Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF74_LEIBR

TriTrypDb:

LbrM.26.2220 , LBRM2903_260027100 , LBRM2903_260027200

Length:

1233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1000	1004	PF00656	0.611
CLV_C14_Caspase3-7	1135	1139	PF00656	0.555
CLV_C14_Caspase3-7	158	162	PF00656	0.581
CLV_C14_Caspase3-7	631	635	PF00656	0.412
CLV_C14_Caspase3-7	759	763	PF00656	0.465
CLV_MEL_PAP_1	536	542	PF00089	0.576
CLV_NRD_NRD_1	100	102	PF00675	0.469
CLV_NRD_NRD_1	1064	1066	PF00675	0.413
CLV_NRD_NRD_1	1166	1168	PF00675	0.529
CLV_NRD_NRD_1	210	212	PF00675	0.454
CLV_NRD_NRD_1	326	328	PF00675	0.663
CLV_NRD_NRD_1	374	376	PF00675	0.538
CLV_NRD_NRD_1	57	59	PF00675	0.467
CLV_NRD_NRD_1	602	604	PF00675	0.473
CLV_NRD_NRD_1	652	654	PF00675	0.590
CLV_NRD_NRD_1	814	816	PF00675	0.534
CLV_PCSK_FUR_1	270	274	PF00082	0.482
CLV_PCSK_KEX2_1	1064	1066	PF00082	0.413
CLV_PCSK_KEX2_1	272	274	PF00082	0.502
CLV_PCSK_KEX2_1	326	328	PF00082	0.505
CLV_PCSK_KEX2_1	374	376	PF00082	0.538
CLV_PCSK_KEX2_1	57	59	PF00082	0.467
CLV_PCSK_KEX2_1	601	603	PF00082	0.486
CLV_PCSK_KEX2_1	651	653	PF00082	0.570
CLV_PCSK_KEX2_1	732	734	PF00082	0.505
CLV_PCSK_KEX2_1	91	93	PF00082	0.478
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.480
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.486
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.453
CLV_PCSK_PC1ET2_1	732	734	PF00082	0.505
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.478
CLV_PCSK_SKI1_1	1147	1151	PF00082	0.465
CLV_PCSK_SKI1_1	154	158	PF00082	0.542
CLV_PCSK_SKI1_1	187	191	PF00082	0.524
CLV_PCSK_SKI1_1	319	323	PF00082	0.496
CLV_PCSK_SKI1_1	345	349	PF00082	0.442
CLV_PCSK_SKI1_1	450	454	PF00082	0.484
CLV_PCSK_SKI1_1	588	592	PF00082	0.506
CLV_PCSK_SKI1_1	652	656	PF00082	0.483
CLV_PCSK_SKI1_1	7	11	PF00082	0.481
CLV_PCSK_SKI1_1	72	76	PF00082	0.390
CLV_Separin_Metazoa	208	212	PF03568	0.411
DEG_APCC_DBOX_1	1063	1071	PF00400	0.420
DEG_APCC_KENBOX_2	300	304	PF00400	0.364
DEG_SPOP_SBC_1	125	129	PF00917	0.440
DOC_ANK_TNKS_1	1035	1042	PF00023	0.431
DOC_CYCLIN_RxL_1	1141	1152	PF00134	0.480
DOC_CYCLIN_RxL_1	649	659	PF00134	0.504
DOC_CYCLIN_yClb5_NLxxxL_5	1208	1217	PF00134	0.528
DOC_MAPK_gen_1	187	195	PF00069	0.527
DOC_MAPK_gen_1	345	355	PF00069	0.522
DOC_MAPK_gen_1	601	609	PF00069	0.474
DOC_MAPK_gen_1	651	657	PF00069	0.450
DOC_MAPK_MEF2A_6	348	357	PF00069	0.529
DOC_MAPK_MEF2A_6	602	611	PF00069	0.519
DOC_USP7_MATH_1	1107	1111	PF00917	0.503
DOC_USP7_MATH_1	169	173	PF00917	0.512
DOC_USP7_MATH_1	35	39	PF00917	0.470
