Serine/threonine protein phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HF54_LEIBR

TriTrypDb:

LbrM.26.2020 , LBRM2903_260024900

Length:

1019

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF54

Function

Biological processes
Term	Name	Level	Count
GO:0000082	G1/S transition of mitotic cell cycle	5	1
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044843	cell cycle G1/S phase transition	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.695
CLV_C14_Caspase3-7	637	641	PF00656	0.511
CLV_C14_Caspase3-7	661	665	PF00656	0.595
CLV_NRD_NRD_1	744	746	PF00675	0.551
CLV_NRD_NRD_1	759	761	PF00675	0.550
CLV_NRD_NRD_1	861	863	PF00675	0.650
CLV_NRD_NRD_1	875	877	PF00675	0.482
CLV_NRD_NRD_1	922	924	PF00675	0.563
CLV_PCSK_KEX2_1	177	179	PF00082	0.614
CLV_PCSK_KEX2_1	457	459	PF00082	0.312
CLV_PCSK_KEX2_1	744	746	PF00082	0.551
CLV_PCSK_KEX2_1	759	761	PF00082	0.550
CLV_PCSK_KEX2_1	861	863	PF00082	0.531
CLV_PCSK_KEX2_1	922	924	PF00082	0.563
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.614
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.312
CLV_PCSK_SKI1_1	1015	1019	PF00082	0.548
CLV_PCSK_SKI1_1	114	118	PF00082	0.523
CLV_PCSK_SKI1_1	295	299	PF00082	0.537
CLV_PCSK_SKI1_1	417	421	PF00082	0.394
CLV_PCSK_SKI1_1	457	461	PF00082	0.312
CLV_PCSK_SKI1_1	545	549	PF00082	0.388
CLV_PCSK_SKI1_1	712	716	PF00082	0.499
CLV_PCSK_SKI1_1	855	859	PF00082	0.525
CLV_PCSK_SKI1_1	982	986	PF00082	0.362
DEG_APCC_DBOX_1	823	831	PF00400	0.506
DEG_SPOP_SBC_1	47	51	PF00917	0.592
DEG_SPOP_SBC_1	771	775	PF00917	0.534
DEG_SPOP_SBC_1	785	789	PF00917	0.503
DOC_ANK_TNKS_1	4	11	PF00023	0.525
DOC_CDC14_PxL_1	562	570	PF14671	0.400
DOC_CKS1_1	155	160	PF01111	0.556
DOC_CKS1_1	396	401	PF01111	0.469
DOC_CKS1_1	622	627	PF01111	0.514
DOC_CKS1_1	81	86	PF01111	0.632
DOC_CKS1_1	87	92	PF01111	0.632
DOC_CYCLIN_RxL_1	411	424	PF00134	0.384
DOC_CYCLIN_RxL_1	454	464	PF00134	0.312
DOC_CYCLIN_RxL_1	549	559	PF00134	0.312
DOC_CYCLIN_yClb1_LxF_4	699	705	PF00134	0.572
DOC_MAPK_gen_1	876	883	PF00069	0.382
DOC_MAPK_gen_1	922	930	PF00069	0.492
DOC_MAPK_gen_1	976	986	PF00069	0.393
DOC_PP1_RVXF_1	175	182	PF00149	0.646
DOC_PP1_RVXF_1	456	463	PF00149	0.312
DOC_PP1_RVXF_1	704	711	PF00149	0.506
DOC_PP2B_LxvP_1	560	563	PF13499	0.356
DOC_PP4_FxxP_1	622	625	PF00568	0.510
DOC_USP7_MATH_1	281	285	PF00917	0.604
DOC_USP7_MATH_1	287	291	PF00917	0.651
DOC_USP7_MATH_1	47	51	PF00917	0.592
DOC_USP7_MATH_1	663	667	PF00917	0.671
DOC_USP7_MATH_1	785	789	PF00917	0.749
DOC_USP7_MATH_1	843	847	PF00917	0.601
