Yip1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF64_LEIBR

TriTrypDb:

LbrM.26.2120 , LBRM2903_260026100

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005802	trans-Golgi network	4	1
GO:0031984	organelle subcompartment	2	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A4HF64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF64

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	7
GO:0009987	cellular process	1	7
GO:0016192	vesicle-mediated transport	4	7
GO:0046907	intracellular transport	3	7
GO:0048193	Golgi vesicle transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048280	vesicle fusion with Golgi apparatus	6	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.558
CLV_NRD_NRD_1	295	297	PF00675	0.422
CLV_NRD_NRD_1	56	58	PF00675	0.528
CLV_NRD_NRD_1	8	10	PF00675	0.640
CLV_PCSK_KEX2_1	151	153	PF00082	0.558
CLV_PCSK_KEX2_1	295	297	PF00082	0.340
CLV_PCSK_KEX2_1	56	58	PF00082	0.528
CLV_PCSK_KEX2_1	8	10	PF00082	0.640
CLV_PCSK_SKI1_1	295	299	PF00082	0.393
CLV_PCSK_SKI1_1	302	306	PF00082	0.392
CLV_PCSK_SKI1_1	358	362	PF00082	0.314
CLV_PCSK_SKI1_1	403	407	PF00082	0.475
DEG_SPOP_SBC_1	40	44	PF00917	0.630
DEG_SPOP_SBC_1	97	101	PF00917	0.750
DOC_CDC14_PxL_1	436	444	PF14671	0.312
DOC_CYCLIN_RxL_1	355	362	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.312
DOC_MAPK_MEF2A_6	367	374	PF00069	0.604
DOC_MAPK_MEF2A_6	403	412	PF00069	0.278
DOC_MAPK_NFAT4_5	403	411	PF00069	0.275
DOC_PIKK_1	282	290	PF02985	0.615
DOC_PP1_RVXF_1	338	344	PF00149	0.366
DOC_PP4_FxxP_1	277	280	PF00568	0.616
DOC_PP4_FxxP_1	35	38	PF00568	0.650
DOC_USP7_MATH_1	222	226	PF00917	0.676
DOC_USP7_MATH_1	41	45	PF00917	0.736
DOC_USP7_MATH_1	97	101	PF00917	0.793
DOC_USP7_MATH_2	16	22	PF00917	0.735
DOC_WW_Pin1_4	121	126	PF00397	0.643
DOC_WW_Pin1_4	195	200	PF00397	0.763
DOC_WW_Pin1_4	213	218	PF00397	0.743
LIG_14-3-3_CanoR_1	151	156	PF00244	0.645
LIG_14-3-3_CanoR_1	39	48	PF00244	0.682
LIG_Actin_WH2_2	388	405	PF00022	0.486
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BIR_III_4	212	216	PF00653	0.631
LIG_CtBP_PxDLS_1	199	203	PF00389	0.671
LIG_EH_1	305	309	PF12763	0.603
LIG_FHA_1	384	390	PF00498	0.312
LIG_FHA_1	419	425	PF00498	0.396
LIG_FHA_1	43	49	PF00498	0.711
LIG_FHA_1	50	56	PF00498	0.695
LIG_GBD_Chelix_1	375	383	PF00786	0.444
LIG_Integrin_RGD_1	367	369	PF01839	0.324
LIG_LIR_Apic_2	11	16	PF02991	0.697
LIG_LIR_Apic_2	154	158	PF02991	0.640
LIG_LIR_Gen_1	432	443	PF02991	0.475
LIG_LIR_Gen_1	446	454	PF02991	0.388
LIG_LIR_LC3C_4	421	425	PF02991	0.231
LIG_LIR_Nem_3	344	350	PF02991	0.346
LIG_LIR_Nem_3	432	438	PF02991	0.475
LIG_LIR_Nem_3	446	451	PF02991	0.388
LIG_LIR_Nem_3	75	80	PF02991	0.683
LIG_LYPXL_S_1	438	442	PF13949	0.312
LIG_LYPXL_yS_3	439	442	PF13949	0.312
LIG_MYND_3	284	288	PF01753	0.610
LIG_NRBOX	330	336	PF00104	0.312
LIG_Pex14_2	444	448	PF04695	0.312
LIG_PTAP_UEV_1	19	24	PF05743	0.641
LIG_PTB_Apo_2	100	107	PF02174	0.749
LIG_PTB_Phospho_1	100	106	PF10480	0.749
LIG_REV1ctd_RIR_1	354	362	PF16727	0.312
LIG_SH2_CRK	155	159	PF00017	0.646
LIG_SH2_CRK	161	165	PF00017	0.612
LIG_SH2_CRK	381	385	PF00017	0.312
LIG_SH2_STAT5	34	37	PF00017	0.711
LIG_SH2_STAT5	435	438	PF00017	0.312
