Putative syntaxin binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

syntaxin binding protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HF70_LEIBR

TriTrypDb:

LbrM.26.2180 , LBRM2903_260026700

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0030141	secretory granule	8	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0099503	secretory vesicle	7	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF70

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	1
GO:0006904	vesicle docking involved in exocytosis	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0140029	exocytic process	2	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	658	662	PF00656	0.263
CLV_NRD_NRD_1	380	382	PF00675	0.273
CLV_NRD_NRD_1	391	393	PF00675	0.247
CLV_NRD_NRD_1	423	425	PF00675	0.197
CLV_NRD_NRD_1	489	491	PF00675	0.389
CLV_NRD_NRD_1	573	575	PF00675	0.366
CLV_NRD_NRD_1	614	616	PF00675	0.330
CLV_PCSK_KEX2_1	380	382	PF00082	0.370
CLV_PCSK_KEX2_1	391	393	PF00082	0.301
CLV_PCSK_KEX2_1	489	491	PF00082	0.469
CLV_PCSK_KEX2_1	573	575	PF00082	0.364
CLV_PCSK_KEX2_1	613	615	PF00082	0.330
CLV_PCSK_SKI1_1	108	112	PF00082	0.342
CLV_PCSK_SKI1_1	315	319	PF00082	0.455
CLV_PCSK_SKI1_1	343	347	PF00082	0.266
CLV_PCSK_SKI1_1	381	385	PF00082	0.295
CLV_PCSK_SKI1_1	406	410	PF00082	0.319
CLV_PCSK_SKI1_1	425	429	PF00082	0.368
CLV_PCSK_SKI1_1	567	571	PF00082	0.433
CLV_PCSK_SKI1_1	615	619	PF00082	0.284
DEG_APCC_DBOX_1	403	411	PF00400	0.269
DEG_APCC_DBOX_1	572	580	PF00400	0.173
DEG_APCC_DBOX_1	614	622	PF00400	0.314
DEG_Nend_Nbox_1	1	3	PF02207	0.363
DOC_CKS1_1	650	655	PF01111	0.397
DOC_MAPK_DCC_7	135	143	PF00069	0.397
DOC_MAPK_gen_1	108	117	PF00069	0.300
DOC_MAPK_gen_1	285	293	PF00069	0.330
DOC_MAPK_gen_1	343	351	PF00069	0.216
DOC_MAPK_gen_1	391	399	PF00069	0.291
DOC_MAPK_gen_1	404	412	PF00069	0.289
DOC_MAPK_gen_1	611	620	PF00069	0.344
DOC_MAPK_MEF2A_6	108	117	PF00069	0.314
DOC_MAPK_MEF2A_6	135	143	PF00069	0.397
DOC_MAPK_MEF2A_6	343	351	PF00069	0.247
DOC_MAPK_MEF2A_6	392	401	PF00069	0.336
DOC_MAPK_MEF2A_6	404	412	PF00069	0.169
DOC_MAPK_MEF2A_6	611	620	PF00069	0.348
DOC_MAPK_NFAT4_5	404	412	PF00069	0.254
DOC_MAPK_NFAT4_5	613	621	PF00069	0.330
DOC_PP1_RVXF_1	613	620	PF00149	0.254
DOC_PP2B_LxvP_1	136	139	PF13499	0.319
DOC_PP2B_LxvP_1	42	45	PF13499	0.422
DOC_PP4_FxxP_1	117	120	PF00568	0.254
DOC_PP4_FxxP_1	57	60	PF00568	0.185
DOC_PP4_FxxP_1	588	591	PF00568	0.178
DOC_PP4_FxxP_1	85	88	PF00568	0.283
DOC_USP7_MATH_1	395	399	PF00917	0.389
DOC_USP7_MATH_1	45	49	PF00917	0.215
DOC_USP7_MATH_1	459	463	PF00917	0.198
DOC_USP7_MATH_1	578	582	PF00917	0.225
DOC_WW_Pin1_4	510	515	PF00397	0.461
DOC_WW_Pin1_4	649	654	PF00397	0.397
DOC_WW_Pin1_4	84	89	PF00397	0.207
LIG_14-3-3_CanoR_1	157	162	PF00244	0.279
LIG_14-3-3_CanoR_1	440	445	PF00244	0.323
LIG_14-3-3_CanoR_1	46	50	PF00244	0.173
LIG_14-3-3_CanoR_1	489	493	PF00244	0.373
LIG_14-3-3_CanoR_1	573	577	PF00244	0.311
LIG_14-3-3_CanoR_1	655	661	PF00244	0.330
LIG_Actin_RPEL_3	232	251	PF02755	0.173
LIG_Actin_WH2_2	563	579	PF00022	0.397
LIG_APCC_ABBA_1	127	132	PF00400	0.330
LIG_APCC_ABBA_1	347	352	PF00400	0.254
