Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF80_LEIBR

TriTrypDb:

LbrM.26.2280 , LBRM2903_260027800

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	518	522	PF00656	0.829
CLV_C14_Caspase3-7	744	748	PF00656	0.617
CLV_NRD_NRD_1	108	110	PF00675	0.389
CLV_NRD_NRD_1	315	317	PF00675	0.601
CLV_NRD_NRD_1	321	323	PF00675	0.652
CLV_NRD_NRD_1	539	541	PF00675	0.838
CLV_NRD_NRD_1	584	586	PF00675	0.823
CLV_NRD_NRD_1	665	667	PF00675	0.826
CLV_NRD_NRD_1	677	679	PF00675	0.659
CLV_NRD_NRD_1	694	696	PF00675	0.736
CLV_NRD_NRD_1	758	760	PF00675	0.705
CLV_PCSK_FUR_1	106	110	PF00082	0.392
CLV_PCSK_KEX2_1	108	110	PF00082	0.389
CLV_PCSK_KEX2_1	315	317	PF00082	0.601
CLV_PCSK_KEX2_1	321	323	PF00082	0.652
CLV_PCSK_KEX2_1	539	541	PF00082	0.838
CLV_PCSK_KEX2_1	584	586	PF00082	0.830
CLV_PCSK_KEX2_1	660	662	PF00082	0.855
CLV_PCSK_KEX2_1	665	667	PF00082	0.767
CLV_PCSK_KEX2_1	696	698	PF00082	0.810
CLV_PCSK_KEX2_1	758	760	PF00082	0.712
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.855
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.771
CLV_PCSK_PC7_1	661	667	PF00082	0.811
CLV_PCSK_SKI1_1	108	112	PF00082	0.621
CLV_PCSK_SKI1_1	467	471	PF00082	0.558
CLV_PCSK_SKI1_1	585	589	PF00082	0.732
CLV_PCSK_SKI1_1	655	659	PF00082	0.650
CLV_PCSK_SKI1_1	805	809	PF00082	0.642
CLV_Separin_Metazoa	598	602	PF03568	0.587
DEG_APCC_DBOX_1	152	160	PF00400	0.778
DEG_COP1_1	40	49	PF00400	0.777
DEG_SCF_FBW7_1	427	432	PF00400	0.609
DEG_SCF_FBW7_1	511	518	PF00400	0.746
DEG_SCF_TRCP1_1	747	753	PF00400	0.582
DEG_SPOP_SBC_1	280	284	PF00917	0.592
DEG_SPOP_SBC_1	436	440	PF00917	0.581
DOC_CDC14_PxL_1	720	728	PF14671	0.805
DOC_CKS1_1	356	361	PF01111	0.552
DOC_CKS1_1	488	493	PF01111	0.799
DOC_CKS1_1	529	534	PF01111	0.561
DOC_CKS1_1	605	610	PF01111	0.593
DOC_CKS1_1	812	817	PF01111	0.566
DOC_CKS1_1	838	843	PF01111	0.806
DOC_CYCLIN_RxL_1	801	811	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.748
DOC_MAPK_gen_1	539	547	PF00069	0.580
DOC_MAPK_MEF2A_6	153	160	PF00069	0.523
DOC_MAPK_MEF2A_6	441	449	PF00069	0.557
DOC_MAPK_MEF2A_6	801	810	PF00069	0.481
DOC_PP2B_LxvP_1	311	314	PF13499	0.544
DOC_PP2B_LxvP_1	649	652	PF13499	0.559
DOC_PP2B_LxvP_1	832	835	PF13499	0.575
DOC_PP4_FxxP_1	303	306	PF00568	0.546
DOC_PP4_FxxP_1	529	532	PF00568	0.812
DOC_USP7_MATH_1	161	165	PF00917	0.541
DOC_USP7_MATH_1	280	284	PF00917	0.677
