Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF43_LEIBR

TriTrypDb:

LbrM.26.1910 , LBRM2903_260023800

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.605
CLV_NRD_NRD_1	142	144	PF00675	0.669
CLV_NRD_NRD_1	168	170	PF00675	0.685
CLV_NRD_NRD_1	67	69	PF00675	0.392
CLV_PCSK_KEX2_1	142	144	PF00082	0.709
CLV_PCSK_KEX2_1	168	170	PF00082	0.685
CLV_PCSK_KEX2_1	66	68	PF00082	0.489
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.489
CLV_PCSK_PC7_1	138	144	PF00082	0.696
CLV_PCSK_SKI1_1	121	125	PF00082	0.450
DOC_MAPK_gen_1	210	220	PF00069	0.747
DOC_MAPK_gen_1	36	46	PF00069	0.443
DOC_MAPK_MEF2A_6	213	222	PF00069	0.746
DOC_PP1_RVXF_1	89	96	PF00149	0.653
DOC_SPAK_OSR1_1	94	98	PF12202	0.531
DOC_WW_Pin1_4	167	172	PF00397	0.776
DOC_WW_Pin1_4	95	100	PF00397	0.578
LIG_14-3-3_CanoR_1	121	131	PF00244	0.401
LIG_14-3-3_CanoR_1	213	220	PF00244	0.694
LIG_14-3-3_CanoR_1	94	98	PF00244	0.380
LIG_FHA_1	213	219	PF00498	0.662
LIG_FHA_1	48	54	PF00498	0.595
LIG_FHA_2	98	104	PF00498	0.552
LIG_LIR_Apic_2	58	63	PF02991	0.562
LIG_LIR_Gen_1	125	135	PF02991	0.632
LIG_LIR_Gen_1	216	226	PF02991	0.690
LIG_LIR_Nem_3	125	131	PF02991	0.487
LIG_LIR_Nem_3	216	222	PF02991	0.691
LIG_LIR_Nem_3	3	9	PF02991	0.513
LIG_PDZ_Class_2	221	226	PF00595	0.656
LIG_PTB_Apo_2	89	96	PF02174	0.503
LIG_REV1ctd_RIR_1	175	184	PF16727	0.673
LIG_SH2_GRB2like	203	206	PF00017	0.517
LIG_SH2_PTP2	219	222	PF00017	0.493
LIG_SH2_STAT3	203	206	PF00017	0.769
LIG_SH2_STAT5	219	222	PF00017	0.493
LIG_SH3_3	141	147	PF00018	0.737
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.514
LIG_TRAF2_1	157	160	PF00917	0.558
MOD_CK2_1	17	23	PF00069	0.748
MOD_GlcNHglycan	116	119	PF01048	0.389
MOD_GlcNHglycan	124	127	PF01048	0.539
MOD_GlcNHglycan	215	218	PF01048	0.704
MOD_GSK3_1	163	170	PF00069	0.733
MOD_GSK3_1	76	83	PF00069	0.509
MOD_GSK3_1	93	100	PF00069	0.320
MOD_N-GLC_1	173	178	PF02516	0.684
MOD_NEK2_1	122	127	PF00069	0.568
MOD_NEK2_1	163	168	PF00069	0.718
MOD_NEK2_1	46	51	PF00069	0.540
MOD_NEK2_1	71	76	PF00069	0.450
MOD_NEK2_1	93	98	PF00069	0.378
MOD_NEK2_2	104	109	PF00069	0.592
MOD_PKA_2	212	218	PF00069	0.693
MOD_PKA_2	93	99	PF00069	0.385
MOD_Plk_1	173	179	PF00069	0.682
MOD_Plk_4	1	7	PF00069	0.515
MOD_Plk_4	173	179	PF00069	0.751
MOD_Plk_4	71	77	PF00069	0.370
MOD_ProDKin_1	167	173	PF00069	0.772
MOD_ProDKin_1	95	101	PF00069	0.574
MOD_SUMO_for_1	209	212	PF00179	0.492
TRG_DiLeu_BaEn_4	159	165	PF01217	0.638
TRG_ENDOCYTIC_2	219	222	PF00928	0.493
TRG_ER_diArg_1	141	143	PF00400	0.715
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIW3	Leptomonas seymouri	57%	100%
A0A1X0P7C9	Trypanosomatidae	40%	100%
A0A3S7X011	Leishmania donovani	74%	100%
A4I2C7	Leishmania infantum	74%	100%
E9AYH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q8Z3	Leishmania major	73%	100%
V5BJ41	Trypanosoma cruzi	39%	100%