Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF73_LEIBR

TriTrypDb:

LbrM.26.2210 , LBRM2903_260027000

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.626
CLV_C14_Caspase3-7	63	67	PF00656	0.479
CLV_NRD_NRD_1	111	113	PF00675	0.617
CLV_NRD_NRD_1	114	116	PF00675	0.600
CLV_NRD_NRD_1	135	137	PF00675	0.565
CLV_NRD_NRD_1	16	18	PF00675	0.757
CLV_NRD_NRD_1	3	5	PF00675	0.561
CLV_NRD_NRD_1	339	341	PF00675	0.512
CLV_NRD_NRD_1	390	392	PF00675	0.454
CLV_NRD_NRD_1	53	55	PF00675	0.513
CLV_PCSK_FUR_1	112	116	PF00082	0.607
CLV_PCSK_KEX2_1	113	115	PF00082	0.621
CLV_PCSK_KEX2_1	135	137	PF00082	0.546
CLV_PCSK_KEX2_1	3	5	PF00082	0.588
CLV_PCSK_KEX2_1	75	77	PF00082	0.696
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.668
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.696
CLV_PCSK_SKI1_1	290	294	PF00082	0.520
CLV_PCSK_SKI1_1	349	353	PF00082	0.486
CLV_PCSK_SKI1_1	396	400	PF00082	0.532
DEG_APCC_DBOX_1	357	365	PF00400	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SPOP_SBC_1	154	158	PF00917	0.623
DOC_CDC14_PxL_1	332	340	PF14671	0.442
DOC_MAPK_gen_1	112	120	PF00069	0.634
DOC_MAPK_gen_1	3	10	PF00069	0.602
DOC_MAPK_gen_1	75	83	PF00069	0.681
DOC_MAPK_MEF2A_6	247	254	PF00069	0.599
DOC_PP1_RVXF_1	360	367	PF00149	0.455
DOC_PP4_FxxP_1	223	226	PF00568	0.413
DOC_WW_Pin1_4	102	107	PF00397	0.728
DOC_WW_Pin1_4	178	183	PF00397	0.545
DOC_WW_Pin1_4	186	191	PF00397	0.404
DOC_WW_Pin1_4	238	243	PF00397	0.392
DOC_WW_Pin1_4	308	313	PF00397	0.491
LIG_14-3-3_CanoR_1	17	26	PF00244	0.756
LIG_14-3-3_CanoR_1	396	405	PF00244	0.676
LIG_Actin_WH2_2	145	162	PF00022	0.597
LIG_Actin_WH2_2	347	364	PF00022	0.494
LIG_deltaCOP1_diTrp_1	263	269	PF00928	0.413
LIG_deltaCOP1_diTrp_1	343	350	PF00928	0.471
LIG_deltaCOP1_diTrp_1	382	390	PF00928	0.386
LIG_FHA_1	20	26	PF00498	0.696
LIG_FHA_1	301	307	PF00498	0.398
LIG_FHA_2	225	231	PF00498	0.423
LIG_FHA_2	289	295	PF00498	0.423
LIG_FHA_2	32	38	PF00498	0.625
LIG_LIR_Gen_1	198	206	PF02991	0.397
LIG_LIR_Gen_1	214	223	PF02991	0.355
LIG_LIR_Gen_1	227	233	PF02991	0.379
LIG_LIR_Gen_1	382	390	PF02991	0.386
LIG_LIR_Nem_3	131	137	PF02991	0.537
LIG_LIR_Nem_3	198	204	PF02991	0.396
LIG_LIR_Nem_3	214	218	PF02991	0.365
LIG_LIR_Nem_3	311	316	PF02991	0.560
LIG_LIR_Nem_3	343	348	PF02991	0.429
LIG_LIR_Nem_3	382	386	PF02991	0.420
LIG_LYPXL_yS_3	199	202	PF13949	0.412
LIG_PCNA_yPIPBox_3	247	258	PF02747	0.467
LIG_PDZ_Class_2	400	405	PF00595	0.680
LIG_Pex14_1	344	348	PF04695	0.489
LIG_PTB_Apo_2	360	367	PF02174	0.455
LIG_Rb_LxCxE_1	74	93	PF01857	0.667
LIG_REV1ctd_RIR_1	220	225	PF16727	0.398
LIG_SH2_CRK	185	189	PF00017	0.419
LIG_SH2_CRK	201	205	PF00017	0.321
LIG_SH2_CRK	326	330	PF00017	0.540
LIG_SH2_NCK_1	185	189	PF00017	0.447
LIG_SH2_PTP2	141	144	PF00017	0.618
LIG_SH2_PTP2	286	289	PF00017	0.405
LIG_SH2_SRC	141	144	PF00017	0.612
LIG_SH2_SRC	334	337	PF00017	0.514
LIG_SH2_STAP1	229	233	PF00017	0.540
LIG_SH2_STAT5	141	144	PF00017	0.593
