Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF77_LEIBR

TriTrypDb:

LbrM.26.2250 , LBRM2903_260027500

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HF77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF77

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	4
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	3
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0030515	snoRNA binding	5	2
GO:0034511	U3 snoRNA binding	6	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0003824	catalytic activity	1	1
GO:0004672	protein kinase activity	3	1
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.412
CLV_C14_Caspase3-7	145	149	PF00656	0.320
CLV_C14_Caspase3-7	344	348	PF00656	0.683
CLV_C14_Caspase3-7	489	493	PF00656	0.558
CLV_C14_Caspase3-7	599	603	PF00656	0.656
CLV_NRD_NRD_1	151	153	PF00675	0.494
CLV_NRD_NRD_1	311	313	PF00675	0.619
CLV_NRD_NRD_1	408	410	PF00675	0.612
CLV_NRD_NRD_1	538	540	PF00675	0.595
CLV_NRD_NRD_1	542	544	PF00675	0.616
CLV_NRD_NRD_1	623	625	PF00675	0.680
CLV_NRD_NRD_1	657	659	PF00675	0.475
CLV_PCSK_FUR_1	222	226	PF00082	0.626
CLV_PCSK_KEX2_1	151	153	PF00082	0.494
CLV_PCSK_KEX2_1	224	226	PF00082	0.652
CLV_PCSK_KEX2_1	311	313	PF00082	0.780
CLV_PCSK_KEX2_1	408	410	PF00082	0.612
CLV_PCSK_KEX2_1	538	540	PF00082	0.591
CLV_PCSK_KEX2_1	542	544	PF00082	0.596
CLV_PCSK_KEX2_1	623	625	PF00082	0.682
CLV_PCSK_KEX2_1	649	651	PF00082	0.446
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.652
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.549
CLV_PCSK_PC7_1	538	544	PF00082	0.663
CLV_PCSK_SKI1_1	104	108	PF00082	0.432
CLV_PCSK_SKI1_1	134	138	PF00082	0.496
CLV_PCSK_SKI1_1	246	250	PF00082	0.628
CLV_PCSK_SKI1_1	400	404	PF00082	0.678
CLV_PCSK_SKI1_1	488	492	PF00082	0.533
CLV_PCSK_SKI1_1	511	515	PF00082	0.571
CLV_PCSK_SKI1_1	528	532	PF00082	0.558
CLV_PCSK_SKI1_1	629	633	PF00082	0.608
CLV_PCSK_SKI1_1	636	640	PF00082	0.557
DEG_APCC_DBOX_1	133	141	PF00400	0.291
DEG_SPOP_SBC_1	108	112	PF00917	0.525
DOC_MAPK_gen_1	311	318	PF00069	0.737
DOC_MAPK_gen_1	488	496	PF00069	0.512
DOC_MAPK_MEF2A_6	311	318	PF00069	0.737
DOC_MAPK_RevD_3	209	225	PF00069	0.603
DOC_PP1_RVXF_1	384	390	PF00149	0.642
DOC_PP2B_LxvP_1	403	406	PF13499	0.746
DOC_PP2B_LxvP_1	47	50	PF13499	0.551
DOC_PP2B_LxvP_1	93	96	PF13499	0.469
DOC_PP4_FxxP_1	192	195	PF00568	0.359
DOC_PP4_FxxP_1	210	213	PF00568	0.491
DOC_USP7_MATH_1	17	21	PF00917	0.440
DOC_USP7_MATH_1	205	209	PF00917	0.562
DOC_USP7_MATH_1	213	217	PF00917	0.589
DOC_USP7_MATH_1	341	345	PF00917	0.741
DOC_USP7_MATH_1	398	402	PF00917	0.620
DOC_USP7_MATH_1	412	416	PF00917	0.574
DOC_USP7_MATH_1	434	438	PF00917	0.520
DOC_USP7_MATH_1	482	486	PF00917	0.605
DOC_USP7_MATH_1	50	54	PF00917	0.574
DOC_USP7_MATH_1	699	703	PF00917	0.583
DOC_USP7_UBL2_3	400	404	PF12436	0.632
DOC_USP7_UBL2_3	491	495	PF12436	0.575
DOC_USP7_UBL2_3	514	518	PF12436	0.645
DOC_WW_Pin1_4	305	310	PF00397	0.721
DOC_WW_Pin1_4	367	372	PF00397	0.818
DOC_WW_Pin1_4	430	435	PF00397	0.626
DOC_WW_Pin1_4	65	70	PF00397	0.573
DOC_WW_Pin1_4	671	676	PF00397	0.570
LIG_14-3-3_CanoR_1	151	156	PF00244	0.509
