Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF69_LEIBR

TriTrypDb:

LbrM.26.2170 , LBRM2903_260026600

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.514
CLV_C14_Caspase3-7	99	103	PF00656	0.485
CLV_NRD_NRD_1	11	13	PF00675	0.609
CLV_NRD_NRD_1	346	348	PF00675	0.748
CLV_NRD_NRD_1	492	494	PF00675	0.593
CLV_NRD_NRD_1	649	651	PF00675	0.682
CLV_NRD_NRD_1	71	73	PF00675	0.615
CLV_NRD_NRD_1	97	99	PF00675	0.555
CLV_PCSK_FUR_1	617	621	PF00082	0.648
CLV_PCSK_KEX2_1	11	13	PF00082	0.609
CLV_PCSK_KEX2_1	345	347	PF00082	0.690
CLV_PCSK_KEX2_1	476	478	PF00082	0.561
CLV_PCSK_KEX2_1	491	493	PF00082	0.590
CLV_PCSK_KEX2_1	619	621	PF00082	0.627
CLV_PCSK_KEX2_1	649	651	PF00082	0.701
CLV_PCSK_KEX2_1	73	75	PF00082	0.512
CLV_PCSK_KEX2_1	97	99	PF00082	0.497
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.561
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.657
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.385
CLV_PCSK_PC7_1	472	478	PF00082	0.545
CLV_PCSK_SKI1_1	33	37	PF00082	0.564
CLV_PCSK_SKI1_1	558	562	PF00082	0.557
CLV_PCSK_SKI1_1	772	776	PF00082	0.532
DEG_COP1_1	672	680	PF00400	0.612
DEG_SPOP_SBC_1	471	475	PF00917	0.546
DOC_CDC14_PxL_1	674	682	PF14671	0.557
DOC_CKS1_1	759	764	PF01111	0.463
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.687
DOC_MAPK_gen_1	476	484	PF00069	0.590
DOC_MAPK_gen_1	554	562	PF00069	0.477
DOC_MAPK_gen_1	649	656	PF00069	0.627
DOC_MAPK_gen_1	70	78	PF00069	0.495
DOC_MAPK_MEF2A_6	408	417	PF00069	0.468
DOC_PP2B_LxvP_1	138	141	PF13499	0.568
DOC_PP2B_LxvP_1	666	669	PF13499	0.538
DOC_PP4_FxxP_1	464	467	PF00568	0.720
DOC_USP7_MATH_1	105	109	PF00917	0.537
DOC_USP7_MATH_1	133	137	PF00917	0.596
DOC_USP7_MATH_1	235	239	PF00917	0.722
DOC_USP7_MATH_1	264	268	PF00917	0.585
DOC_USP7_MATH_1	326	330	PF00917	0.554
DOC_USP7_MATH_1	396	400	PF00917	0.572
DOC_USP7_MATH_1	495	499	PF00917	0.720
DOC_USP7_UBL2_3	772	776	PF12436	0.551
DOC_WW_Pin1_4	289	294	PF00397	0.755
DOC_WW_Pin1_4	425	430	PF00397	0.553
DOC_WW_Pin1_4	447	452	PF00397	0.700
DOC_WW_Pin1_4	724	729	PF00397	0.701
DOC_WW_Pin1_4	758	763	PF00397	0.457
LIG_14-3-3_CanoR_1	171	177	PF00244	0.672
LIG_14-3-3_CanoR_1	265	271	PF00244	0.695
LIG_14-3-3_CanoR_1	362	366	PF00244	0.572
LIG_14-3-3_CanoR_1	431	440	PF00244	0.743
LIG_14-3-3_CanoR_1	472	479	PF00244	0.548
LIG_14-3-3_CanoR_1	558	563	PF00244	0.599
