Protein MCM10 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Primase zinc finger/Mcm10 replication factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HF84_LEIBR

TriTrypDb:

LbrM.26.2320 , LBRM2903_260029100

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0031298	replication fork protection complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HF84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF84

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006270	DNA replication initiation	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003690	double-stranded DNA binding	5	8
GO:0003697	single-stranded DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003688	DNA replication origin binding	7	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.665
CLV_C14_Caspase3-7	588	592	PF00656	0.781
CLV_C14_Caspase3-7	668	672	PF00656	0.560
CLV_C14_Caspase3-7	751	755	PF00656	0.516
CLV_C14_Caspase3-7	786	790	PF00656	0.556
CLV_NRD_NRD_1	200	202	PF00675	0.440
CLV_NRD_NRD_1	229	231	PF00675	0.501
CLV_NRD_NRD_1	244	246	PF00675	0.307
CLV_NRD_NRD_1	312	314	PF00675	0.589
CLV_NRD_NRD_1	364	366	PF00675	0.331
CLV_NRD_NRD_1	376	378	PF00675	0.421
CLV_NRD_NRD_1	39	41	PF00675	0.505
CLV_NRD_NRD_1	626	628	PF00675	0.542
CLV_NRD_NRD_1	686	688	PF00675	0.626
CLV_NRD_NRD_1	715	717	PF00675	0.573
CLV_PCSK_FUR_1	198	202	PF00082	0.421
CLV_PCSK_FUR_1	624	628	PF00082	0.543
CLV_PCSK_KEX2_1	200	202	PF00082	0.440
CLV_PCSK_KEX2_1	229	231	PF00082	0.515
CLV_PCSK_KEX2_1	312	314	PF00082	0.601
CLV_PCSK_KEX2_1	364	366	PF00082	0.325
CLV_PCSK_KEX2_1	623	625	PF00082	0.689
CLV_PCSK_KEX2_1	626	628	PF00082	0.668
CLV_PCSK_KEX2_1	686	688	PF00082	0.654
CLV_PCSK_KEX2_1	715	717	PF00082	0.582
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.694
CLV_PCSK_PC7_1	196	202	PF00082	0.421
CLV_PCSK_PC7_1	225	231	PF00082	0.475
CLV_PCSK_SKI1_1	200	204	PF00082	0.473
CLV_PCSK_SKI1_1	540	544	PF00082	0.488
CLV_PCSK_SKI1_1	743	747	PF00082	0.719
CLV_PCSK_SKI1_1	813	817	PF00082	0.261
CLV_PCSK_SKI1_1	861	865	PF00082	0.352
CLV_PCSK_SKI1_1	866	870	PF00082	0.369
DEG_APCC_KENBOX_2	638	642	PF00400	0.502
DEG_SCF_FBW7_1	692	698	PF00400	0.612
DEG_SCF_TRCP1_1	776	782	PF00400	0.458
DEG_SPOP_SBC_1	150	154	PF00917	0.504
DEG_SPOP_SBC_1	568	572	PF00917	0.542
DEG_SPOP_SBC_1	585	589	PF00917	0.496
DEG_SPOP_SBC_1	654	658	PF00917	0.560
DEG_SPOP_SBC_1	705	709	PF00917	0.515
DOC_CDC14_PxL_1	415	423	PF14671	0.495
DOC_CKS1_1	692	697	PF01111	0.676
DOC_CYCLIN_RxL_1	332	342	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.496
DOC_MAPK_gen_1	198	206	PF00069	0.409
DOC_MAPK_gen_1	257	266	PF00069	0.423
