Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF91_LEIBR

TriTrypDb:

LbrM.26.2390 , LBRM2903_260029800

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HF91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.651
CLV_C14_Caspase3-7	30	34	PF00656	0.599
CLV_NRD_NRD_1	108	110	PF00675	0.568
CLV_NRD_NRD_1	119	121	PF00675	0.464
CLV_NRD_NRD_1	149	151	PF00675	0.599
CLV_NRD_NRD_1	191	193	PF00675	0.526
CLV_NRD_NRD_1	276	278	PF00675	0.578
CLV_NRD_NRD_1	315	317	PF00675	0.700
CLV_NRD_NRD_1	389	391	PF00675	0.707
CLV_NRD_NRD_1	397	399	PF00675	0.703
CLV_NRD_NRD_1	487	489	PF00675	0.621
CLV_PCSK_KEX2_1	108	110	PF00082	0.568
CLV_PCSK_KEX2_1	119	121	PF00082	0.464
CLV_PCSK_KEX2_1	149	151	PF00082	0.594
CLV_PCSK_KEX2_1	191	193	PF00082	0.533
CLV_PCSK_KEX2_1	276	278	PF00082	0.642
CLV_PCSK_KEX2_1	315	317	PF00082	0.700
CLV_PCSK_KEX2_1	389	391	PF00082	0.701
CLV_PCSK_KEX2_1	397	399	PF00082	0.693
CLV_PCSK_PC7_1	272	278	PF00082	0.611
CLV_PCSK_SKI1_1	109	113	PF00082	0.524
CLV_PCSK_SKI1_1	325	329	PF00082	0.609
CLV_PCSK_SKI1_1	432	436	PF00082	0.678
CLV_PCSK_SKI1_1	442	446	PF00082	0.526
CLV_PCSK_SKI1_1	93	97	PF00082	0.396
CLV_Separin_Metazoa	188	192	PF03568	0.651
DEG_SPOP_SBC_1	125	129	PF00917	0.819
DEG_SPOP_SBC_1	152	156	PF00917	0.697
DOC_CYCLIN_RxL_1	429	438	PF00134	0.454
DOC_MAPK_DCC_7	93	103	PF00069	0.574
DOC_MAPK_FxFP_2	260	263	PF00069	0.528
DOC_MAPK_gen_1	108	114	PF00069	0.695
DOC_MAPK_gen_1	276	282	PF00069	0.441
DOC_MAPK_gen_1	359	367	PF00069	0.524
DOC_PP1_RVXF_1	217	223	PF00149	0.560
DOC_PP2B_LxvP_1	15	18	PF13499	0.587
DOC_PP2B_LxvP_1	24	27	PF13499	0.597
DOC_PP2B_LxvP_1	96	99	PF13499	0.568
DOC_PP4_FxxP_1	260	263	PF00568	0.528
DOC_USP7_MATH_1	124	128	PF00917	0.700
DOC_USP7_MATH_1	164	168	PF00917	0.757
DOC_USP7_MATH_1	176	180	PF00917	0.604
DOC_USP7_MATH_1	399	403	PF00917	0.484
DOC_USP7_MATH_1	524	528	PF00917	0.303
DOC_USP7_UBL2_3	432	436	PF12436	0.364
DOC_WW_Pin1_4	13	18	PF00397	0.588
DOC_WW_Pin1_4	139	144	PF00397	0.812
DOC_WW_Pin1_4	249	254	PF00397	0.522
DOC_WW_Pin1_4	382	387	PF00397	0.420
DOC_WW_Pin1_4	416	421	PF00397	0.515
DOC_WW_Pin1_4	423	428	PF00397	0.546
DOC_WW_Pin1_4	94	99	PF00397	0.564
LIG_14-3-3_CanoR_1	119	125	PF00244	0.731
LIG_14-3-3_CanoR_1	149	153	PF00244	0.696
LIG_14-3-3_CanoR_1	191	195	PF00244	0.744
LIG_14-3-3_CanoR_1	217	223	PF00244	0.630
LIG_14-3-3_CanoR_1	255	259	PF00244	0.563
LIG_14-3-3_CanoR_1	272	280	PF00244	0.330
LIG_14-3-3_CanoR_1	362	366	PF00244	0.568
LIG_14-3-3_CanoR_1	381	386	PF00244	0.387
LIG_14-3-3_CanoR_1	397	406	PF00244	0.538
LIG_14-3-3_CanoR_1	453	457	PF00244	0.343
LIG_14-3-3_CanoR_1	471	476	PF00244	0.246
LIG_Actin_WH2_2	474	490	PF00022	0.462
LIG_Actin_WH2_2	80	95	PF00022	0.549
LIG_BRCT_BRCA1_1	256	260	PF00533	0.498
LIG_BRCT_BRCA1_1	33	37	PF00533	0.598
LIG_BRCT_BRCA1_1	363	367	PF00533	0.571
