BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF87_LEIBR

TriTrypDb:

LbrM.26.2350 , LBRM2903_260029400

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF87

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	436	438	PF00675	0.350
CLV_NRD_NRD_1	443	445	PF00675	0.401
CLV_NRD_NRD_1	537	539	PF00675	0.436
CLV_PCSK_KEX2_1	436	438	PF00082	0.350
CLV_PCSK_KEX2_1	537	539	PF00082	0.438
CLV_PCSK_KEX2_1	568	570	PF00082	0.448
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.448
CLV_PCSK_SKI1_1	158	162	PF00082	0.738
CLV_PCSK_SKI1_1	383	387	PF00082	0.356
CLV_PCSK_SKI1_1	491	495	PF00082	0.285
CLV_PCSK_SKI1_1	497	501	PF00082	0.287
CLV_PCSK_SKI1_1	530	534	PF00082	0.375
CLV_PCSK_SKI1_1	634	638	PF00082	0.508
DEG_Nend_UBRbox_2	1	3	PF02207	0.396
DEG_SCF_FBW7_1	164	169	PF00400	0.719
DEG_SCF_TRCP1_1	146	151	PF00400	0.446
DOC_CKS1_1	385	390	PF01111	0.465
DOC_CYCLIN_RxL_1	380	389	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.367
DOC_MAPK_gen_1	16	25	PF00069	0.334
DOC_MAPK_gen_1	436	442	PF00069	0.366
DOC_MAPK_MEF2A_6	16	25	PF00069	0.457
DOC_MAPK_MEF2A_6	526	535	PF00069	0.239
DOC_PP1_RVXF_1	133	140	PF00149	0.478
DOC_PP1_RVXF_1	460	467	PF00149	0.329
DOC_PP1_RVXF_1	495	502	PF00149	0.279
DOC_SPAK_OSR1_1	48	52	PF12202	0.438
DOC_USP7_MATH_1	156	160	PF00917	0.690
DOC_USP7_MATH_1	166	170	PF00917	0.592
DOC_USP7_MATH_1	452	456	PF00917	0.318
DOC_USP7_MATH_1	495	499	PF00917	0.262
DOC_USP7_MATH_1	512	516	PF00917	0.273
DOC_USP7_MATH_1	628	632	PF00917	0.481
DOC_USP7_MATH_1	88	92	PF00917	0.481
DOC_WW_Pin1_4	162	167	PF00397	0.654
DOC_WW_Pin1_4	181	186	PF00397	0.482
DOC_WW_Pin1_4	209	214	PF00397	0.579
DOC_WW_Pin1_4	384	389	PF00397	0.473
DOC_WW_Pin1_4	506	511	PF00397	0.378
DOC_WW_Pin1_4	67	72	PF00397	0.468
LIG_14-3-3_CanoR_1	20	26	PF00244	0.349
LIG_14-3-3_CanoR_1	208	212	PF00244	0.626
LIG_14-3-3_CanoR_1	274	280	PF00244	0.356
LIG_14-3-3_CanoR_1	341	349	PF00244	0.298
LIG_14-3-3_CanoR_1	35	42	PF00244	0.338
LIG_14-3-3_CanoR_1	436	441	PF00244	0.345
LIG_14-3-3_CanoR_1	634	642	PF00244	0.487
LIG_14-3-3_CanoR_1	92	97	PF00244	0.430
LIG_Actin_WH2_2	328	343	PF00022	0.300
LIG_APCC_ABBA_1	7	12	PF00400	0.522
LIG_BRCT_BRCA1_1	36	40	PF00533	0.336
LIG_BRCT_BRCA1_1	497	501	PF00533	0.197
LIG_BRCT_BRCA1_1	74	78	PF00533	0.522
LIG_BRCT_BRCA1_1	92	96	PF00533	0.290
LIG_Clathr_ClatBox_1	221	225	PF01394	0.708
LIG_FHA_1	132	138	PF00498	0.490
LIG_FHA_1	140	146	PF00498	0.504
LIG_FHA_1	159	165	PF00498	0.716
LIG_FHA_1	335	341	PF00498	0.351
LIG_FHA_1	576	582	PF00498	0.484
LIG_FHA_1	68	74	PF00498	0.265
LIG_FHA_2	126	132	PF00498	0.496
LIG_FHA_2	540	546	PF00498	0.412
LIG_FHA_2	633	639	PF00498	0.399
LIG_LIR_Gen_1	278	287	PF02991	0.465
LIG_LIR_Gen_1	334	344	PF02991	0.319
LIG_LIR_Gen_1	407	418	PF02991	0.390
LIG_LIR_Gen_1	424	435	PF02991	0.314
LIG_LIR_Gen_1	474	482	PF02991	0.328