LIG_APCC_ABBAyCdc20_2	346	352	PF00400	0.254
LIG_BRCT_BRCA1_1	121	125	PF00533	0.352
LIG_BRCT_BRCA1_1	159	163	PF00533	0.397
LIG_Clathr_ClatBox_1	222	226	PF01394	0.288
LIG_Clathr_ClatBox_1	248	252	PF01394	0.269
LIG_deltaCOP1_diTrp_1	278	288	PF00928	0.258
LIG_FHA_1	154	160	PF00498	0.407
LIG_FHA_1	403	409	PF00498	0.409
LIG_FHA_1	597	603	PF00498	0.361
LIG_FHA_1	636	642	PF00498	0.303
LIG_FHA_1	646	652	PF00498	0.270
LIG_FHA_2	107	113	PF00498	0.397
LIG_FHA_2	257	263	PF00498	0.173
LIG_FHA_2	35	41	PF00498	0.269
LIG_FHA_2	623	629	PF00498	0.254
LIG_Integrin_isoDGR_2	469	471	PF01839	0.173
LIG_LIR_Apic_2	116	120	PF02991	0.269
LIG_LIR_Gen_1	226	236	PF02991	0.269
LIG_LIR_Gen_1	238	249	PF02991	0.269
LIG_LIR_Gen_1	385	395	PF02991	0.288
LIG_LIR_Gen_1	443	451	PF02991	0.410
LIG_LIR_Gen_1	8	13	PF02991	0.429
LIG_LIR_Nem_3	160	165	PF02991	0.348
LIG_LIR_Nem_3	226	232	PF02991	0.269
LIG_LIR_Nem_3	238	244	PF02991	0.269
LIG_LIR_Nem_3	278	284	PF02991	0.254
LIG_LIR_Nem_3	385	390	PF02991	0.326
LIG_LIR_Nem_3	443	447	PF02991	0.410
LIG_LIR_Nem_3	548	554	PF02991	0.326
LIG_LIR_Nem_3	625	629	PF02991	0.361
LIG_LIR_Nem_3	8	12	PF02991	0.339
LIG_MLH1_MIPbox_1	159	163	PF16413	0.397
LIG_NRBOX	406	412	PF00104	0.275
LIG_PCNA_yPIPBox_3	239	249	PF02747	0.269
LIG_PCNA_yPIPBox_3	481	493	PF02747	0.173
LIG_Pex14_2	336	340	PF04695	0.173
LIG_PTB_Apo_2	250	257	PF02174	0.269
LIG_PTB_Apo_2	529	536	PF02174	0.314
LIG_PTB_Phospho_1	250	256	PF10480	0.269
LIG_PTB_Phospho_1	529	535	PF10480	0.314
LIG_SH2_CRK	241	245	PF00017	0.279
LIG_SH2_CRK	387	391	PF00017	0.397
LIG_SH2_CRK	9	13	PF00017	0.348
LIG_SH2_SRC	633	636	PF00017	0.288
LIG_SH2_STAP1	256	260	PF00017	0.348
LIG_SH2_STAT3	280	283	PF00017	0.314
LIG_SH2_STAT3	361	364	PF00017	0.288
LIG_SH2_STAT3	530	533	PF00017	0.397
LIG_SH2_STAT3	604	607	PF00017	0.173
LIG_SH2_STAT5	535	538	PF00017	0.321
LIG_SH2_STAT5	56	59	PF00017	0.287
LIG_SH3_3	394	400	PF00018	0.348
LIG_SH3_3	647	653	PF00018	0.173
LIG_Sin3_3	534	541	PF02671	0.173
LIG_SUMO_SIM_anti_2	247	252	PF11976	0.173
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.193
LIG_SUMO_SIM_par_1	220	226	PF11976	0.244
LIG_SUMO_SIM_par_1	398	405	PF11976	0.361
LIG_TRAF2_1	264	267	PF00917	0.330
LIG_TRAF2_1	60	63	PF00917	0.397
LIG_TYR_ITIM	624	629	PF00017	0.330
MOD_CDC14_SPxK_1	513	516	PF00782	0.173
MOD_CDK_SPxK_1	510	516	PF00069	0.173
MOD_CDK_SPxK_1	649	655	PF00069	0.397
MOD_CK1_1	207	213	PF00069	0.373
MOD_CK1_1	268	274	PF00069	0.173
MOD_CK1_1	462	468	PF00069	0.293
MOD_CK1_1	48	54	PF00069	0.173
MOD_CK1_1	491	497	PF00069	0.351
MOD_CK1_1	649	655	PF00069	0.397
MOD_CK1_1	87	93	PF00069	0.330
MOD_CK2_1	251	257	PF00069	0.386
MOD_CK2_1	261	267	PF00069	0.366
MOD_CK2_1	34	40	PF00069	0.269
MOD_CK2_1	622	628	PF00069	0.269
MOD_Cter_Amidation	378	381	PF01082	0.277
MOD_GlcNHglycan	143	146	PF01048	0.397
MOD_GlcNHglycan	212	215	PF01048	0.469
MOD_GlcNHglycan	261	266	PF01048	0.373
MOD_GlcNHglycan	331	334	PF01048	0.353
MOD_GlcNHglycan	473	476	PF01048	0.237
MOD_GlcNHglycan	507	511	PF01048	0.372
MOD_GlcNHglycan	51	54	PF01048	0.397
MOD_GlcNHglycan	580	583	PF01048	0.287
MOD_GSK3_1	153	160	PF00069	0.283
MOD_GSK3_1	195	202	PF00069	0.430