DOC_USP7_MATH_1	560	564	PF00917	0.559
DOC_USP7_MATH_1	699	703	PF00917	0.393
DOC_USP7_MATH_1	742	746	PF00917	0.611
DOC_USP7_MATH_1	761	765	PF00917	0.579
DOC_USP7_MATH_1	803	807	PF00917	0.493
DOC_USP7_MATH_1	85	89	PF00917	0.543
DOC_USP7_MATH_1	994	998	PF00917	0.527
DOC_WW_Pin1_4	477	482	PF00397	0.526
DOC_WW_Pin1_4	483	488	PF00397	0.756
DOC_WW_Pin1_4	489	494	PF00397	0.658
DOC_WW_Pin1_4	522	527	PF00397	0.561
DOC_WW_Pin1_4	530	535	PF00397	0.555
DOC_WW_Pin1_4	588	593	PF00397	0.512
DOC_WW_Pin1_4	821	826	PF00397	0.630
DOC_WW_Pin1_4	883	888	PF00397	0.597
LIG_14-3-3_CanoR_1	199	204	PF00244	0.391
LIG_14-3-3_CanoR_1	245	253	PF00244	0.464
LIG_14-3-3_CanoR_1	356	361	PF00244	0.453
LIG_14-3-3_CanoR_1	382	390	PF00244	0.558
LIG_14-3-3_CanoR_1	392	396	PF00244	0.439
LIG_14-3-3_CanoR_1	450	456	PF00244	0.482
LIG_14-3-3_CanoR_1	509	513	PF00244	0.558
LIG_14-3-3_CanoR_1	539	547	PF00244	0.406
LIG_14-3-3_CanoR_1	687	691	PF00244	0.484
LIG_14-3-3_CanoR_1	72	78	PF00244	0.478
LIG_14-3-3_CanoR_1	781	789	PF00244	0.440
LIG_14-3-3_CanoR_1	872	881	PF00244	0.476
LIG_14-3-3_CanoR_1	92	100	PF00244	0.350
LIG_14-3-3_CanoR_1	928	937	PF00244	0.566
LIG_Actin_WH2_1	574	590	PF00022	0.429
LIG_Actin_WH2_2	675	693	PF00022	0.566
LIG_Clathr_ClatBox_1	867	871	PF01394	0.563
LIG_CORNRBOX	1025	1033	PF00104	0.428
LIG_deltaCOP1_diTrp_1	15	22	PF00928	0.471
LIG_deltaCOP1_diTrp_1	506	512	PF00928	0.562
LIG_DLG_GKlike_1	199	207	PF00625	0.390
LIG_eIF4E_1	1144	1150	PF01652	0.548
LIG_FHA_1	1056	1062	PF00498	0.418
LIG_FHA_1	1144	1150	PF00498	0.480
LIG_FHA_1	127	133	PF00498	0.451
LIG_FHA_1	150	156	PF00498	0.679
LIG_FHA_1	168	174	PF00498	0.542
LIG_FHA_1	50	56	PF00498	0.513
LIG_FHA_1	519	525	PF00498	0.583
LIG_FHA_1	546	552	PF00498	0.492
LIG_FHA_1	556	562	PF00498	0.508
LIG_FHA_1	589	595	PF00498	0.442
LIG_FHA_1	687	693	PF00498	0.598
LIG_FHA_1	69	75	PF00498	0.362
LIG_FHA_1	695	701	PF00498	0.465
LIG_FHA_1	789	795	PF00498	0.458
LIG_FHA_1	825	831	PF00498	0.494
LIG_FHA_1	903	909	PF00498	0.427
LIG_FHA_1	92	98	PF00498	0.529
LIG_FHA_1	979	985	PF00498	0.427
LIG_FHA_2	1022	1028	PF00498	0.556
LIG_FHA_2	1029	1035	PF00498	0.504
LIG_FHA_2	1092	1098	PF00498	0.556
LIG_FHA_2	1164	1170	PF00498	0.409
LIG_FHA_2	145	151	PF00498	0.564
LIG_FHA_2	214	220	PF00498	0.395
LIG_FHA_2	239	245	PF00498	0.398
LIG_FHA_2	263	269	PF00498	0.381
LIG_FHA_2	332	338	PF00498	0.445
LIG_FHA_2	360	366	PF00498	0.563
LIG_FHA_2	724	730	PF00498	0.530
LIG_FHA_2	757	763	PF00498	0.473
LIG_FHA_2	998	1004	PF00498	0.598
LIG_LIR_Gen_1	1155	1165	PF02991	0.487
LIG_LIR_Gen_1	14	24	PF02991	0.469
