ADP-ribosylation_factor_family_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor family, putative

Species:

Leishmania braziliensis

UniProt:

A4HF63_LEIBR

TriTrypDb:

LbrM.26.2110 , LBRM2903_260025900

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF63

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034067	protein localization to Golgi apparatus	6	1
GO:0043001	Golgi to plasma membrane protein transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061951	establishment of protein localization to plasma membrane	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072659	protein localization to plasma membrane	5	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:1990778	protein localization to cell periphery	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.528
CLV_C14_Caspase3-7	381	385	PF00656	0.413
CLV_C14_Caspase3-7	73	77	PF00656	0.522
CLV_C14_Caspase3-7	86	90	PF00656	0.479
CLV_NRD_NRD_1	100	102	PF00675	0.661
CLV_PCSK_SKI1_1	102	106	PF00082	0.514
CLV_PCSK_SKI1_1	165	169	PF00082	0.466
CLV_PCSK_SKI1_1	189	193	PF00082	0.425
CLV_PCSK_SKI1_1	253	257	PF00082	0.304
DEG_APCC_DBOX_1	188	196	PF00400	0.360
DEG_APCC_DBOX_1	252	260	PF00400	0.360
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DEG_SPOP_SBC_1	88	92	PF00917	0.526
DOC_CDC14_PxL_1	265	273	PF14671	0.300
DOC_CKS1_1	13	18	PF01111	0.503
DOC_CKS1_1	40	45	PF01111	0.503
DOC_CYCLIN_RxL_1	98	109	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	104	107	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.376
DOC_MAPK_gen_1	121	129	PF00069	0.483
DOC_MAPK_MEF2A_6	121	129	PF00069	0.483
DOC_PP2B_LxvP_1	104	107	PF13499	0.448
DOC_PP2B_LxvP_1	160	163	PF13499	0.523
DOC_PP4_FxxP_1	13	16	PF00568	0.531
DOC_USP7_MATH_1	28	32	PF00917	0.396
DOC_USP7_MATH_1	68	72	PF00917	0.663
DOC_USP7_MATH_1	88	92	PF00917	0.662
DOC_USP7_UBL2_3	246	250	PF12436	0.321
DOC_WW_Pin1_4	12	17	PF00397	0.526
DOC_WW_Pin1_4	136	141	PF00397	0.447
DOC_WW_Pin1_4	228	233	PF00397	0.353
DOC_WW_Pin1_4	331	336	PF00397	0.598
DOC_WW_Pin1_4	347	352	PF00397	0.594
DOC_WW_Pin1_4	39	44	PF00397	0.491
LIG_14-3-3_CanoR_1	83	88	PF00244	0.531
LIG_Actin_WH2_2	216	231	PF00022	0.219
LIG_BRCT_BRCA1_1	183	187	PF00533	0.415
LIG_EVH1_1	160	164	PF00568	0.546
LIG_FHA_1	124	130	PF00498	0.416
LIG_FHA_1	142	148	PF00498	0.651
LIG_FHA_1	186	192	PF00498	0.410
LIG_FHA_1	275	281	PF00498	0.391
LIG_FHA_1	300	306	PF00498	0.279
LIG_FHA_1	372	378	PF00498	0.411
LIG_FHA_2	239	245	PF00498	0.360
LIG_FHA_2	285	291	PF00498	0.350
LIG_FHA_2	30	36	PF00498	0.357
LIG_FHA_2	354	360	PF00498	0.654
LIG_FHA_2	84	90	PF00498	0.726
LIG_GBD_Chelix_1	215	223	PF00786	0.376
LIG_LIR_Apic_2	11	16	PF02991	0.538
LIG_LIR_Gen_1	17	23	PF02991	0.423
LIG_LIR_Gen_1	184	195	PF02991	0.323
LIG_LIR_Gen_1	6	16	PF02991	0.543
LIG_LIR_LC3C_4	139	143	PF02991	0.411
LIG_LIR_Nem_3	137	141	PF02991	0.400
LIG_LIR_Nem_3	15	21	PF02991	0.455
LIG_LIR_Nem_3	184	190	PF02991	0.364
LIG_LIR_Nem_3	203	208	PF02991	0.360
LIG_LIR_Nem_3	222	228	PF02991	0.247
LIG_LIR_Nem_3	302	306	PF02991	0.426
LIG_LIR_Nem_3	368	373	PF02991	0.592
LIG_LIR_Nem_3	6	12	PF02991	0.546
LIG_NRBOX	255	261	PF00104	0.360
LIG_PCNA_PIPBox_1	198	207	PF02747	0.360
LIG_PCNA_yPIPBox_3	193	205	PF02747	0.360
LIG_PCNA_yPIPBox_3	237	249	PF02747	0.219
LIG_PDZ_Class_3	405	410	PF00595	0.464
LIG_Pex14_1	205	209	PF04695	0.300
LIG_PTB_Apo_2	297	304	PF02174	0.328
LIG_PTB_Apo_2	7	14	PF02174	0.542
LIG_SH2_CRK	131	135	PF00017	0.445
LIG_SH2_CRK	18	22	PF00017	0.355
