PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF45_LEIBR

TriTrypDb:

LbrM.26.1930 , LBRM2903_260024000

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF45

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.421
CLV_C14_Caspase3-7	302	306	PF00656	0.666
CLV_C14_Caspase3-7	358	362	PF00656	0.504
CLV_C14_Caspase3-7	576	580	PF00656	0.640
CLV_NRD_NRD_1	130	132	PF00675	0.509
CLV_NRD_NRD_1	147	149	PF00675	0.342
CLV_NRD_NRD_1	157	159	PF00675	0.419
CLV_NRD_NRD_1	371	373	PF00675	0.371
CLV_NRD_NRD_1	472	474	PF00675	0.691
CLV_NRD_NRD_1	545	547	PF00675	0.690
CLV_NRD_NRD_1	550	552	PF00675	0.708
CLV_NRD_NRD_1	553	555	PF00675	0.679
CLV_NRD_NRD_1	565	567	PF00675	0.556
CLV_NRD_NRD_1	569	571	PF00675	0.545
CLV_NRD_NRD_1	624	626	PF00675	0.684
CLV_NRD_NRD_1	648	650	PF00675	0.588
CLV_NRD_NRD_1	705	707	PF00675	0.627
CLV_PCSK_FUR_1	550	554	PF00082	0.720
CLV_PCSK_KEX2_1	130	132	PF00082	0.509
CLV_PCSK_KEX2_1	147	149	PF00082	0.342
CLV_PCSK_KEX2_1	371	373	PF00082	0.503
CLV_PCSK_KEX2_1	471	473	PF00082	0.648
CLV_PCSK_KEX2_1	516	518	PF00082	0.677
CLV_PCSK_KEX2_1	550	552	PF00082	0.719
CLV_PCSK_KEX2_1	553	555	PF00082	0.690
CLV_PCSK_KEX2_1	564	566	PF00082	0.574
CLV_PCSK_KEX2_1	569	571	PF00082	0.545
CLV_PCSK_KEX2_1	6	8	PF00082	0.349
CLV_PCSK_KEX2_1	648	650	PF00082	0.588
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.648
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.649
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.721
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.563
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.349
CLV_PCSK_PC7_1	546	552	PF00082	0.691
CLV_PCSK_PC7_1	565	571	PF00082	0.567
CLV_PCSK_SKI1_1	130	134	PF00082	0.348
CLV_PCSK_SKI1_1	171	175	PF00082	0.351
CLV_PCSK_SKI1_1	372	376	PF00082	0.466
CLV_PCSK_SKI1_1	600	604	PF00082	0.603
CLV_PCSK_SKI1_1	64	68	PF00082	0.448
DEG_APCC_DBOX_1	214	222	PF00400	0.524
DEG_SPOP_SBC_1	249	253	PF00917	0.679
DEG_SPOP_SBC_1	489	493	PF00917	0.568
DEG_SPOP_SBC_1	50	54	PF00917	0.391
DEG_SPOP_SBC_1	713	717	PF00917	0.699
DOC_CKS1_1	141	146	PF01111	0.474
DOC_CKS1_1	294	299	PF01111	0.519
DOC_CYCLIN_RxL_1	168	177	PF00134	0.351
DOC_CYCLIN_RxL_1	371	383	PF00134	0.440
DOC_MAPK_gen_1	147	155	PF00069	0.499
DOC_MAPK_gen_1	371	379	PF00069	0.466
DOC_MAPK_gen_1	706	712	PF00069	0.561
DOC_MAPK_MEF2A_6	585	594	PF00069	0.541
DOC_PP2B_LxvP_1	685	688	PF13499	0.655
DOC_USP7_MATH_1	206	210	PF00917	0.646
DOC_USP7_MATH_1	235	239	PF00917	0.677
DOC_USP7_MATH_1	256	260	PF00917	0.624
DOC_USP7_MATH_1	355	359	PF00917	0.499
DOC_USP7_MATH_1	489	493	PF00917	0.613
