FATC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF86_LEIBR

TriTrypDb:

LbrM.26.2340 , LBRM2903_260029300

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.506
CLV_NRD_NRD_1	184	186	PF00675	0.465
CLV_NRD_NRD_1	207	209	PF00675	0.471
CLV_NRD_NRD_1	65	67	PF00675	0.537
CLV_NRD_NRD_1	96	98	PF00675	0.386
CLV_PCSK_FUR_1	182	186	PF00082	0.472
CLV_PCSK_KEX2_1	184	186	PF00082	0.465
CLV_PCSK_KEX2_1	328	330	PF00082	0.422
CLV_PCSK_KEX2_1	335	337	PF00082	0.391
CLV_PCSK_KEX2_1	65	67	PF00082	0.540
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.516
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.585
CLV_PCSK_PC7_1	180	186	PF00082	0.466
CLV_PCSK_SKI1_1	139	143	PF00082	0.482
CLV_PCSK_SKI1_1	309	313	PF00082	0.419
CLV_PCSK_SKI1_1	329	333	PF00082	0.316
CLV_PCSK_SKI1_1	336	340	PF00082	0.280
CLV_PCSK_SKI1_1	98	102	PF00082	0.447
DEG_APCC_DBOX_1	210	218	PF00400	0.482
DEG_APCC_KENBOX_2	18	22	PF00400	0.499
DOC_CYCLIN_RxL_1	306	313	PF00134	0.412
DOC_MAPK_gen_1	306	314	PF00069	0.277
DOC_MAPK_gen_1	409	418	PF00069	0.609
DOC_MAPK_gen_1	97	103	PF00069	0.487
DOC_MAPK_MEF2A_6	266	275	PF00069	0.371
DOC_MAPK_MEF2A_6	306	314	PF00069	0.277
DOC_PIKK_1	215	223	PF02985	0.290
DOC_PP4_FxxP_1	302	305	PF00568	0.351
DOC_USP7_MATH_1	134	138	PF00917	0.409
DOC_USP7_UBL2_3	335	339	PF12436	0.301
DOC_WW_Pin1_4	301	306	PF00397	0.496
LIG_14-3-3_CanoR_1	182	192	PF00244	0.479
LIG_14-3-3_CanoR_1	289	293	PF00244	0.306
LIG_14-3-3_CanoR_1	309	315	PF00244	0.500
LIG_14-3-3_CanoR_1	329	338	PF00244	0.446
LIG_14-3-3_CanoR_1	65	74	PF00244	0.531
LIG_APCC_ABBAyCdc20_2	28	34	PF00400	0.313
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BRCT_BRCA1_1	188	192	PF00533	0.492
LIG_BRCT_BRCA1_1	226	230	PF00533	0.391
LIG_CaM_IQ_9	167	182	PF13499	0.505
LIG_Clathr_ClatBox_1	242	246	PF01394	0.417
LIG_deltaCOP1_diTrp_1	125	131	PF00928	0.435
LIG_FHA_1	155	161	PF00498	0.427
LIG_FHA_1	28	34	PF00498	0.552
LIG_FHA_1	376	382	PF00498	0.461
LIG_FHA_1	66	72	PF00498	0.587
LIG_FHA_1	86	92	PF00498	0.440
LIG_FHA_2	211	217	PF00498	0.402
LIG_FHA_2	353	359	PF00498	0.472
LIG_FHA_2	39	45	PF00498	0.510
LIG_LIR_Apic_2	300	305	PF02991	0.287
LIG_LIR_Gen_1	125	134	PF02991	0.435
LIG_LIR_Gen_1	229	237	PF02991	0.432
LIG_LIR_Gen_1	238	245	PF02991	0.410
LIG_LIR_Gen_1	267	276	PF02991	0.402
LIG_LIR_Gen_1	414	422	PF02991	0.567
LIG_LIR_Nem_3	125	130	PF02991	0.364
LIG_LIR_Nem_3	229	234	PF02991	0.437
LIG_LIR_Nem_3	238	244	PF02991	0.407
LIG_LIR_Nem_3	267	271	PF02991	0.354
LIG_LIR_Nem_3	274	279	PF02991	0.377
LIG_LIR_Nem_3	382	386	PF02991	0.520
LIG_LIR_Nem_3	404	408	PF02991	0.571
LIG_LIR_Nem_3	414	418	PF02991	0.516
LIG_NRBOX	100	106	PF00104	0.489
LIG_NRBOX	306	312	PF00104	0.509
LIG_Pex14_1	127	131	PF04695	0.484
LIG_Pex14_2	192	196	PF04695	0.442
LIG_Pex14_2	226	230	PF04695	0.374
LIG_PTB_Apo_2	225	232	PF02174	0.507
LIG_PTB_Phospho_1	225	231	PF10480	0.503
LIG_SH2_CRK	231	235	PF00017	0.498
LIG_SH2_CRK	276	280	PF00017	0.443
LIG_SH2_CRK	415	419	PF00017	0.430
LIG_SH2_GRB2like	231	234	PF00017	0.522
LIG_SH2_NCK_1	231	235	PF00017	0.526
LIG_SH2_NCK_1	386	390	PF00017	0.383
LIG_SH2_STAT3	32	35	PF00017	0.526
LIG_SH2_STAT5	231	234	PF00017	0.406
LIG_SH2_STAT5	32	35	PF00017	0.307
LIG_SH2_STAT5	83	86	PF00017	0.421
LIG_SH3_3	432	438	PF00018	0.613
LIG_SH3_3	70	76	PF00018	0.440
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.269