LIG_LIR_Gen_1	527	536	PF02991	0.320
LIG_LIR_Gen_1	605	615	PF02991	0.301
LIG_LIR_Nem_3	278	284	PF02991	0.467
LIG_LIR_Nem_3	334	339	PF02991	0.291
LIG_LIR_Nem_3	370	374	PF02991	0.279
LIG_LIR_Nem_3	407	413	PF02991	0.379
LIG_LIR_Nem_3	416	421	PF02991	0.346
LIG_LIR_Nem_3	424	430	PF02991	0.319
LIG_LIR_Nem_3	470	476	PF02991	0.384
LIG_LIR_Nem_3	527	531	PF02991	0.320
LIG_LIR_Nem_3	631	636	PF02991	0.353
LIG_MYND_1	384	388	PF01753	0.464
LIG_NRBOX	410	416	PF00104	0.313
LIG_PCNA_PIPBox_1	626	635	PF02747	0.365
LIG_PCNA_yPIPBox_3	526	536	PF02747	0.410
LIG_PCNA_yPIPBox_3	626	634	PF02747	0.366
LIG_Pex14_1	45	49	PF04695	0.448
LIG_Pex14_2	96	100	PF04695	0.371
LIG_SH2_CRK	19	23	PF00017	0.306
LIG_SH2_CRK	418	422	PF00017	0.375
LIG_SH2_NCK_1	244	248	PF00017	0.700
LIG_SH2_NCK_1	399	403	PF00017	0.513
LIG_SH2_PTP2	381	384	PF00017	0.410
LIG_SH2_SRC	410	413	PF00017	0.460
LIG_SH2_STAP1	344	348	PF00017	0.297
LIG_SH2_STAP1	36	40	PF00017	0.435
LIG_SH2_STAP1	372	376	PF00017	0.361
LIG_SH2_STAP1	418	422	PF00017	0.349
LIG_SH2_STAP1	476	480	PF00017	0.410
LIG_SH2_STAP1	485	489	PF00017	0.410
LIG_SH2_STAT3	127	130	PF00017	0.517
LIG_SH2_STAT5	127	130	PF00017	0.402
LIG_SH2_STAT5	342	345	PF00017	0.279
LIG_SH2_STAT5	363	366	PF00017	0.279
LIG_SH2_STAT5	381	384	PF00017	0.410
LIG_SH2_STAT5	410	413	PF00017	0.303
LIG_SH2_STAT5	492	495	PF00017	0.305
LIG_SH3_1	309	315	PF00018	0.279
LIG_SH3_3	167	173	PF00018	0.495
LIG_SH3_3	225	231	PF00018	0.657
LIG_SH3_3	234	240	PF00018	0.658
LIG_SH3_3	270	276	PF00018	0.577
LIG_SH3_3	309	315	PF00018	0.279
LIG_SH3_3	350	356	PF00018	0.351
LIG_SH3_3	446	452	PF00018	0.383
LIG_SH3_3	476	482	PF00018	0.322
LIG_SH3_3	504	510	PF00018	0.342
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.197
LIG_SUMO_SIM_par_1	251	257	PF11976	0.635
LIG_SUMO_SIM_par_1	331	338	PF11976	0.389
LIG_SUMO_SIM_par_1	392	397	PF11976	0.414
LIG_TRAF2_1	128	131	PF00917	0.510
LIG_WRC_WIRS_1	336	341	PF05994	0.357
LIG_WRC_WIRS_1	513	518	PF05994	0.385
MOD_CDC14_SPxK_1	184	187	PF00782	0.584
MOD_CDC14_SPxK_1	212	215	PF00782	0.643
MOD_CDK_SPxK_1	162	168	PF00069	0.727
MOD_CDK_SPxK_1	181	187	PF00069	0.705
MOD_CDK_SPxK_1	209	215	PF00069	0.647
MOD_CK1_1	11	17	PF00069	0.402
MOD_CK1_1	199	205	PF00069	0.567
MOD_CK1_1	207	213	PF00069	0.569
MOD_CK1_1	257	263	PF00069	0.566
MOD_CK1_1	34	40	PF00069	0.361
MOD_CK1_1	515	521	PF00069	0.297
MOD_CK1_1	524	530	PF00069	0.270
MOD_CK1_1	605	611	PF00069	0.403
MOD_CK2_1	125	131	PF00069	0.485
MOD_CK2_1	471	477	PF00069	0.357
MOD_CK2_1	632	638	PF00069	0.387
MOD_DYRK1A_RPxSP_1	162	166	PF00069	0.658
MOD_GlcNHglycan	104	107	PF01048	0.374
MOD_GlcNHglycan	12	16	PF01048	0.426
MOD_GlcNHglycan	146	149	PF01048	0.639
MOD_GlcNHglycan	150	153	PF01048	0.718
MOD_GlcNHglycan	158	161	PF01048	0.643
MOD_GlcNHglycan	198	201	PF01048	0.714
MOD_GlcNHglycan	256	259	PF01048	0.570
