Putative sec1 family transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sec1 family transport protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HF81_LEIBR

TriTrypDb:

LbrM.26.2290 , LBRM2903_260027900

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF81

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.333
CLV_C14_Caspase3-7	338	342	PF00656	0.276
CLV_NRD_NRD_1	211	213	PF00675	0.257
CLV_NRD_NRD_1	315	317	PF00675	0.362
CLV_NRD_NRD_1	357	359	PF00675	0.379
CLV_NRD_NRD_1	609	611	PF00675	0.280
CLV_PCSK_KEX2_1	211	213	PF00082	0.257
CLV_PCSK_KEX2_1	315	317	PF00082	0.328
CLV_PCSK_KEX2_1	359	361	PF00082	0.257
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.257
CLV_PCSK_SKI1_1	224	228	PF00082	0.328
CLV_PCSK_SKI1_1	236	240	PF00082	0.250
CLV_PCSK_SKI1_1	259	263	PF00082	0.257
CLV_PCSK_SKI1_1	367	371	PF00082	0.290
DEG_APCC_DBOX_1	114	122	PF00400	0.280
DEG_APCC_DBOX_1	235	243	PF00400	0.281
DEG_APCC_DBOX_1	258	266	PF00400	0.257
DEG_APCC_DBOX_1	415	423	PF00400	0.257
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DEG_SCF_FBW7_1	226	231	PF00400	0.333
DOC_ANK_TNKS_1	70	77	PF00023	0.257
DOC_CDC14_PxL_1	192	200	PF14671	0.333
DOC_CDC14_PxL_1	349	357	PF14671	0.257
DOC_CKS1_1	225	230	PF01111	0.333
DOC_CKS1_1	275	280	PF01111	0.333
DOC_CKS1_1	326	331	PF01111	0.357
DOC_CYCLIN_RxL_1	233	243	PF00134	0.257
DOC_CYCLIN_RxL_1	253	264	PF00134	0.128
DOC_CYCLIN_RxL_1	32	41	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.257
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.257
DOC_MAPK_gen_1	211	217	PF00069	0.257
DOC_MAPK_gen_1	570	577	PF00069	0.257
DOC_MAPK_JIP1_4	236	242	PF00069	0.257
DOC_MAPK_MEF2A_6	44	53	PF00069	0.257
DOC_MAPK_MEF2A_6	57	65	PF00069	0.257
DOC_PP1_RVXF_1	33	40	PF00149	0.389
DOC_PP1_RVXF_1	365	371	PF00149	0.389
DOC_PP4_FxxP_1	82	85	PF00568	0.257
DOC_USP7_MATH_1	129	133	PF00917	0.399
DOC_USP7_MATH_1	228	232	PF00917	0.304
DOC_USP7_MATH_1	23	27	PF00917	0.581
DOC_USP7_MATH_1	474	478	PF00917	0.419
DOC_USP7_MATH_1	524	528	PF00917	0.176
DOC_USP7_MATH_1	550	554	PF00917	0.377
DOC_USP7_MATH_1	609	613	PF00917	0.353
DOC_USP7_MATH_1	635	639	PF00917	0.452
DOC_USP7_UBL2_3	166	170	PF12436	0.364
DOC_WW_Pin1_4	125	130	PF00397	0.389
DOC_WW_Pin1_4	224	229	PF00397	0.336
DOC_WW_Pin1_4	274	279	PF00397	0.333
DOC_WW_Pin1_4	325	330	PF00397	0.357
DOC_WW_Pin1_4	462	467	PF00397	0.414
DOC_WW_Pin1_4	536	541	PF00397	0.443
LIG_14-3-3_CanoR_1	141	146	PF00244	0.389
LIG_14-3-3_CanoR_1	211	216	PF00244	0.302
LIG_14-3-3_CanoR_1	244	252	PF00244	0.268
LIG_14-3-3_CanoR_1	272	278	PF00244	0.214