DOC_USP7_MATH_1	50	54	PF00917	0.458
DOC_USP7_MATH_1	580	584	PF00917	0.654
DOC_USP7_MATH_1	676	680	PF00917	0.686
DOC_USP7_MATH_1	688	692	PF00917	0.596
DOC_USP7_MATH_1	713	717	PF00917	0.612
DOC_USP7_MATH_2	483	489	PF00917	0.567
DOC_USP7_UBL2_3	515	519	PF12436	0.692
DOC_USP7_UBL2_3	603	607	PF12436	0.544
DOC_WW_Pin1_4	140	145	PF00397	0.535
DOC_WW_Pin1_4	293	298	PF00397	0.590
DOC_WW_Pin1_4	303	308	PF00397	0.520
DOC_WW_Pin1_4	314	319	PF00397	0.533
DOC_WW_Pin1_4	616	621	PF00397	0.657
DOC_WW_Pin1_4	641	646	PF00397	0.718
DOC_WW_Pin1_4	95	100	PF00397	0.506
LIG_14-3-3_CanoR_1	131	141	PF00244	0.489
LIG_14-3-3_CanoR_1	502	507	PF00244	0.660
LIG_14-3-3_CanoR_1	585	591	PF00244	0.545
LIG_14-3-3_CanoR_1	648	655	PF00244	0.568
LIG_14-3-3_CanoR_1	706	710	PF00244	0.558
LIG_Actin_WH2_2	587	605	PF00022	0.534
LIG_BIR_II_1	1	5	PF00653	0.393
LIG_BRCT_BRCA1_1	53	57	PF00533	0.492
LIG_BRCT_BRCA1_1	97	101	PF00533	0.403
LIG_deltaCOP1_diTrp_1	301	308	PF00928	0.541
LIG_DLG_GKlike_1	502	510	PF00625	0.658
LIG_FAT_LD_1	106	114	PF03623	0.411
LIG_FHA_1	116	122	PF00498	0.500
LIG_FHA_1	162	168	PF00498	0.525
LIG_FHA_1	269	275	PF00498	0.636
LIG_FHA_1	279	285	PF00498	0.549
LIG_FHA_1	294	300	PF00498	0.502
LIG_FHA_1	364	370	PF00498	0.485
LIG_FHA_1	594	600	PF00498	0.614
LIG_FHA_1	670	676	PF00498	0.527
LIG_FHA_2	193	199	PF00498	0.523
LIG_FHA_2	300	306	PF00498	0.682
LIG_FHA_2	40	46	PF00498	0.633
LIG_FHA_2	416	422	PF00498	0.687
LIG_FHA_2	426	432	PF00498	0.575
LIG_FHA_2	87	93	PF00498	0.585
LIG_LIR_Apic_2	629	634	PF02991	0.572
LIG_LIR_Gen_1	161	167	PF02991	0.514
LIG_LIR_Nem_3	135	141	PF02991	0.489
LIG_LIR_Nem_3	14	19	PF02991	0.350
LIG_LIR_Nem_3	161	166	PF02991	0.519
LIG_LIR_Nem_3	227	232	PF02991	0.659
LIG_LIR_Nem_3	29	35	PF02991	0.473
LIG_LIR_Nem_3	54	60	PF02991	0.482
LIG_LIR_Nem_3	98	103	PF02991	0.367
LIG_MLH1_MIPbox_1	53	57	PF16413	0.350
LIG_PTB_Apo_2	273	280	PF02174	0.633
LIG_PTB_Phospho_1	273	279	PF10480	0.631
LIG_SH2_CRK	163	167	PF00017	0.654
LIG_SH2_PTP2	60	63	PF00017	0.452
LIG_SH2_STAP1	163	167	PF00017	0.526
LIG_SH2_STAT3	56	59	PF00017	0.333
LIG_SH2_STAT3	82	85	PF00017	0.498
LIG_SH2_STAT5	112	115	PF00017	0.434
LIG_SH2_STAT5	163	166	PF00017	0.532
LIG_SH2_STAT5	401	404	PF00017	0.659
LIG_SH2_STAT5	56	59	PF00017	0.447
LIG_SH2_STAT5	60	63	PF00017	0.443
LIG_SH3_1	93	99	PF00018	0.465
LIG_SH3_2	354	359	PF14604	0.495
LIG_SH3_2	620	625	PF14604	0.675
LIG_SH3_3	14	20	PF00018	0.347
LIG_SH3_3	196	202	PF00018	0.567
LIG_SH3_3	291	297	PF00018	0.520
LIG_SH3_3	349	355	PF00018	0.631
LIG_SH3_3	617	623	PF00018	0.673
LIG_SH3_3	629	635	PF00018	0.599
LIG_SH3_3	684	690	PF00018	0.688