DOC_USP7_MATH_1	860	864	PF00917	0.606
DOC_WW_Pin1_4	102	107	PF00397	0.610
DOC_WW_Pin1_4	142	147	PF00397	0.789
DOC_WW_Pin1_4	154	159	PF00397	0.567
DOC_WW_Pin1_4	230	235	PF00397	0.515
DOC_WW_Pin1_4	290	295	PF00397	0.776
DOC_WW_Pin1_4	319	324	PF00397	0.710
DOC_WW_Pin1_4	376	381	PF00397	0.418
DOC_WW_Pin1_4	395	400	PF00397	0.389
DOC_WW_Pin1_4	423	428	PF00397	0.467
DOC_WW_Pin1_4	465	470	PF00397	0.312
DOC_WW_Pin1_4	621	626	PF00397	0.575
DOC_WW_Pin1_4	650	655	PF00397	0.597
DOC_WW_Pin1_4	692	697	PF00397	0.616
DOC_WW_Pin1_4	777	782	PF00397	0.605
DOC_WW_Pin1_4	80	85	PF00397	0.628
DOC_WW_Pin1_4	837	842	PF00397	0.692
DOC_WW_Pin1_4	86	91	PF00397	0.630
LIG_14-3-3_CanoR_1	114	119	PF00244	0.650
LIG_14-3-3_CanoR_1	178	188	PF00244	0.608
LIG_14-3-3_CanoR_1	303	313	PF00244	0.508
LIG_14-3-3_CanoR_1	481	487	PF00244	0.312
LIG_14-3-3_CanoR_1	572	578	PF00244	0.558
LIG_14-3-3_CanoR_1	598	608	PF00244	0.671
LIG_14-3-3_CanoR_1	706	711	PF00244	0.532
LIG_14-3-3_CanoR_1	712	717	PF00244	0.473
LIG_14-3-3_CanoR_1	794	801	PF00244	0.564
LIG_14-3-3_CanoR_1	824	828	PF00244	0.561
LIG_14-3-3_CanoR_1	861	870	PF00244	0.598
LIG_Actin_WH2_2	165	182	PF00022	0.570
LIG_APCC_ABBA_1	459	464	PF00400	0.312
LIG_APCC_ABBAyCdc20_2	458	464	PF00400	0.312
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BRCT_BRCA1_1	618	622	PF00533	0.511
LIG_BRCT_BRCA1_1	706	710	PF00533	0.485
LIG_BRCT_BRCA1_1	862	866	PF00533	0.522
LIG_BRCT_BRCA1_1	961	965	PF00533	0.359
LIG_deltaCOP1_diTrp_1	932	935	PF00928	0.487
LIG_DLG_GKlike_1	225	232	PF00625	0.511
LIG_eIF4E_1	880	886	PF01652	0.432
LIG_eIF4E_1	959	965	PF01652	0.455
LIG_FHA_1	174	180	PF00498	0.563
LIG_FHA_1	224	230	PF00498	0.513
LIG_FHA_1	4	10	PF00498	0.525
LIG_FHA_1	47	53	PF00498	0.591
LIG_FHA_1	75	81	PF00498	0.611
LIG_FHA_1	772	778	PF00498	0.516
LIG_FHA_1	87	93	PF00498	0.627
LIG_FHA_2	252	258	PF00498	0.522
LIG_FHA_2	320	326	PF00498	0.664
LIG_FHA_2	37	43	PF00498	0.541
LIG_FHA_2	659	665	PF00498	0.595
LIG_FHA_2	81	87	PF00498	0.544
LIG_FHA_2	869	875	PF00498	0.538
LIG_FHA_2	889	895	PF00498	0.340
LIG_HCF-1_HBM_1	42	45	PF13415	0.674
LIG_IBAR_NPY_1	55	57	PF08397	0.553
LIG_LIR_Apic_2	367	372	PF02991	0.562
LIG_LIR_Apic_2	619	625	PF02991	0.509
LIG_LIR_Apic_2	666	672	PF02991	0.522
LIG_LIR_Apic_2	884	890	PF02991	0.412
LIG_LIR_Gen_1	160	169	PF02991	0.545
LIG_LIR_Gen_1	378	389	PF02991	0.370
LIG_LIR_Gen_1	657	667	PF02991	0.672
LIG_LIR_Nem_3	160	164	PF02991	0.544
LIG_LIR_Nem_3	378	384	PF02991	0.371
LIG_LIR_Nem_3	392	396	PF02991	0.363
