RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF90_LEIBR

TriTrypDb:

LbrM.26.2380 , LBRM2903_260029700

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF90

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.499
CLV_C14_Caspase3-7	41	45	PF00656	0.629
CLV_NRD_NRD_1	117	119	PF00675	0.600
CLV_NRD_NRD_1	120	122	PF00675	0.561
CLV_NRD_NRD_1	124	126	PF00675	0.502
CLV_NRD_NRD_1	148	150	PF00675	0.527
CLV_NRD_NRD_1	202	204	PF00675	0.616
CLV_NRD_NRD_1	72	74	PF00675	0.599
CLV_PCSK_KEX2_1	117	119	PF00082	0.585
CLV_PCSK_KEX2_1	124	126	PF00082	0.484
CLV_PCSK_KEX2_1	148	150	PF00082	0.526
CLV_PCSK_KEX2_1	200	202	PF00082	0.587
CLV_PCSK_KEX2_1	32	34	PF00082	0.637
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.587
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.637
CLV_PCSK_SKI1_1	125	129	PF00082	0.596
CLV_PCSK_SKI1_1	148	152	PF00082	0.592
CLV_PCSK_SKI1_1	158	162	PF00082	0.467
DEG_APCC_DBOX_1	124	132	PF00400	0.635
DEG_APCC_KENBOX_2	181	185	PF00400	0.536
DEG_SPOP_SBC_1	140	144	PF00917	0.605
DOC_MAPK_gen_1	148	155	PF00069	0.506
DOC_MAPK_gen_1	200	209	PF00069	0.600
DOC_MAPK_RevD_3	186	202	PF00069	0.427
DOC_USP7_MATH_1	108	112	PF00917	0.557
DOC_USP7_MATH_1	19	23	PF00917	0.611
DOC_WW_Pin1_4	141	146	PF00397	0.578
LIG_14-3-3_CanoR_1	117	123	PF00244	0.454
LIG_14-3-3_CanoR_1	8	14	PF00244	0.503
LIG_BIR_III_2	82	86	PF00653	0.559
LIG_CaM_IQ_9	116	132	PF13499	0.439
LIG_CtBP_PxDLS_1	2	6	PF00389	0.567
LIG_FHA_1	10	16	PF00498	0.528
LIG_FHA_1	135	141	PF00498	0.532
LIG_FHA_1	204	210	PF00498	0.550
LIG_FHA_1	70	76	PF00498	0.543
LIG_FHA_1	98	104	PF00498	0.703
LIG_FHA_2	107	113	PF00498	0.644
LIG_FHA_2	133	139	PF00498	0.626
LIG_FHA_2	99	105	PF00498	0.668
LIG_LIR_Gen_1	67	75	PF02991	0.657
LIG_LIR_Nem_3	154	160	PF02991	0.609
LIG_LIR_Nem_3	62	66	PF02991	0.559
LIG_LIR_Nem_3	67	71	PF02991	0.561
LIG_NRBOX	26	32	PF00104	0.573
LIG_PCNA_yPIPBox_3	23	33	PF02747	0.621
LIG_PDZ_Class_2	216	221	PF00595	0.467
LIG_SH2_CRK	157	161	PF00017	0.604
LIG_SH2_STAT5	14	17	PF00017	0.550
LIG_SUMO_SIM_par_1	204	213	PF11976	0.640
LIG_TYR_ITIM	155	160	PF00017	0.607
LIG_UBA3_1	26	32	PF00899	0.535
MOD_CDK_SPxxK_3	141	148	PF00069	0.570
MOD_CK1_1	134	140	PF00069	0.719
MOD_CK1_1	53	59	PF00069	0.527
MOD_CK1_1	97	103	PF00069	0.598
MOD_CK2_1	106	112	PF00069	0.709
MOD_CK2_1	140	146	PF00069	0.606
MOD_Cter_Amidation	146	149	PF01082	0.547
MOD_GlcNHglycan	166	169	PF01048	0.582
MOD_GSK3_1	55	62	PF00069	0.552
MOD_GSK3_1	9	16	PF00069	0.649
MOD_GSK3_1	94	101	PF00069	0.651
MOD_N-GLC_1	132	137	PF02516	0.446
MOD_NEK2_1	132	137	PF00069	0.484
MOD_NEK2_1	9	14	PF00069	0.522
MOD_PIKK_1	116	122	PF00454	0.462
MOD_PIKK_1	19	25	PF00454	0.627
MOD_PIKK_1	191	197	PF00454	0.610
MOD_PKA_2	116	122	PF00069	0.480
MOD_PKB_1	201	209	PF00069	0.510
MOD_Plk_4	64	70	PF00069	0.687
MOD_ProDKin_1	141	147	PF00069	0.571
MOD_SUMO_for_1	174	177	PF00179	0.405
MOD_SUMO_rev_2	167	176	PF00179	0.525
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.666
TRG_ENDOCYTIC_2	157	160	PF00928	0.606
TRG_ER_diArg_1	116	118	PF00400	0.522
TRG_ER_diArg_1	123	125	PF00400	0.436
TRG_ER_diArg_1	201	203	PF00400	0.470
TRG_ER_diArg_1	218	221	PF00400	0.641
TRG_NLS_MonoExtC_3	120	125	PF00514	0.441
TRG_NLS_MonoExtN_4	118	125	PF00514	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L0	Leptomonas seymouri	67%	100%
A0A0S4JIP0	Bodo saltans	34%	100%
A0A1X0P7J1	Trypanosomatidae	44%	78%
A0A3S7X077	Leishmania donovani	81%	100%
A0A422P3P4	Trypanosoma rangeli	46%	87%
A4I2H2	Leishmania infantum	81%	100%
C9ZX22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	91%
E9AYM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q8U6	Leishmania major	80%	100%