LIG_SH2_CRK	9	13	PF00017	0.508
LIG_SH2_NCK_1	131	135	PF00017	0.445
LIG_SH2_NCK_1	41	45	PF00017	0.410
LIG_SH2_STAT3	208	211	PF00017	0.247
LIG_SH2_STAT3	304	307	PF00017	0.349
LIG_SH2_STAT5	217	220	PF00017	0.360
LIG_SH2_STAT5	304	307	PF00017	0.394
LIG_SH2_STAT5	354	357	PF00017	0.508
LIG_SH2_STAT5	41	44	PF00017	0.492
LIG_SH3_1	229	235	PF00018	0.219
LIG_SH3_2	232	237	PF14604	0.219
LIG_SH3_3	158	164	PF00018	0.658
LIG_SH3_3	229	235	PF00018	0.445
LIG_SUMO_SIM_par_1	139	144	PF11976	0.420
LIG_SUMO_SIM_par_1	269	274	PF11976	0.303
LIG_SUMO_SIM_par_1	376	381	PF11976	0.416
LIG_TRAF2_1	287	290	PF00917	0.328
LIG_TYR_ITIM	129	134	PF00017	0.446
LIG_UBA3_1	270	276	PF00899	0.219
LIG_UBA3_1	33	38	PF00899	0.416
MOD_CDC14_SPxK_1	234	237	PF00782	0.219
MOD_CDC14_SPxK_1	350	353	PF00782	0.518
MOD_CDK_SPxK_1	231	237	PF00069	0.219
MOD_CDK_SPxK_1	347	353	PF00069	0.518
MOD_CK1_1	11	17	PF00069	0.546
MOD_CK1_1	153	159	PF00069	0.569
MOD_CK1_1	231	237	PF00069	0.364
MOD_CK1_1	274	280	PF00069	0.378
MOD_CK1_1	281	287	PF00069	0.363
MOD_CK1_1	330	336	PF00069	0.740
MOD_CK1_1	337	343	PF00069	0.677
MOD_CK1_1	90	96	PF00069	0.735
MOD_CK2_1	11	17	PF00069	0.530
MOD_CK2_1	238	244	PF00069	0.312
MOD_CK2_1	284	290	PF00069	0.350
MOD_CK2_1	29	35	PF00069	0.357
MOD_CK2_1	353	359	PF00069	0.680
MOD_GlcNHglycan	26	29	PF01048	0.324
MOD_GlcNHglycan	308	311	PF01048	0.522
MOD_GlcNHglycan	315	318	PF01048	0.521
MOD_GlcNHglycan	329	332	PF01048	0.668
MOD_GlcNHglycan	367	370	PF01048	0.537
MOD_GlcNHglycan	379	383	PF01048	0.398
MOD_GlcNHglycan	66	69	PF01048	0.633
MOD_GlcNHglycan	93	96	PF01048	0.574
MOD_GSK3_1	181	188	PF00069	0.577
MOD_GSK3_1	24	31	PF00069	0.243
MOD_GSK3_1	274	281	PF00069	0.376
MOD_GSK3_1	326	333	PF00069	0.606
MOD_GSK3_1	349	356	PF00069	0.690
MOD_GSK3_1	51	58	PF00069	0.466
MOD_GSK3_1	64	71	PF00069	0.635
MOD_GSK3_1	8	15	PF00069	0.541
MOD_GSK3_1	83	90	PF00069	0.646
MOD_LATS_1	81	87	PF00433	0.528
MOD_N-GLC_1	274	279	PF02516	0.360
MOD_NEK2_1	141	146	PF00069	0.576
MOD_NEK2_1	271	276	PF00069	0.316
MOD_NEK2_1	325	330	PF00069	0.653
MOD_NEK2_2	371	376	PF00069	0.487
MOD_PIKK_1	151	157	PF00454	0.622
MOD_PIKK_1	209	215	PF00454	0.360
MOD_PIKK_1	238	244	PF00454	0.250
MOD_PIKK_1	318	324	PF00454	0.697
MOD_PIKK_1	42	48	PF00454	0.471
MOD_PIKK_1	55	61	PF00454	0.474
MOD_PKA_2	123	129	PF00069	0.416
MOD_PKA_2	24	30	PF00069	0.293
MOD_PKA_2	69	75	PF00069	0.662
MOD_Plk_1	219	225	PF00069	0.305
MOD_Plk_1	278	284	PF00069	0.376
MOD_Plk_1	378	384	PF00069	0.358
MOD_Plk_4	106	112	PF00069	0.471
MOD_Plk_4	29	35	PF00069	0.416
MOD_Plk_4	299	305	PF00069	0.473
MOD_Plk_4	8	14	PF00069	0.483
MOD_ProDKin_1	12	18	PF00069	0.510
MOD_ProDKin_1	136	142	PF00069	0.464
MOD_ProDKin_1	228	234	PF00069	0.353
MOD_ProDKin_1	331	337	PF00069	0.596
MOD_ProDKin_1	347	353	PF00069	0.597
MOD_ProDKin_1	39	45	PF00069	0.496
MOD_SUMO_rev_2	238	248	PF00179	0.315
MOD_SUMO_rev_2	71	80	PF00179	0.523
TRG_DiLeu_BaEn_1	17	22	PF01217	0.425
TRG_DiLeu_BaEn_1	290	295	PF01217	0.219
TRG_DiLeu_BaEn_2	34	40	PF01217	0.431
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.311
TRG_ENDOCYTIC_2	131	134	PF00928	0.440
TRG_ENDOCYTIC_2	18	21	PF00928	0.357
TRG_ENDOCYTIC_2	9	12	PF00928	0.488
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD1	Leptomonas seymouri	55%	100%
A0A3Q8ICC5	Leishmania donovani	71%	100%
A4I2E6	Leishmania infantum	72%	100%
C9ZX62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AYJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q8X3	Leishmania major	70%	97%