LIG_BRCT_BRCA1_1	526	530	PF00533	0.299
LIG_Clathr_ClatBox_1	336	340	PF01394	0.491
LIG_EVH1_1	24	28	PF00568	0.614
LIG_FHA_1	221	227	PF00498	0.420
LIG_FHA_1	242	248	PF00498	0.397
LIG_FHA_1	277	283	PF00498	0.471
LIG_FHA_1	300	306	PF00498	0.452
LIG_FHA_1	331	337	PF00498	0.440
LIG_FHA_1	429	435	PF00498	0.491
LIG_FHA_1	43	49	PF00498	0.654
LIG_FHA_1	472	478	PF00498	0.369
LIG_FHA_1	507	513	PF00498	0.418
LIG_FHA_1	538	544	PF00498	0.299
LIG_FHA_2	28	34	PF00498	0.692
LIG_FHA_2	339	345	PF00498	0.321
LIG_FHA_2	505	511	PF00498	0.427
LIG_FXI_DFP_1	6	10	PF00024	0.390
LIG_LIR_Apic_2	257	263	PF02991	0.544
LIG_LIR_Apic_2	79	84	PF02991	0.555
LIG_LIR_Gen_1	198	208	PF02991	0.633
LIG_LIR_Gen_1	241	251	PF02991	0.586
LIG_LIR_Gen_1	455	464	PF02991	0.471
LIG_LIR_Nem_3	198	203	PF02991	0.639
LIG_LIR_Nem_3	221	225	PF02991	0.298
LIG_LIR_Nem_3	241	246	PF02991	0.494
LIG_LIR_Nem_3	257	262	PF02991	0.439
LIG_LIR_Nem_3	371	377	PF02991	0.421
LIG_LIR_Nem_3	455	459	PF02991	0.480
LIG_LIR_Nem_3	8	12	PF02991	0.584
LIG_MLH1_MIPbox_1	256	260	PF16413	0.568
LIG_PCNA_yPIPBox_3	315	327	PF02747	0.405
LIG_SH2_CRK	200	204	PF00017	0.633
LIG_SH2_CRK	243	247	PF00017	0.487
LIG_SH2_CRK	473	477	PF00017	0.377
LIG_SH2_CRK	484	488	PF00017	0.420
LIG_SH2_NCK_1	200	204	PF00017	0.616
LIG_SH2_PTP2	81	84	PF00017	0.553
LIG_SH2_STAP1	243	247	PF00017	0.398
LIG_SH2_STAP1	278	282	PF00017	0.363
LIG_SH2_STAP1	456	460	PF00017	0.400
LIG_SH2_STAP1	473	477	PF00017	0.392
LIG_SH2_STAP1	491	495	PF00017	0.285
LIG_SH2_STAP1	537	541	PF00017	0.407
LIG_SH2_STAT5	225	228	PF00017	0.459
LIG_SH2_STAT5	235	238	PF00017	0.353
LIG_SH2_STAT5	239	242	PF00017	0.328
LIG_SH2_STAT5	243	246	PF00017	0.322
LIG_SH2_STAT5	278	281	PF00017	0.367
LIG_SH2_STAT5	329	332	PF00017	0.393
LIG_SH2_STAT5	454	457	PF00017	0.334
LIG_SH2_STAT5	473	476	PF00017	0.470
LIG_SH2_STAT5	539	542	PF00017	0.470
LIG_SH2_STAT5	81	84	PF00017	0.553
LIG_SH3_2	427	432	PF14604	0.532
LIG_SH3_3	140	146	PF00018	0.669
LIG_SH3_3	19	25	PF00018	0.620
LIG_SH3_3	424	430	PF00018	0.550
LIG_SH3_3	45	51	PF00018	0.598
LIG_SH3_3	54	60	PF00018	0.610
LIG_SH3_3	92	98	PF00018	0.555
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.518
LIG_SUMO_SIM_par_1	10	16	PF11976	0.585
LIG_SUMO_SIM_par_1	333	341	PF11976	0.485
LIG_TRAF2_1	185	188	PF00917	0.805
LIG_TYR_ITSM	239	246	PF00017	0.480
LIG_WW_3	188	192	PF00397	0.559
LIG_WW_3	26	30	PF00397	0.499
MOD_CDC14_SPxK_1	252	255	PF00782	0.694
MOD_CDK_SPxK_1	249	255	PF00069	0.673
MOD_CDK_SPxxK_3	382	389	PF00069	0.513
MOD_CK1_1	128	134	PF00069	0.733
MOD_CK1_1	13	19	PF00069	0.475
MOD_CK1_1	141	147	PF00069	0.542
MOD_CK1_1	20	26	PF00069	0.492
MOD_CK1_1	361	367	PF00069	0.689
MOD_CK1_1	411	417	PF00069	0.765
MOD_CK2_1	338	344	PF00069	0.380
MOD_CK2_1	504	510	PF00069	0.535
MOD_CMANNOS	391	394	PF00535	0.600
MOD_GlcNHglycan	130	133	PF01048	0.716