DOC_MAPK_MEF2A_6	757	764	PF00069	0.507
DOC_PP1_RVXF_1	333	340	PF00149	0.412
DOC_PP2B_LxvP_1	131	134	PF13499	0.630
DOC_PP2B_LxvP_1	629	632	PF13499	0.488
DOC_PP4_FxxP_1	120	123	PF00568	0.501
DOC_PP4_FxxP_1	651	654	PF00568	0.499
DOC_USP7_MATH_1	123	127	PF00917	0.581
DOC_USP7_MATH_1	202	206	PF00917	0.402
DOC_USP7_MATH_1	217	221	PF00917	0.357
DOC_USP7_MATH_1	255	259	PF00917	0.590
DOC_USP7_MATH_1	347	351	PF00917	0.243
DOC_USP7_MATH_1	393	397	PF00917	0.595
DOC_USP7_MATH_1	406	410	PF00917	0.677
DOC_USP7_MATH_1	437	441	PF00917	0.658
DOC_USP7_MATH_1	446	450	PF00917	0.668
DOC_USP7_MATH_1	491	495	PF00917	0.550
DOC_USP7_MATH_1	523	527	PF00917	0.652
DOC_USP7_MATH_1	585	589	PF00917	0.571
DOC_USP7_MATH_1	645	649	PF00917	0.587
DOC_USP7_MATH_1	65	69	PF00917	0.674
DOC_USP7_MATH_1	654	658	PF00917	0.597
DOC_USP7_MATH_1	695	699	PF00917	0.686
DOC_USP7_MATH_1	730	734	PF00917	0.613
DOC_USP7_MATH_1	760	764	PF00917	0.668
DOC_USP7_MATH_1	83	87	PF00917	0.658
DOC_USP7_MATH_1	95	99	PF00917	0.634
DOC_USP7_UBL2_3	246	250	PF12436	0.412
DOC_USP7_UBL2_3	757	761	PF12436	0.500
DOC_USP7_UBL2_3	813	817	PF12436	0.253
DOC_USP7_UBL2_3	861	865	PF12436	0.360
DOC_WW_Pin1_4	126	131	PF00397	0.778
DOC_WW_Pin1_4	146	151	PF00397	0.647
DOC_WW_Pin1_4	178	183	PF00397	0.522
DOC_WW_Pin1_4	270	275	PF00397	0.380
DOC_WW_Pin1_4	508	513	PF00397	0.700
DOC_WW_Pin1_4	612	617	PF00397	0.680
DOC_WW_Pin1_4	68	73	PF00397	0.699
DOC_WW_Pin1_4	691	696	PF00397	0.682
DOC_WW_Pin1_4	755	760	PF00397	0.659
LIG_14-3-3_CanoR_1	124	130	PF00244	0.737
LIG_14-3-3_CanoR_1	200	205	PF00244	0.449
LIG_14-3-3_CanoR_1	229	235	PF00244	0.533
LIG_14-3-3_CanoR_1	245	249	PF00244	0.329
LIG_14-3-3_CanoR_1	327	337	PF00244	0.301
LIG_14-3-3_CanoR_1	364	371	PF00244	0.443
LIG_14-3-3_CanoR_1	397	404	PF00244	0.641
LIG_14-3-3_CanoR_1	427	436	PF00244	0.510
LIG_14-3-3_CanoR_1	451	459	PF00244	0.691
LIG_14-3-3_CanoR_1	463	471	PF00244	0.594
LIG_14-3-3_CanoR_1	472	477	PF00244	0.636
LIG_14-3-3_CanoR_1	52	62	PF00244	0.537
LIG_14-3-3_CanoR_1	522	528	PF00244	0.649
LIG_14-3-3_CanoR_1	567	577	PF00244	0.720
LIG_14-3-3_CanoR_1	614	622	PF00244	0.561
LIG_14-3-3_CanoR_1	715	719	PF00244	0.659
LIG_14-3-3_CanoR_1	806	811	PF00244	0.221
LIG_14-3-3_CanoR_1	896	904	PF00244	0.459
LIG_Actin_WH2_2	478	495	PF00022	0.508
LIG_Actin_WH2_2	671	688	PF00022	0.586
LIG_Actin_WH2_2	848	863	PF00022	0.207
LIG_APCC_ABBA_1	635	640	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BIR_III_2	12	16	PF00653	0.524
LIG_BIR_III_4	591	595	PF00653	0.531
LIG_BRCT_BRCA1_1	647	651	PF00533	0.565
LIG_FHA_1	127	133	PF00498	0.505
LIG_FHA_1	136	142	PF00498	0.707
