PQ-loop repeat-containing protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PQ loop repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HF48_LEIBR

TriTrypDb:

LbrM.26.1960 , LBRM2903_260024300

Length:

357

Annotations

LeishMANIAdb annotations

Shows homology to LAAT transporters found in mammals (SLC66 family).. Localization: Lysosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005768	endosome	7	1
GO:0005802	trans-Golgi network	4	1
GO:0005829	cytosol	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0031984	organelle subcompartment	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A4HF48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF48

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0009987	cellular process	1	1
GO:0015748	organophosphate ester transport	5	1
GO:0015914	phospholipid transport	6	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0034204	lipid translocation	4	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0045332	phospholipid translocation	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071702	organic substance transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097035	regulation of membrane lipid distribution	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	266	268	PF00675	0.292
CLV_PCSK_KEX2_1	131	133	PF00082	0.414
CLV_PCSK_KEX2_1	265	267	PF00082	0.291
CLV_PCSK_KEX2_1	326	328	PF00082	0.404
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.414
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.485
CLV_PCSK_PC7_1	262	268	PF00082	0.361
CLV_PCSK_SKI1_1	295	299	PF00082	0.607
CLV_PCSK_SKI1_1	59	63	PF00082	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.477
DEG_ODPH_VHL_1	14	27	PF01847	0.339
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.584
DOC_MAPK_gen_1	326	333	PF00069	0.683
DOC_MAPK_MEF2A_6	5	14	PF00069	0.408
DOC_MAPK_RevD_3	313	327	PF00069	0.524
DOC_PP1_RVXF_1	285	292	PF00149	0.401
DOC_PP1_RVXF_1	3	9	PF00149	0.391
DOC_PP2B_LxvP_1	112	115	PF13499	0.576
DOC_PP2B_LxvP_1	255	258	PF13499	0.369
DOC_USP7_MATH_1	104	108	PF00917	0.621
DOC_USP7_MATH_1	118	122	PF00917	0.776
DOC_USP7_MATH_1	147	151	PF00917	0.754
DOC_USP7_MATH_1	171	175	PF00917	0.661
DOC_USP7_MATH_1	38	42	PF00917	0.344
DOC_WW_Pin1_4	116	121	PF00397	0.755
DOC_WW_Pin1_4	140	145	PF00397	0.688
DOC_WW_Pin1_4	169	174	PF00397	0.677
DOC_WW_Pin1_4	34	39	PF00397	0.508
DOC_WW_Pin1_4	342	347	PF00397	0.630
LIG_14-3-3_CanoR_1	265	275	PF00244	0.477
LIG_14-3-3_CanoR_1	349	357	PF00244	0.599
LIG_Actin_WH2_2	192	207	PF00022	0.564
LIG_Actin_WH2_2	247	264	PF00022	0.444
LIG_BIR_III_2	170	174	PF00653	0.621
LIG_Clathr_ClatBox_1	192	196	PF01394	0.587
LIG_CSL_BTD_1	153	156	PF09270	0.600
LIG_FHA_1	107	113	PF00498	0.702
LIG_FHA_1	267	273	PF00498	0.496
LIG_FHA_1	28	34	PF00498	0.577
LIG_FHA_1	47	53	PF00498	0.401
LIG_HP1_1	38	42	PF01393	0.401
LIG_LIR_Gen_1	214	223	PF02991	0.233
LIG_LIR_Nem_3	214	218	PF02991	0.370
LIG_LIR_Nem_3	34	39	PF02991	0.506
LIG_NBox_RRM_1	8	18	PF00076	0.447
LIG_NRBOX	271	277	PF00104	0.444
LIG_NRBOX	60	66	PF00104	0.481
LIG_SH2_CRK	206	210	PF00017	0.599
LIG_SH2_CRK	213	217	PF00017	0.399
LIG_SH2_CRK	246	250	PF00017	0.409
LIG_SH2_CRK	321	325	PF00017	0.653
LIG_SH2_CRK	36	40	PF00017	0.369
LIG_SH2_PTP2	230	233	PF00017	0.527
