FtsJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF59_LEIBR

TriTrypDb:

LbrM.26.2070 , LBRM2903_260025400

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF59

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	5
GO:0032259	methylation	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0008168	methyltransferase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016741	transferase activity, transferring one-carbon groups	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.552
CLV_NRD_NRD_1	125	127	PF00675	0.479
CLV_NRD_NRD_1	47	49	PF00675	0.520
CLV_NRD_NRD_1	523	525	PF00675	0.397
CLV_NRD_NRD_1	68	70	PF00675	0.497
CLV_PCSK_FUR_1	521	525	PF00082	0.385
CLV_PCSK_KEX2_1	118	120	PF00082	0.443
CLV_PCSK_KEX2_1	125	127	PF00082	0.420
CLV_PCSK_KEX2_1	47	49	PF00082	0.551
CLV_PCSK_KEX2_1	523	525	PF00082	0.387
CLV_PCSK_KEX2_1	551	553	PF00082	0.543
CLV_PCSK_KEX2_1	68	70	PF00082	0.497
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.405
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.592
CLV_PCSK_SKI1_1	354	358	PF00082	0.331
CLV_PCSK_SKI1_1	477	481	PF00082	0.529
CLV_PCSK_SKI1_1	88	92	PF00082	0.611
CLV_PCSK_SKI1_1	9	13	PF00082	0.665
DEG_APCC_DBOX_1	353	361	PF00400	0.381
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DEG_SPOP_SBC_1	246	250	PF00917	0.381
DEG_SPOP_SBC_1	393	397	PF00917	0.381
DEG_SPOP_SBC_1	450	454	PF00917	0.433
DEG_SPOP_SBC_1	467	471	PF00917	0.406
DOC_CYCLIN_RxL_1	474	482	PF00134	0.353
DOC_CYCLIN_yCln2_LP_2	11	14	PF00134	0.439
DOC_PP2B_LxvP_1	11	14	PF13499	0.567
DOC_PP2B_LxvP_1	348	351	PF13499	0.506
DOC_USP7_MATH_1	140	144	PF00917	0.423
DOC_USP7_MATH_1	154	158	PF00917	0.625
DOC_USP7_MATH_1	247	251	PF00917	0.421
DOC_USP7_MATH_1	303	307	PF00917	0.530
DOC_USP7_MATH_1	327	331	PF00917	0.562
DOC_USP7_MATH_1	393	397	PF00917	0.449
DOC_USP7_MATH_1	460	464	PF00917	0.594
DOC_USP7_MATH_1	84	88	PF00917	0.697
DOC_WW_Pin1_4	323	328	PF00397	0.563
DOC_WW_Pin1_4	452	457	PF00397	0.531
DOC_WW_Pin1_4	463	468	PF00397	0.655
DOC_WW_Pin1_4	469	474	PF00397	0.642
DOC_WW_Pin1_4	71	76	PF00397	0.571
DOC_WW_Pin1_4	82	87	PF00397	0.724
LIG_14-3-3_CanoR_1	141	146	PF00244	0.601
LIG_14-3-3_CanoR_1	34	39	PF00244	0.522
LIG_14-3-3_CanoR_1	354	360	PF00244	0.381
LIG_14-3-3_CanoR_1	428	437	PF00244	0.487
LIG_14-3-3_CanoR_1	543	553	PF00244	0.745
LIG_14-3-3_CanoR_1	55	65	PF00244	0.491
LIG_14-3-3_CanoR_1	69	75	PF00244	0.461