LIG_FHA_1	189	195	PF00498	0.554
LIG_FHA_1	201	207	PF00498	0.397
LIG_FHA_1	43	49	PF00498	0.651
LIG_FHA_1	528	534	PF00498	0.519
LIG_FHA_1	54	60	PF00498	0.459
LIG_FHA_1	616	622	PF00498	0.613
LIG_FHA_1	847	853	PF00498	0.394
LIG_FHA_1	875	881	PF00498	0.382
LIG_FHA_2	569	575	PF00498	0.703
LIG_FHA_2	848	854	PF00498	0.376
LIG_Integrin_RGD_1	905	907	PF01839	0.431
LIG_LIR_Apic_2	118	123	PF02991	0.502
LIG_LIR_Apic_2	648	654	PF02991	0.499
LIG_LIR_Gen_1	215	224	PF02991	0.427
LIG_LIR_Gen_1	258	269	PF02991	0.448
LIG_LIR_Gen_1	287	297	PF02991	0.379
LIG_LIR_Gen_1	3	14	PF02991	0.574
LIG_LIR_Nem_3	215	221	PF02991	0.421
LIG_LIR_Nem_3	258	264	PF02991	0.473
LIG_LIR_Nem_3	287	292	PF02991	0.413
LIG_LIR_Nem_3	3	9	PF02991	0.570
LIG_LIR_Nem_3	417	421	PF02991	0.495
LIG_LIR_Nem_3	474	479	PF02991	0.643
LIG_LIR_Nem_3	501	507	PF02991	0.644
LIG_LYPXL_yS_3	418	421	PF13949	0.493
LIG_MYND_1	130	134	PF01753	0.496
LIG_NRBOX	279	285	PF00104	0.446
LIG_SH2_CRK	261	265	PF00017	0.362
LIG_SH2_CRK	504	508	PF00017	0.583
LIG_SH2_CRK	836	840	PF00017	0.372
LIG_SH2_CRK	844	848	PF00017	0.351
LIG_SH2_STAP1	293	297	PF00017	0.367
LIG_SH2_STAT5	836	839	PF00017	0.360
LIG_SH2_STAT5	867	870	PF00017	0.382
LIG_SH3_1	179	185	PF00018	0.542
LIG_SH3_1	889	895	PF00018	0.406
LIG_SH3_3	12	18	PF00018	0.569
LIG_SH3_3	144	150	PF00018	0.519
LIG_SH3_3	179	185	PF00018	0.518
LIG_SH3_3	484	490	PF00018	0.507
LIG_SH3_3	57	63	PF00018	0.583
LIG_SH3_3	689	695	PF00018	0.662
LIG_SH3_3	85	91	PF00018	0.584
LIG_SH3_3	889	895	PF00018	0.406
LIG_SH3_3	913	919	PF00018	0.572
LIG_SH3_4	861	868	PF00018	0.360
LIG_SUMO_SIM_anti_2	779	786	PF11976	0.587
LIG_SUMO_SIM_par_1	202	207	PF11976	0.455
LIG_SUMO_SIM_par_1	22	28	PF11976	0.647
LIG_SUMO_SIM_par_1	262	268	PF11976	0.269
LIG_SUMO_SIM_par_1	300	305	PF11976	0.379
LIG_SxIP_EBH_1	40	54	PF03271	0.509
LIG_TYR_ITIM	291	296	PF00017	0.335
LIG_WRC_WIRS_1	218	223	PF05994	0.368
LIG_WRC_WIRS_1	807	812	PF05994	0.247
LIG_WRC_WIRS_1	875	880	PF05994	0.445
MOD_CDC14_SPxK_1	758	761	PF00782	0.493
MOD_CDK_SPxK_1	755	761	PF00069	0.505
MOD_CDK_SPxxK_3	72	79	PF00069	0.518
MOD_CK1_1	103	109	PF00069	0.489
MOD_CK1_1	126	132	PF00069	0.532
MOD_CK1_1	148	154	PF00069	0.760
MOD_CK1_1	178	184	PF00069	0.625
MOD_CK1_1	228	234	PF00069	0.504
MOD_CK1_1	268	274	PF00069	0.345
MOD_CK1_1	30	36	PF00069	0.747
MOD_CK1_1	305	311	PF00069	0.349
MOD_CK1_1	315	321	PF00069	0.434
MOD_CK1_1	350	356	PF00069	0.297
MOD_CK1_1	396	402	PF00069	0.578
MOD_CK1_1	409	415	PF00069	0.594
MOD_CK1_1	43	49	PF00069	0.573
MOD_CK1_1	450	456	PF00069	0.721
MOD_CK1_1	498	504	PF00069	0.601
MOD_CK1_1	526	532	PF00069	0.629
