Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF40_LEIBR

TriTrypDb:

LbrM.26.1880 , LBRM2903_260023500

Length:

878

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0005875	microtubule associated complex	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

A4HF40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF40

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008569	minus-end-directed microtubule motor activity	3	2
GO:0045505	dynein intermediate chain binding	3	2
GO:0051959	dynein light intermediate chain binding	3	2
GO:0140657	ATP-dependent activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	808	812	PF00656	0.772
CLV_NRD_NRD_1	209	211	PF00675	0.470
CLV_NRD_NRD_1	315	317	PF00675	0.517
CLV_NRD_NRD_1	336	338	PF00675	0.735
CLV_NRD_NRD_1	518	520	PF00675	0.631
CLV_NRD_NRD_1	563	565	PF00675	0.525
CLV_PCSK_FUR_1	313	317	PF00082	0.628
CLV_PCSK_KEX2_1	209	211	PF00082	0.476
CLV_PCSK_KEX2_1	313	315	PF00082	0.544
CLV_PCSK_KEX2_1	334	336	PF00082	0.747
CLV_PCSK_KEX2_1	451	453	PF00082	0.581
CLV_PCSK_KEX2_1	563	565	PF00082	0.525
CLV_PCSK_KEX2_1	590	592	PF00082	0.673
CLV_PCSK_KEX2_1	866	868	PF00082	0.650
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.797
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.613
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.679
CLV_PCSK_PC1ET2_1	866	868	PF00082	0.592
CLV_PCSK_SKI1_1	149	153	PF00082	0.512
CLV_PCSK_SKI1_1	190	194	PF00082	0.579
CLV_PCSK_SKI1_1	209	213	PF00082	0.350
CLV_PCSK_SKI1_1	240	244	PF00082	0.585
CLV_PCSK_SKI1_1	315	319	PF00082	0.430
CLV_PCSK_SKI1_1	400	404	PF00082	0.580
CLV_PCSK_SKI1_1	525	529	PF00082	0.634
CLV_PCSK_SKI1_1	540	544	PF00082	0.477
CLV_PCSK_SKI1_1	583	587	PF00082	0.639
CLV_PCSK_SKI1_1	608	612	PF00082	0.493
CLV_PCSK_SKI1_1	828	832	PF00082	0.705
DEG_APCC_DBOX_1	193	201	PF00400	0.421
DEG_APCC_DBOX_1	239	247	PF00400	0.603
DEG_APCC_DBOX_1	399	407	PF00400	0.571
DOC_CKS1_1	259	264	PF01111	0.539
DOC_CYCLIN_RxL_1	203	216	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	708	714	PF00134	0.639
DOC_MAPK_gen_1	313	319	PF00069	0.557
DOC_MAPK_gen_1	580	589	PF00069	0.636
DOC_MAPK_HePTP_8	401	413	PF00069	0.419
DOC_MAPK_MEF2A_6	404	413	PF00069	0.625
DOC_MAPK_MEF2A_6	468	475	PF00069	0.466
DOC_MAPK_MEF2A_6	580	589	PF00069	0.666
DOC_MAPK_MEF2A_6	748	756	PF00069	0.788
DOC_PP1_RVXF_1	139	146	PF00149	0.426
DOC_PP1_RVXF_1	150	157	PF00149	0.408
DOC_PP1_RVXF_1	682	688	PF00149	0.562
DOC_PP2B_LxvP_1	632	635	PF13499	0.467
DOC_USP7_MATH_1	202	206	PF00917	0.592
DOC_USP7_MATH_1	352	356	PF00917	0.733
DOC_USP7_MATH_1	785	789	PF00917	0.667
DOC_USP7_UBL2_3	684	688	PF12436	0.558
DOC_USP7_UBL2_3	866	870	PF12436	0.594
DOC_WW_Pin1_4	18	23	PF00397	0.558
DOC_WW_Pin1_4	258	263	PF00397	0.498
DOC_WW_Pin1_4	304	309	PF00397	0.507
DOC_WW_Pin1_4	339	344	PF00397	0.795
DOC_WW_Pin1_4	430	435	PF00397	0.569
DOC_WW_Pin1_4	688	693	PF00397	0.573
DOC_WW_Pin1_4	7	12	PF00397	0.593
DOC_WW_Pin1_4	841	846	PF00397	0.796
LIG_14-3-3_CanoR_1	255	259	PF00244	0.684
LIG_14-3-3_CanoR_1	298	303	PF00244	0.517
LIG_14-3-3_CanoR_1	314	320	PF00244	0.482
LIG_14-3-3_CanoR_1	359	365	PF00244	0.560
LIG_14-3-3_CanoR_1	410	420	PF00244	0.567
LIG_14-3-3_CanoR_1	452	462	PF00244	0.547
LIG_14-3-3_CanoR_1	488	497	PF00244	0.614
LIG_14-3-3_CanoR_1	498	502	PF00244	0.627