LIG_LIR_Nem_3	541	547	PF02991	0.349
LIG_LIR_Nem_3	548	554	PF02991	0.279
LIG_LIR_Nem_3	657	662	PF02991	0.674
LIG_LIR_Nem_3	740	746	PF02991	0.554
LIG_MYND_1	90	94	PF01753	0.638
LIG_NRBOX	455	461	PF00104	0.312
LIG_NRBOX	71	77	PF00104	0.545
LIG_OCRL_FandH_1	110	122	PF00620	0.520
LIG_OCRL_FandH_1	441	453	PF00620	0.312
LIG_Pex14_1	879	883	PF04695	0.454
LIG_Pex14_2	883	887	PF04695	0.423
LIG_PTAP_UEV_1	562	567	PF05743	0.376
LIG_REV1ctd_RIR_1	452	462	PF16727	0.312
LIG_RPA_C_Fungi	755	767	PF08784	0.539
LIG_SH2_CRK	381	385	PF00017	0.356
LIG_SH2_CRK	659	663	PF00017	0.594
LIG_SH2_CRK	669	673	PF00017	0.605
LIG_SH2_CRK	961	965	PF00017	0.359
LIG_SH2_NCK_1	659	663	PF00017	0.594
LIG_SH2_STAP1	659	663	PF00017	0.646
LIG_SH2_STAP1	961	965	PF00017	0.359
LIG_SH2_STAT3	583	586	PF00017	0.592
LIG_SH2_STAT5	349	352	PF00017	0.706
LIG_SH2_STAT5	383	386	PF00017	0.362
LIG_SH2_STAT5	388	391	PF00017	0.396
LIG_SH2_STAT5	404	407	PF00017	0.363
LIG_SH2_STAT5	478	481	PF00017	0.312
LIG_SH2_STAT5	537	540	PF00017	0.260
LIG_SH2_STAT5	553	556	PF00017	0.420
LIG_SH2_STAT5	57	60	PF00017	0.532
LIG_SH2_STAT5	583	586	PF00017	0.592
LIG_SH2_STAT5	733	736	PF00017	0.527
LIG_SH2_STAT5	880	883	PF00017	0.396
LIG_SH3_3	152	158	PF00018	0.574
LIG_SH3_3	560	566	PF00018	0.411
LIG_SH3_3	574	580	PF00018	0.564
LIG_SH3_3	581	587	PF00018	0.589
LIG_SH3_3	715	721	PF00018	0.537
LIG_SH3_3	81	87	PF00018	0.625
LIG_Sin3_3	558	565	PF02671	0.296
LIG_SUMO_SIM_anti_2	219	228	PF11976	0.575
LIG_SUMO_SIM_anti_2	487	494	PF11976	0.312
LIG_SUMO_SIM_par_1	195	200	PF11976	0.543
LIG_SUMO_SIM_par_1	360	367	PF11976	0.508
LIG_SUMO_SIM_par_1	773	780	PF11976	0.520
LIG_SUMO_SIM_par_1	982	990	PF11976	0.354
LIG_TRAF2_1	272	275	PF00917	0.500
LIG_TRAF2_1	677	680	PF00917	0.507
LIG_TRAF2_1	71	74	PF00917	0.611
LIG_TRAF2_1	846	849	PF00917	0.546
LIG_TRAF2_1	967	970	PF00917	0.383
LIG_TRFH_1	465	469	PF08558	0.312
LIG_TYR_ITSM	655	662	PF00017	0.670
LIG_UBA3_1	171	177	PF00899	0.621
LIG_UBA3_1	491	496	PF00899	0.311
LIG_ULM_U2AF65_1	177	182	PF00076	0.653
LIG_WRC_WIRS_1	108	113	PF05994	0.583
LIG_WRC_WIRS_1	614	619	PF05994	0.514
LIG_WRC_WIRS_1	944	949	PF05994	0.430
LIG_WRC_WIRS_1	952	957	PF05994	0.402
MOD_CDK_SPK_2	290	295	PF00069	0.521
MOD_CDK_SPxK_1	621	627	PF00069	0.509
MOD_CDK_SPxxK_3	395	402	PF00069	0.459
MOD_CDK_SPxxK_3	86	93	PF00069	0.639
MOD_CK1_1	154	160	PF00069	0.714
MOD_CK1_1	173	179	PF00069	0.713
MOD_CK1_1	228	234	PF00069	0.575
MOD_CK1_1	290	296	PF00069	0.626
MOD_CK1_1	306	312	PF00069	0.501
MOD_CK1_1	329	335	PF00069	0.598
