LeishMANIAdb
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Yip1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Yip1 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HF64_LEIBR
TriTrypDb:
LbrM.26.2120 , LBRM2903_260026100 *
Length:
454

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 6
GO:0005802 trans-Golgi network 4 1
GO:0016020 membrane 2 7
GO:0031984 organelle subcompartment 2 1
GO:0098791 Golgi apparatus subcompartment 3 1
GO:0110165 cellular anatomical entity 1 7
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Expansion

Sequence features

A4HF64
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF64

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 7
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 7
GO:0006906 vesicle fusion 6 1
GO:0006996 organelle organization 4 1
GO:0007030 Golgi organization 5 1
GO:0009987 cellular process 1 7
GO:0016043 cellular component organization 3 1
GO:0016050 vesicle organization 5 1
GO:0016192 vesicle-mediated transport 4 7
GO:0046907 intracellular transport 3 7
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 151 153 PF00675 0.558
CLV_NRD_NRD_1 295 297 PF00675 0.422
CLV_NRD_NRD_1 56 58 PF00675 0.528
CLV_NRD_NRD_1 8 10 PF00675 0.640
CLV_PCSK_KEX2_1 151 153 PF00082 0.558
CLV_PCSK_KEX2_1 295 297 PF00082 0.340
CLV_PCSK_KEX2_1 56 58 PF00082 0.528
CLV_PCSK_KEX2_1 8 10 PF00082 0.640
CLV_PCSK_SKI1_1 295 299 PF00082 0.393
CLV_PCSK_SKI1_1 302 306 PF00082 0.392
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PAG4 Leptomonas seymouri 57% 81%
A0A3S7X055 Leishmania donovani 78% 85%
A4I2E7 Leishmania infantum 79% 85%
E9AYK0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 85%
Q4Q8X2 Leishmania major 79% 85%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS