Putative GDP-mannose 4,6 dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GDP-mannose 4,6 dehydratase, putative

Species:

Leishmania braziliensis

UniProt:

A4HF67_LEIBR

TriTrypDb:

LbrM.26.2150 , LBRM2903_260026400

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF67

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009225	nucleotide-sugar metabolic process	4	9
GO:0009987	cellular process	1	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044281	small molecule metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0055086	nucleobase-containing small molecule metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:1901135	carbohydrate derivative metabolic process	3	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008460	dTDP-glucose 4,6-dehydratase activity	5	9
GO:0016829	lyase activity	2	9
GO:0016835	carbon-oxygen lyase activity	3	9
GO:0016836	hydro-lyase activity	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.325
CLV_C14_Caspase3-7	9	13	PF00656	0.499
CLV_PCSK_SKI1_1	188	192	PF00082	0.271
CLV_PCSK_SKI1_1	291	295	PF00082	0.179
CLV_PCSK_SKI1_1	312	316	PF00082	0.222
CLV_PCSK_SKI1_1	77	81	PF00082	0.433
DEG_Nend_UBRbox_3	1	3	PF02207	0.480
DEG_SPOP_SBC_1	13	17	PF00917	0.493
DOC_CYCLIN_RxL_1	185	193	PF00134	0.170
DOC_MAPK_gen_1	166	174	PF00069	0.170
DOC_MAPK_MEF2A_6	166	174	PF00069	0.325
DOC_PP1_RVXF_1	186	193	PF00149	0.271
DOC_PP1_RVXF_1	414	421	PF00149	0.339
DOC_PP4_FxxP_1	266	269	PF00568	0.235
DOC_USP7_MATH_1	14	18	PF00917	0.700
DOC_USP7_MATH_1	440	444	PF00917	0.445
DOC_WW_Pin1_4	140	145	PF00397	0.515
DOC_WW_Pin1_4	15	20	PF00397	0.562
DOC_WW_Pin1_4	225	230	PF00397	0.233
DOC_WW_Pin1_4	444	449	PF00397	0.441
LIG_14-3-3_CanoR_1	116	120	PF00244	0.434
LIG_14-3-3_CanoR_1	29	35	PF00244	0.526
LIG_14-3-3_CanoR_1	322	329	PF00244	0.170
LIG_14-3-3_CanoR_1	391	399	PF00244	0.325
LIG_14-3-3_CanoR_1	416	421	PF00244	0.384
LIG_APCC_ABBAyCdc20_2	312	318	PF00400	0.278
LIG_BRCT_BRCA1_1	188	192	PF00533	0.235
LIG_BRCT_BRCA1_2	188	194	PF00533	0.170
LIG_EH1_1	167	175	PF00400	0.266
LIG_FHA_1	157	163	PF00498	0.271
LIG_FHA_1	165	171	PF00498	0.219
LIG_FHA_1	198	204	PF00498	0.235
LIG_FHA_1	212	218	PF00498	0.235
LIG_FHA_1	219	225	PF00498	0.208
LIG_FHA_1	22	28	PF00498	0.531
LIG_FHA_1	236	242	PF00498	0.248
LIG_FHA_1	292	298	PF00498	0.213
LIG_FHA_1	30	36	PF00498	0.545
LIG_FHA_1	324	330	PF00498	0.325
LIG_FHA_1	403	409	PF00498	0.170
LIG_FHA_1	84	90	PF00498	0.215
LIG_FHA_2	178	184	PF00498	0.325
LIG_FHA_2	200	206	PF00498	0.369
LIG_FHA_2	29	35	PF00498	0.598
LIG_FHA_2	330	336	PF00498	0.170
LIG_FHA_2	7	13	PF00498	0.595
LIG_GBD_Chelix_1	320	328	PF00786	0.271
LIG_IBAR_NPY_1	246	248	PF08397	0.235
LIG_IRF3_LxIS_1	213	220	PF10401	0.170
LIG_LIR_Apic_2	265	269	PF02991	0.235
LIG_LIR_Gen_1	146	156	PF02991	0.268
LIG_LIR_Gen_1	189	198	PF02991	0.275
LIG_LIR_Gen_1	214	224	PF02991	0.266
LIG_LIR_Gen_1	313	321	PF02991	0.295
LIG_LIR_Nem_3	146	151	PF02991	0.268
LIG_LIR_Nem_3	189	195	PF02991	0.275
LIG_LIR_Nem_3	209	213	PF02991	0.312
LIG_LIR_Nem_3	214	219	PF02991	0.309
LIG_LIR_Nem_3	313	317	PF02991	0.295
LIG_LIR_Nem_3	375	381	PF02991	0.334
