Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF49_LEIBR

TriTrypDb:

LbrM.26.1970 , LBRM2903_260024400

Length:

897

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.631
CLV_C14_Caspase3-7	434	438	PF00656	0.552
CLV_C14_Caspase3-7	507	511	PF00656	0.549
CLV_C14_Caspase3-7	660	664	PF00656	0.562
CLV_C14_Caspase3-7	719	723	PF00656	0.520
CLV_C14_Caspase3-7	772	776	PF00656	0.619
CLV_NRD_NRD_1	225	227	PF00675	0.588
CLV_NRD_NRD_1	270	272	PF00675	0.567
CLV_NRD_NRD_1	445	447	PF00675	0.677
CLV_NRD_NRD_1	470	472	PF00675	0.656
CLV_NRD_NRD_1	601	603	PF00675	0.544
CLV_NRD_NRD_1	604	606	PF00675	0.530
CLV_NRD_NRD_1	668	670	PF00675	0.610
CLV_PCSK_KEX2_1	225	227	PF00082	0.588
CLV_PCSK_KEX2_1	269	271	PF00082	0.579
CLV_PCSK_KEX2_1	470	472	PF00082	0.660
CLV_PCSK_KEX2_1	601	603	PF00082	0.544
CLV_PCSK_KEX2_1	653	655	PF00082	0.666
CLV_PCSK_KEX2_1	668	670	PF00082	0.566
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.666
CLV_PCSK_SKI1_1	13	17	PF00082	0.633
CLV_PCSK_SKI1_1	210	214	PF00082	0.587
CLV_PCSK_SKI1_1	233	237	PF00082	0.610
CLV_PCSK_SKI1_1	25	29	PF00082	0.531
CLV_PCSK_SKI1_1	30	34	PF00082	0.477
CLV_PCSK_SKI1_1	37	41	PF00082	0.532
CLV_PCSK_SKI1_1	606	610	PF00082	0.536
CLV_PCSK_SKI1_1	65	69	PF00082	0.527
DEG_APCC_DBOX_1	12	20	PF00400	0.637
DEG_MDM2_SWIB_1	730	737	PF02201	0.543
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DEG_SPOP_SBC_1	810	814	PF00917	0.553
DOC_CDC14_PxL_1	637	645	PF14671	0.596
DOC_CKS1_1	396	401	PF01111	0.657
DOC_CKS1_1	567	572	PF01111	0.674
DOC_CKS1_1	799	804	PF01111	0.627
DOC_MAPK_gen_1	225	236	PF00069	0.603
DOC_MAPK_gen_1	601	610	PF00069	0.538
DOC_MAPK_gen_1	65	74	PF00069	0.528
DOC_PP2B_LxvP_1	140	143	PF13499	0.576
DOC_PP2B_LxvP_1	150	153	PF13499	0.491
DOC_PP2B_LxvP_1	475	478	PF13499	0.686
DOC_PP2B_LxvP_1	785	788	PF13499	0.535
DOC_USP7_MATH_1	119	123	PF00917	0.617
DOC_USP7_MATH_1	136	140	PF00917	0.555
DOC_USP7_MATH_1	153	157	PF00917	0.554
DOC_USP7_MATH_1	435	439	PF00917	0.622
DOC_USP7_MATH_1	481	485	PF00917	0.689
DOC_USP7_MATH_1	487	491	PF00917	0.627
DOC_USP7_MATH_1	60	64	PF00917	0.738
DOC_USP7_MATH_1	604	608	PF00917	0.536
DOC_USP7_MATH_1	810	814	PF00917	0.677
DOC_USP7_MATH_1	835	839	PF00917	0.577
DOC_WW_Pin1_4	109	114	PF00397	0.772
DOC_WW_Pin1_4	364	369	PF00397	0.561
DOC_WW_Pin1_4	395	400	PF00397	0.552
DOC_WW_Pin1_4	42	47	PF00397	0.673
DOC_WW_Pin1_4	526	531	PF00397	0.704