LIG_14-3-3_CanoR_1	434	443	PF00244	0.330
LIG_14-3-3_CanoR_1	460	465	PF00244	0.275
LIG_14-3-3_CanoR_1	570	576	PF00244	0.271
LIG_14-3-3_CanoR_1	610	614	PF00244	0.289
LIG_14-3-3_CanoR_1	628	633	PF00244	0.372
LIG_Actin_WH2_2	149	167	PF00022	0.386
LIG_APCC_ABBA_1	36	41	PF00400	0.257
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.386
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.257
LIG_BRCT_BRCA1_1	299	303	PF00533	0.176
LIG_BRCT_BRCA1_1	476	480	PF00533	0.333
LIG_Clathr_ClatBox_1	239	243	PF01394	0.257
LIG_Clathr_ClatBox_1	36	40	PF01394	0.389
LIG_DCNL_PONY_1	1	4	PF03556	0.267
LIG_deltaCOP1_diTrp_1	103	109	PF00928	0.257
LIG_DLG_GKlike_1	141	148	PF00625	0.389
LIG_eIF4E_1	420	426	PF01652	0.276
LIG_FHA_1	108	114	PF00498	0.301
LIG_FHA_1	31	37	PF00498	0.380
LIG_FHA_1	505	511	PF00498	0.290
LIG_FHA_1	539	545	PF00498	0.333
LIG_FHA_1	60	66	PF00498	0.389
LIG_FHA_1	616	622	PF00498	0.297
LIG_FHA_2	274	280	PF00498	0.357
LIG_FHA_2	410	416	PF00498	0.257
LIG_FHA_2	67	73	PF00498	0.389
LIG_GBD_Chelix_1	209	217	PF00786	0.257
LIG_GBD_Chelix_1	488	496	PF00786	0.257
LIG_IRF3_LxIS_1	181	186	PF10401	0.336
LIG_LIR_Gen_1	103	114	PF02991	0.273
LIG_LIR_Gen_1	142	153	PF02991	0.257
LIG_LIR_Gen_1	319	329	PF02991	0.363
LIG_LIR_Gen_1	399	410	PF02991	0.280
LIG_LIR_Gen_1	597	606	PF02991	0.274
LIG_LIR_Gen_1	62	68	PF02991	0.389
LIG_LIR_Nem_3	103	109	PF02991	0.266
LIG_LIR_Nem_3	142	148	PF02991	0.257
LIG_LIR_Nem_3	160	164	PF02991	0.349
LIG_LIR_Nem_3	257	261	PF02991	0.257
LIG_LIR_Nem_3	300	306	PF02991	0.275
LIG_LIR_Nem_3	319	324	PF02991	0.281
LIG_LIR_Nem_3	32	37	PF02991	0.342
LIG_LIR_Nem_3	382	387	PF02991	0.267
LIG_LIR_Nem_3	399	405	PF02991	0.257
LIG_LIR_Nem_3	448	453	PF02991	0.196
LIG_LIR_Nem_3	597	601	PF02991	0.274
LIG_LIR_Nem_3	62	67	PF02991	0.301
LIG_Pex14_2	480	484	PF04695	0.389
LIG_PTB_Apo_2	147	154	PF02174	0.298
LIG_PTB_Apo_2	155	162	PF02174	0.333
LIG_SH2_CRK	258	262	PF00017	0.257
LIG_SH2_CRK	321	325	PF00017	0.307
LIG_SH2_CRK	537	541	PF00017	0.441
LIG_SH2_CRK	598	602	PF00017	0.389
LIG_SH2_GRB2like	106	109	PF00017	0.257
LIG_SH2_GRB2like	598	601	PF00017	0.389
LIG_SH2_PTP2	145	148	PF00017	0.257
LIG_SH2_SRC	361	364	PF00017	0.271
LIG_SH2_SRC	420	423	PF00017	0.276
LIG_SH2_SRC	64	67	PF00017	0.389
LIG_SH2_STAP1	102	106	PF00017	0.257
LIG_SH2_STAP1	139	143	PF00017	0.333
LIG_SH2_STAP1	321	325	PF00017	0.389
LIG_SH2_STAT5	106	109	PF00017	0.266
LIG_SH2_STAT5	145	148	PF00017	0.257
LIG_SH2_STAT5	361	364	PF00017	0.249
LIG_SH2_STAT5	420	423	PF00017	0.290
LIG_SH2_STAT5	424	427	PF00017	0.296
LIG_SH2_STAT5	435	438	PF00017	0.316