LIG_LIR_Gen_1	247	256	PF02991	0.458
LIG_LIR_Gen_1	291	300	PF02991	0.451
LIG_LIR_Nem_3	14	20	PF02991	0.473
LIG_LIR_Nem_3	291	296	PF02991	0.458
LIG_LIR_Nem_3	857	863	PF02991	0.434
LIG_MYND_1	526	530	PF01753	0.479
LIG_NRBOX	295	301	PF00104	0.363
LIG_NRBOX	699	705	PF00104	0.482
LIG_PCNA_yPIPBox_3	953	967	PF02747	0.552
LIG_Pex14_1	508	512	PF04695	0.559
LIG_Pex14_2	367	371	PF04695	0.479
LIG_Rb_LxCxE_1	980	1003	PF01857	0.427
LIG_RPA_C_Fungi	34	46	PF08784	0.529
LIG_SH2_CRK	531	535	PF00017	0.531
LIG_SH2_NCK_1	163	167	PF00017	0.443
LIG_SH2_NCK_1	531	535	PF00017	0.465
LIG_SH2_STAP1	1145	1149	PF00017	0.457
LIG_SH2_STAP1	557	561	PF00017	0.553
LIG_SH2_STAP1	86	90	PF00017	0.394
LIG_SH2_STAT3	440	443	PF00017	0.563
LIG_SH2_STAT5	1145	1148	PF00017	0.503
LIG_SH2_STAT5	163	166	PF00017	0.442
LIG_SH2_STAT5	440	443	PF00017	0.416
LIG_SH2_STAT5	531	534	PF00017	0.473
LIG_SH2_STAT5	557	560	PF00017	0.577
LIG_SH2_STAT5	903	906	PF00017	0.423
LIG_SH2_STAT5	99	102	PF00017	0.437
LIG_SH3_3	15	21	PF00018	0.470
LIG_SH3_3	743	749	PF00018	0.754
LIG_SH3_3	819	825	PF00018	0.646
LIG_SUMO_SIM_anti_2	1159	1166	PF11976	0.358
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.397
LIG_SUMO_SIM_anti_2	386	394	PF11976	0.401
LIG_SUMO_SIM_anti_2	913	919	PF11976	0.529
LIG_SUMO_SIM_par_1	1159	1166	PF11976	0.358
LIG_SUMO_SIM_par_1	232	238	PF11976	0.368
LIG_SUMO_SIM_par_1	639	644	PF11976	0.562
LIG_SUMO_SIM_par_1	653	659	PF11976	0.381
LIG_SUMO_SIM_par_1	866	871	PF11976	0.551
LIG_TRAF2_1	215	218	PF00917	0.394
LIG_TRAF2_1	285	288	PF00917	0.527
LIG_UBA3_1	1161	1168	PF00899	0.526
LIG_UBA3_1	877	883	PF00899	0.475
MOD_CK1_1	1091	1097	PF00069	0.404
MOD_CK1_1	1139	1145	PF00069	0.455
MOD_CK1_1	1160	1166	PF00069	0.361
MOD_CK1_1	128	134	PF00069	0.572
MOD_CK1_1	359	365	PF00069	0.603
MOD_CK1_1	412	418	PF00069	0.558
MOD_CK1_1	610	616	PF00069	0.423
MOD_CK1_1	632	638	PF00069	0.453
MOD_CK1_1	757	763	PF00069	0.510
MOD_CK1_1	764	770	PF00069	0.565
MOD_CK1_1	823	829	PF00069	0.512
MOD_CK1_1	894	900	PF00069	0.565
MOD_CK1_1	997	1003	PF00069	0.609
MOD_CK2_1	1021	1027	PF00069	0.536
MOD_CK2_1	1028	1034	PF00069	0.501
MOD_CK2_1	1087	1093	PF00069	0.629
MOD_CK2_1	1107	1113	PF00069	0.447
MOD_CK2_1	113	119	PF00069	0.392
MOD_CK2_1	1163	1169	PF00069	0.401
MOD_CK2_1	144	150	PF00069	0.591
MOD_CK2_1	212	218	PF00069	0.638
MOD_CK2_1	262	268	PF00069	0.378
MOD_CK2_1	282	288	PF00069	0.496
MOD_CK2_1	359	365	PF00069	0.560
MOD_CK2_1	451	457	PF00069	0.544
MOD_CK2_1	723	729	PF00069	0.532
MOD_CK2_1	928	934	PF00069	0.500
MOD_CMANNOS	505	508	PF00535	0.507