DOC_WW_Pin1_4	566	571	PF00397	0.674
DOC_WW_Pin1_4	748	753	PF00397	0.646
DOC_WW_Pin1_4	795	800	PF00397	0.698
DOC_WW_Pin1_4	86	91	PF00397	0.562
LIG_14-3-3_CanoR_1	130	134	PF00244	0.590
LIG_14-3-3_CanoR_1	154	158	PF00244	0.451
LIG_14-3-3_CanoR_1	18	26	PF00244	0.644
LIG_14-3-3_CanoR_1	316	326	PF00244	0.536
LIG_14-3-3_CanoR_1	397	403	PF00244	0.653
LIG_14-3-3_CanoR_1	470	479	PF00244	0.591
LIG_14-3-3_CanoR_1	512	522	PF00244	0.635
LIG_14-3-3_CanoR_1	605	611	PF00244	0.632
LIG_14-3-3_CanoR_1	849	854	PF00244	0.640
LIG_14-3-3_CanoR_1	870	874	PF00244	0.460
LIG_Actin_WH2_2	749	767	PF00022	0.634
LIG_BIR_III_4	779	783	PF00653	0.508
LIG_BRCT_BRCA1_1	457	461	PF00533	0.483
LIG_BRCT_BRCA1_1	738	742	PF00533	0.469
LIG_FHA_1	167	173	PF00498	0.593
LIG_FHA_1	246	252	PF00498	0.658
LIG_FHA_1	318	324	PF00498	0.542
LIG_FHA_1	338	344	PF00498	0.591
LIG_FHA_1	365	371	PF00498	0.537
LIG_FHA_1	483	489	PF00498	0.722
LIG_FHA_1	529	535	PF00498	0.547
LIG_FHA_1	710	716	PF00498	0.557
LIG_FHA_1	749	755	PF00498	0.595
LIG_FHA_1	799	805	PF00498	0.641
LIG_FHA_1	812	818	PF00498	0.602
LIG_FHA_2	280	286	PF00498	0.569
LIG_FHA_2	622	628	PF00498	0.494
LIG_FHA_2	717	723	PF00498	0.658
LIG_FHA_2	858	864	PF00498	0.473
LIG_LIR_Gen_1	379	390	PF02991	0.540
LIG_LIR_Gen_1	863	871	PF02991	0.469
LIG_LIR_Nem_3	355	360	PF02991	0.658
LIG_LIR_Nem_3	379	385	PF02991	0.542
LIG_LIR_Nem_3	645	650	PF02991	0.453
LIG_LIR_Nem_3	863	867	PF02991	0.466
LIG_LYPXL_L_2	50	59	PF13949	0.521
LIG_MYND_1	143	147	PF01753	0.550
LIG_NRBOX	70	76	PF00104	0.530
LIG_PDZ_Class_2	892	897	PF00595	0.517
LIG_Pex14_2	647	651	PF04695	0.462
LIG_Pex14_2	730	734	PF04695	0.601
LIG_RPA_C_Fungi	804	816	PF08784	0.529
LIG_SH2_CRK	382	386	PF00017	0.612
LIG_SH2_CRK	567	571	PF00017	0.517
LIG_SH2_CRK	637	641	PF00017	0.601
LIG_SH2_CRK	770	774	PF00017	0.497
LIG_SH2_STAP1	162	166	PF00017	0.595
LIG_SH2_STAP1	382	386	PF00017	0.542
LIG_SH2_STAP1	760	764	PF00017	0.615
LIG_SH2_STAT5	241	244	PF00017	0.628
LIG_SH2_STAT5	360	363	PF00017	0.657
LIG_SH3_3	128	134	PF00018	0.654
LIG_SH3_3	141	147	PF00018	0.574
LIG_SH3_3	49	55	PF00018	0.521
LIG_SH3_3	712	718	PF00018	0.521
LIG_SH3_3	791	797	PF00018	0.694
LIG_SH3_3	95	101	PF00018	0.575
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.614
LIG_SUMO_SIM_anti_2	607	612	PF11976	0.530
LIG_SUMO_SIM_anti_2	755	760	PF11976	0.472
LIG_SUMO_SIM_par_1	751	757	PF11976	0.494
LIG_TRAF2_1	624	627	PF00917	0.470