LIG_SH3_3	93	99	PF00018	0.529
LIG_SUMO_SIM_par_1	216	223	PF11976	0.525
LIG_TRAF2_1	419	422	PF00917	0.545
LIG_UBA3_1	152	159	PF00899	0.505
LIG_WW_2	687	690	PF00397	0.568
MOD_CDC14_SPxK_1	306	309	PF00782	0.535
MOD_CDC14_SPxK_1	622	625	PF00782	0.666
MOD_CDK_SPxK_1	303	309	PF00069	0.542
MOD_CDK_SPxK_1	619	625	PF00069	0.653
MOD_CDK_SPxxK_3	140	147	PF00069	0.487
MOD_CDK_SPxxK_3	619	626	PF00069	0.558
MOD_CDK_SPxxK_3	641	648	PF00069	0.718
MOD_CK1_1	124	130	PF00069	0.560
MOD_CK1_1	220	226	PF00069	0.571
MOD_CK1_1	25	31	PF00069	0.579
MOD_CK1_1	250	256	PF00069	0.540
MOD_CK1_1	268	274	PF00069	0.455
MOD_CK1_1	380	386	PF00069	0.639
MOD_CK1_1	388	394	PF00069	0.631
MOD_CK1_1	409	415	PF00069	0.670
MOD_CK1_1	44	50	PF00069	0.512
MOD_CK1_1	458	464	PF00069	0.550
MOD_CK1_1	488	494	PF00069	0.680
MOD_CK1_1	578	584	PF00069	0.695
MOD_CK1_1	588	594	PF00069	0.585
MOD_CK1_1	610	616	PF00069	0.580
MOD_CK1_1	678	684	PF00069	0.693
MOD_CK1_1	714	720	PF00069	0.698
MOD_CK2_1	143	149	PF00069	0.593
MOD_CK2_1	210	216	PF00069	0.551
MOD_CK2_1	25	31	PF00069	0.515
MOD_CK2_1	295	301	PF00069	0.521
MOD_CK2_1	388	394	PF00069	0.662
MOD_CK2_1	39	45	PF00069	0.601
MOD_CK2_1	415	421	PF00069	0.542
MOD_CK2_1	49	55	PF00069	0.448
MOD_CK2_1	555	561	PF00069	0.588
MOD_Cter_Amidation	544	547	PF01082	0.588
MOD_Cter_Amidation	704	707	PF01082	0.638
MOD_GlcNHglycan	118	121	PF01048	0.420
MOD_GlcNHglycan	187	190	PF01048	0.471
MOD_GlcNHglycan	198	202	PF01048	0.513
MOD_GlcNHglycan	20	23	PF01048	0.548
MOD_GlcNHglycan	237	240	PF01048	0.662
MOD_GlcNHglycan	242	245	PF01048	0.616
MOD_GlcNHglycan	271	274	PF01048	0.579
MOD_GlcNHglycan	286	289	PF01048	0.512
MOD_GlcNHglycan	411	414	PF01048	0.674
MOD_GlcNHglycan	474	477	PF01048	0.600
MOD_GlcNHglycan	487	490	PF01048	0.631
MOD_GlcNHglycan	493	496	PF01048	0.532
MOD_GlcNHglycan	502	505	PF01048	0.581
MOD_GlcNHglycan	538	541	PF01048	0.582
MOD_GlcNHglycan	615	618	PF01048	0.664
MOD_GlcNHglycan	649	652	PF01048	0.668
MOD_GlcNHglycan	678	681	PF01048	0.609
MOD_GlcNHglycan	703	706	PF01048	0.663
MOD_GlcNHglycan	717	720	PF01048	0.527
MOD_GSK3_1	161	168	PF00069	0.526
MOD_GSK3_1	18	25	PF00069	0.419
MOD_GSK3_1	206	213	PF00069	0.563
MOD_GSK3_1	220	227	PF00069	0.518
MOD_GSK3_1	235	242	PF00069	0.533
MOD_GSK3_1	265	272	PF00069	0.581
MOD_GSK3_1	295	302	PF00069	0.634
MOD_GSK3_1	310	317	PF00069	0.489
MOD_GSK3_1	377	384	PF00069	0.672
MOD_GSK3_1	385	392	PF00069	0.671
MOD_GSK3_1	425	432	PF00069	0.577
MOD_GSK3_1	477	484	PF00069	0.707
MOD_GSK3_1	485	492	PF00069	0.629
MOD_GSK3_1	494	501	PF00069	0.551
MOD_GSK3_1	536	543	PF00069	0.560
MOD_GSK3_1	575	582	PF00069	0.697