DOC_USP7_MATH_1	288	292	PF00917	0.626
DOC_USP7_MATH_1	314	318	PF00917	0.810
DOC_USP7_MATH_1	332	336	PF00917	0.510
DOC_USP7_MATH_1	429	433	PF00917	0.730
DOC_USP7_MATH_1	436	440	PF00917	0.629
DOC_USP7_MATH_1	45	49	PF00917	0.789
DOC_USP7_MATH_1	579	583	PF00917	0.667
DOC_USP7_MATH_1	624	628	PF00917	0.574
DOC_USP7_MATH_1	728	732	PF00917	0.515
DOC_USP7_MATH_1	816	820	PF00917	0.733
DOC_WW_Pin1_4	229	234	PF00397	0.811
DOC_WW_Pin1_4	265	270	PF00397	0.579
DOC_WW_Pin1_4	309	314	PF00397	0.765
DOC_WW_Pin1_4	352	357	PF00397	0.812
DOC_WW_Pin1_4	384	389	PF00397	0.756
DOC_WW_Pin1_4	41	46	PF00397	0.807
DOC_WW_Pin1_4	423	428	PF00397	0.806
DOC_WW_Pin1_4	441	446	PF00397	0.541
DOC_WW_Pin1_4	451	456	PF00397	0.618
DOC_WW_Pin1_4	458	463	PF00397	0.511
DOC_WW_Pin1_4	487	492	PF00397	0.837
DOC_WW_Pin1_4	500	505	PF00397	0.639
DOC_WW_Pin1_4	511	516	PF00397	0.665
DOC_WW_Pin1_4	528	533	PF00397	0.535
DOC_WW_Pin1_4	604	609	PF00397	0.598
DOC_WW_Pin1_4	629	634	PF00397	0.797
DOC_WW_Pin1_4	659	664	PF00397	0.597
DOC_WW_Pin1_4	811	816	PF00397	0.713
DOC_WW_Pin1_4	826	831	PF00397	0.584
DOC_WW_Pin1_4	837	842	PF00397	0.651
LIG_14-3-3_CanoR_1	108	117	PF00244	0.645
LIG_14-3-3_CanoR_1	153	157	PF00244	0.566
LIG_14-3-3_CanoR_1	183	188	PF00244	0.661
LIG_14-3-3_CanoR_1	19	24	PF00244	0.551
LIG_14-3-3_CanoR_1	315	323	PF00244	0.633
LIG_14-3-3_CanoR_1	467	472	PF00244	0.812
LIG_14-3-3_CanoR_1	805	811	PF00244	0.519
LIG_14-3-3_CanoR_1	87	93	PF00244	0.643
LIG_BRCT_BRCA1_1	299	303	PF00533	0.554
LIG_EVH1_1	529	533	PF00568	0.812
LIG_FHA_1	109	115	PF00498	0.637
LIG_FHA_1	138	144	PF00498	0.554
LIG_FHA_1	176	182	PF00498	0.537
LIG_FHA_1	233	239	PF00498	0.630
LIG_FHA_1	257	263	PF00498	0.675
LIG_FHA_1	282	288	PF00498	0.675
LIG_FHA_1	324	330	PF00498	0.572
LIG_FHA_1	514	520	PF00498	0.590
LIG_FHA_1	6	12	PF00498	0.583
LIG_FHA_1	605	611	PF00498	0.591
LIG_FHA_1	624	630	PF00498	0.724
LIG_FHA_1	632	638	PF00498	0.744
LIG_FHA_1	732	738	PF00498	0.495
LIG_FHA_2	11	17	PF00498	0.571
LIG_FHA_2	235	241	PF00498	0.562
LIG_FHA_2	516	522	PF00498	0.832
LIG_FHA_2	610	616	PF00498	0.583
LIG_FHA_2	636	642	PF00498	0.737
LIG_FHA_2	696	702	PF00498	0.551
LIG_FHA_2	766	772	PF00498	0.724
LIG_FHA_2	93	99	PF00498	0.410
LIG_HP1_1	445	449	PF01393	0.552
LIG_LIR_Apic_2	300	306	PF02991	0.736
LIG_LIR_Gen_1	198	208	PF02991	0.457
LIG_LIR_Gen_1	444	452	PF02991	0.603