MOD_GlcNHglycan	1071	1074	PF01048	0.494
MOD_GlcNHglycan	1105	1108	PF01048	0.512
MOD_GlcNHglycan	1109	1112	PF01048	0.483
MOD_GlcNHglycan	1169	1174	PF01048	0.634
MOD_GlcNHglycan	175	179	PF01048	0.627
MOD_GlcNHglycan	196	199	PF01048	0.518
MOD_GlcNHglycan	631	634	PF01048	0.420
MOD_GlcNHglycan	759	762	PF01048	0.746
MOD_GlcNHglycan	768	771	PF01048	0.577
MOD_GlcNHglycan	782	785	PF01048	0.448
MOD_GlcNHglycan	878	881	PF01048	0.508
MOD_GlcNHglycan	887	890	PF01048	0.592
MOD_GSK3_1	1084	1091	PF00069	0.604
MOD_GSK3_1	1103	1110	PF00069	0.466
MOD_GSK3_1	1136	1143	PF00069	0.550
MOD_GSK3_1	1156	1163	PF00069	0.315
MOD_GSK3_1	1221	1228	PF00069	0.569
MOD_GSK3_1	124	131	PF00069	0.621
MOD_GSK3_1	140	147	PF00069	0.424
MOD_GSK3_1	169	176	PF00069	0.632
MOD_GSK3_1	199	206	PF00069	0.570
MOD_GSK3_1	245	252	PF00069	0.556
MOD_GSK3_1	262	269	PF00069	0.453
MOD_GSK3_1	391	398	PF00069	0.535
MOD_GSK3_1	408	415	PF00069	0.390
MOD_GSK3_1	504	511	PF00069	0.637
MOD_GSK3_1	518	525	PF00069	0.471
MOD_GSK3_1	628	635	PF00069	0.456
MOD_GSK3_1	699	706	PF00069	0.416
MOD_GSK3_1	708	715	PF00069	0.500
MOD_GSK3_1	719	726	PF00069	0.474
MOD_GSK3_1	757	764	PF00069	0.634
MOD_GSK3_1	820	827	PF00069	0.530
MOD_GSK3_1	872	879	PF00069	0.587
MOD_GSK3_1	959	966	PF00069	0.565
MOD_LATS_1	1077	1083	PF00433	0.497
MOD_N-GLC_1	460	465	PF02516	0.455
MOD_N-GLC_1	820	825	PF02516	0.499
MOD_N-GLC_2	925	927	PF02516	0.625
MOD_NEK2_1	1140	1145	PF00069	0.560
MOD_NEK2_1	126	131	PF00069	0.611
MOD_NEK2_1	173	178	PF00069	0.533
MOD_NEK2_1	367	372	PF00069	0.625
MOD_NEK2_1	409	414	PF00069	0.438
MOD_NEK2_1	712	717	PF00069	0.400
MOD_NEK2_1	959	964	PF00069	0.567
MOD_NEK2_2	761	766	PF00069	0.451
MOD_NEK2_2	86	91	PF00069	0.394
MOD_PIKK_1	119	125	PF00454	0.406
MOD_PIKK_1	213	219	PF00454	0.462
MOD_PIKK_1	229	235	PF00454	0.368
MOD_PIKK_1	340	346	PF00454	0.571
MOD_PIKK_1	381	387	PF00454	0.571
MOD_PIKK_1	401	407	PF00454	0.354
MOD_PIKK_1	439	445	PF00454	0.493
MOD_PIKK_1	538	544	PF00454	0.470
MOD_PIKK_1	555	561	PF00454	0.420
MOD_PIKK_1	754	760	PF00454	0.495
MOD_PIKK_1	959	965	PF00454	0.568
MOD_PK_1	351	357	PF00069	0.576
MOD_PKA_1	211	217	PF00069	0.396
MOD_PKA_1	91	97	PF00069	0.469
MOD_PKA_2	167	173	PF00069	0.582
MOD_PKA_2	244	250	PF00069	0.468
MOD_PKA_2	381	387	PF00069	0.571
MOD_PKA_2	391	397	PF00069	0.446
MOD_PKA_2	508	514	PF00069	0.558
MOD_PKA_2	538	544	PF00069	0.455
MOD_PKA_2	686	692	PF00069	0.417
MOD_PKA_2	780	786	PF00069	0.437
MOD_PKA_2	91	97	PF00069	0.531
MOD_Plk_1	1079	1085	PF00069	0.551
MOD_Plk_1	1169	1175	PF00069	0.477
MOD_Plk_1	174	180	PF00069	0.436