LIG_SH2_STAT5	79	82	PF00017	0.690
LIG_SH3_3	160	166	PF00018	0.682
LIG_SH3_3	17	23	PF00018	0.660
LIG_SH3_3	202	208	PF00018	0.673
LIG_SH3_3	265	271	PF00018	0.587
LIG_SH3_3	301	307	PF00018	0.598
LIG_SH3_3	35	41	PF00018	0.640
LIG_SH3_3	434	440	PF00018	0.312
LIG_SUMO_SIM_anti_2	330	336	PF11976	0.352
LIG_SUMO_SIM_par_1	409	414	PF11976	0.231
LIG_TRFH_1	381	385	PF08558	0.312
LIG_TYR_ITIM	379	384	PF00017	0.312
LIG_TYR_ITIM	437	442	PF00017	0.312
LIG_UBA3_1	334	340	PF00899	0.316
MOD_CDK_SPK_2	121	126	PF00069	0.643
MOD_CK1_1	111	117	PF00069	0.742
MOD_CK1_1	168	174	PF00069	0.721
MOD_CK1_1	21	27	PF00069	0.780
MOD_CK1_1	225	231	PF00069	0.694
MOD_CK1_1	263	269	PF00069	0.605
MOD_CK1_1	42	48	PF00069	0.737
MOD_CK1_1	49	55	PF00069	0.694
MOD_CK1_1	99	105	PF00069	0.695
MOD_CK2_1	263	269	PF00069	0.642
MOD_CMANNOS	415	418	PF00535	0.312
MOD_GlcNHglycan	110	113	PF01048	0.443
MOD_GlcNHglycan	178	181	PF01048	0.494
MOD_GlcNHglycan	191	194	PF01048	0.500
MOD_GlcNHglycan	20	23	PF01048	0.619
MOD_GlcNHglycan	202	205	PF01048	0.476
MOD_GlcNHglycan	212	216	PF01048	0.478
MOD_GlcNHglycan	224	227	PF01048	0.486
MOD_GlcNHglycan	233	236	PF01048	0.491
MOD_GlcNHglycan	249	253	PF01048	0.481
MOD_GlcNHglycan	262	265	PF01048	0.392
MOD_GlcNHglycan	343	346	PF01048	0.475
MOD_GlcNHglycan	415	418	PF01048	0.301
MOD_GlcNHglycan	445	448	PF01048	0.334
MOD_GlcNHglycan	49	52	PF01048	0.518
MOD_GlcNHglycan	57	60	PF01048	0.468
MOD_GSK3_1	111	118	PF00069	0.829
MOD_GSK3_1	129	136	PF00069	0.774
MOD_GSK3_1	139	146	PF00069	0.742
MOD_GSK3_1	14	21	PF00069	0.711
MOD_GSK3_1	211	218	PF00069	0.732
MOD_GSK3_1	39	46	PF00069	0.707
MOD_GSK3_1	55	62	PF00069	0.715
MOD_GSK3_1	64	71	PF00069	0.736
MOD_GSK3_1	88	95	PF00069	0.678
MOD_N-GLC_1	116	121	PF02516	0.503
MOD_N-GLC_1	200	205	PF02516	0.514
MOD_N-GLC_1	68	73	PF02516	0.598
MOD_NEK2_1	139	144	PF00069	0.691
MOD_NEK2_1	248	253	PF00069	0.662
MOD_NEK2_1	327	332	PF00069	0.313
MOD_NEK2_1	359	364	PF00069	0.388
MOD_NEK2_1	374	379	PF00069	0.391
MOD_NEK2_1	411	416	PF00069	0.231
MOD_NEK2_1	443	448	PF00069	0.490
MOD_PKA_1	151	157	PF00069	0.644
MOD_PKA_2	151	157	PF00069	0.644
MOD_PKA_2	55	61	PF00069	0.726
MOD_Plk_4	129	135	PF00069	0.728
MOD_Plk_4	263	269	PF00069	0.598
MOD_Plk_4	359	365	PF00069	0.312
MOD_Plk_4	374	380	PF00069	0.337
MOD_Plk_4	383	389	PF00069	0.319
MOD_Plk_4	394	400	PF00069	0.367
MOD_Plk_4	406	412	PF00069	0.314
MOD_Plk_4	419	425	PF00069	0.359
MOD_ProDKin_1	121	127	PF00069	0.638
MOD_ProDKin_1	195	201	PF00069	0.763
MOD_ProDKin_1	213	219	PF00069	0.743
TRG_DiLeu_BaEn_1	432	437	PF01217	0.475
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.617
TRG_ENDOCYTIC_2	347	350	PF00928	0.312
TRG_ENDOCYTIC_2	381	384	PF00928	0.312
TRG_ENDOCYTIC_2	435	438	PF00928	0.352
TRG_ENDOCYTIC_2	439	442	PF00928	0.352
TRG_ENDOCYTIC_2	445	448	PF00928	0.341
TRG_ENDOCYTIC_2	77	80	PF00928	0.683
TRG_ER_diArg_1	294	296	PF00400	0.548
TRG_ER_diArg_1	55	57	PF00400	0.758
TRG_ER_diArg_1	8	10	PF00400	0.788
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG4	Leptomonas seymouri	57%	81%
A0A3S7X055	Leishmania donovani	78%	85%
A4I2E7	Leishmania infantum	79%	85%
E9AYK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	85%
Q4Q8X2	Leishmania major	79%	85%