MOD_GlcNHglycan	166	169	PF01048	0.605
MOD_GlcNHglycan	173	176	PF01048	0.505
MOD_GlcNHglycan	208	211	PF01048	0.709
MOD_GlcNHglycan	399	402	PF01048	0.600
MOD_GlcNHglycan	410	413	PF01048	0.691
MOD_GlcNHglycan	501	504	PF01048	0.433
MOD_GlcNHglycan	525	529	PF01048	0.351
MOD_GSK3_1	114	121	PF00069	0.641
MOD_GSK3_1	124	131	PF00069	0.738
MOD_GSK3_1	13	20	PF00069	0.480
MOD_GSK3_1	137	144	PF00069	0.667
MOD_GSK3_1	148	155	PF00069	0.640
MOD_GSK3_1	241	248	PF00069	0.440
MOD_GSK3_1	27	34	PF00069	0.451
MOD_GSK3_1	393	400	PF00069	0.506
MOD_GSK3_1	411	418	PF00069	0.664
MOD_GSK3_1	42	49	PF00069	0.436
MOD_GSK3_1	72	79	PF00069	0.460
MOD_N-GLC_1	249	254	PF02516	0.563
MOD_N-GLC_1	382	387	PF02516	0.515
MOD_NEK2_1	114	119	PF00069	0.543
MOD_NEK2_1	130	135	PF00069	0.608
MOD_NEK2_1	206	211	PF00069	0.622
MOD_NEK2_1	227	232	PF00069	0.411
MOD_NEK2_1	338	343	PF00069	0.455
MOD_NEK2_1	434	439	PF00069	0.571
MOD_NEK2_1	72	77	PF00069	0.580
MOD_NEK2_2	190	195	PF00069	0.698
MOD_NEK2_2	539	544	PF00069	0.380
MOD_PIKK_1	338	344	PF00454	0.380
MOD_PIKK_1	384	390	PF00454	0.675
MOD_PIKK_1	73	79	PF00454	0.454
MOD_PKA_1	276	282	PF00069	0.639
MOD_PKA_1	397	403	PF00069	0.485
MOD_PKA_2	118	124	PF00069	0.764
MOD_PKA_2	148	154	PF00069	0.584
MOD_PKA_2	190	196	PF00069	0.759
MOD_PKA_2	206	212	PF00069	0.529
MOD_PKA_2	218	224	PF00069	0.402
MOD_PKA_2	254	260	PF00069	0.720
MOD_PKA_2	271	277	PF00069	0.299
MOD_PKA_2	28	34	PF00069	0.489
MOD_PKA_2	361	367	PF00069	0.723
MOD_PKA_2	397	403	PF00069	0.495
MOD_PKA_2	452	458	PF00069	0.416
MOD_PKB_1	440	448	PF00069	0.418
MOD_Plk_2-3	504	510	PF00069	0.535
MOD_Plk_4	10	16	PF00069	0.466
MOD_Plk_4	241	247	PF00069	0.500
MOD_Plk_4	254	260	PF00069	0.619
MOD_Plk_4	332	338	PF00069	0.481
MOD_Plk_4	471	477	PF00069	0.322
MOD_Plk_4	76	82	PF00069	0.437
MOD_ProDKin_1	13	19	PF00069	0.475
MOD_ProDKin_1	139	145	PF00069	0.775
MOD_ProDKin_1	249	255	PF00069	0.667
MOD_ProDKin_1	382	388	PF00069	0.514
MOD_ProDKin_1	416	422	PF00069	0.647
MOD_ProDKin_1	423	429	PF00069	0.679
MOD_ProDKin_1	94	100	PF00069	0.441
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.595
TRG_ENDOCYTIC_2	200	203	PF00928	0.615
TRG_ENDOCYTIC_2	243	246	PF00928	0.619
TRG_ENDOCYTIC_2	324	327	PF00928	0.333
TRG_ENDOCYTIC_2	456	459	PF00928	0.589
TRG_ENDOCYTIC_2	473	476	PF00928	0.330
TRG_ENDOCYTIC_2	484	487	PF00928	0.536
TRG_ER_diArg_1	148	150	PF00400	0.664
TRG_ER_diArg_1	190	192	PF00400	0.674
TRG_ER_diArg_1	217	220	PF00400	0.436
TRG_ER_diArg_1	276	278	PF00400	0.462
TRG_ER_diArg_1	315	317	PF00400	0.550
TRG_ER_diArg_1	389	391	PF00400	0.636
TRG_ER_diArg_1	439	442	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV3	Leptomonas seymouri	48%	100%
A0A3S7X083	Leishmania donovani	68%	100%
A4I2H3	Leishmania infantum	68%	100%
E9AYM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q8U5	Leishmania major	66%	100%