MOD_GSK3_1	203	210	PF00069	0.453
MOD_GSK3_1	261	268	PF00069	0.318
MOD_GSK3_1	414	421	PF00069	0.269
MOD_GSK3_1	429	436	PF00069	0.269
MOD_GSK3_1	442	449	PF00069	0.454
MOD_GSK3_1	45	52	PF00069	0.191
MOD_GSK3_1	491	498	PF00069	0.421
MOD_GSK3_1	506	513	PF00069	0.173
MOD_GSK3_1	645	652	PF00069	0.397
MOD_GSK3_1	655	662	PF00069	0.397
MOD_GSK3_1	83	90	PF00069	0.386
MOD_N-GLC_1	207	212	PF02516	0.258
MOD_N-GLC_1	517	522	PF02516	0.449
MOD_N-GLC_1	596	601	PF02516	0.173
MOD_NEK2_1	203	208	PF00069	0.417
MOD_NEK2_1	251	256	PF00069	0.173
MOD_NEK2_1	386	391	PF00069	0.192
MOD_NEK2_1	429	434	PF00069	0.357
MOD_NEK2_1	446	451	PF00069	0.378
MOD_NEK2_1	483	488	PF00069	0.344
MOD_NEK2_2	106	111	PF00069	0.330
MOD_NEK2_2	345	350	PF00069	0.254
MOD_NEK2_2	562	567	PF00069	0.283
MOD_PIKK_1	433	439	PF00454	0.449
MOD_PIKK_1	633	639	PF00454	0.173
MOD_PK_1	157	163	PF00069	0.277
MOD_PKA_2	203	209	PF00069	0.330
MOD_PKA_2	45	51	PF00069	0.173
MOD_PKA_2	459	465	PF00069	0.374
MOD_PKA_2	488	494	PF00069	0.412
MOD_PKA_2	572	578	PF00069	0.431
MOD_Plk_1	225	231	PF00069	0.288
MOD_Plk_1	237	243	PF00069	0.281
MOD_Plk_1	251	257	PF00069	0.192
MOD_Plk_1	395	401	PF00069	0.314
MOD_Plk_1	596	602	PF00069	0.173
MOD_Plk_1	61	67	PF00069	0.293
MOD_Plk_4	119	125	PF00069	0.314
MOD_Plk_4	157	163	PF00069	0.304
MOD_Plk_4	251	257	PF00069	0.252
MOD_Plk_4	306	312	PF00069	0.275
MOD_Plk_4	34	40	PF00069	0.304
MOD_Plk_4	45	51	PF00069	0.288
MOD_Plk_4	459	465	PF00069	0.173
MOD_Plk_4	483	489	PF00069	0.283
MOD_Plk_4	646	652	PF00069	0.254
MOD_ProDKin_1	510	516	PF00069	0.461
MOD_ProDKin_1	649	655	PF00069	0.397
MOD_ProDKin_1	84	90	PF00069	0.207
TRG_DiLeu_BaEn_1	218	223	PF01217	0.397
TRG_DiLeu_BaEn_1	422	427	PF01217	0.397
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.373
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.294
TRG_ENDOCYTIC_2	241	244	PF00928	0.254
TRG_ENDOCYTIC_2	387	390	PF00928	0.382
TRG_ENDOCYTIC_2	535	538	PF00928	0.269
TRG_ENDOCYTIC_2	626	629	PF00928	0.406
TRG_ENDOCYTIC_2	9	12	PF00928	0.410
TRG_ER_diArg_1	284	287	PF00400	0.235
TRG_ER_diArg_1	380	382	PF00400	0.361
TRG_ER_diArg_1	390	392	PF00400	0.240
TRG_ER_diArg_1	403	406	PF00400	0.353
TRG_ER_diArg_1	488	490	PF00400	0.283
TRG_ER_diArg_1	613	615	PF00400	0.397
TRG_NES_CRM1_1	105	116	PF08389	0.306
TRG_NLS_Bipartite_1	298	319	PF00514	0.173
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUY7	Leptomonas seymouri	63%	91%
A0A0S4J1J9	Bodo saltans	41%	100%
A0A1X0P7K8	Trypanosomatidae	41%	100%
A0A3Q8ID43	Leishmania donovani	77%	90%
A0A3R7MWF2	Trypanosoma rangeli	40%	100%
A4I2F3	Leishmania infantum	77%	90%
C9ZX51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AYK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	90%
O00186	Homo sapiens	23%	100%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	100%
Q4Q8W6	Leishmania major	77%	100%
Q54QC8	Dictyostelium discoideum	25%	100%
Q5VNU3	Oryza sativa subsp. japonica	26%	100%
Q60770	Mus musculus	23%	100%
Q62753	Rattus norvegicus	25%	100%
Q64324	Mus musculus	26%	100%
Q851W1	Oryza sativa subsp. japonica	23%	100%
Q9C5X3	Arabidopsis thaliana	25%	100%
V5AUI0	Trypanosoma cruzi	40%	100%