LIG_SH2_STAT5	286	289	PF00017	0.405
LIG_SH2_STAT5	334	337	PF00017	0.475
LIG_SH2_STAT5	389	392	PF00017	0.423
LIG_SH3_3	115	121	PF00018	0.599
LIG_SH3_3	200	206	PF00018	0.383
LIG_SH3_3	309	315	PF00018	0.509
LIG_SH3_3	330	336	PF00018	0.391
LIG_SH3_3	354	360	PF00018	0.566
LIG_SUMO_SIM_par_1	201	207	PF11976	0.383
LIG_TYR_ITIM	183	188	PF00017	0.484
LIG_UBA3_1	10	18	PF00899	0.516
MOD_CDC14_SPxK_1	311	314	PF00782	0.567
MOD_CDK_SPxK_1	308	314	PF00069	0.500
MOD_CK1_1	186	192	PF00069	0.359
MOD_CK1_1	19	25	PF00069	0.733
MOD_CK1_1	64	70	PF00069	0.474
MOD_CK1_1	71	77	PF00069	0.417
MOD_CK2_1	192	198	PF00069	0.403
MOD_CK2_1	224	230	PF00069	0.462
MOD_CK2_1	288	294	PF00069	0.419
MOD_CK2_1	31	37	PF00069	0.618
MOD_GlcNHglycan	170	174	PF01048	0.508
MOD_GlcNHglycan	27	30	PF01048	0.792
MOD_GlcNHglycan	400	403	PF01048	0.601
MOD_GlcNHglycan	42	45	PF01048	0.540
MOD_GSK3_1	12	19	PF00069	0.738
MOD_GSK3_1	21	28	PF00069	0.703
MOD_GSK3_1	60	67	PF00069	0.742
MOD_GSK3_1	98	105	PF00069	0.715
MOD_LATS_1	394	400	PF00433	0.407
MOD_LATS_1	59	65	PF00433	0.493
MOD_N-GLC_1	129	134	PF02516	0.604
MOD_N-GLC_1	308	313	PF02516	0.383
MOD_N-GLC_1	47	52	PF02516	0.787
MOD_N-GLC_1	61	66	PF02516	0.757
MOD_NEK2_1	155	160	PF00069	0.608
MOD_NEK2_1	300	305	PF00069	0.405
MOD_NEK2_1	60	65	PF00069	0.743
MOD_NEK2_1	96	101	PF00069	0.650
MOD_PIKK_1	31	37	PF00454	0.681
MOD_PIKK_1	88	94	PF00454	0.579
MOD_PK_1	61	67	PF00069	0.719
MOD_PKA_1	17	23	PF00069	0.769
MOD_PKA_2	16	22	PF00069	0.754
MOD_PKA_2	224	230	PF00069	0.462
MOD_Plk_1	129	135	PF00069	0.565
MOD_Plk_1	169	175	PF00069	0.503
MOD_Plk_1	47	53	PF00069	0.692
MOD_Plk_1	61	67	PF00069	0.752
MOD_Plk_1	68	74	PF00069	0.685
MOD_Plk_2-3	192	198	PF00069	0.324
MOD_Plk_4	183	189	PF00069	0.431
MOD_Plk_4	328	334	PF00069	0.399
MOD_Plk_4	68	74	PF00069	0.559
MOD_ProDKin_1	102	108	PF00069	0.723
MOD_ProDKin_1	178	184	PF00069	0.540
MOD_ProDKin_1	186	192	PF00069	0.407
MOD_ProDKin_1	238	244	PF00069	0.396
MOD_ProDKin_1	308	314	PF00069	0.500
MOD_SUMO_rev_2	158	166	PF00179	0.569
TRG_ENDOCYTIC_2	185	188	PF00928	0.418
TRG_ENDOCYTIC_2	199	202	PF00928	0.342
TRG_ENDOCYTIC_2	229	232	PF00928	0.539
TRG_ENDOCYTIC_2	286	289	PF00928	0.405
TRG_ENDOCYTIC_2	326	329	PF00928	0.567
TRG_ENDOCYTIC_2	345	348	PF00928	0.304
TRG_ENDOCYTIC_2	375	378	PF00928	0.392
TRG_ER_diArg_1	111	114	PF00400	0.616
TRG_ER_diArg_1	134	136	PF00400	0.543
TRG_ER_diArg_1	2	4	PF00400	0.582
TRG_ER_diArg_1	356	359	PF00400	0.476
TRG_NLS_MonoCore_2	111	116	PF00514	0.654
TRG_NLS_MonoExtN_4	112	117	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P2	Leptomonas seymouri	85%	100%
A0A0S4JRL5	Bodo saltans	61%	100%
A0A1X0P7G6	Trypanosomatidae	67%	100%
A0A3S7X061	Leishmania donovani	86%	100%
A4I2F6	Leishmania infantum	86%	100%
C9ZX41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AYK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8W3	Leishmania major	87%	100%
V5BI14	Trypanosoma cruzi	64%	100%