MOD_Plk_1	203	209	PF00069	0.559
MOD_Plk_1	219	225	PF00069	0.412
MOD_Plk_1	229	235	PF00069	0.475
MOD_Plk_1	274	280	PF00069	0.538
MOD_Plk_1	351	357	PF00069	0.534
MOD_Plk_1	460	466	PF00069	0.475
MOD_Plk_1	50	56	PF00069	0.366
MOD_Plk_1	607	613	PF00069	0.418
MOD_Plk_1	706	712	PF00069	0.488
MOD_Plk_1	848	854	PF00069	0.446
MOD_Plk_1	86	92	PF00069	0.394
MOD_Plk_2-3	1225	1231	PF00069	0.436
MOD_Plk_2-3	723	729	PF00069	0.408
MOD_Plk_4	1028	1034	PF00069	0.578
MOD_Plk_4	1084	1090	PF00069	0.543
MOD_Plk_4	1140	1146	PF00069	0.649
MOD_Plk_4	1157	1163	PF00069	0.339
MOD_Plk_4	169	175	PF00069	0.602
MOD_Plk_4	288	294	PF00069	0.461
MOD_Plk_4	367	373	PF00069	0.622
MOD_Plk_4	433	439	PF00069	0.485
MOD_Plk_4	50	56	PF00069	0.366
MOD_Plk_4	508	514	PF00069	0.575
MOD_Plk_4	632	638	PF00069	0.485
MOD_Plk_4	699	705	PF00069	0.461
MOD_Plk_4	723	729	PF00069	0.408
MOD_ProDKin_1	477	483	PF00069	0.528
MOD_ProDKin_1	489	495	PF00069	0.668
MOD_ProDKin_1	522	528	PF00069	0.563
MOD_ProDKin_1	530	536	PF00069	0.549
MOD_ProDKin_1	588	594	PF00069	0.511
MOD_ProDKin_1	821	827	PF00069	0.627
MOD_ProDKin_1	883	889	PF00069	0.596
MOD_SUMO_rev_2	105	111	PF00179	0.452
MOD_SUMO_rev_2	1090	1096	PF00179	0.544
MOD_SUMO_rev_2	1125	1131	PF00179	0.585
MOD_SUMO_rev_2	232	241	PF00179	0.597
MOD_SUMO_rev_2	282	292	PF00179	0.467
MOD_SUMO_rev_2	43	52	PF00179	0.455
MOD_SUMO_rev_2	515	521	PF00179	0.439
TRG_DiLeu_BaEn_1	137	142	PF01217	0.571
TRG_DiLeu_BaEn_1	295	300	PF01217	0.509
TRG_DiLeu_BaEn_1	51	56	PF01217	0.454
TRG_DiLeu_BaEn_4	287	293	PF01217	0.519
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.543
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.450
TRG_DiLeu_BaLyEn_6	863	868	PF01217	0.569
TRG_ENDOCYTIC_2	293	296	PF00928	0.464
TRG_ENDOCYTIC_2	839	842	PF00928	0.604
TRG_ER_diArg_1	1063	1065	PF00400	0.423
TRG_ER_diArg_1	326	328	PF00400	0.595
TRG_ER_diArg_1	56	58	PF00400	0.471
TRG_ER_diArg_1	602	604	PF00400	0.473
TRG_ER_diArg_1	652	654	PF00400	0.608
TRG_NLS_MonoExtC_3	650	656	PF00514	0.450
TRG_Pf-PMV_PEXEL_1	1023	1027	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	1079	1084	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	1147	1151	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	639	644	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	866	871	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P331	Leptomonas seymouri	41%	100%
A0A3S5H7G8	Leishmania donovani	77%	99%
A4I2F7	Leishmania infantum	77%	99%
E9AYL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q8W2	Leishmania major	76%	100%