LIG_LIR_Gen_1	794	803	PF02991	0.522
LIG_LIR_Nem_3	198	203	PF02991	0.460
LIG_LIR_Nem_3	454	460	PF02991	0.629
LIG_LIR_Nem_3	703	708	PF02991	0.766
LIG_LIR_Nem_3	794	800	PF02991	0.522
LIG_LYPXL_S_1	456	460	PF13949	0.537
LIG_LYPXL_yS_3	457	460	PF13949	0.537
LIG_MLH1_MIPbox_1	299	303	PF16413	0.554
LIG_MYND_1	830	834	PF01753	0.577
LIG_PCNA_PIPBox_1	479	488	PF02747	0.580
LIG_Pex14_1	845	849	PF04695	0.793
LIG_Pex14_2	386	390	PF04695	0.544
LIG_SH2_CRK	200	204	PF00017	0.625
LIG_SH2_NCK_1	592	596	PF00017	0.582
LIG_SH2_SRC	592	595	PF00017	0.583
LIG_SH2_STAT5	200	203	PF00017	0.450
LIG_SH2_STAT5	210	213	PF00017	0.440
LIG_SH2_STAT5	446	449	PF00017	0.563
LIG_SH2_STAT5	528	531	PF00017	0.819
LIG_SH2_STAT5	561	564	PF00017	0.565
LIG_SH2_STAT5	779	782	PF00017	0.619
LIG_SH3_3	182	188	PF00018	0.744
LIG_SH3_3	353	359	PF00018	0.771
LIG_SH3_3	44	50	PF00018	0.550
LIG_SH3_3	449	455	PF00018	0.757
LIG_SH3_3	488	494	PF00018	0.761
LIG_SH3_3	527	533	PF00018	0.816
LIG_SH3_3	597	603	PF00018	0.585
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.590
LIG_SUMO_SIM_anti_2	111	119	PF11976	0.443
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.546
LIG_SUMO_SIM_par_1	111	119	PF11976	0.402
LIG_SUMO_SIM_par_1	806	811	PF11976	0.530
LIG_TRAF2_1	400	403	PF00917	0.576
LIG_TRAF2_1	522	525	PF00917	0.830
LIG_TRAF2_1	95	98	PF00917	0.408
LIG_TRAF2_2	841	846	PF00917	0.806
LIG_WW_2	495	498	PF00397	0.571
LIG_WW_3	312	316	PF00397	0.550
LIG_WW_3	598	602	PF00397	0.587
LIG_WW_3	814	818	PF00397	0.784
MOD_CDC14_SPxK_1	312	315	PF00782	0.622
MOD_CDK_SPK_2	837	842	PF00069	0.807
MOD_CDK_SPxK_1	309	315	PF00069	0.625
MOD_CDK_SPxK_1	659	665	PF00069	0.598
MOD_CDK_SPxK_1	811	817	PF00069	0.814
MOD_CDK_SPxxK_3	309	316	PF00069	0.707
MOD_CDK_SPxxK_3	659	666	PF00069	0.598
MOD_CK1_1	116	122	PF00069	0.439
MOD_CK1_1	218	224	PF00069	0.629
MOD_CK1_1	22	28	PF00069	0.794
MOD_CK1_1	232	238	PF00069	0.728
MOD_CK1_1	29	35	PF00069	0.679
MOD_CK1_1	347	353	PF00069	0.712
MOD_CK1_1	355	361	PF00069	0.698
MOD_CK1_1	432	438	PF00069	0.821
MOD_CK1_1	48	54	PF00069	0.488
MOD_CK1_1	627	633	PF00069	0.565
MOD_CK1_1	653	659	PF00069	0.828
MOD_CK1_1	69	75	PF00069	0.526
MOD_CK1_1	731	737	PF00069	0.493
MOD_CK1_1	78	84	PF00069	0.432
MOD_CK1_1	811	817	PF00069	0.814
MOD_CK1_1	837	843	PF00069	0.807
MOD_CK2_1	10	16	PF00069	0.575
MOD_CK2_1	391	397	PF00069	0.810