LIG_BIR_III_2	324	328	PF00653	0.539
LIG_BRCT_BRCA1_1	42	46	PF00533	0.413
LIG_deltaCOP1_diTrp_1	510	519	PF00928	0.343
LIG_FHA_1	104	110	PF00498	0.627
LIG_FHA_1	407	413	PF00498	0.365
LIG_FHA_1	430	436	PF00498	0.471
LIG_FHA_1	443	449	PF00498	0.393
LIG_FHA_1	545	551	PF00498	0.602
LIG_FHA_2	253	259	PF00498	0.477
LIG_FHA_2	332	338	PF00498	0.381
LIG_LIR_Gen_1	134	142	PF02991	0.312
LIG_LIR_Gen_1	209	219	PF02991	0.478
LIG_LIR_Gen_1	229	240	PF02991	0.371
LIG_LIR_Gen_1	276	287	PF02991	0.414
LIG_LIR_Gen_1	377	385	PF02991	0.492
LIG_LIR_Gen_1	510	520	PF02991	0.357
LIG_LIR_Nem_3	134	139	PF02991	0.378
LIG_LIR_Nem_3	178	184	PF02991	0.522
LIG_LIR_Nem_3	209	215	PF02991	0.509
LIG_LIR_Nem_3	229	235	PF02991	0.371
LIG_LIR_Nem_3	276	282	PF02991	0.396
LIG_LIR_Nem_3	43	49	PF02991	0.352
LIG_LIR_Nem_3	500	505	PF02991	0.442
LIG_NRBOX	263	269	PF00104	0.381
LIG_PALB2_WD40_1	341	349	PF16756	0.436
LIG_PTAP_UEV_1	155	160	PF05743	0.340
LIG_SH2_NCK_1	232	236	PF00017	0.381
LIG_SH2_SRC	232	235	PF00017	0.381
LIG_SH2_STAP1	240	244	PF00017	0.488
LIG_SH2_STAP1	475	479	PF00017	0.361
LIG_SH2_STAP1	66	70	PF00017	0.336
LIG_SH2_STAT5	174	177	PF00017	0.492
LIG_SH2_STAT5	29	32	PF00017	0.463
LIG_SH2_STAT5	359	362	PF00017	0.531
LIG_SH2_STAT5	38	41	PF00017	0.346
LIG_SH2_STAT5	418	421	PF00017	0.310
LIG_SH3_3	153	159	PF00018	0.426
LIG_SH3_3	216	222	PF00018	0.531
LIG_SH3_3	241	247	PF00018	0.381
LIG_SH3_3	338	344	PF00018	0.451
LIG_SH3_3	421	427	PF00018	0.424
LIG_SH3_3	83	89	PF00018	0.722
LIG_SUMO_SIM_par_1	198	204	PF11976	0.381
LIG_UBA3_1	263	270	PF00899	0.381
LIG_WW_3	425	429	PF00397	0.492
MOD_CDC14_SPxK_1	85	88	PF00782	0.574
MOD_CDK_SPK_2	452	457	PF00069	0.531
MOD_CDK_SPxK_1	82	88	PF00069	0.725
MOD_CK1_1	144	150	PF00069	0.630
MOD_CK1_1	208	214	PF00069	0.490
MOD_CK1_1	224	230	PF00069	0.371
MOD_CK1_1	239	245	PF00069	0.443
MOD_CK1_1	248	254	PF00069	0.419
MOD_CK1_1	271	277	PF00069	0.474
MOD_CK1_1	326	332	PF00069	0.532
MOD_CK1_1	452	458	PF00069	0.621
MOD_CK1_1	463	469	PF00069	0.609
MOD_CK1_1	76	82	PF00069	0.639
MOD_CK2_1	252	258	PF00069	0.381
MOD_CK2_1	270	276	PF00069	0.353
MOD_CK2_1	331	337	PF00069	0.381
MOD_GlcNHglycan	156	159	PF01048	0.440
MOD_GlcNHglycan	189	192	PF01048	0.247
MOD_GlcNHglycan	228	231	PF01048	0.331
MOD_GlcNHglycan	23	27	PF01048	0.519
MOD_GlcNHglycan	244	247	PF01048	0.331
MOD_GlcNHglycan	250	253	PF01048	0.249
MOD_GlcNHglycan	305	308	PF01048	0.302