LIG_14-3-3_CanoR_1	763	768	PF00244	0.626
LIG_14-3-3_CanoR_1	784	793	PF00244	0.593
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_2	426	430	PF00653	0.520
LIG_BRCT_BRCA1_1	135	139	PF00533	0.617
LIG_BRCT_BRCA1_1	442	446	PF00533	0.586
LIG_Clathr_ClatBox_1	481	485	PF01394	0.655
LIG_eIF4E_1	183	189	PF01652	0.541
LIG_FHA_1	123	129	PF00498	0.523
LIG_FHA_1	156	162	PF00498	0.695
LIG_FHA_1	17	23	PF00498	0.616
LIG_FHA_1	183	189	PF00498	0.600
LIG_FHA_1	202	208	PF00498	0.545
LIG_FHA_1	300	306	PF00498	0.582
LIG_FHA_1	412	418	PF00498	0.533
LIG_FHA_1	473	479	PF00498	0.564
LIG_FHA_1	514	520	PF00498	0.476
LIG_FHA_1	576	582	PF00498	0.517
LIG_FHA_1	688	694	PF00498	0.686
LIG_FHA_1	725	731	PF00498	0.728
LIG_FHA_1	755	761	PF00498	0.657
LIG_FHA_2	19	25	PF00498	0.589
LIG_FHA_2	362	368	PF00498	0.627
LIG_FHA_2	404	410	PF00498	0.664
LIG_FHA_2	421	427	PF00498	0.548
LIG_FHA_2	741	747	PF00498	0.456
LIG_FHA_2	94	100	PF00498	0.630
LIG_LIR_Apic_2	462	467	PF02991	0.714
LIG_LIR_Apic_2	757	762	PF02991	0.660
LIG_LIR_Gen_1	170	181	PF02991	0.660
LIG_LIR_Gen_1	190	201	PF02991	0.362
LIG_LIR_Gen_1	787	798	PF02991	0.551
LIG_LIR_Gen_1	804	811	PF02991	0.635
LIG_LIR_Nem_3	170	176	PF02991	0.669
LIG_LIR_Nem_3	190	196	PF02991	0.369
LIG_LIR_Nem_3	197	202	PF02991	0.454
LIG_LIR_Nem_3	462	468	PF02991	0.559
LIG_LIR_Nem_3	610	614	PF02991	0.626
LIG_LIR_Nem_3	787	793	PF02991	0.605
LIG_LIR_Nem_3	804	810	PF02991	0.572
LIG_LYPXL_yS_3	468	471	PF13949	0.677
LIG_MAD2	369	377	PF02301	0.690
LIG_NBox_RRM_1	6	16	PF00076	0.471
LIG_PTAP_UEV_1	794	799	PF05743	0.524
LIG_SH2_NCK_1	193	197	PF00017	0.629
LIG_SH2_NCK_1	363	367	PF00017	0.627
LIG_SH2_NCK_1	807	811	PF00017	0.531
LIG_SH2_PTP2	173	176	PF00017	0.674
LIG_SH2_PTP2	374	377	PF00017	0.661
LIG_SH2_STAP1	803	807	PF00017	0.626
LIG_SH2_STAT5	173	176	PF00017	0.674
LIG_SH2_STAT5	363	366	PF00017	0.593
LIG_SH2_STAT5	374	377	PF00017	0.587
LIG_SH2_STAT5	4	7	PF00017	0.624
LIG_SH2_STAT5	717	720	PF00017	0.719
LIG_SH2_STAT5	759	762	PF00017	0.680
LIG_SH2_STAT5	790	793	PF00017	0.660
LIG_SH2_STAT5	803	806	PF00017	0.593
LIG_SH3_1	374	380	PF00018	0.664
LIG_SH3_2	377	382	PF14604	0.517
LIG_SH3_3	138	144	PF00018	0.687
LIG_SH3_3	215	221	PF00018	0.659
LIG_SH3_3	287	293	PF00018	0.789
LIG_SH3_3	362	368	PF00018	0.682
LIG_SH3_3	374	380	PF00018	0.720
LIG_SH3_3	652	658	PF00018	0.570
LIG_SH3_3	792	798	PF00018	0.499