LIG_TRAF2_1	860	863	PF00917	0.471
LIG_WW_2	135	138	PF00397	0.516
MOD_CDK_SPK_2	395	400	PF00069	0.669
MOD_CDK_SPK_2	86	91	PF00069	0.695
MOD_CK1_1	112	118	PF00069	0.640
MOD_CK1_1	352	358	PF00069	0.561
MOD_CK1_1	381	387	PF00069	0.680
MOD_CK1_1	42	48	PF00069	0.502
MOD_CK1_1	455	461	PF00069	0.491
MOD_CK1_1	61	67	PF00069	0.500
MOD_CK1_1	736	742	PF00069	0.620
MOD_CK1_1	76	82	PF00069	0.575
MOD_CK1_1	798	804	PF00069	0.699
MOD_CK1_1	866	872	PF00069	0.622
MOD_CK2_1	279	285	PF00069	0.572
MOD_CK2_1	487	493	PF00069	0.590
MOD_CK2_1	621	627	PF00069	0.501
MOD_CK2_1	653	659	PF00069	0.549
MOD_CK2_1	686	692	PF00069	0.600
MOD_CK2_1	857	863	PF00069	0.468
MOD_Cter_Amidation	666	669	PF01082	0.566
MOD_GlcNHglycan	117	120	PF01048	0.590
MOD_GlcNHglycan	131	134	PF01048	0.641
MOD_GlcNHglycan	162	165	PF01048	0.596
MOD_GlcNHglycan	2	5	PF01048	0.492
MOD_GlcNHglycan	302	305	PF01048	0.686
MOD_GlcNHglycan	326	329	PF01048	0.692
MOD_GlcNHglycan	344	347	PF01048	0.520
MOD_GlcNHglycan	41	44	PF01048	0.632
MOD_GlcNHglycan	425	428	PF01048	0.596
MOD_GlcNHglycan	433	436	PF01048	0.570
MOD_GlcNHglycan	447	450	PF01048	0.508
MOD_GlcNHglycan	456	460	PF01048	0.466
MOD_GlcNHglycan	472	475	PF01048	0.518
MOD_GlcNHglycan	479	482	PF01048	0.505
MOD_GlcNHglycan	506	509	PF01048	0.552
MOD_GlcNHglycan	688	691	PF01048	0.675
MOD_GlcNHglycan	700	703	PF01048	0.569
MOD_GlcNHglycan	748	751	PF01048	0.566
MOD_GlcNHglycan	75	78	PF01048	0.626
MOD_GlcNHglycan	837	840	PF01048	0.518
MOD_GlcNHglycan	84	87	PF01048	0.603
MOD_GlcNHglycan	846	849	PF01048	0.461
MOD_GSK3_1	111	118	PF00069	0.621
MOD_GSK3_1	241	248	PF00069	0.626
MOD_GSK3_1	284	291	PF00069	0.535
MOD_GSK3_1	317	324	PF00069	0.652
MOD_GSK3_1	431	438	PF00069	0.692
MOD_GSK3_1	477	484	PF00069	0.527
MOD_GSK3_1	524	531	PF00069	0.622
MOD_GSK3_1	54	61	PF00069	0.666
MOD_GSK3_1	612	619	PF00069	0.653
MOD_GSK3_1	769	776	PF00069	0.589
MOD_GSK3_1	82	89	PF00069	0.565
MOD_GSK3_1	844	851	PF00069	0.641
MOD_GSK3_1	869	876	PF00069	0.571
MOD_N-GLC_1	421	426	PF02516	0.558
MOD_N-GLC_1	463	468	PF02516	0.604
MOD_N-GLC_1	504	509	PF02516	0.543
MOD_N-GLC_1	654	659	PF02516	0.525
MOD_N-GLC_1	835	840	PF02516	0.564
MOD_N-GLC_1	86	91	PF02516	0.543
MOD_NEK2_1	39	44	PF00069	0.488
MOD_NEK2_1	445	450	PF00069	0.648
MOD_NEK2_1	534	539	PF00069	0.527
MOD_NEK2_1	769	774	PF00069	0.619
MOD_NEK2_1	844	849	PF00069	0.621
MOD_NEK2_2	435	440	PF00069	0.551
MOD_NEK2_2	878	883	PF00069	0.464
MOD_OFUCOSY	318	325	PF10250	0.525
MOD_PIKK_1	166	172	PF00454	0.582
MOD_PIKK_1	328	334	PF00454	0.681
MOD_PIKK_1	362	368	PF00454	0.678
MOD_PIKK_1	516	522	PF00454	0.595
MOD_PIKK_1	642	648	PF00454	0.596
MOD_PKA_1	470	476	PF00069	0.585
MOD_PKA_1	653	659	PF00069	0.523
MOD_PKA_2	129	135	PF00069	0.588
MOD_PKA_2	153	159	PF00069	0.451
MOD_PKA_2	17	23	PF00069	0.720
MOD_PKA_2	445	451	PF00069	0.607
MOD_PKA_2	470	476	PF00069	0.585
MOD_PKA_2	604	610	PF00069	0.629
MOD_PKA_2	653	659	PF00069	0.523
MOD_PKA_2	667	673	PF00069	0.528
MOD_PKA_2	726	732	PF00069	0.451
MOD_PKA_2	817	823	PF00069	0.615
MOD_PKA_2	848	854	PF00069	0.620
MOD_PKA_2	869	875	PF00069	0.462
MOD_PKB_1	23	31	PF00069	0.654
MOD_Plk_1	321	327	PF00069	0.629
MOD_Plk_1	378	384	PF00069	0.604
MOD_Plk_1	421	427	PF00069	0.558
MOD_Plk_1	754	760	PF00069	0.475
MOD_Plk_1	810	816	PF00069	0.616
MOD_Plk_2-3	863	869	PF00069	0.467
MOD_Plk_4	145	151	PF00069	0.588
MOD_Plk_4	203	209	PF00069	0.437
MOD_Plk_4	352	358	PF00069	0.658
MOD_Plk_4	381	387	PF00069	0.539
MOD_Plk_4	435	441	PF00069	0.683
MOD_Plk_4	54	60	PF00069	0.588
MOD_Plk_4	67	73	PF00069	0.644
MOD_Plk_4	726	732	PF00069	0.511
MOD_Plk_4	754	760	PF00069	0.518
MOD_Plk_4	769	775	PF00069	0.473
MOD_Plk_4	79	85	PF00069	0.568
MOD_Plk_4	800	806	PF00069	0.547
MOD_ProDKin_1	109	115	PF00069	0.771
MOD_ProDKin_1	364	370	PF00069	0.563
MOD_ProDKin_1	395	401	PF00069	0.544
MOD_ProDKin_1	42	48	PF00069	0.675
MOD_ProDKin_1	526	532	PF00069	0.697
MOD_ProDKin_1	566	572	PF00069	0.674
MOD_ProDKin_1	748	754	PF00069	0.644
MOD_ProDKin_1	795	801	PF00069	0.700
MOD_ProDKin_1	86	92	PF00069	0.564
MOD_SUMO_rev_2	670	675	PF00179	0.555
TRG_DiLeu_BaEn_1	54	59	PF01217	0.527
TRG_DiLeu_BaEn_4	321	327	PF01217	0.532
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.639
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.645
TRG_ENDOCYTIC_2	162	165	PF00928	0.590
TRG_ENDOCYTIC_2	360	363	PF00928	0.657
TRG_ENDOCYTIC_2	382	385	PF00928	0.562
TRG_ENDOCYTIC_2	637	640	PF00928	0.600
TRG_ENDOCYTIC_2	770	773	PF00928	0.502
TRG_ER_diArg_1	225	227	PF00400	0.588
TRG_ER_diArg_1	23	26	PF00400	0.654
TRG_ER_diArg_1	268	271	PF00400	0.577
TRG_ER_diArg_1	469	471	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICB4	Leishmania donovani	59%	88%
A4I2D3	Leishmania infantum	60%	100%
E9AYI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q8Y7	Leishmania major	59%	99%