LIG_SH2_STAT5	455	458	PF00017	0.257
LIG_SH2_STAT5	64	67	PF00017	0.354
LIG_SH2_STAT5	81	84	PF00017	0.161
LIG_SH3_3	12	18	PF00018	0.513
LIG_SH3_3	463	469	PF00018	0.378
LIG_SH3_3	530	536	PF00018	0.360
LIG_SH3_3	72	78	PF00018	0.257
LIG_SH3_5	451	455	PF00018	0.176
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.389
LIG_SUMO_SIM_par_1	195	201	PF11976	0.336
LIG_SUMO_SIM_par_1	237	243	PF11976	0.257
LIG_SUMO_SIM_par_1	282	288	PF11976	0.389
LIG_SxIP_EBH_1	106	115	PF03271	0.333
LIG_TRAF2_1	428	431	PF00917	0.379
LIG_TRAF2_1	85	88	PF00917	0.336
LIG_TYR_ITIM	143	148	PF00017	0.257
LIG_TYR_ITSM	60	67	PF00017	0.301
LIG_UBA3_1	261	269	PF00899	0.333
LIG_UBA3_1	46	52	PF00899	0.389
LIG_UBA3_1	503	508	PF00899	0.389
MOD_CDK_SPxxK_3	274	281	PF00069	0.333
MOD_CK1_1	371	377	PF00069	0.404
MOD_CK1_1	495	501	PF00069	0.389
MOD_CK1_1	528	534	PF00069	0.270
MOD_CK1_1	539	545	PF00069	0.283
MOD_CK1_1	551	557	PF00069	0.415
MOD_CK1_1	619	625	PF00069	0.393
MOD_CK2_1	125	131	PF00069	0.333
MOD_CK2_1	495	501	PF00069	0.391
MOD_CK2_1	591	597	PF00069	0.403
MOD_GlcNHglycan	125	128	PF01048	0.345
MOD_GlcNHglycan	202	205	PF01048	0.416
MOD_GlcNHglycan	25	28	PF01048	0.483
MOD_GlcNHglycan	469	472	PF01048	0.334
MOD_GlcNHglycan	527	530	PF01048	0.270
MOD_GlcNHglycan	541	544	PF01048	0.422
MOD_GlcNHglycan	553	556	PF01048	0.408
MOD_GlcNHglycan	621	624	PF01048	0.396
MOD_GSK3_1	125	132	PF00069	0.384
MOD_GSK3_1	13	20	PF00069	0.438
MOD_GSK3_1	211	218	PF00069	0.382
MOD_GSK3_1	224	231	PF00069	0.363
MOD_GSK3_1	243	250	PF00069	0.193
MOD_GSK3_1	371	378	PF00069	0.353
MOD_GSK3_1	441	448	PF00069	0.312
MOD_GSK3_1	458	465	PF00069	0.335
MOD_GSK3_1	491	498	PF00069	0.389
MOD_GSK3_1	524	531	PF00069	0.297
MOD_GSK3_1	600	607	PF00069	0.274
MOD_GSK3_1	615	622	PF00069	0.414
MOD_LATS_1	458	464	PF00433	0.257
MOD_N-GLC_1	107	112	PF02516	0.142
MOD_N-GLC_1	157	162	PF02516	0.427
MOD_N-GLC_1	164	169	PF02516	0.336
MOD_N-GLC_1	297	302	PF02516	0.271
MOD_N-GLC_1	548	553	PF02516	0.176
MOD_N-GLC_1	88	93	PF02516	0.389
MOD_N-GLC_2	271	273	PF02516	0.389
MOD_N-GLC_2	95	97	PF02516	0.176
MOD_NEK2_1	107	112	PF00069	0.389
MOD_NEK2_1	157	162	PF00069	0.404
MOD_NEK2_1	164	169	PF00069	0.404
MOD_NEK2_1	183	188	PF00069	0.276
MOD_NEK2_1	198	203	PF00069	0.247
MOD_NEK2_1	368	373	PF00069	0.257
MOD_NEK2_1	59	64	PF00069	0.257
MOD_NEK2_1	633	638	PF00069	0.503
MOD_NEK2_2	129	134	PF00069	0.391
MOD_PIKK_1	108	114	PF00454	0.276
MOD_PIKK_1	474	480	PF00454	0.416
MOD_PIKK_1	580	586	PF00454	0.257
MOD_PIKK_1	633	639	PF00454	0.522
MOD_PK_1	211	217	PF00069	0.276
MOD_PKA_1	211	217	PF00069	0.257