MOD_GSK3_1	586	593	PF00069	0.574
MOD_GSK3_1	608	615	PF00069	0.681
MOD_GSK3_1	676	683	PF00069	0.675
MOD_GSK3_1	701	708	PF00069	0.666
MOD_GSK3_1	711	718	PF00069	0.575
MOD_N-GLC_1	266	271	PF02516	0.503
MOD_N-GLC_1	377	382	PF02516	0.590
MOD_N-GLC_1	416	421	PF02516	0.685
MOD_N-GLC_1	455	460	PF02516	0.546
MOD_N-GLC_1	700	705	PF02516	0.698
MOD_N-GLC_2	368	370	PF02516	0.430
MOD_NEK2_1	114	119	PF00069	0.482
MOD_NEK2_1	121	126	PF00069	0.502
MOD_NEK2_1	133	138	PF00069	0.294
MOD_NEK2_1	174	179	PF00069	0.497
MOD_NEK2_1	192	197	PF00069	0.490
MOD_NEK2_1	210	215	PF00069	0.555
MOD_NEK2_1	247	252	PF00069	0.538
MOD_NEK2_1	284	289	PF00069	0.517
MOD_NEK2_1	336	341	PF00069	0.524
MOD_NEK2_1	377	382	PF00069	0.590
MOD_NEK2_1	386	391	PF00069	0.593
MOD_NEK2_1	487	492	PF00069	0.584
MOD_NEK2_2	257	262	PF00069	0.534
MOD_NEK2_2	580	585	PF00069	0.550
MOD_PIKK_1	166	172	PF00454	0.493
MOD_PIKK_1	174	180	PF00454	0.423
MOD_PIKK_1	192	198	PF00454	0.494
MOD_PIKK_1	220	226	PF00454	0.526
MOD_PIKK_1	336	342	PF00454	0.531
MOD_PKA_1	472	478	PF00069	0.592
MOD_PKA_2	386	392	PF00069	0.672
MOD_PKA_2	472	478	PF00069	0.592
MOD_PKA_2	647	653	PF00069	0.578
MOD_PKA_2	701	707	PF00069	0.596
MOD_Plk_1	206	212	PF00069	0.631
MOD_Plk_1	22	28	PF00069	0.472
MOD_Plk_1	266	272	PF00069	0.503
MOD_Plk_1	406	412	PF00069	0.656
MOD_Plk_1	44	50	PF00069	0.481
MOD_Plk_1	455	461	PF00069	0.664
MOD_Plk_1	626	632	PF00069	0.576
MOD_Plk_2-3	295	301	PF00069	0.521
MOD_Plk_2-3	400	406	PF00069	0.519
MOD_Plk_2-3	425	431	PF00069	0.576
MOD_Plk_4	161	167	PF00069	0.514
MOD_Plk_4	680	686	PF00069	0.558
MOD_Plk_4	705	711	PF00069	0.559
MOD_ProDKin_1	140	146	PF00069	0.535
MOD_ProDKin_1	293	299	PF00069	0.592
MOD_ProDKin_1	303	309	PF00069	0.520
MOD_ProDKin_1	314	320	PF00069	0.529
MOD_ProDKin_1	616	622	PF00069	0.658
MOD_ProDKin_1	641	647	PF00069	0.718
MOD_ProDKin_1	95	101	PF00069	0.489
TRG_DiLeu_BaEn_4	668	674	PF01217	0.663
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.419
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.520
TRG_ENDOCYTIC_2	163	166	PF00928	0.518
TRG_ENDOCYTIC_2	32	35	PF00928	0.472
TRG_ER_diArg_1	550	553	PF00400	0.721
TRG_ER_diArg_1	564	566	PF00400	0.574
TRG_NLS_MonoCore_2	550	555	PF00514	0.719
TRG_NLS_MonoExtC_3	514	519	PF00514	0.633
TRG_NLS_MonoExtC_3	550	556	PF00514	0.717
TRG_NLS_MonoExtN_4	515	520	PF00514	0.583
TRG_NLS_MonoExtN_4	550	555	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7G6	Leishmania donovani	63%	99%
A4I2C9	Leishmania infantum	63%	99%
E9AYI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
Q4Q8Z1	Leishmania major	60%	100%