Putative peroxisomal membrane protein 4

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal membrane protein 4, putative

Species:

Leishmania braziliensis

UniProt:

A4HF85_LEIBR

TriTrypDb:

LbrM.26.2330 , LBRM2903_260029200

Length:

226

Annotations

LeishMANIAdb annotations

Similar to animal PXMP4 proteins. Presumed to have a 5TM topology in eukaryotes.. Localization: Peroxisomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	8
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HF85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	104	108	PF00082	0.263
CLV_PCSK_SKI1_1	81	85	PF00082	0.182
DEG_APCC_DBOX_1	103	111	PF00400	0.500
DEG_SCF_TRCP1_1	207	213	PF00400	0.418
DOC_MAPK_gen_1	57	66	PF00069	0.462
DOC_MAPK_gen_1	84	93	PF00069	0.385
DOC_MAPK_MEF2A_6	59	68	PF00069	0.479
DOC_PP1_SILK_1	104	109	PF00149	0.462
DOC_PP4_FxxP_1	18	21	PF00568	0.669
DOC_USP7_MATH_1	74	78	PF00917	0.551
DOC_USP7_UBL2_3	206	210	PF12436	0.408
DOC_WW_Pin1_4	186	191	PF00397	0.379
DOC_WW_Pin1_4	70	75	PF00397	0.520
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BRCT_BRCA1_1	207	211	PF00533	0.364
LIG_BRCT_BRCA1_1	34	38	PF00533	0.609
LIG_BRCT_BRCA1_1	96	100	PF00533	0.551
LIG_FHA_1	86	92	PF00498	0.469
LIG_FHA_1	97	103	PF00498	0.398
LIG_GBD_Chelix_1	150	158	PF00786	0.445
LIG_LIR_Apic_2	17	21	PF02991	0.646
LIG_LIR_Gen_1	212	223	PF02991	0.321
LIG_LIR_Gen_1	35	45	PF02991	0.589
LIG_LIR_Gen_1	73	83	PF02991	0.490
LIG_LIR_Gen_1	97	107	PF02991	0.484
LIG_LIR_LC3C_4	216	219	PF02991	0.405
LIG_LIR_Nem_3	212	218	PF02991	0.322
LIG_LIR_Nem_3	35	41	PF02991	0.519
LIG_LIR_Nem_3	97	103	PF02991	0.484
LIG_NRBOX	153	159	PF00104	0.420
LIG_PDZ_Class_3	221	226	PF00595	0.374
LIG_Pex14_2	38	42	PF04695	0.547
LIG_SH2_CRK	155	159	PF00017	0.413
LIG_SH2_CRK	215	219	PF00017	0.366
LIG_SH2_NCK_1	95	99	PF00017	0.551
LIG_SH2_STAP1	215	219	PF00017	0.339
LIG_SH2_STAT5	203	206	PF00017	0.307
LIG_SH3_3	55	61	PF00018	0.528
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.321
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.396
LIG_SUMO_SIM_par_1	216	222	PF11976	0.348
LIG_UBA3_1	183	192	PF00899	0.519
LIG_WRC_WIRS_1	15	20	PF05994	0.647
MOD_CDC14_SPxK_1	189	192	PF00782	0.389
MOD_CDK_SPxK_1	186	192	PF00069	0.383
MOD_CK1_1	73	79	PF00069	0.488
MOD_CK1_1	96	102	PF00069	0.561
MOD_GlcNHglycan	18	21	PF01048	0.400
MOD_GlcNHglycan	207	210	PF01048	0.578
MOD_GlcNHglycan	34	37	PF01048	0.260
MOD_GlcNHglycan	96	99	PF01048	0.241
MOD_GSK3_1	158	165	PF00069	0.414
MOD_GSK3_1	193	200	PF00069	0.323
MOD_GSK3_1	205	212	PF00069	0.297
MOD_GSK3_1	70	77	PF00069	0.474
MOD_NEK2_1	110	115	PF00069	0.551
MOD_NEK2_1	157	162	PF00069	0.464
MOD_NEK2_1	193	198	PF00069	0.315
MOD_NEK2_1	205	210	PF00069	0.300
MOD_NEK2_1	32	37	PF00069	0.460
MOD_NEK2_1	68	73	PF00069	0.467
MOD_NEK2_1	83	88	PF00069	0.403
MOD_NEK2_1	93	98	PF00069	0.426
MOD_Plk_4	210	216	PF00069	0.348
MOD_ProDKin_1	186	192	PF00069	0.383
MOD_ProDKin_1	70	76	PF00069	0.520
TRG_AP2beta_CARGO_1	39	49	PF09066	0.528
TRG_ENDOCYTIC_2	155	158	PF00928	0.413
TRG_ENDOCYTIC_2	215	218	PF00928	0.329
TRG_ENDOCYTIC_2	75	78	PF00928	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9U5	Leptomonas seymouri	74%	97%
A0A0S4JK51	Bodo saltans	32%	100%
A0A1X0P776	Trypanosomatidae	44%	100%
A0A3Q8IG25	Leishmania donovani	87%	100%
A0A3R7P3X1	Trypanosoma rangeli	49%	100%
A5PJL1	Bos taurus	28%	100%
C9ZX28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	74%
E9AYM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P59382	Rattus norvegicus	29%	100%
Q4Q8V1	Leishmania major	88%	100%
Q9JJW0	Mus musculus	28%	100%
Q9Y6I8	Homo sapiens	30%	100%