MOD_CK2_1	609	615	PF00069	0.787
MOD_CK2_1	695	701	PF00069	0.619
MOD_CK2_1	765	771	PF00069	0.832
MOD_CK2_1	92	98	PF00069	0.415
MOD_DYRK1A_RPxSP_1	265	269	PF00069	0.555
MOD_GlcNHglycan	118	121	PF01048	0.465
MOD_GlcNHglycan	13	16	PF01048	0.660
MOD_GlcNHglycan	163	166	PF01048	0.515
MOD_GlcNHglycan	192	195	PF01048	0.678
MOD_GlcNHglycan	220	223	PF01048	0.656
MOD_GlcNHglycan	299	302	PF01048	0.645
MOD_GlcNHglycan	318	321	PF01048	0.477
MOD_GlcNHglycan	333	337	PF01048	0.618
MOD_GlcNHglycan	342	345	PF01048	0.769
MOD_GlcNHglycan	365	368	PF01048	0.569
MOD_GlcNHglycan	394	397	PF01048	0.672
MOD_GlcNHglycan	411	417	PF01048	0.562
MOD_GlcNHglycan	431	434	PF01048	0.596
MOD_GlcNHglycan	511	514	PF01048	0.848
MOD_GlcNHglycan	556	559	PF01048	0.811
MOD_GlcNHglycan	566	570	PF01048	0.673
MOD_GlcNHglycan	621	624	PF01048	0.826
MOD_GlcNHglycan	71	74	PF01048	0.712
MOD_GlcNHglycan	726	729	PF01048	0.719
MOD_GlcNHglycan	747	750	PF01048	0.638
MOD_GlcNHglycan	753	756	PF01048	0.668
MOD_GlcNHglycan	797	800	PF01048	0.631
MOD_GlcNHglycan	80	83	PF01048	0.513
MOD_GlcNHglycan	818	821	PF01048	0.577
MOD_GSK3_1	211	218	PF00069	0.553
MOD_GSK3_1	22	29	PF00069	0.676
MOD_GSK3_1	225	232	PF00069	0.709
MOD_GSK3_1	297	304	PF00069	0.714
MOD_GSK3_1	332	339	PF00069	0.689
MOD_GSK3_1	340	347	PF00069	0.773
MOD_GSK3_1	37	44	PF00069	0.512
MOD_GSK3_1	419	426	PF00069	0.761
MOD_GSK3_1	428	435	PF00069	0.769
MOD_GSK3_1	437	444	PF00069	0.607
MOD_GSK3_1	496	503	PF00069	0.797
MOD_GSK3_1	5	12	PF00069	0.670
MOD_GSK3_1	505	512	PF00069	0.648
MOD_GSK3_1	570	577	PF00069	0.753
MOD_GSK3_1	619	626	PF00069	0.709
MOD_GSK3_1	627	634	PF00069	0.764
MOD_GSK3_1	724	731	PF00069	0.536
MOD_GSK3_1	745	752	PF00069	0.728
MOD_GSK3_1	826	833	PF00069	0.753
MOD_GSK3_1	88	95	PF00069	0.421
MOD_LATS_1	538	544	PF00433	0.583
MOD_N-GLC_1	419	424	PF02516	0.572
MOD_N-GLC_1	69	74	PF02516	0.516
MOD_N-GLC_1	9	14	PF02516	0.680
MOD_N-GLC_2	229	231	PF02516	0.552
MOD_NEK2_1	110	115	PF00069	0.383
MOD_NEK2_1	152	157	PF00069	0.570
MOD_NEK2_1	203	208	PF00069	0.412
MOD_NEK2_1	554	559	PF00069	0.600
MOD_NEK2_1	609	614	PF00069	0.585
MOD_NEK2_1	628	633	PF00069	0.491
MOD_NEK2_1	76	81	PF00069	0.581
MOD_NEK2_1	808	813	PF00069	0.546
MOD_NEK2_2	579	584	PF00069	0.555
MOD_PIKK_1	281	287	PF00454	0.613
MOD_PIKK_1	475	481	PF00454	0.679
MOD_PIKK_1	505	511	PF00454	0.847
