Copper transport protein 86

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF47_LEIBR

TriTrypDb:

LbrM.26.1950 , LBRM2903_260024200

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	627	631	PF00656	0.580
CLV_NRD_NRD_1	3	5	PF00675	0.559
CLV_NRD_NRD_1	320	322	PF00675	0.505
CLV_NRD_NRD_1	454	456	PF00675	0.488
CLV_NRD_NRD_1	528	530	PF00675	0.518
CLV_NRD_NRD_1	548	550	PF00675	0.624
CLV_PCSK_KEX2_1	3	5	PF00082	0.577
CLV_PCSK_KEX2_1	320	322	PF00082	0.507
CLV_PCSK_KEX2_1	528	530	PF00082	0.518
CLV_PCSK_KEX2_1	548	550	PF00082	0.556
CLV_PCSK_SKI1_1	294	298	PF00082	0.404
CLV_PCSK_SKI1_1	54	58	PF00082	0.389
CLV_PCSK_SKI1_1	703	707	PF00082	0.607
CLV_PCSK_SKI1_1	714	718	PF00082	0.720
CLV_PCSK_SKI1_1	731	735	PF00082	0.422
CLV_PCSK_SKI1_1	86	90	PF00082	0.670
CLV_Separin_Metazoa	111	115	PF03568	0.504
DEG_APCC_DBOX_1	3	11	PF00400	0.615
DEG_APCC_DBOX_1	608	616	PF00400	0.281
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DEG_SIAH_1	155	163	PF03145	0.430
DOC_CKS1_1	117	122	PF01111	0.418
DOC_CYCLIN_RxL_1	291	300	PF00134	0.423
DOC_CYCLIN_RxL_1	728	738	PF00134	0.489
DOC_MAPK_DCC_7	686	695	PF00069	0.285
DOC_MAPK_gen_1	3	12	PF00069	0.541
DOC_MAPK_gen_1	320	327	PF00069	0.459
DOC_MAPK_MEF2A_6	686	695	PF00069	0.565
DOC_PP1_RVXF_1	292	299	PF00149	0.344
DOC_PP1_RVXF_1	637	643	PF00149	0.494
DOC_PP2B_LxvP_1	78	81	PF13499	0.516
DOC_USP7_MATH_1	268	272	PF00917	0.421
DOC_USP7_MATH_1	30	34	PF00917	0.378
DOC_USP7_MATH_1	351	355	PF00917	0.387
DOC_USP7_MATH_1	466	470	PF00917	0.573
DOC_USP7_MATH_1	487	491	PF00917	0.561
DOC_USP7_MATH_1	497	501	PF00917	0.293
DOC_USP7_MATH_1	716	720	PF00917	0.569
DOC_USP7_MATH_1	81	85	PF00917	0.537
DOC_WW_Pin1_4	116	121	PF00397	0.365
DOC_WW_Pin1_4	152	157	PF00397	0.603
DOC_WW_Pin1_4	158	163	PF00397	0.483
LIG_14-3-3_CanoR_1	185	193	PF00244	0.370
LIG_14-3-3_CanoR_1	211	218	PF00244	0.488
LIG_14-3-3_CanoR_1	245	253	PF00244	0.334
LIG_14-3-3_CanoR_1	639	643	PF00244	0.485
LIG_14-3-3_CanoR_1	714	719	PF00244	0.455
LIG_14-3-3_CanoR_1	8	13	PF00244	0.437
LIG_Actin_WH2_2	645	663	PF00022	0.461
LIG_APCC_ABBA_1	519	524	PF00400	0.481
LIG_BIR_III_4	21	25	PF00653	0.515
LIG_BRCT_BRCA1_1	294	298	PF00533	0.381
LIG_Clathr_ClatBox_1	226	230	PF01394	0.452
LIG_DLG_GKlike_1	8	16	PF00625	0.405
LIG_EH1_1	106	114	PF00400	0.304
LIG_FHA_1	108	114	PF00498	0.444
LIG_FHA_1	117	123	PF00498	0.427
LIG_FHA_1	142	148	PF00498	0.550
LIG_FHA_1	261	267	PF00498	0.344
LIG_FHA_1	272	278	PF00498	0.515
LIG_FHA_1	334	340	PF00498	0.377
LIG_FHA_1	381	387	PF00498	0.529
LIG_FHA_1	417	423	PF00498	0.449
LIG_FHA_1	483	489	PF00498	0.741