LIG_14-3-3_CanoR_1	300	309	PF00244	0.626
LIG_14-3-3_CanoR_1	311	315	PF00244	0.616
LIG_14-3-3_CanoR_1	408	412	PF00244	0.382
LIG_14-3-3_CanoR_1	425	434	PF00244	0.336
LIG_14-3-3_CanoR_1	440	449	PF00244	0.398
LIG_14-3-3_CanoR_1	58	67	PF00244	0.553
LIG_14-3-3_CanoR_1	623	629	PF00244	0.663
LIG_14-3-3_CanoR_1	658	662	PF00244	0.578
LIG_Actin_WH2_2	476	493	PF00022	0.566
LIG_Actin_WH2_2	501	516	PF00022	0.618
LIG_APCC_ABBA_1	248	253	PF00400	0.665
LIG_BRCT_BRCA1_1	109	113	PF00533	0.304
LIG_BRCT_BRCA1_1	444	448	PF00533	0.539
LIG_CaM_IQ_9	473	489	PF13499	0.355
LIG_EH1_1	114	122	PF00400	0.531
LIG_FHA_1	163	169	PF00498	0.597
LIG_FHA_1	179	185	PF00498	0.501
LIG_FHA_1	201	207	PF00498	0.490
LIG_FHA_1	243	249	PF00498	0.698
LIG_FHA_1	270	276	PF00498	0.412
LIG_FHA_1	333	339	PF00498	0.782
LIG_FHA_1	417	423	PF00498	0.441
LIG_FHA_1	60	66	PF00498	0.416
LIG_FHA_1	72	78	PF00498	0.447
LIG_FHA_1	96	102	PF00498	0.638
LIG_FHA_2	143	149	PF00498	0.495
LIG_FHA_2	372	378	PF00498	0.735
LIG_FHA_2	487	493	PF00498	0.544
LIG_LIR_Apic_2	189	195	PF02991	0.358
LIG_LIR_Apic_2	207	213	PF02991	0.491
LIG_LIR_Gen_1	317	326	PF02991	0.503
LIG_LIR_Gen_1	37	47	PF02991	0.554
LIG_LIR_Gen_1	681	691	PF02991	0.624
LIG_LIR_Nem_3	317	321	PF02991	0.502
LIG_LIR_Nem_3	37	42	PF02991	0.428
LIG_LIR_Nem_3	626	631	PF02991	0.643
LIG_LIR_Nem_3	681	686	PF02991	0.547
LIG_PCNA_TLS_4	636	643	PF02747	0.617
LIG_PDZ_Class_1	730	735	PF00595	0.450
LIG_Pex14_1	188	192	PF04695	0.555
LIG_PTB_Apo_2	682	689	PF02174	0.579
LIG_PTB_Phospho_1	682	688	PF10480	0.583
LIG_RPA_C_Fungi	53	65	PF08784	0.503
LIG_SH2_CRK	39	43	PF00017	0.355
LIG_SH2_GRB2like	13	16	PF00017	0.393
LIG_SH2_NCK_1	251	255	PF00017	0.672
LIG_SH2_NCK_1	39	43	PF00017	0.355
LIG_SH2_NCK_1	497	501	PF00017	0.566
LIG_SH2_SRC	251	254	PF00017	0.678
LIG_SH2_SRC	455	458	PF00017	0.292
LIG_SH2_STAP1	13	17	PF00017	0.495
LIG_SH2_STAP1	497	501	PF00017	0.560
LIG_SH2_STAP1	596	600	PF00017	0.539
LIG_SH2_STAP1	73	77	PF00017	0.281
LIG_SH2_STAT3	716	719	PF00017	0.518
LIG_SH2_STAT5	13	16	PF00017	0.604
LIG_SH2_STAT5	186	189	PF00017	0.423
LIG_SH2_STAT5	455	458	PF00017	0.315
LIG_SH2_STAT5	497	500	PF00017	0.550
LIG_SH2_STAT5	596	599	PF00017	0.539
LIG_SH2_STAT5	688	691	PF00017	0.559
LIG_SH2_STAT5	716	719	PF00017	0.307
LIG_SH2_STAT5	73	76	PF00017	0.269
LIG_SH3_1	224	230	PF00018	0.712
LIG_SH3_3	209	215	PF00018	0.524
LIG_SH3_3	224	230	PF00018	0.671
LIG_SH3_3	417	423	PF00018	0.495
LIG_SH3_3	619	625	PF00018	0.685
LIG_SUMO_SIM_anti_2	143	148	PF11976	0.513
LIG_SUMO_SIM_par_1	164	169	PF11976	0.272
LIG_SUMO_SIM_par_1	62	68	PF11976	0.503
LIG_SxIP_EBH_1	211	225	PF03271	0.609
LIG_TRAF2_1	644	647	PF00917	0.581
MOD_CDC14_SPxK_1	308	311	PF00782	0.515
MOD_CDK_SPxK_1	305	311	PF00069	0.506
MOD_CDK_SPxxK_3	305	312	PF00069	0.508
MOD_CDK_SPxxK_3	671	678	PF00069	0.609
MOD_CK1_1	175	181	PF00069	0.348
MOD_CK1_1	268	274	PF00069	0.445
MOD_CK1_1	3	9	PF00069	0.560
MOD_CK1_1	332	338	PF00069	0.666
MOD_CK1_1	342	348	PF00069	0.601
MOD_CK1_1	430	436	PF00069	0.670
MOD_CK1_1	442	448	PF00069	0.338
MOD_CK1_1	94	100	PF00069	0.710
MOD_CK2_1	263	269	PF00069	0.545