LIG_SH2_CRK	148	152	PF00017	0.235
LIG_SH2_CRK	210	214	PF00017	0.296
LIG_SH2_NCK_1	337	341	PF00017	0.315
LIG_SH2_NCK_1	82	86	PF00017	0.326
LIG_SH2_SRC	82	85	PF00017	0.319
LIG_SH2_STAT5	316	319	PF00017	0.271
LIG_SH2_STAT5	378	381	PF00017	0.325
LIG_SH2_STAT5	392	395	PF00017	0.325
LIG_SH2_STAT5	97	100	PF00017	0.382
LIG_SH3_3	238	244	PF00018	0.243
LIG_SH3_3	275	281	PF00018	0.203
LIG_SH3_3	78	84	PF00018	0.212
LIG_SUMO_SIM_par_1	157	163	PF11976	0.225
LIG_SUMO_SIM_par_1	268	273	PF11976	0.288
LIG_TRAF2_1	340	343	PF00917	0.170
MOD_CDK_SPxxK_3	140	147	PF00069	0.472
MOD_CK1_1	135	141	PF00069	0.717
MOD_CK1_1	143	149	PF00069	0.253
MOD_CK1_1	15	21	PF00069	0.581
MOD_CK1_1	3	9	PF00069	0.548
MOD_CK2_1	121	127	PF00069	0.600
MOD_CK2_1	177	183	PF00069	0.170
MOD_CK2_1	199	205	PF00069	0.443
MOD_CK2_1	217	223	PF00069	0.234
MOD_CK2_1	329	335	PF00069	0.281
MOD_CK2_1	343	349	PF00069	0.242
MOD_CK2_1	367	373	PF00069	0.196
MOD_CK2_1	391	397	PF00069	0.271
MOD_CK2_1	406	412	PF00069	0.172
MOD_GlcNHglycan	108	111	PF01048	0.499
MOD_GlcNHglycan	122	126	PF01048	0.579
MOD_GlcNHglycan	435	438	PF01048	0.421
MOD_GlcNHglycan	444	447	PF01048	0.429
MOD_GlcNHglycan	72	75	PF01048	0.410
MOD_GSK3_1	123	130	PF00069	0.737
MOD_GSK3_1	132	139	PF00069	0.547
MOD_GSK3_1	182	189	PF00069	0.235
MOD_GSK3_1	258	265	PF00069	0.170
MOD_GSK3_1	29	36	PF00069	0.659
MOD_GSK3_1	402	409	PF00069	0.170
MOD_GSK3_1	438	445	PF00069	0.541
MOD_N-GLC_1	3	8	PF02516	0.584
MOD_NEK2_1	156	161	PF00069	0.271
MOD_NEK2_1	186	191	PF00069	0.235
MOD_NEK2_1	258	263	PF00069	0.189
MOD_NEK2_1	374	379	PF00069	0.271
MOD_NEK2_1	402	407	PF00069	0.211
MOD_NEK2_1	414	419	PF00069	0.322
MOD_NEK2_1	70	75	PF00069	0.275
MOD_NEK2_2	262	267	PF00069	0.325
MOD_OFUCOSY	444	450	PF10250	0.443
MOD_PIKK_1	402	408	PF00454	0.170
MOD_PKA_2	115	121	PF00069	0.440
MOD_PKA_2	242	248	PF00069	0.213
MOD_PKA_2	28	34	PF00069	0.608
MOD_PKA_2	329	335	PF00069	0.170
MOD_Plk_1	156	162	PF00069	0.271
MOD_Plk_1	182	188	PF00069	0.235
MOD_Plk_1	236	242	PF00069	0.446
MOD_Plk_1	3	9	PF00069	0.485
MOD_Plk_1	343	349	PF00069	0.235
MOD_Plk_1	374	380	PF00069	0.390
MOD_Plk_2-3	343	349	PF00069	0.180
MOD_Plk_4	151	157	PF00069	0.309
MOD_Plk_4	186	192	PF00069	0.369
MOD_Plk_4	199	205	PF00069	0.252
MOD_Plk_4	237	243	PF00069	0.350
MOD_Plk_4	323	329	PF00069	0.325
MOD_Plk_4	374	380	PF00069	0.271
MOD_Plk_4	416	422	PF00069	0.244
MOD_ProDKin_1	140	146	PF00069	0.493
MOD_ProDKin_1	15	21	PF00069	0.564
MOD_ProDKin_1	225	231	PF00069	0.233
MOD_ProDKin_1	444	450	PF00069	0.443
TRG_DiLeu_BaEn_1	37	42	PF01217	0.456
TRG_ENDOCYTIC_2	148	151	PF00928	0.235
TRG_ENDOCYTIC_2	210	213	PF00928	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L5	Leptomonas seymouri	58%	100%
A0A0S4JG28	Bodo saltans	24%	100%
A0A0S4KEP1	Bodo saltans	24%	100%
A0A1X0NTG2	Trypanosomatidae	24%	100%
A0A1X0P7H6	Trypanosomatidae	38%	100%
A0A3Q8IH81	Leishmania donovani	76%	100%
A0A3R7NVB4	Trypanosoma rangeli	42%	100%
A0QSK6	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	33%	100%
A0R5C5	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	27%	100%