MOD_GlcNHglycan	350	353	PF01048	0.367
MOD_GlcNHglycan	36	39	PF01048	0.477
MOD_GlcNHglycan	373	377	PF01048	0.323
MOD_GlcNHglycan	469	472	PF01048	0.279
MOD_GlcNHglycan	545	549	PF01048	0.308
MOD_GlcNHglycan	607	610	PF01048	0.454
MOD_GSK3_1	125	132	PF00069	0.452
MOD_GSK3_1	144	151	PF00069	0.447
MOD_GSK3_1	156	163	PF00069	0.647
MOD_GSK3_1	452	459	PF00069	0.371
MOD_GSK3_1	467	474	PF00069	0.313
MOD_GSK3_1	495	502	PF00069	0.344
MOD_GSK3_1	628	635	PF00069	0.427
MOD_GSK3_1	88	95	PF00069	0.407
MOD_N-GLC_1	605	610	PF02516	0.447
MOD_N-GLC_1	96	101	PF02516	0.469
MOD_NEK2_1	125	130	PF00069	0.477
MOD_NEK2_1	139	144	PF00069	0.365
MOD_NEK2_1	456	461	PF00069	0.493
MOD_NEK2_1	521	526	PF00069	0.283
MOD_NEK2_1	575	580	PF00069	0.528
MOD_NEK2_1	632	637	PF00069	0.416
MOD_NEK2_1	78	83	PF00069	0.388
MOD_NEK2_1	96	101	PF00069	0.295
MOD_NEK2_2	269	274	PF00069	0.412
MOD_NEK2_2	628	633	PF00069	0.431
MOD_NEK2_2	72	77	PF00069	0.501
MOD_PIKK_1	499	505	PF00454	0.279
MOD_PKA_1	436	442	PF00069	0.348
MOD_PKA_1	444	450	PF00069	0.391
MOD_PKA_2	196	202	PF00069	0.639
MOD_PKA_2	207	213	PF00069	0.677
MOD_PKA_2	34	40	PF00069	0.435
MOD_PKA_2	436	442	PF00069	0.348
MOD_Plk_1	139	145	PF00069	0.329
MOD_Plk_1	224	230	PF00069	0.598
MOD_Plk_1	288	294	PF00069	0.279
MOD_Plk_1	372	378	PF00069	0.385
MOD_Plk_1	521	527	PF00069	0.410
MOD_Plk_1	605	611	PF00069	0.445
MOD_Plk_1	96	102	PF00069	0.519
MOD_Plk_4	21	27	PF00069	0.456
MOD_Plk_4	335	341	PF00069	0.394
MOD_Plk_4	355	361	PF00069	0.410
MOD_Plk_4	405	411	PF00069	0.439
MOD_Plk_4	436	442	PF00069	0.365
MOD_Plk_4	628	634	PF00069	0.440
MOD_ProDKin_1	162	168	PF00069	0.654
MOD_ProDKin_1	181	187	PF00069	0.485
MOD_ProDKin_1	209	215	PF00069	0.579
MOD_ProDKin_1	384	390	PF00069	0.470
MOD_ProDKin_1	506	512	PF00069	0.378
MOD_ProDKin_1	67	73	PF00069	0.477
MOD_SUMO_for_1	567	570	PF00179	0.378
TRG_DiLeu_BaEn_1	114	119	PF01217	0.261
TRG_DiLeu_BaEn_2	56	62	PF01217	0.447
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.297
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.327
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.336
TRG_ENDOCYTIC_2	410	413	PF00928	0.357
TRG_ENDOCYTIC_2	418	421	PF00928	0.365
TRG_ENDOCYTIC_2	476	479	PF00928	0.289
TRG_ER_diArg_1	435	437	PF00400	0.370
TRG_ER_diArg_1	536	538	PF00400	0.436
TRG_NES_CRM1_1	404	419	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	538	543	PF00026	0.197

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K5	Leptomonas seymouri	77%	97%
A0A1X0P796	Trypanosomatidae	56%	100%
A0A3Q8IPI1	Leishmania donovani	87%	100%
A0A3R7KRV6	Trypanosoma rangeli	55%	100%
A4I2H0	Leishmania infantum	87%	100%
C9ZX25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AYM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8U9	Leishmania major	87%	100%
V5B8Y7	Trypanosoma cruzi	56%	100%