MOD_CK2_1	371	377	PF00069	0.756
MOD_CK2_1	551	557	PF00069	0.629
MOD_CK2_1	583	589	PF00069	0.632
MOD_CK2_1	65	71	PF00069	0.452
MOD_GlcNHglycan	172	175	PF01048	0.432
MOD_GlcNHglycan	18	22	PF01048	0.455
MOD_GlcNHglycan	259	262	PF01048	0.550
MOD_GlcNHglycan	341	344	PF01048	0.577
MOD_GlcNHglycan	358	361	PF01048	0.722
MOD_GlcNHglycan	400	403	PF01048	0.598
MOD_GlcNHglycan	414	417	PF01048	0.492
MOD_GlcNHglycan	429	432	PF01048	0.443
MOD_GlcNHglycan	441	444	PF01048	0.419
MOD_GlcNHglycan	697	700	PF01048	0.582
MOD_GSK3_1	200	207	PF00069	0.574
MOD_GSK3_1	265	272	PF00069	0.473
MOD_GSK3_1	310	317	PF00069	0.645
MOD_GSK3_1	339	346	PF00069	0.683
MOD_GSK3_1	362	369	PF00069	0.749
MOD_GSK3_1	394	401	PF00069	0.575
MOD_GSK3_1	412	419	PF00069	0.527
MOD_GSK3_1	430	437	PF00069	0.536
MOD_GSK3_1	482	489	PF00069	0.510
MOD_GSK3_1	695	702	PF00069	0.631
MOD_GSK3_1	715	722	PF00069	0.520
MOD_GSK3_1	73	80	PF00069	0.498
MOD_GSK3_1	91	98	PF00069	0.538
MOD_N-GLC_1	140	145	PF02516	0.559
MOD_N-GLC_1	170	175	PF02516	0.485
MOD_N-GLC_1	356	361	PF02516	0.536
MOD_NEK2_1	107	112	PF00069	0.484
MOD_NEK2_1	232	237	PF00069	0.746
MOD_NEK2_1	427	432	PF00069	0.652
MOD_NEK2_1	611	616	PF00069	0.546
MOD_NEK2_1	730	735	PF00069	0.540
MOD_NEK2_1	77	82	PF00069	0.448
MOD_NEK2_2	205	210	PF00069	0.301
MOD_NEK2_2	50	55	PF00069	0.492
MOD_OFUCOSY	262	267	PF10250	0.296
MOD_PIKK_1	377	383	PF00454	0.675
MOD_PIKK_1	715	721	PF00454	0.531
MOD_PKA_1	151	157	PF00069	0.369
MOD_PKA_1	623	629	PF00069	0.656
MOD_PKA_2	150	156	PF00069	0.492
MOD_PKA_2	3	9	PF00069	0.588
MOD_PKA_2	310	316	PF00069	0.690
MOD_PKA_2	407	413	PF00069	0.398
MOD_PKA_2	439	445	PF00069	0.464
MOD_PKA_2	623	629	PF00069	0.653
MOD_PKA_2	657	663	PF00069	0.571
MOD_Plk_1	268	274	PF00069	0.339
MOD_Plk_1	332	338	PF00069	0.772
MOD_Plk_2-3	32	38	PF00069	0.440
MOD_Plk_2-3	329	335	PF00069	0.533
MOD_Plk_2-3	551	557	PF00069	0.765
MOD_Plk_4	116	122	PF00069	0.516
MOD_Plk_4	142	148	PF00069	0.490
MOD_Plk_4	172	178	PF00069	0.466
MOD_Plk_4	205	211	PF00069	0.417
MOD_Plk_4	50	56	PF00069	0.456
MOD_Plk_4	704	710	PF00069	0.618
MOD_ProDKin_1	305	311	PF00069	0.725
MOD_ProDKin_1	367	373	PF00069	0.816
MOD_ProDKin_1	430	436	PF00069	0.632
MOD_ProDKin_1	65	71	PF00069	0.571
MOD_ProDKin_1	671	677	PF00069	0.568
MOD_SUMO_rev_2	243	248	PF00179	0.706
MOD_SUMO_rev_2	509	516	PF00179	0.621
TRG_DiLeu_BaEn_1	322	327	PF01217	0.506
TRG_DiLeu_BaEn_4	562	568	PF01217	0.697
TRG_DiLeu_BaEn_4	589	595	PF01217	0.556
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.529
TRG_ENDOCYTIC_2	39	42	PF00928	0.515
TRG_ENDOCYTIC_2	688	691	PF00928	0.408
TRG_ER_diArg_1	101	104	PF00400	0.633
TRG_ER_diArg_1	622	624	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	462	467	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTI6	Leptomonas seymouri	53%	100%
A0A3Q8IDU6	Leishmania donovani	79%	100%
A0A422P3R9	Trypanosoma rangeli	27%	100%
A4I2G0	Leishmania infantum	79%	100%
C9ZX37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AYL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q8V9	Leishmania major	73%	99%
V5ATI5	Trypanosoma cruzi	26%	100%