LIG_SH2_SRC	215	218	PF00017	0.388
LIG_SH2_SRC	24	27	PF00017	0.523
LIG_SH2_STAP1	213	217	PF00017	0.408
LIG_SH2_STAP1	293	297	PF00017	0.340
LIG_SH2_STAT3	20	23	PF00017	0.378
LIG_SH2_STAT3	293	296	PF00017	0.361
LIG_SH2_STAT5	20	23	PF00017	0.417
LIG_SH2_STAT5	215	218	PF00017	0.349
LIG_SH2_STAT5	230	233	PF00017	0.432
LIG_SH2_STAT5	24	27	PF00017	0.564
LIG_SH2_STAT5	290	293	PF00017	0.370
LIG_SH2_STAT5	55	58	PF00017	0.351
LIG_SH3_3	10	16	PF00018	0.369
LIG_SH3_3	340	346	PF00018	0.605
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.396
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.376
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.319
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.344
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.376
LIG_SUMO_SIM_par_1	107	113	PF11976	0.555
LIG_SUMO_SIM_par_1	216	221	PF11976	0.344
LIG_SUMO_SIM_par_1	273	279	PF11976	0.369
LIG_SUMO_SIM_par_1	41	47	PF11976	0.369
LIG_TYR_ITIM	204	209	PF00017	0.544
LIG_TYR_ITIM	228	233	PF00017	0.339
LIG_TYR_ITIM	244	249	PF00017	0.376
LIG_TYR_ITIM	318	323	PF00017	0.522
MOD_CDK_SPxxK_3	342	349	PF00069	0.591
MOD_CK1_1	100	106	PF00069	0.612
MOD_CK1_1	172	178	PF00069	0.658
MOD_CK1_1	345	351	PF00069	0.689
MOD_CK1_1	92	98	PF00069	0.511
MOD_CK2_1	154	160	PF00069	0.620
MOD_Cter_Amidation	129	132	PF01082	0.413
MOD_GlcNHglycan	106	109	PF01048	0.530
MOD_GlcNHglycan	125	128	PF01048	0.525
MOD_GlcNHglycan	149	152	PF01048	0.571
MOD_GlcNHglycan	167	170	PF01048	0.565
MOD_GlcNHglycan	174	177	PF01048	0.516
MOD_GlcNHglycan	220	223	PF01048	0.396
MOD_GlcNHglycan	91	94	PF01048	0.412
MOD_GlcNHglycan	99	102	PF01048	0.487
MOD_GSK3_1	100	107	PF00069	0.627
MOD_GSK3_1	119	126	PF00069	0.702
MOD_GSK3_1	165	172	PF00069	0.695
MOD_GSK3_1	175	182	PF00069	0.657
MOD_GSK3_1	266	273	PF00069	0.487
MOD_GSK3_1	34	41	PF00069	0.512
MOD_GSK3_1	345	352	PF00069	0.684
MOD_LATS_1	263	269	PF00433	0.490
MOD_NEK2_1	211	216	PF00069	0.291
MOD_NEK2_1	232	237	PF00069	0.306
MOD_NEK2_1	276	281	PF00069	0.337
MOD_NEK2_1	44	49	PF00069	0.401
MOD_PK_1	29	35	PF00069	0.595
MOD_PKA_1	265	271	PF00069	0.492
MOD_PKA_2	265	271	PF00069	0.491
MOD_PKA_2	348	354	PF00069	0.593
MOD_Plk_4	211	217	PF00069	0.320
MOD_Plk_4	232	238	PF00069	0.306
MOD_Plk_4	271	277	PF00069	0.389
MOD_Plk_4	38	44	PF00069	0.337
MOD_ProDKin_1	116	122	PF00069	0.756
MOD_ProDKin_1	140	146	PF00069	0.690
MOD_ProDKin_1	169	175	PF00069	0.674
MOD_ProDKin_1	34	40	PF00069	0.508
MOD_ProDKin_1	342	348	PF00069	0.631
MOD_SUMO_for_1	325	328	PF00179	0.682
TRG_ENDOCYTIC_2	206	209	PF00928	0.531
TRG_ENDOCYTIC_2	213	216	PF00928	0.335
TRG_ENDOCYTIC_2	229	232	PF00928	0.320
TRG_ENDOCYTIC_2	24	27	PF00928	0.536
TRG_ENDOCYTIC_2	246	249	PF00928	0.282
TRG_ENDOCYTIC_2	320	323	PF00928	0.590
TRG_ENDOCYTIC_2	36	39	PF00928	0.375
TRG_ENDOCYTIC_2	53	56	PF00928	0.361
TRG_ER_diArg_1	265	267	PF00400	0.561
TRG_NES_CRM1_1	296	311	PF08389	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE3	Leptomonas seymouri	51%	100%
A0A0S4JM63	Bodo saltans	30%	82%
A0A3Q8IDX3	Leishmania donovani	71%	97%
A0A422N3F4	Trypanosoma rangeli	39%	100%
A4I2D2	Leishmania infantum	71%	97%
C9ZX76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	89%
E9AYI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q8Y8	Leishmania major	70%	100%