LIG_SUMO_SIM_par_1	269	274	PF11976	0.467
LIG_TRAF2_1	213	216	PF00917	0.287
LIG_TRAF2_1	260	263	PF00917	0.326
LIG_TRAF2_1	428	431	PF00917	0.352
LIG_UBA3_1	270	278	PF00899	0.476
LIG_UBA3_1	418	426	PF00899	0.561
LIG_WRC_WIRS_1	100	105	PF05994	0.483
MOD_CDK_SPK_2	301	306	PF00069	0.394
MOD_CK1_1	118	124	PF00069	0.286
MOD_CK1_1	133	139	PF00069	0.426
MOD_CK1_1	186	192	PF00069	0.567
MOD_CK1_1	229	235	PF00069	0.302
MOD_CK1_1	27	33	PF00069	0.599
MOD_CK1_1	352	358	PF00069	0.413
MOD_CK1_1	375	381	PF00069	0.392
MOD_CK2_1	185	191	PF00069	0.532
MOD_CK2_1	210	216	PF00069	0.327
MOD_CK2_1	287	293	PF00069	0.384
MOD_CK2_1	352	358	PF00069	0.427
MOD_CK2_1	38	44	PF00069	0.423
MOD_GlcNHglycan	107	110	PF01048	0.413
MOD_GlcNHglycan	132	135	PF01048	0.360
MOD_GlcNHglycan	364	367	PF01048	0.565
MOD_GSK3_1	126	133	PF00069	0.487
MOD_GSK3_1	145	152	PF00069	0.451
MOD_GSK3_1	297	304	PF00069	0.375
MOD_GSK3_1	371	378	PF00069	0.486
MOD_GSK3_1	407	414	PF00069	0.615
MOD_GSK3_1	99	106	PF00069	0.370
MOD_N-GLC_1	149	154	PF02516	0.563
MOD_N-GLC_1	21	26	PF02516	0.428
MOD_NEK2_1	103	108	PF00069	0.474
MOD_NEK2_1	196	201	PF00069	0.462
MOD_NEK2_1	226	231	PF00069	0.361
MOD_NEK2_1	279	284	PF00069	0.412
MOD_NEK2_1	310	315	PF00069	0.491
MOD_NEK2_1	330	335	PF00069	0.542
MOD_NEK2_1	372	377	PF00069	0.409
MOD_NEK2_1	422	427	PF00069	0.539
MOD_NEK2_2	134	139	PF00069	0.488
MOD_PIKK_1	196	202	PF00454	0.442
MOD_PIKK_1	297	303	PF00454	0.383
MOD_PIKK_1	407	413	PF00454	0.549
MOD_PKA_1	184	190	PF00069	0.480
MOD_PKA_1	65	71	PF00069	0.713
MOD_PKA_2	145	151	PF00069	0.532
MOD_PKA_2	183	189	PF00069	0.494
MOD_PKA_2	210	216	PF00069	0.480
MOD_PKA_2	288	294	PF00069	0.313
MOD_PKA_2	65	71	PF00069	0.593
MOD_PKB_1	182	190	PF00069	0.481
MOD_Plk_1	115	121	PF00069	0.452
MOD_Plk_1	134	140	PF00069	0.406
MOD_Plk_1	21	27	PF00069	0.428
MOD_Plk_1	352	358	PF00069	0.420
MOD_Plk_1	44	50	PF00069	0.340
MOD_Plk_4	115	121	PF00069	0.285
MOD_Plk_4	126	132	PF00069	0.401
MOD_Plk_4	21	27	PF00069	0.628
MOD_Plk_4	226	232	PF00069	0.374
MOD_Plk_4	376	382	PF00069	0.372
MOD_Plk_4	411	417	PF00069	0.634
MOD_Plk_4	86	92	PF00069	0.385
MOD_Plk_4	99	105	PF00069	0.417
MOD_ProDKin_1	301	307	PF00069	0.495
MOD_SUMO_for_1	368	371	PF00179	0.533
MOD_SUMO_for_1	39	42	PF00179	0.318
MOD_SUMO_for_1	57	60	PF00179	0.488
MOD_SUMO_rev_2	106	115	PF00179	0.525
MOD_SUMO_rev_2	323	330	PF00179	0.557
MOD_SUMO_rev_2	401	410	PF00179	0.518
TRG_DiLeu_BaEn_2	98	104	PF01217	0.489
TRG_DiLeu_BaEn_4	215	221	PF01217	0.302
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.573
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.365
TRG_ENDOCYTIC_2	161	164	PF00928	0.379
TRG_ENDOCYTIC_2	231	234	PF00928	0.477
TRG_ENDOCYTIC_2	276	279	PF00928	0.434
TRG_ENDOCYTIC_2	415	418	PF00928	0.502
TRG_ER_diArg_1	183	185	PF00400	0.470
TRG_ER_diArg_1	395	398	PF00400	0.341
TRG_ER_diArg_1	64	66	PF00400	0.559
TRG_NES_CRM1_1	162	173	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM42	Leptomonas seymouri	67%	100%
A0A1X0P7I7	Trypanosomatidae	35%	92%
A0A3Q8ID54	Leishmania donovani	77%	100%
A0A3R7LDN5	Trypanosoma rangeli	30%	95%
A4I2G9	Leishmania infantum	76%	100%
C9ZX27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
D0A343	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	91%
E9AYM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q8V0	Leishmania major	76%	100%
V5ATI0	Trypanosoma cruzi	29%	100%