MOD_PKA_2	211	217	PF00069	0.258
MOD_PKA_2	243	249	PF00069	0.268
MOD_PKA_2	609	615	PF00069	0.336
MOD_PKA_2	91	97	PF00069	0.186
MOD_Plk_1	139	145	PF00069	0.257
MOD_Plk_1	157	163	PF00069	0.301
MOD_Plk_1	297	303	PF00069	0.187
MOD_Plk_1	548	554	PF00069	0.200
MOD_Plk_1	88	94	PF00069	0.389
MOD_Plk_2-3	297	303	PF00069	0.271
MOD_Plk_4	141	147	PF00069	0.389
MOD_Plk_4	229	235	PF00069	0.295
MOD_Plk_4	499	505	PF00069	0.359
MOD_Plk_4	59	65	PF00069	0.336
MOD_Plk_4	609	615	PF00069	0.389
MOD_Plk_4	616	622	PF00069	0.328
MOD_Plk_4	628	634	PF00069	0.322
MOD_ProDKin_1	125	131	PF00069	0.389
MOD_ProDKin_1	224	230	PF00069	0.336
MOD_ProDKin_1	274	280	PF00069	0.333
MOD_ProDKin_1	325	331	PF00069	0.357
MOD_ProDKin_1	462	468	PF00069	0.414
MOD_ProDKin_1	536	542	PF00069	0.351
TRG_DiLeu_BaEn_1	10	15	PF01217	0.319
TRG_DiLeu_BaEn_1	401	406	PF01217	0.301
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.333
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.257
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.323
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.257
TRG_ENDOCYTIC_2	102	105	PF00928	0.264
TRG_ENDOCYTIC_2	106	109	PF00928	0.269
TRG_ENDOCYTIC_2	145	148	PF00928	0.257
TRG_ENDOCYTIC_2	258	261	PF00928	0.257
TRG_ENDOCYTIC_2	321	324	PF00928	0.309
TRG_ENDOCYTIC_2	384	387	PF00928	0.328
TRG_ENDOCYTIC_2	598	601	PF00928	0.257
TRG_ENDOCYTIC_2	64	67	PF00928	0.301
TRG_ER_diArg_1	211	213	PF00400	0.257
TRG_ER_diArg_1	314	316	PF00400	0.362
TRG_ER_diArg_1	358	361	PF00400	0.310
TRG_ER_diArg_1	376	379	PF00400	0.466
TRG_ER_diArg_1	416	419	PF00400	0.289
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	35	40	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P0	Leptomonas seymouri	78%	93%
A0A1X0P7J8	Trypanosomatidae	58%	100%
A0A3Q8ICD5	Leishmania donovani	90%	94%
A0A3R7MBF0	Trypanosoma rangeli	57%	100%
A4I2G4	Leishmania infantum	90%	94%
C9ZX33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AYL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	95%
O18637	Drosophila virilis	31%	97%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P22213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	96%
Q24179	Drosophila melanogaster	30%	100%
Q4Q8V5	Leishmania major	89%	100%
Q54IJ1	Dictyostelium discoideum	29%	95%
Q5VNU3	Oryza sativa subsp. japonica	21%	97%
Q62991	Rattus norvegicus	29%	100%
Q851W1	Oryza sativa subsp. japonica	32%	100%
Q8BRF7	Mus musculus	29%	100%
Q8SS97	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8WVM8	Homo sapiens	29%	100%
Q9SL48	Arabidopsis thaliana	31%	100%
V5BI09	Trypanosoma cruzi	57%	100%