Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HF44_LEIBR

TriTrypDb:

LbrM.26.1920 , LBRM2903_260023900

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HF44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF44

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.384
CLV_NRD_NRD_1	300	302	PF00675	0.453
CLV_NRD_NRD_1	349	351	PF00675	0.517
CLV_NRD_NRD_1	49	51	PF00675	0.740
CLV_NRD_NRD_1	57	59	PF00675	0.704
CLV_PCSK_KEX2_1	128	130	PF00082	0.472
CLV_PCSK_KEX2_1	179	181	PF00082	0.412
CLV_PCSK_KEX2_1	49	51	PF00082	0.710
CLV_PCSK_KEX2_1	57	59	PF00082	0.753
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.495
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.412
CLV_PCSK_SKI1_1	313	317	PF00082	0.494
DEG_APCC_KENBOX_2	301	305	PF00400	0.184
DEG_Nend_UBRbox_3	1	3	PF02207	0.688
DOC_MAPK_gen_1	128	136	PF00069	0.274
DOC_PP2B_LxvP_1	197	200	PF13499	0.336
DOC_PP2B_PxIxI_1	40	46	PF00149	0.197
DOC_USP7_MATH_1	315	319	PF00917	0.372
DOC_USP7_MATH_1	6	10	PF00917	0.544
DOC_USP7_UBL2_3	224	228	PF12436	0.184
DOC_WW_Pin1_4	17	22	PF00397	0.609
DOC_WW_Pin1_4	37	42	PF00397	0.150
DOC_WW_Pin1_4	90	95	PF00397	0.351
LIG_14-3-3_CanoR_1	102	107	PF00244	0.392
LIG_14-3-3_CanoR_1	180	186	PF00244	0.216
LIG_APCC_ABBA_1	216	221	PF00400	0.298
LIG_BRCT_BRCA1_1	147	151	PF00533	0.242
LIG_BRCT_BRCA1_1	160	164	PF00533	0.242
LIG_FHA_1	182	188	PF00498	0.301
LIG_FHA_1	31	37	PF00498	0.351
LIG_FHA_1	38	44	PF00498	0.290
LIG_FHA_1	98	104	PF00498	0.469
LIG_LIR_Apic_2	107	113	PF02991	0.316
LIG_LIR_Gen_1	159	168	PF02991	0.268
LIG_LIR_Gen_1	267	274	PF02991	0.200
LIG_LIR_Nem_3	159	163	PF02991	0.277
LIG_LIR_Nem_3	230	236	PF02991	0.254
LIG_LIR_Nem_3	245	250	PF02991	0.225
LIG_LIR_Nem_3	267	272	PF02991	0.213
LIG_LYPXL_S_1	232	236	PF13949	0.496
LIG_LYPXL_yS_3	233	236	PF13949	0.336
LIG_PCNA_yPIPBox_3	17	30	PF02747	0.534
LIG_Pex14_2	160	164	PF04695	0.336
LIG_PTB_Apo_2	232	239	PF02174	0.184
LIG_PTB_Phospho_1	232	238	PF10480	0.184
LIG_SH2_CRK	110	114	PF00017	0.359
LIG_SH2_CRK	183	187	PF00017	0.336
LIG_SH2_CRK	27	31	PF00017	0.410
LIG_SH2_STAP1	78	82	PF00017	0.368
LIG_SH2_STAP1	99	103	PF00017	0.416
LIG_SH2_STAT5	123	126	PF00017	0.318
LIG_SH2_STAT5	183	186	PF00017	0.298
LIG_SH2_STAT5	92	95	PF00017	0.337
LIG_SH2_STAT5	99	102	PF00017	0.383
LIG_SH3_3	256	262	PF00018	0.242
LIG_SUMO_SIM_anti_2	275	283	PF11976	0.299
LIG_SUMO_SIM_anti_2	318	328	PF11976	0.233
LIG_SUMO_SIM_par_1	275	283	PF11976	0.247
LIG_SUMO_SIM_par_1	28	33	PF11976	0.197
LIG_WRC_WIRS_1	266	271	PF05994	0.277
MOD_CK1_1	13	19	PF00069	0.527
MOD_CK1_1	344	350	PF00069	0.280
MOD_CK1_1	72	78	PF00069	0.457
MOD_CK1_1	95	101	PF00069	0.399
MOD_CK2_1	102	108	PF00069	0.380
MOD_CK2_1	140	146	PF00069	0.253
MOD_CK2_1	283	289	PF00069	0.258
MOD_CK2_1	315	321	PF00069	0.301
MOD_Cter_Amidation	126	129	PF01082	0.479
MOD_Cter_Amidation	177	180	PF01082	0.496
MOD_Cter_Amidation	299	302	PF01082	0.453
MOD_GlcNHglycan	176	179	PF01048	0.513
MOD_GlcNHglycan	4	7	PF01048	0.431
MOD_GSK3_1	119	126	PF00069	0.301
MOD_GSK3_1	13	20	PF00069	0.702
MOD_GSK3_1	2	9	PF00069	0.688
MOD_GSK3_1	223	230	PF00069	0.318
MOD_GSK3_1	65	72	PF00069	0.537
MOD_NEK2_1	145	150	PF00069	0.242
MOD_NEK2_1	15	20	PF00069	0.601
MOD_NEK2_1	265	270	PF00069	0.302
MOD_NEK2_1	341	346	PF00069	0.308
MOD_NEK2_1	67	72	PF00069	0.502
MOD_PIKK_1	97	103	PF00454	0.430
MOD_PK_1	102	108	PF00069	0.415
MOD_Plk_1	292	298	PF00069	0.279
MOD_Plk_2-3	283	289	PF00069	0.336
MOD_Plk_2-3	321	327	PF00069	0.296
MOD_Plk_4	140	146	PF00069	0.255
MOD_Plk_4	283	289	PF00069	0.201
MOD_Plk_4	344	350	PF00069	0.255
MOD_Plk_4	43	49	PF00069	0.621
MOD_ProDKin_1	17	23	PF00069	0.610
MOD_ProDKin_1	37	43	PF00069	0.150
MOD_ProDKin_1	90	96	PF00069	0.355
MOD_SUMO_rev_2	220	226	PF00179	0.343
TRG_DiLeu_BaEn_1	275	280	PF01217	0.184
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.266
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.242
TRG_ENDOCYTIC_2	233	236	PF00928	0.255
TRG_ENDOCYTIC_2	27	30	PF00928	0.364
TRG_ENDOCYTIC_2	87	90	PF00928	0.335
TRG_ER_diArg_1	48	50	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D1	Leptomonas seymouri	65%	100%
A0A1X0P7E4	Trypanosomatidae	49%	97%
A0A3S7X035	Leishmania donovani	83%	100%
A0A422N3J7	Trypanosoma rangeli	55%	100%
A4I2C8	Leishmania infantum	82%	100%
C9ZX82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	96%
E9AYI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8Z2	Leishmania major	81%	98%
V5AUM3	Trypanosoma cruzi	52%	85%