LIG_FHA_1	500	506	PF00498	0.302
LIG_FHA_1	68	74	PF00498	0.470
LIG_FHA_2	418	424	PF00498	0.427
LIG_FHA_2	554	560	PF00498	0.371
LIG_FHA_2	675	681	PF00498	0.294
LIG_FHA_2	722	728	PF00498	0.521
LIG_GBD_Chelix_1	221	229	PF00786	0.387
LIG_LIR_Gen_1	223	232	PF02991	0.450
LIG_LIR_Gen_1	285	293	PF02991	0.390
LIG_LIR_LC3C_4	564	569	PF02991	0.324
LIG_LIR_Nem_3	223	227	PF02991	0.442
LIG_LIR_Nem_3	285	289	PF02991	0.368
LIG_LIR_Nem_3	319	325	PF02991	0.358
LIG_MYND_2	105	109	PF01753	0.450
LIG_PDZ_Class_1	750	755	PF00595	0.603
LIG_SH2_CRK	322	326	PF00017	0.419
LIG_SH2_NCK_1	281	285	PF00017	0.397
LIG_SH2_NCK_1	286	290	PF00017	0.353
LIG_SH2_NCK_1	370	374	PF00017	0.517
LIG_SH2_SRC	689	692	PF00017	0.430
LIG_SH2_STAP1	653	657	PF00017	0.327
LIG_SH2_STAT5	404	407	PF00017	0.516
LIG_SH2_STAT5	443	446	PF00017	0.381
LIG_SH2_STAT5	555	558	PF00017	0.383
LIG_SH2_STAT5	689	692	PF00017	0.430
LIG_SH3_1	114	120	PF00018	0.435
LIG_SH3_3	114	120	PF00018	0.292
LIG_SH3_3	29	35	PF00018	0.447
LIG_SH3_3	337	343	PF00018	0.491
LIG_SH3_3	548	554	PF00018	0.561
LIG_SH3_3	99	105	PF00018	0.641
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.424
LIG_SUMO_SIM_anti_2	423	429	PF11976	0.409
LIG_SUMO_SIM_anti_2	559	564	PF11976	0.483
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.414
LIG_SUMO_SIM_par_1	8	14	PF11976	0.418
LIG_TRAF2_1	375	378	PF00917	0.593
LIG_TRAF2_1	724	727	PF00917	0.559
LIG_UBA3_1	341	347	PF00899	0.386
MOD_CDK_SPxxK_3	116	123	PF00069	0.413
MOD_CK1_1	210	216	PF00069	0.459
MOD_CK1_1	236	242	PF00069	0.673
MOD_CK1_1	248	254	PF00069	0.327
MOD_CK1_1	271	277	PF00069	0.510
MOD_CK1_1	285	291	PF00069	0.326
MOD_CK1_1	316	322	PF00069	0.635
MOD_CK1_1	328	334	PF00069	0.339
MOD_CK1_1	354	360	PF00069	0.388
MOD_CK1_1	542	548	PF00069	0.602
MOD_CK1_1	747	753	PF00069	0.605
MOD_CK2_1	326	332	PF00069	0.560
MOD_CK2_1	385	391	PF00069	0.437
MOD_CK2_1	417	423	PF00069	0.419
MOD_CK2_1	443	449	PF00069	0.415
MOD_CK2_1	674	680	PF00069	0.362
MOD_CK2_1	681	687	PF00069	0.403
MOD_CK2_1	721	727	PF00069	0.534
MOD_CK2_1	8	14	PF00069	0.458
MOD_Cter_Amidation	546	549	PF01082	0.473
MOD_GlcNHglycan	151	155	PF01048	0.644
MOD_GlcNHglycan	235	238	PF01048	0.539
MOD_GlcNHglycan	274	277	PF01048	0.495
MOD_GlcNHglycan	299	302	PF01048	0.363
MOD_GlcNHglycan	328	331	PF01048	0.486
MOD_GlcNHglycan	466	469	PF01048	0.711
MOD_GlcNHglycan	489	492	PF01048	0.517
MOD_GlcNHglycan	582	585	PF01048	0.474
MOD_GlcNHglycan	630	634	PF01048	0.677
MOD_GSK3_1	10	17	PF00069	0.329
MOD_GSK3_1	112	119	PF00069	0.408
MOD_GSK3_1	233	240	PF00069	0.541
MOD_GSK3_1	245	252	PF00069	0.387
MOD_GSK3_1	268	275	PF00069	0.413