MOD_CK1_1	58	64	PF00069	0.573
MOD_CK1_1	644	650	PF00069	0.623
MOD_CK1_1	68	74	PF00069	0.635
MOD_CK1_1	725	731	PF00069	0.608
MOD_CK1_1	752	758	PF00069	0.692
MOD_CK1_1	779	785	PF00069	0.709
MOD_CK1_1	93	99	PF00069	0.614
MOD_CK2_1	109	115	PF00069	0.575
MOD_CK2_1	151	157	PF00069	0.732
MOD_CK2_1	568	574	PF00069	0.688
MOD_CK2_1	847	853	PF00069	0.360
MOD_GlcNHglycan	135	138	PF01048	0.590
MOD_GlcNHglycan	157	160	PF01048	0.677
MOD_GlcNHglycan	186	189	PF01048	0.519
MOD_GlcNHglycan	28	32	PF01048	0.785
MOD_GlcNHglycan	286	289	PF01048	0.452
MOD_GlcNHglycan	314	317	PF01048	0.574
MOD_GlcNHglycan	33	36	PF01048	0.744
MOD_GlcNHglycan	399	402	PF01048	0.583
MOD_GlcNHglycan	406	409	PF01048	0.716
MOD_GlcNHglycan	412	415	PF01048	0.696
MOD_GlcNHglycan	421	424	PF01048	0.622
MOD_GlcNHglycan	430	433	PF01048	0.632
MOD_GlcNHglycan	439	442	PF01048	0.639
MOD_GlcNHglycan	455	458	PF01048	0.638
MOD_GlcNHglycan	493	496	PF01048	0.605
MOD_GlcNHglycan	497	500	PF01048	0.605
MOD_GlcNHglycan	588	591	PF01048	0.775
MOD_GlcNHglycan	63	66	PF01048	0.656
MOD_GlcNHglycan	643	646	PF01048	0.571
MOD_GlcNHglycan	667	670	PF01048	0.731
MOD_GlcNHglycan	720	723	PF01048	0.662
MOD_GlcNHglycan	730	733	PF01048	0.515
MOD_GlcNHglycan	766	769	PF01048	0.647
MOD_GlcNHglycan	774	779	PF01048	0.644
MOD_GlcNHglycan	792	795	PF01048	0.470
MOD_GlcNHglycan	85	88	PF01048	0.690
MOD_GlcNHglycan	92	95	PF01048	0.650
MOD_GlcNHglycan	97	100	PF01048	0.679
MOD_GSK3_1	135	142	PF00069	0.622
MOD_GSK3_1	145	152	PF00069	0.721
MOD_GSK3_1	184	191	PF00069	0.528
MOD_GSK3_1	251	258	PF00069	0.702
MOD_GSK3_1	27	34	PF00069	0.658
MOD_GSK3_1	393	400	PF00069	0.593
MOD_GSK3_1	40	47	PF00069	0.754
MOD_GSK3_1	406	413	PF00069	0.646
MOD_GSK3_1	446	453	PF00069	0.725
MOD_GSK3_1	455	462	PF00069	0.586
MOD_GSK3_1	491	498	PF00069	0.671
MOD_GSK3_1	523	530	PF00069	0.480
MOD_GSK3_1	606	613	PF00069	0.658
MOD_GSK3_1	61	68	PF00069	0.768
MOD_GSK3_1	640	647	PF00069	0.626
MOD_GSK3_1	649	656	PF00069	0.536
MOD_GSK3_1	691	698	PF00069	0.635
MOD_GSK3_1	714	721	PF00069	0.657
MOD_GSK3_1	748	755	PF00069	0.627
MOD_GSK3_1	760	767	PF00069	0.542
MOD_GSK3_1	77	84	PF00069	0.592
MOD_GSK3_1	779	786	PF00069	0.542
MOD_N-GLC_1	305	310	PF02516	0.296
MOD_N-GLC_1	640	645	PF02516	0.494
MOD_N-GLC_2	125	127	PF02516	0.497
MOD_NEK2_1	101	106	PF00069	0.519
MOD_NEK2_1	223	228	PF00069	0.350
MOD_NEK2_1	284	289	PF00069	0.364
MOD_NEK2_1	291	296	PF00069	0.368
MOD_NEK2_1	360	365	PF00069	0.329
MOD_NEK2_1	404	409	PF00069	0.612
MOD_NEK2_1	410	415	PF00069	0.629
MOD_NEK2_1	428	433	PF00069	0.557
MOD_NEK2_1	44	49	PF00069	0.662
MOD_NEK2_1	464	469	PF00069	0.642
MOD_NEK2_1	471	476	PF00069	0.634