MOD_CK1_1	340	346	PF00069	0.622
MOD_CK1_1	573	579	PF00069	0.561
MOD_CK1_1	602	608	PF00069	0.675
MOD_CK1_1	616	622	PF00069	0.668
MOD_CK1_1	780	786	PF00069	0.538
MOD_CK1_1	787	793	PF00069	0.565
MOD_CK1_1	797	803	PF00069	0.712
MOD_CK1_1	823	829	PF00069	0.645
MOD_CK1_1	832	838	PF00069	0.760
MOD_CK1_1	888	894	PF00069	0.472
MOD_CK2_1	251	257	PF00069	0.518
MOD_CK2_1	36	42	PF00069	0.586
MOD_CK2_1	670	676	PF00069	0.597
MOD_CK2_1	68	74	PF00069	0.536
MOD_CK2_1	80	86	PF00069	0.622
MOD_CK2_1	843	849	PF00069	0.555
MOD_CK2_1	888	894	PF00069	0.530
MOD_GlcNHglycan	1	4	PF01048	0.636
MOD_GlcNHglycan	119	122	PF01048	0.601
MOD_GlcNHglycan	135	138	PF01048	0.547
MOD_GlcNHglycan	359	362	PF01048	0.520
MOD_GlcNHglycan	563	566	PF01048	0.384
MOD_GlcNHglycan	601	604	PF01048	0.612
MOD_GlcNHglycan	609	612	PF01048	0.604
MOD_GlcNHglycan	63	66	PF01048	0.548
MOD_GlcNHglycan	632	635	PF01048	0.601
MOD_GlcNHglycan	637	640	PF01048	0.595
MOD_GlcNHglycan	645	648	PF01048	0.589
MOD_GlcNHglycan	747	750	PF01048	0.619
MOD_GlcNHglycan	803	806	PF01048	0.646
MOD_GlcNHglycan	841	844	PF01048	0.598
MOD_GlcNHglycan	947	950	PF01048	0.418
MOD_GSK3_1	102	109	PF00069	0.618
MOD_GSK3_1	124	131	PF00069	0.545
MOD_GSK3_1	303	310	PF00069	0.560
MOD_GSK3_1	337	344	PF00069	0.625
MOD_GSK3_1	518	525	PF00069	0.231
MOD_GSK3_1	566	573	PF00069	0.582
MOD_GSK3_1	609	616	PF00069	0.567
MOD_GSK3_1	650	657	PF00069	0.783
MOD_GSK3_1	771	778	PF00069	0.588
MOD_GSK3_1	780	787	PF00069	0.639
MOD_GSK3_1	797	804	PF00069	0.602
MOD_GSK3_1	818	825	PF00069	0.627
MOD_GSK3_1	826	833	PF00069	0.683
MOD_GSK3_1	835	842	PF00069	0.625
MOD_GSK3_1	885	892	PF00069	0.338
MOD_GSK3_1	913	920	PF00069	0.660
MOD_GSK3_1	939	946	PF00069	0.500
MOD_GSK3_1	982	989	PF00069	0.346
MOD_N-GLC_1	465	470	PF02516	0.312
MOD_N-GLC_1	498	503	PF02516	0.312
MOD_N-GLC_1	566	571	PF02516	0.610
MOD_N-GLC_2	791	793	PF02516	0.530
MOD_NEK2_1	27	32	PF00069	0.517
MOD_NEK2_1	491	496	PF00069	0.312
MOD_NEK2_1	498	503	PF00069	0.312
MOD_NEK2_1	570	575	PF00069	0.548
MOD_NEK2_1	582	587	PF00069	0.591
MOD_NEK2_1	643	648	PF00069	0.504
MOD_NEK2_1	704	709	PF00069	0.567
MOD_NEK2_1	786	791	PF00069	0.548
MOD_NEK2_1	795	800	PF00069	0.495
MOD_NEK2_1	822	827	PF00069	0.506
MOD_NEK2_1	834	839	PF00069	0.592
MOD_NEK2_1	975	980	PF00069	0.407
MOD_NEK2_1	987	992	PF00069	0.372
MOD_NEK2_2	364	369	PF00069	0.496
MOD_NEK2_2	522	527	PF00069	0.231
MOD_PIKK_1	124	130	PF00454	0.523
MOD_PIKK_1	355	361	PF00454	0.537
MOD_PIKK_1	570	576	PF00454	0.549
MOD_PIKK_1	582	588	PF00454	0.592
MOD_PIKK_1	74	80	PF00454	0.650
