LeishMANIAdb
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Serine/threonine protein phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine protein phosphatase-like protein
Gene product:
serine/threonine protein phosphatase-like protein
Species:
Leishmania braziliensis
UniProt:
A4HF54_LEIBR
TriTrypDb:
LbrM.26.2020 , LBRM2903_260024900 *
Length:
1019

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4HF54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF54

Function

Biological processes
TermNameLevelCount
GO:0000082 G1/S transition of mitotic cell cycle 5 1
GO:0009987 cellular process 1 1
GO:0022402 cell cycle process 2 1
GO:0044770 cell cycle phase transition 3 1
GO:0044772 mitotic cell cycle phase transition 4 1
GO:0044843 cell cycle G1/S phase transition 4 1
GO:1903047 mitotic cell cycle process 3 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 7
GO:0004721 phosphoprotein phosphatase activity 3 1
GO:0004722 protein serine/threonine phosphatase activity 4 1
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016791 phosphatase activity 5 1
GO:0042578 phosphoric ester hydrolase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 214 218 PF00656 0.695
CLV_C14_Caspase3-7 637 641 PF00656 0.511
CLV_C14_Caspase3-7 661 665 PF00656 0.595
CLV_NRD_NRD_1 744 746 PF00675 0.551
CLV_NRD_NRD_1 759 761 PF00675 0.550
CLV_NRD_NRD_1 861 863 PF00675 0.650
CLV_NRD_NRD_1 875 877 PF00675 0.482
CLV_NRD_NRD_1 922 924 PF00675 0.563
CLV_PCSK_KEX2_1 177 179 PF00082 0.614
CLV_PCSK_KEX2_1 457 459 PF00082 0.312
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1II84 Leptomonas seymouri 56% 96%
A0A3Q8IG06 Leishmania donovani 73% 100%
A4I2D8 Leishmania infantum 74% 100%
E9AYJ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
Q4Q8Y2 Leishmania major 73% 98%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS