RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF57_LEIBR

TriTrypDb:

LbrM.26.2050 , LBRM2903_260025200

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.744
CLV_NRD_NRD_1	115	117	PF00675	0.471
CLV_NRD_NRD_1	120	122	PF00675	0.435
CLV_NRD_NRD_1	250	252	PF00675	0.524
CLV_NRD_NRD_1	70	72	PF00675	0.525
CLV_PCSK_KEX2_1	115	117	PF00082	0.447
CLV_PCSK_KEX2_1	120	122	PF00082	0.473
CLV_PCSK_KEX2_1	250	252	PF00082	0.521
CLV_PCSK_KEX2_1	70	72	PF00082	0.525
CLV_PCSK_PC7_1	116	122	PF00082	0.536
CLV_PCSK_SKI1_1	106	110	PF00082	0.334
CLV_PCSK_SKI1_1	231	235	PF00082	0.411
CLV_PCSK_SKI1_1	245	249	PF00082	0.391
CLV_PCSK_SKI1_1	70	74	PF00082	0.459
DOC_CKS1_1	72	77	PF01111	0.348
DOC_CYCLIN_yCln2_LP_2	145	148	PF00134	0.519
DOC_PP1_RVXF_1	104	110	PF00149	0.321
DOC_PP2B_LxvP_1	145	148	PF13499	0.487
DOC_PP4_FxxP_1	144	147	PF00568	0.506
DOC_PP4_FxxP_1	72	75	PF00568	0.469
DOC_USP7_MATH_1	181	185	PF00917	0.718
DOC_USP7_MATH_1	198	202	PF00917	0.550
DOC_USP7_MATH_1	23	27	PF00917	0.539
DOC_USP7_MATH_1	3	7	PF00917	0.529
DOC_WW_Pin1_4	184	189	PF00397	0.592
DOC_WW_Pin1_4	71	76	PF00397	0.362
DOC_WW_Pin1_4	9	14	PF00397	0.666
LIG_14-3-3_CanoR_1	102	109	PF00244	0.447
LIG_14-3-3_CanoR_1	216	222	PF00244	0.477
LIG_APCC_ABBA_1	244	249	PF00400	0.403
LIG_BIR_III_4	197	201	PF00653	0.658
LIG_eIF4E_1	48	54	PF01652	0.496
LIG_FHA_1	102	108	PF00498	0.414
LIG_FHA_1	175	181	PF00498	0.599
LIG_FHA_1	239	245	PF00498	0.459
LIG_FHA_1	41	47	PF00498	0.444
LIG_FHA_1	92	98	PF00498	0.417
LIG_FHA_2	168	174	PF00498	0.579
LIG_LIR_Apic_2	142	147	PF02991	0.498
LIG_PCNA_yPIPBox_3	62	73	PF02747	0.549
LIG_Pex14_1	122	126	PF04695	0.456
LIG_REV1ctd_RIR_1	106	114	PF16727	0.553
LIG_SH2_CRK	61	65	PF00017	0.571
LIG_SH2_STAT3	209	212	PF00017	0.651
LIG_SH2_STAT5	126	129	PF00017	0.572
LIG_SH3_3	10	16	PF00018	0.703
LIG_SxIP_EBH_1	156	167	PF03271	0.529
LIG_TYR_ITIM	59	64	PF00017	0.608
LIG_UBA3_1	53	62	PF00899	0.554
LIG_WRC_WIRS_1	164	169	PF05994	0.540
LIG_WRC_WIRS_1	218	223	PF05994	0.394
MOD_CK1_1	101	107	PF00069	0.553
MOD_CK1_1	174	180	PF00069	0.604
MOD_CK1_1	184	190	PF00069	0.633
MOD_CK1_1	8	14	PF00069	0.746
MOD_CK2_1	127	133	PF00069	0.508
MOD_CK2_1	167	173	PF00069	0.560
MOD_Cter_Amidation	118	121	PF01082	0.481
MOD_GlcNHglycan	129	132	PF01048	0.524
MOD_GlcNHglycan	158	161	PF01048	0.515
MOD_GlcNHglycan	223	228	PF01048	0.409
MOD_GlcNHglycan	234	237	PF01048	0.411
MOD_GlcNHglycan	241	244	PF01048	0.431
MOD_GlcNHglycan	253	256	PF01048	0.482
MOD_GSK3_1	129	136	PF00069	0.386
MOD_GSK3_1	163	170	PF00069	0.496
MOD_GSK3_1	171	178	PF00069	0.552
MOD_GSK3_1	48	55	PF00069	0.377
MOD_GSK3_1	5	12	PF00069	0.731
MOD_N-GLC_1	193	198	PF02516	0.712
MOD_N-GLC_1	65	70	PF02516	0.544
MOD_N-GLC_1	91	96	PF02516	0.540
MOD_NEK2_1	171	176	PF00069	0.562
MOD_NEK2_1	217	222	PF00069	0.503
MOD_NEK2_1	238	243	PF00069	0.449
MOD_NEK2_1	38	43	PF00069	0.474
MOD_NEK2_2	65	70	PF00069	0.466
MOD_PKA_2	101	107	PF00069	0.518
MOD_Plk_1	171	177	PF00069	0.519
MOD_Plk_1	65	71	PF00069	0.555
MOD_Plk_1	91	97	PF00069	0.535
MOD_Plk_4	163	169	PF00069	0.497
MOD_Plk_4	48	54	PF00069	0.457
MOD_ProDKin_1	184	190	PF00069	0.596
MOD_ProDKin_1	71	77	PF00069	0.356
MOD_ProDKin_1	9	15	PF00069	0.668
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.574
TRG_ENDOCYTIC_2	61	64	PF00928	0.582
TRG_ER_diArg_1	115	117	PF00400	0.465
TRG_ER_diArg_1	120	122	PF00400	0.447
TRG_ER_diArg_1	69	71	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA87	Leptomonas seymouri	71%	100%
A0A0S4J0K3	Bodo saltans	35%	100%
A0A1X0P8R4	Trypanosomatidae	38%	88%
A0A3R7JYN8	Trypanosoma rangeli	41%	100%
A0A3S7X040	Leishmania donovani	79%	100%
A4I2E1	Leishmania infantum	79%	100%
C9ZX66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	93%
E9AYJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q8X9	Leishmania major	81%	100%
V5BA09	Trypanosoma cruzi	37%	84%