MOD_PIKK_1	834	840	PF00454	0.816
MOD_PKA_1	108	114	PF00069	0.386
MOD_PKA_1	695	701	PF00069	0.556
MOD_PKA_2	108	114	PF00069	0.444
MOD_PKA_2	152	158	PF00069	0.569
MOD_PKA_2	256	262	PF00069	0.747
MOD_PKA_2	288	294	PF00069	0.712
MOD_PKA_2	297	303	PF00069	0.770
MOD_PKA_2	314	320	PF00069	0.527
MOD_PKA_2	323	329	PF00069	0.520
MOD_PKA_2	664	670	PF00069	0.650
MOD_PKA_2	816	822	PF00069	0.578
MOD_PKA_2	86	92	PF00069	0.679
MOD_PKB_1	106	114	PF00069	0.642
MOD_Plk_1	475	481	PF00069	0.672
MOD_Plk_1	565	571	PF00069	0.651
MOD_Plk_1	63	69	PF00069	0.517
MOD_Plk_1	728	734	PF00069	0.723
MOD_Plk_1	99	105	PF00069	0.549
MOD_Plk_2-3	215	221	PF00069	0.511
MOD_Plk_2-3	240	246	PF00069	0.547
MOD_Plk_4	110	116	PF00069	0.441
MOD_Plk_4	624	630	PF00069	0.572
MOD_Plk_4	765	771	PF00069	0.579
MOD_Plk_4	99	105	PF00069	0.604
MOD_ProDKin_1	229	235	PF00069	0.812
MOD_ProDKin_1	265	271	PF00069	0.578
MOD_ProDKin_1	309	315	PF00069	0.769
MOD_ProDKin_1	352	358	PF00069	0.812
MOD_ProDKin_1	384	390	PF00069	0.757
MOD_ProDKin_1	41	47	PF00069	0.805
MOD_ProDKin_1	423	429	PF00069	0.801
MOD_ProDKin_1	441	447	PF00069	0.540
MOD_ProDKin_1	451	457	PF00069	0.619
MOD_ProDKin_1	458	464	PF00069	0.511
MOD_ProDKin_1	487	493	PF00069	0.837
MOD_ProDKin_1	500	506	PF00069	0.639
MOD_ProDKin_1	511	517	PF00069	0.663
MOD_ProDKin_1	528	534	PF00069	0.536
MOD_ProDKin_1	604	610	PF00069	0.596
MOD_ProDKin_1	629	635	PF00069	0.793
MOD_ProDKin_1	659	665	PF00069	0.598
MOD_ProDKin_1	811	817	PF00069	0.718
MOD_ProDKin_1	826	832	PF00069	0.585
MOD_ProDKin_1	837	843	PF00069	0.650
MOD_SUMO_rev_2	139	146	PF00179	0.555
TRG_DiLeu_BaEn_1	100	105	PF01217	0.388
TRG_DiLeu_BaLyEn_6	803	808	PF01217	0.482
TRG_ENDOCYTIC_2	200	203	PF00928	0.664
TRG_ENDOCYTIC_2	446	449	PF00928	0.556
TRG_ENDOCYTIC_2	457	460	PF00928	0.494
TRG_ER_diArg_1	105	108	PF00400	0.648
TRG_ER_diArg_1	314	316	PF00400	0.610
TRG_ER_diArg_1	321	323	PF00400	0.643
TRG_ER_diArg_1	539	541	PF00400	0.740
TRG_ER_diArg_1	583	585	PF00400	0.826
TRG_ER_diArg_1	780	783	PF00400	0.546
TRG_NLS_Bipartite_1	678	700	PF00514	0.686
TRG_NLS_MonoExtC_3	694	699	PF00514	0.563
TRG_NLS_MonoExtN_4	695	700	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X067	Leishmania donovani	55%	99%
A4I2G3	Leishmania infantum	55%	99%
E9AYL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	99%
Q4Q8V6	Leishmania major	54%	100%