LIG_SUMO_SIM_anti_2	578	585	PF11976	0.460
LIG_SUMO_SIM_par_1	542	548	PF11976	0.675
LIG_SUMO_SIM_par_1	577	585	PF11976	0.504
LIG_TRAF2_1	743	746	PF00917	0.459
LIG_TRAF2_2	392	397	PF00917	0.517
LIG_TYR_ITIM	361	366	PF00017	0.632
LIG_TYR_ITIM	805	810	PF00017	0.592
LIG_UBA3_1	27	36	PF00899	0.607
LIG_WRC_WIRS_1	196	201	PF05994	0.493
MOD_CDK_SPK_2	289	294	PF00069	0.775
MOD_CDK_SPK_2	447	452	PF00069	0.709
MOD_CDK_SPK_2	758	763	PF00069	0.457
MOD_CDK_SPxK_1	425	431	PF00069	0.558
MOD_CDK_SPxxK_3	758	765	PF00069	0.461
MOD_CK1_1	120	126	PF00069	0.694
MOD_CK1_1	292	298	PF00069	0.726
MOD_CK1_1	34	40	PF00069	0.543
MOD_CK1_1	420	426	PF00069	0.584
MOD_CK1_1	572	578	PF00069	0.503
MOD_CK1_1	63	69	PF00069	0.657
MOD_CK1_1	687	693	PF00069	0.686
MOD_CK2_1	361	367	PF00069	0.572
MOD_CK2_1	403	409	PF00069	0.635
MOD_CK2_1	500	506	PF00069	0.659
MOD_CK2_1	740	746	PF00069	0.458
MOD_CK2_1	805	811	PF00069	0.635
MOD_GlcNHglycan	122	125	PF01048	0.746
MOD_GlcNHglycan	217	221	PF01048	0.545
MOD_GlcNHglycan	270	273	PF01048	0.570
MOD_GlcNHglycan	328	331	PF01048	0.810
MOD_GlcNHglycan	33	36	PF01048	0.562
MOD_GlcNHglycan	333	336	PF01048	0.775
MOD_GlcNHglycan	397	401	PF01048	0.746
MOD_GlcNHglycan	497	500	PF01048	0.626
MOD_GlcNHglycan	570	574	PF01048	0.482
MOD_GlcNHglycan	61	65	PF01048	0.609
MOD_GlcNHglycan	686	689	PF01048	0.638
MOD_GlcNHglycan	7	10	PF01048	0.650
MOD_GlcNHglycan	795	798	PF01048	0.529
MOD_GSK3_1	105	112	PF00069	0.584
MOD_GSK3_1	118	125	PF00069	0.572
MOD_GSK3_1	129	136	PF00069	0.570
MOD_GSK3_1	142	149	PF00069	0.505
MOD_GSK3_1	179	186	PF00069	0.557
MOD_GSK3_1	18	25	PF00069	0.530
MOD_GSK3_1	264	271	PF00069	0.621
MOD_GSK3_1	27	34	PF00069	0.561
MOD_GSK3_1	309	316	PF00069	0.609
MOD_GSK3_1	441	448	PF00069	0.637
MOD_GSK3_1	521	528	PF00069	0.690
MOD_GSK3_1	644	651	PF00069	0.698
MOD_GSK3_1	676	683	PF00069	0.650
MOD_GSK3_1	726	733	PF00069	0.796
MOD_GSK3_1	754	761	PF00069	0.447
MOD_GSK3_1	801	808	PF00069	0.615
MOD_LATS_1	567	573	PF00433	0.486
MOD_N-GLC_1	183	188	PF02516	0.542
MOD_N-GLC_1	48	53	PF02516	0.598
MOD_N-GLC_1	513	518	PF02516	0.736
MOD_N-GLC_1	669	674	PF02516	0.610
MOD_N-GLC_1	805	810	PF02516	0.576
MOD_NEK2_1	117	122	PF00069	0.572
MOD_NEK2_1	161	166	PF00069	0.558
MOD_NEK2_1	195	200	PF00069	0.496
MOD_NEK2_1	22	27	PF00069	0.526
MOD_NEK2_1	31	36	PF00069	0.566
MOD_NEK2_1	403	408	PF00069	0.626
MOD_NEK2_1	417	422	PF00069	0.741