MOD_GlcNHglycan	314	317	PF01048	0.346
MOD_GlcNHglycan	397	400	PF01048	0.649
MOD_GlcNHglycan	5	8	PF01048	0.647
MOD_GlcNHglycan	58	61	PF01048	0.473
MOD_GlcNHglycan	76	79	PF01048	0.690
MOD_GSK3_1	1	8	PF00069	0.662
MOD_GSK3_1	140	147	PF00069	0.635
MOD_GSK3_1	217	224	PF00069	0.531
MOD_GSK3_1	24	31	PF00069	0.525
MOD_GSK3_1	242	249	PF00069	0.437
MOD_GSK3_1	268	275	PF00069	0.388
MOD_GSK3_1	308	315	PF00069	0.490
MOD_GSK3_1	323	330	PF00069	0.502
MOD_GSK3_1	331	338	PF00069	0.477
MOD_GSK3_1	355	362	PF00069	0.482
MOD_GSK3_1	462	469	PF00069	0.716
MOD_GSK3_1	70	77	PF00069	0.585
MOD_N-GLC_1	102	107	PF02516	0.412
MOD_N-GLC_1	242	247	PF02516	0.201
MOD_N-GLC_1	71	76	PF02516	0.595
MOD_NEK2_1	1	6	PF00069	0.535
MOD_NEK2_1	145	150	PF00069	0.628
MOD_NEK2_1	262	267	PF00069	0.452
MOD_NEK2_1	268	273	PF00069	0.425
MOD_NEK2_1	28	33	PF00069	0.507
MOD_NEK2_1	40	45	PF00069	0.308
MOD_NEK2_1	451	456	PF00069	0.516
MOD_NEK2_1	461	466	PF00069	0.652
MOD_NEK2_1	70	75	PF00069	0.412
MOD_NEK2_2	131	136	PF00069	0.360
MOD_NEK2_2	400	405	PF00069	0.313
MOD_PIKK_1	217	223	PF00454	0.531
MOD_PIKK_1	96	102	PF00454	0.580
MOD_PKA_2	140	146	PF00069	0.549
MOD_PKA_2	400	406	PF00069	0.305
MOD_Plk_1	1	7	PF00069	0.594
MOD_Plk_1	208	214	PF00069	0.472
MOD_Plk_1	40	46	PF00069	0.419
MOD_Plk_4	131	137	PF00069	0.313
MOD_Plk_4	208	214	PF00069	0.492
MOD_Plk_4	24	30	PF00069	0.636
MOD_Plk_4	262	268	PF00069	0.472
MOD_Plk_4	355	361	PF00069	0.582
MOD_Plk_4	374	380	PF00069	0.358
MOD_ProDKin_1	323	329	PF00069	0.563
MOD_ProDKin_1	452	458	PF00069	0.531
MOD_ProDKin_1	463	469	PF00069	0.654
MOD_ProDKin_1	71	77	PF00069	0.581
MOD_ProDKin_1	82	88	PF00069	0.725
TRG_DiLeu_BaEn_1	258	263	PF01217	0.381
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.381
TRG_ENDOCYTIC_2	232	235	PF00928	0.428
TRG_ENDOCYTIC_2	505	508	PF00928	0.461
TRG_ER_diArg_1	125	127	PF00400	0.479
TRG_ER_diArg_1	293	296	PF00400	0.529
TRG_ER_diArg_1	46	48	PF00400	0.551
TRG_ER_diArg_1	520	523	PF00400	0.392
TRG_ER_diArg_1	68	70	PF00400	0.384
TRG_NLS_MonoExtC_3	550	556	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL5	Leptomonas seymouri	48%	97%
A0A1X0P8D1	Trypanosomatidae	31%	100%
A0A3S7X044	Leishmania donovani	75%	100%
A0A422N0J7	Trypanosoma rangeli	34%	100%
A4I2E3	Leishmania infantum	75%	100%
C9ZX64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q8X7	Leishmania major	75%	100%
V5BJ25	Trypanosoma cruzi	32%	100%