735	Homo sapiens	36%	100%
P06197	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P70500	Rattus norvegicus	36%	100%
Q10153	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	95%
Q4Q8U3	Leishmania major	77%	100%
Q59RA2	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	98%
Q8GUK6	Arabidopsis thaliana	42%	100%
Q8LBA6	Arabidopsis thaliana	41%	100%
Q8SX37	Drosophila melanogaster	31%	100%
Q8VDP6	Mus musculus	36%	100%