MOD_NEK2_1	533	538	PF00069	0.510
MOD_NEK2_1	559	564	PF00069	0.473
MOD_NEK2_1	748	753	PF00069	0.543
MOD_NEK2_1	764	769	PF00069	0.485
MOD_NEK2_1	77	82	PF00069	0.702
MOD_NEK2_1	783	788	PF00069	0.564
MOD_NEK2_2	406	411	PF00069	0.495
MOD_PIKK_1	363	369	PF00454	0.353
MOD_PIKK_1	464	470	PF00454	0.640
MOD_PIKK_1	527	533	PF00454	0.466
MOD_PIKK_1	730	736	PF00454	0.621
MOD_PKA_1	200	206	PF00069	0.420
MOD_PKA_1	312	318	PF00069	0.593
MOD_PKA_1	40	46	PF00069	0.512
MOD_PKA_2	115	121	PF00069	0.625
MOD_PKA_2	123	129	PF00069	0.476
MOD_PKA_2	200	206	PF00069	0.401
MOD_PKA_2	228	234	PF00069	0.598
MOD_PKA_2	244	250	PF00069	0.324
MOD_PKA_2	256	262	PF00069	0.460
MOD_PKA_2	312	318	PF00069	0.693
MOD_PKA_2	363	369	PF00069	0.219
MOD_PKA_2	396	402	PF00069	0.510
MOD_PKA_2	450	456	PF00069	0.741
MOD_PKA_2	471	477	PF00069	0.652
MOD_PKA_2	714	720	PF00069	0.662
MOD_PKB_1	198	206	PF00069	0.452
MOD_PKB_1	804	812	PF00069	0.247
MOD_Plk_1	278	284	PF00069	0.413
MOD_Plk_4	103	109	PF00069	0.562
MOD_Plk_4	139	145	PF00069	0.660
MOD_Plk_4	262	268	PF00069	0.410
MOD_Plk_4	278	284	PF00069	0.396
MOD_Plk_4	472	478	PF00069	0.637
MOD_Plk_4	779	785	PF00069	0.516
MOD_Plk_4	874	880	PF00069	0.360
MOD_Plk_4	898	904	PF00069	0.401
MOD_ProDKin_1	126	132	PF00069	0.666
MOD_ProDKin_1	146	152	PF00069	0.645
MOD_ProDKin_1	178	184	PF00069	0.519
MOD_ProDKin_1	270	276	PF00069	0.389
MOD_ProDKin_1	508	514	PF00069	0.702
MOD_ProDKin_1	612	618	PF00069	0.682
MOD_ProDKin_1	68	74	PF00069	0.702
MOD_ProDKin_1	691	697	PF00069	0.682
MOD_ProDKin_1	755	761	PF00069	0.662
MOD_SUMO_for_1	868	871	PF00179	0.360
MOD_SUMO_rev_2	853	863	PF00179	0.360
TRG_AP2beta_CARGO_1	215	225	PF09066	0.443
TRG_DiLeu_BaEn_1	279	284	PF01217	0.393
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.505
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.510
TRG_ENDOCYTIC_2	261	264	PF00928	0.366
TRG_ENDOCYTIC_2	293	296	PF00928	0.405
TRG_ENDOCYTIC_2	418	421	PF00928	0.493
TRG_ENDOCYTIC_2	504	507	PF00928	0.586
TRG_ENDOCYTIC_2	836	839	PF00928	0.219
TRG_ENDOCYTIC_2	875	878	PF00928	0.364
TRG_ER_diArg_1	196	199	PF00400	0.445
TRG_ER_diArg_1	624	627	PF00400	0.704
TRG_ER_diArg_1	685	687	PF00400	0.628
TRG_ER_diArg_1	714	716	PF00400	0.645
TRG_ER_diArg_1	804	807	PF00400	0.224
TRG_NLS_MonoExtC_3	622	627	PF00514	0.679
TRG_NLS_MonoExtN_4	622	627	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I857	Leptomonas seymouri	55%	100%
A0A1X0P7F7	Trypanosomatidae	29%	100%
A0A3S7X073	Leishmania donovani	72%	100%
A4I2G7	Leishmania infantum	72%	100%
E9AYM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q8V2	Leishmania major	71%	100%