MOD_NEK2_1	521	526	PF00069	0.662
MOD_NEK2_1	550	555	PF00069	0.672
MOD_NEK2_1	680	685	PF00069	0.710
MOD_NEK2_1	91	96	PF00069	0.644
MOD_NEK2_2	105	110	PF00069	0.510
MOD_PIKK_1	133	139	PF00454	0.614
MOD_PIKK_1	381	387	PF00454	0.806
MOD_PIKK_1	403	409	PF00454	0.635
MOD_PIKK_1	486	492	PF00454	0.566
MOD_PIKK_1	600	606	PF00454	0.626
MOD_PIKK_1	644	650	PF00454	0.553
MOD_PIKK_1	805	811	PF00454	0.635
MOD_PK_1	763	769	PF00069	0.484
MOD_PKA_2	109	115	PF00069	0.472
MOD_PKA_2	264	270	PF00069	0.550
MOD_PKA_2	361	367	PF00069	0.560
MOD_PKA_2	381	387	PF00069	0.561
MOD_PKA_2	471	477	PF00069	0.540
MOD_PKA_2	522	528	PF00069	0.531
MOD_PKA_2	550	556	PF00069	0.670
MOD_PKA_2	638	644	PF00069	0.528
MOD_PKA_2	648	654	PF00069	0.609
MOD_PKA_2	91	97	PF00069	0.693
MOD_Plk_1	105	111	PF00069	0.766
MOD_Plk_1	133	139	PF00069	0.614
MOD_Plk_1	183	189	PF00069	0.541
MOD_Plk_1	2	8	PF00069	0.531
MOD_Plk_1	22	28	PF00069	0.403
MOD_Plk_1	582	588	PF00069	0.520
MOD_Plk_1	707	713	PF00069	0.628
MOD_Plk_1	805	811	PF00069	0.567
MOD_Plk_4	172	178	PF00069	0.577
MOD_Plk_4	23	29	PF00069	0.570
MOD_Plk_4	361	367	PF00069	0.629
MOD_Plk_4	398	404	PF00069	0.549
MOD_Plk_4	441	447	PF00069	0.632
MOD_Plk_4	500	506	PF00069	0.666
MOD_Plk_4	558	564	PF00069	0.564
MOD_ProDKin_1	289	295	PF00069	0.756
MOD_ProDKin_1	425	431	PF00069	0.557
MOD_ProDKin_1	447	453	PF00069	0.699
MOD_ProDKin_1	724	730	PF00069	0.704
MOD_ProDKin_1	758	764	PF00069	0.459
MOD_SUMO_for_1	618	621	PF00179	0.392
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.545
TRG_ENDOCYTIC_2	173	176	PF00928	0.543
TRG_ENDOCYTIC_2	193	196	PF00928	0.369
TRG_ENDOCYTIC_2	363	366	PF00928	0.573
TRG_ENDOCYTIC_2	468	471	PF00928	0.546
TRG_ENDOCYTIC_2	790	793	PF00928	0.608
TRG_ENDOCYTIC_2	807	810	PF00928	0.590
TRG_ER_diArg_1	10	12	PF00400	0.711
TRG_ER_diArg_1	257	260	PF00400	0.539
TRG_ER_diArg_1	345	347	PF00400	0.686
TRG_ER_diArg_1	491	493	PF00400	0.669
TRG_ER_diArg_1	649	652	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z2	Leptomonas seymouri	56%	98%
A0A1X0P794	Trypanosomatidae	32%	100%
A0A3Q8IG16	Leishmania donovani	76%	98%
A0A3R7KYT8	Trypanosoma rangeli	35%	100%
A4I2F2	Leishmania infantum	76%	98%
C9ZX52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AYK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4Q8W7	Leishmania major	75%	100%
V5AUK1	Trypanosoma cruzi	34%	100%