A4I2F0	Leishmania infantum	75%	100%
A6QLW2	Bos taurus	39%	100%
B0RVL0	Xanthomonas campestris pv. campestris (strain B100)	36%	100%
B9J8R3	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	25%	100%
D4GU72	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	38%	100%
E9AYK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O95455	Homo sapiens	40%	100%
P09147	Escherichia coli (strain K12)	23%	100%
P0C7J0	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	35%	100%
P13226	Streptomyces lividans	27%	100%
P14169	Salmonella typhi	23%	100%
P22715	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	22%	100%
P24325	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
P26391	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
P27830	Escherichia coli (strain K12)	34%	100%
P29782	Streptomyces griseus	35%	100%
P33119	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	24%	100%
P35673	Erwinia amylovora	24%	100%
P37759	Escherichia coli (strain K12)	35%	100%
P37761	Neisseria gonorrhoeae	37%	100%
P37777	Shigella flexneri	34%	100%
P39630	Bacillus subtilis (strain 168)	34%	100%
P44914	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	100%
P55293	Escherichia coli	34%	100%
P55294	Neisseria meningitidis serogroup B (strain MC58)	34%	100%
P55462	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	34%	100%
P95780	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	33%	100%
P9WN64	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WN65	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
P9WN66	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WN67	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q04973	Salmonella typhi	26%	100%
Q2SYH7	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	26%	100%
Q331Q7	Streptomyces sp.	27%	100%
Q4Q8W9	Leishmania major	76%	100%
Q54WS6	Dictyostelium discoideum	34%	100%
Q56093	Salmonella typhi	23%	100%
Q57301	Yersinia enterocolitica	23%	100%
Q57664	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	100%
Q58455	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q59083	Azospirillum brasilense	26%	100%
Q5SFA6	Streptomyces bikiniensis	27%	100%
Q5UR12	Acanthamoeba polyphaga mimivirus	40%	100%
Q6E7F4	Escherichia coli	33%	100%
Q6K2E1	Oryza sativa subsp. japonica	26%	100%
Q8VDR7	Mus musculus	40%	100%
Q8VZC0	Arabidopsis thaliana	26%	100%
Q9FIE8	Arabidopsis thaliana	24%	100%
Q9HDU4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9KDV3	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	28%	100%
Q9L9E8	Streptomyces niveus	37%	100%
Q9LH76	Arabidopsis thaliana	40%	68%
Q9LPG6	Arabidopsis thaliana	39%	67%
Q9LZI2	Arabidopsis thaliana	25%	100%
Q9RR28	Streptomyces antibioticus	35%	100%
Q9S642	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	35%	100%
Q9SA77	Arabidopsis thaliana	26%	100%
Q9SN95	Arabidopsis thaliana	25%	100%
Q9SYM5	Arabidopsis thaliana	40%	67%
Q9T0A7	Arabidopsis thaliana	25%	100%
Q9W0P5	Drosophila melanogaster	25%	100%
Q9ZAE8	Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)	34%	100%
Q9ZV36	Arabidopsis thaliana	26%	100%
V5BEL1	Trypanosoma cruzi	44%	79%