LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HF75_LEIBR
TriTrypDb:
LbrM.26.2230 , LBRM2903_260027300
Length:
115

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF75
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF75

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.514
CLV_PCSK_KEX2_1 4 6 PF00082 0.514
CLV_PCSK_SKI1_1 4 8 PF00082 0.467
CLV_PCSK_SKI1_1 75 79 PF00082 0.583
DEG_Nend_Nbox_1 1 3 PF02207 0.529
DEG_SCF_FBW7_1 36 43 PF00400 0.491
DOC_CKS1_1 37 42 PF01111 0.489
DOC_MAPK_MEF2A_6 30 38 PF00069 0.577
DOC_USP7_MATH_1 54 58 PF00917 0.584
DOC_WW_Pin1_4 21 26 PF00397 0.527
DOC_WW_Pin1_4 36 41 PF00397 0.577
DOC_WW_Pin1_4 79 84 PF00397 0.554
LIG_14-3-3_CanoR_1 19 25 PF00244 0.495
LIG_BRCT_BRCA1_1 88 92 PF00533 0.530
LIG_FHA_1 37 43 PF00498 0.548
LIG_FHA_1 61 67 PF00498 0.671
LIG_FHA_1 99 105 PF00498 0.567
LIG_MYND_1 33 37 PF01753 0.451
LIG_MYND_3 61 65 PF01753 0.600
LIG_NRBOX 73 79 PF00104 0.569
LIG_Pex14_2 88 92 PF04695 0.636
LIG_SH2_CRK 17 21 PF00017 0.405
LIG_SH2_STAT5 17 20 PF00017 0.445
LIG_SH3_3 31 37 PF00018 0.471
LIG_SUMO_SIM_par_1 100 106 PF11976 0.574
LIG_SUMO_SIM_par_1 62 68 PF11976 0.560
LIG_SxIP_EBH_1 4 18 PF03271 0.467
MOD_CK1_1 57 63 PF00069 0.683
MOD_Cter_Amidation 2 5 PF01082 0.521
MOD_GlcNHglycan 50 53 PF01048 0.483
MOD_GSK3_1 36 43 PF00069 0.511
MOD_GSK3_1 98 105 PF00069 0.613
MOD_NEK2_1 103 108 PF00069 0.540
MOD_NEK2_1 15 20 PF00069 0.447
MOD_NEK2_1 42 47 PF00069 0.540
MOD_NEK2_1 7 12 PF00069 0.486
MOD_NEK2_1 77 82 PF00069 0.536
MOD_NEK2_1 86 91 PF00069 0.555
MOD_PIKK_1 40 46 PF00454 0.533
MOD_PKA_2 98 104 PF00069 0.531
MOD_Plk_4 98 104 PF00069 0.609
MOD_ProDKin_1 21 27 PF00069 0.522
MOD_ProDKin_1 36 42 PF00069 0.579
MOD_ProDKin_1 79 85 PF00069 0.557
TRG_ENDOCYTIC_2 17 20 PF00928 0.401
TRG_ER_diArg_1 4 6 PF00400 0.513
TRG_Pf-PMV_PEXEL_1 75 79 PF00026 0.605

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3I1 Leptomonas seymouri 41% 97%
A0A0N1I021 Leptomonas seymouri 81% 99%
A0A0S4J296 Bodo saltans 41% 95%
A0A1X0P697 Trypanosomatidae 36% 92%
A0A1X0P784 Trypanosomatidae 59% 100%
A0A3Q8IE17 Leishmania donovani 92% 96%
A0A3R7RT45 Trypanosoma rangeli 56% 100%
A4HA86 Leishmania braziliensis 36% 100%
A4I2F8 Leishmania infantum 92% 96%
C9ZX39 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AYL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 96%
Q4Q8W1 Leishmania major 89% 100%
Q4QD74 Leishmania major 40% 93%
V5D1C6 Trypanosoma cruzi 37% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS