Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF42_LEIBR

TriTrypDb:

LbrM.26.1900 , LBRM2903_260023700

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.679
CLV_NRD_NRD_1	123	125	PF00675	0.639
CLV_NRD_NRD_1	143	145	PF00675	0.629
CLV_NRD_NRD_1	146	148	PF00675	0.654
CLV_NRD_NRD_1	17	19	PF00675	0.548
CLV_NRD_NRD_1	24	26	PF00675	0.612
CLV_NRD_NRD_1	3	5	PF00675	0.648
CLV_NRD_NRD_1	32	34	PF00675	0.611
CLV_NRD_NRD_1	90	92	PF00675	0.656
CLV_PCSK_FUR_1	144	148	PF00082	0.621
CLV_PCSK_KEX2_1	145	147	PF00082	0.573
CLV_PCSK_KEX2_1	17	19	PF00082	0.546
CLV_PCSK_KEX2_1	170	172	PF00082	0.648
CLV_PCSK_KEX2_1	24	26	PF00082	0.614
CLV_PCSK_KEX2_1	3	5	PF00082	0.646
CLV_PCSK_KEX2_1	32	34	PF00082	0.615
CLV_PCSK_KEX2_1	90	92	PF00082	0.656
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.575
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.650
CLV_PCSK_PC7_1	141	147	PF00082	0.447
CLV_PCSK_SKI1_1	170	174	PF00082	0.666
DOC_CKS1_1	48	53	PF01111	0.720
DOC_CKS1_1	65	70	PF01111	0.735
DOC_MAPK_gen_1	124	134	PF00069	0.627
DOC_MAPK_gen_1	173	182	PF00069	0.671
DOC_MAPK_gen_1	193	201	PF00069	0.683
DOC_MAPK_HePTP_8	172	184	PF00069	0.693
DOC_MAPK_MEF2A_6	175	184	PF00069	0.687
DOC_USP7_MATH_1	113	117	PF00917	0.669
DOC_USP7_MATH_1	123	127	PF00917	0.576
DOC_USP7_MATH_1	76	80	PF00917	0.724
DOC_USP7_UBL2_3	121	125	PF12436	0.509
DOC_WW_Pin1_4	47	52	PF00397	0.704
DOC_WW_Pin1_4	64	69	PF00397	0.551
LIG_14-3-3_CanoR_1	144	154	PF00244	0.556
LIG_14-3-3_CanoR_1	17	22	PF00244	0.641
LIG_14-3-3_CanoR_1	24	29	PF00244	0.646
LIG_14-3-3_CanoR_1	32	37	PF00244	0.588
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_CSL_BTD_1	8	11	PF09270	0.681
LIG_FHA_1	94	100	PF00498	0.697
LIG_FHA_2	184	190	PF00498	0.511
LIG_FHA_2	212	218	PF00498	0.702
LIG_FHA_2	65	71	PF00498	0.763
LIG_Integrin_RGD_1	53	55	PF01839	0.520
LIG_LIR_Nem_3	181	187	PF02991	0.652
LIG_SH2_CRK	204	208	PF00017	0.603
LIG_SH2_STAT5	213	216	PF00017	0.681
LIG_SH3_2	48	53	PF14604	0.616
LIG_SH3_3	42	48	PF00018	0.651
LIG_SH3_3	62	68	PF00018	0.441
LIG_TRAF2_1	215	218	PF00917	0.480
LIG_WRC_WIRS_1	151	156	PF05994	0.432
LIG_WRC_WIRS_1	213	218	PF05994	0.730
MOD_CDK_SPK_2	64	69	PF00069	0.687
MOD_CDK_SPxK_1	47	53	PF00069	0.613
MOD_CK1_1	20	26	PF00069	0.687
MOD_CK2_1	150	156	PF00069	0.505
MOD_CK2_1	183	189	PF00069	0.475
MOD_CK2_1	211	217	PF00069	0.695
MOD_CK2_1	54	60	PF00069	0.652
MOD_CK2_1	64	70	PF00069	0.739
MOD_Cter_Amidation	30	33	PF01082	0.733
MOD_GlcNHglycan	116	119	PF01048	0.516
MOD_GlcNHglycan	55	59	PF01048	0.725
MOD_GSK3_1	145	152	PF00069	0.593
MOD_GSK3_1	16	23	PF00069	0.669
MOD_GSK3_1	183	190	PF00069	0.724
MOD_NEK2_1	180	185	PF00069	0.618
MOD_PIKK_1	99	105	PF00454	0.694
MOD_PK_1	17	23	PF00069	0.727
MOD_PKA_1	145	151	PF00069	0.546
MOD_PKA_1	17	23	PF00069	0.560
MOD_PKA_1	24	30	PF00069	0.615
MOD_PKA_1	3	9	PF00069	0.676
MOD_PKA_1	32	38	PF00069	0.587
MOD_PKA_2	123	129	PF00069	0.736
MOD_PKA_2	145	151	PF00069	0.696
MOD_PKA_2	16	22	PF00069	0.535
MOD_PKA_2	24	30	PF00069	0.606
MOD_PKA_2	3	9	PF00069	0.659
MOD_PKA_2	32	38	PF00069	0.593
MOD_Plk_1	180	186	PF00069	0.679
MOD_Plk_1	99	105	PF00069	0.506
MOD_Plk_4	150	156	PF00069	0.671
MOD_Plk_4	160	166	PF00069	0.643
MOD_Plk_4	180	186	PF00069	0.635
MOD_ProDKin_1	47	53	PF00069	0.706
MOD_ProDKin_1	64	70	PF00069	0.552
MOD_SUMO_rev_2	116	123	PF00179	0.617
MOD_SUMO_rev_2	163	172	PF00179	0.606
TRG_DiLeu_BaEn_4	109	115	PF01217	0.501
TRG_ENDOCYTIC_2	213	216	PF00928	0.646
TRG_ER_diArg_1	143	146	PF00400	0.670
TRG_ER_diArg_1	16	18	PF00400	0.569
TRG_NLS_MonoCore_2	143	148	PF00514	0.551
TRG_NLS_MonoExtC_3	143	149	PF00514	0.632
TRG_NLS_MonoExtN_4	121	128	PF00514	0.513
TRG_NLS_MonoExtN_4	141	148	PF00514	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I142	Leptomonas seymouri	55%	90%
A0A1X0P8F5	Trypanosomatidae	23%	96%
A0A1X0P8T2	Trypanosomatidae	24%	96%
A0A3Q8IPD3	Leishmania donovani	70%	100%
A0A3R7KEM3	Trypanosoma rangeli	26%	100%
A4I2C6	Leishmania infantum	70%	100%
E9AYH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q8Z4	Leishmania major	70%	95%