MOD_PKA_1	861	867	PF00069	0.524
MOD_PKA_1	922	928	PF00069	0.507
MOD_PKA_2	173	179	PF00069	0.586
MOD_PKA_2	823	829	PF00069	0.662
MOD_PKA_2	860	866	PF00069	0.608
MOD_PKA_2	92	98	PF00069	0.628
MOD_PKA_2	922	928	PF00069	0.690
MOD_PKA_2	939	945	PF00069	0.402
MOD_PKA_2	975	981	PF00069	0.413
MOD_PKB_1	792	800	PF00069	0.523
MOD_Plk_1	106	112	PF00069	0.520
MOD_Plk_1	326	332	PF00069	0.532
MOD_Plk_1	450	456	PF00069	0.312
MOD_Plk_1	545	551	PF00069	0.312
MOD_Plk_1	566	572	PF00069	0.614
MOD_Plk_1	663	669	PF00069	0.597
MOD_Plk_2-3	107	113	PF00069	0.706
MOD_Plk_2-3	210	216	PF00069	0.673
MOD_Plk_2-3	889	895	PF00069	0.388
MOD_Plk_4	389	395	PF00069	0.383
MOD_Plk_4	450	456	PF00069	0.312
MOD_Plk_4	530	536	PF00069	0.312
MOD_Plk_4	566	572	PF00069	0.574
MOD_Plk_4	573	579	PF00069	0.528
MOD_Plk_4	712	718	PF00069	0.507
MOD_Plk_4	8	14	PF00069	0.525
MOD_Plk_4	951	957	PF00069	0.400
MOD_Plk_4	959	965	PF00069	0.379
MOD_Plk_4	982	988	PF00069	0.360
MOD_ProDKin_1	102	108	PF00069	0.668
MOD_ProDKin_1	142	148	PF00069	0.786
MOD_ProDKin_1	154	160	PF00069	0.560
MOD_ProDKin_1	230	236	PF00069	0.515
MOD_ProDKin_1	290	296	PF00069	0.779
MOD_ProDKin_1	319	325	PF00069	0.713
MOD_ProDKin_1	376	382	PF00069	0.415
MOD_ProDKin_1	395	401	PF00069	0.385
MOD_ProDKin_1	423	429	PF00069	0.471
MOD_ProDKin_1	465	471	PF00069	0.312
MOD_ProDKin_1	621	627	PF00069	0.577
MOD_ProDKin_1	650	656	PF00069	0.592
MOD_ProDKin_1	692	698	PF00069	0.615
MOD_ProDKin_1	777	783	PF00069	0.604
MOD_ProDKin_1	80	86	PF00069	0.630
MOD_ProDKin_1	837	843	PF00069	0.693
MOD_SUMO_for_1	735	738	PF00179	0.502
MOD_SUMO_rev_2	208	218	PF00179	0.546
MOD_SUMO_rev_2	327	337	PF00179	0.531
MOD_SUMO_rev_2	616	622	PF00179	0.513
TRG_DiLeu_BaEn_1	487	492	PF01217	0.312
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.380
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.312
TRG_ENDOCYTIC_2	381	384	PF00928	0.358
TRG_ENDOCYTIC_2	553	556	PF00928	0.312
TRG_ENDOCYTIC_2	659	662	PF00928	0.598
TRG_ENDOCYTIC_2	880	883	PF00928	0.460
TRG_ENDOCYTIC_2	961	964	PF00928	0.365
TRG_ER_diArg_1	178	181	PF00400	0.581
TRG_ER_diArg_1	743	745	PF00400	0.531
TRG_ER_diArg_1	792	795	PF00400	0.567
TRG_ER_diArg_1	922	924	PF00400	0.533
TRG_NES_CRM1_1	450	464	PF08389	0.312
TRG_NLS_MonoExtN_4	174	181	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II84	Leptomonas seymouri	56%	96%
A0A3Q8IG06	Leishmania donovani	73%	100%
A4I2D8	Leishmania infantum	74%	100%
E9AYJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q8Y2	Leishmania major	73%	98%