MOD_GSK3_1	321	328	PF00069	0.479
MOD_GSK3_1	376	383	PF00069	0.644
MOD_GSK3_1	482	489	PF00069	0.689
MOD_GSK3_1	63	70	PF00069	0.419
MOD_GSK3_1	655	662	PF00069	0.425
MOD_GSK3_1	670	677	PF00069	0.385
MOD_GSK3_1	699	706	PF00069	0.658
MOD_GSK3_1	721	728	PF00069	0.553
MOD_GSK3_1	746	753	PF00069	0.521
MOD_N-GLC_1	158	163	PF02516	0.510
MOD_N-GLC_1	199	204	PF02516	0.447
MOD_N-GLC_1	272	277	PF02516	0.492
MOD_N-GLC_2	132	134	PF02516	0.299
MOD_NEK2_1	112	117	PF00069	0.313
MOD_NEK2_1	199	204	PF00069	0.478
MOD_NEK2_1	2	7	PF00069	0.538
MOD_NEK2_1	233	238	PF00069	0.518
MOD_NEK2_1	297	302	PF00069	0.322
MOD_NEK2_1	394	399	PF00069	0.600
MOD_NEK2_1	451	456	PF00069	0.405
MOD_NEK2_1	563	568	PF00069	0.358
MOD_NEK2_1	656	661	PF00069	0.465
MOD_NEK2_1	670	675	PF00069	0.408
MOD_NEK2_1	746	751	PF00069	0.516
MOD_PIKK_1	141	147	PF00454	0.645
MOD_PIKK_1	542	548	PF00454	0.590
MOD_PKA_2	184	190	PF00069	0.386
MOD_PKA_2	2	8	PF00069	0.550
MOD_PKA_2	210	216	PF00069	0.487
MOD_PKA_2	325	331	PF00069	0.291
MOD_PKA_2	616	622	PF00069	0.634
MOD_PKA_2	638	644	PF00069	0.479
MOD_PKA_2	698	704	PF00069	0.558
MOD_PKB_1	6	14	PF00069	0.355
MOD_PKB_1	697	705	PF00069	0.393
MOD_Plk_1	199	205	PF00069	0.447
MOD_Plk_1	248	254	PF00069	0.474
MOD_Plk_1	558	564	PF00069	0.410
MOD_Plk_1	725	731	PF00069	0.483
MOD_Plk_4	14	20	PF00069	0.547
MOD_Plk_4	376	382	PF00069	0.599
MOD_Plk_4	443	449	PF00069	0.339
MOD_Plk_4	558	564	PF00069	0.419
MOD_Plk_4	638	644	PF00069	0.479
MOD_Plk_4	665	671	PF00069	0.542
MOD_Plk_4	716	722	PF00069	0.648
MOD_Plk_4	725	731	PF00069	0.437
MOD_ProDKin_1	116	122	PF00069	0.357
MOD_ProDKin_1	152	158	PF00069	0.601
TRG_DiLeu_BaEn_1	14	19	PF01217	0.437
TRG_DiLeu_BaEn_2	222	228	PF01217	0.427
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.438
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.484
TRG_DiLeu_BaLyEn_6	728	733	PF01217	0.426
TRG_ENDOCYTIC_2	286	289	PF00928	0.317
TRG_ENDOCYTIC_2	322	325	PF00928	0.420
TRG_ENDOCYTIC_2	653	656	PF00928	0.318
TRG_ER_diArg_1	2	4	PF00400	0.556
TRG_ER_diArg_1	320	322	PF00400	0.422
TRG_ER_diArg_1	528	531	PF00400	0.404
TRG_ER_diArg_1	6	9	PF00400	0.529
TRG_NES_CRM1_1	219	231	PF08389	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P479	Leptomonas seymouri	60%	98%
A0A1X0P8E3	Trypanosomatidae	31%	98%
A0A3Q8IDS4	Leishmania donovani	79%	100%
A0A3R7LMQ0	Trypanosoma rangeli	34%	100%
A4I2D1	Leishmania infantum	79%	95%
C9ZX77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	91%
E9AYI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	95%
Q4Q8Y9	Leishmania major	79%	100%
V5BJ35	Trypanosoma cruzi	34%	96%