LIG_14-3-3_CanoR_1	564	570	PF00244	0.587
LIG_Actin_WH2_2	229	246	PF00022	0.608
LIG_APCC_ABBA_1	273	278	PF00400	0.568
LIG_APCC_ABBA_1	678	683	PF00400	0.548
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BIR_III_2	811	815	PF00653	0.582
LIG_Clathr_ClatBox_1	551	555	PF01394	0.386
LIG_CtBP_PxDLS_1	308	312	PF00389	0.619
LIG_deltaCOP1_diTrp_1	250	258	PF00928	0.406
LIG_FHA_1	148	154	PF00498	0.614
LIG_FHA_1	206	212	PF00498	0.529
LIG_FHA_1	216	222	PF00498	0.557
LIG_FHA_1	259	265	PF00498	0.469
LIG_FHA_1	489	495	PF00498	0.594
LIG_FHA_1	532	538	PF00498	0.407
LIG_FHA_1	584	590	PF00498	0.645
LIG_FHA_1	688	694	PF00498	0.566
LIG_FHA_1	736	742	PF00498	0.491
LIG_FHA_2	222	228	PF00498	0.581
LIG_FHA_2	279	285	PF00498	0.566
LIG_FHA_2	320	326	PF00498	0.442
LIG_FHA_2	375	381	PF00498	0.518
LIG_FHA_2	477	483	PF00498	0.578
LIG_FHA_2	490	496	PF00498	0.496
LIG_FHA_2	542	548	PF00498	0.577
LIG_FHA_2	720	726	PF00498	0.604
LIG_FHA_2	730	736	PF00498	0.636
LIG_LIR_Gen_1	249	259	PF02991	0.661
LIG_LIR_Gen_1	281	290	PF02991	0.462
LIG_LIR_Gen_1	294	300	PF02991	0.417
LIG_LIR_Gen_1	483	494	PF02991	0.603
LIG_LIR_Gen_1	615	624	PF02991	0.550
LIG_LIR_Gen_1	679	687	PF02991	0.447
LIG_LIR_Gen_1	759	769	PF02991	0.740
LIG_LIR_Nem_3	122	126	PF02991	0.483
LIG_LIR_Nem_3	249	254	PF02991	0.553
LIG_LIR_Nem_3	281	286	PF02991	0.636
LIG_LIR_Nem_3	294	299	PF02991	0.382
LIG_LIR_Nem_3	483	489	PF02991	0.608
LIG_LIR_Nem_3	604	610	PF02991	0.463
LIG_LIR_Nem_3	679	685	PF02991	0.445
LIG_LIR_Nem_3	759	764	PF02991	0.739
LIG_NRBOX	553	559	PF00104	0.577
LIG_REV1ctd_RIR_1	293	302	PF16727	0.354
LIG_SH2_CRK	596	600	PF00017	0.582
LIG_SH2_NCK_1	454	458	PF00017	0.495
LIG_SH2_NCK_1	682	686	PF00017	0.519
LIG_SH2_PTP2	486	489	PF00017	0.618
LIG_SH2_SRC	276	279	PF00017	0.508
LIG_SH2_SRC	728	731	PF00017	0.487
LIG_SH2_STAP1	276	280	PF00017	0.595
LIG_SH2_STAT5	123	126	PF00017	0.451
LIG_SH2_STAT5	461	464	PF00017	0.517
LIG_SH2_STAT5	486	489	PF00017	0.593
LIG_SH2_STAT5	596	599	PF00017	0.562
LIG_SH2_STAT5	638	641	PF00017	0.559
LIG_SH3_3	140	146	PF00018	0.559
LIG_SH3_3	287	293	PF00018	0.362
LIG_SH3_3	323	329	PF00018	0.505
LIG_SH3_3	342	348	PF00018	0.767
LIG_SH3_3	433	439	PF00018	0.775
LIG_SH3_3	763	769	PF00018	0.753
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.543
LIG_SUMO_SIM_par_1	270	279	PF11976	0.450
LIG_SUMO_SIM_par_1	638	643	PF11976	0.585
LIG_TRAF2_1	282	285	PF00917	0.547
LIG_TRAF2_1	544	547	PF00917	0.635
LIG_TRAF2_1	834	837	PF00917	0.763
LIG_UBA3_1	420	424	PF00899	0.599
LIG_UBA3_1	427	435	PF00899	0.684
LIG_UBA3_1	551	556	PF00899	0.392
MOD_CDK_SPK_2	430	435	PF00069	0.624
MOD_CDK_SPxK_1	841	847	PF00069	0.831
MOD_CK1_1	205	211	PF00069	0.366
MOD_CK1_1	279	285	PF00069	0.421
MOD_CK1_1	676	682	PF00069	0.552
MOD_CK1_1	850	856	PF00069	0.574
MOD_CK1_1	859	865	PF00069	0.772
MOD_CK1_1	869	875	PF00069	0.783
MOD_CK2_1	278	284	PF00069	0.546
MOD_CK2_1	374	380	PF00069	0.568
MOD_CK2_1	411	417	PF00069	0.574
MOD_CK2_1	452	458	PF00069	0.475
MOD_CK2_1	541	547	PF00069	0.634
MOD_CK2_1	7	13	PF00069	0.595
MOD_CK2_1	729	735	PF00069	0.641
MOD_GlcNHglycan	330	333	PF01048	0.742
MOD_GlcNHglycan	455	458	PF01048	0.505
MOD_GlcNHglycan	603	606	PF01048	0.494
MOD_GlcNHglycan	621	624	PF01048	0.313
MOD_GlcNHglycan	635	638	PF01048	0.370
MOD_GlcNHglycan	675	678	PF01048	0.513
MOD_GlcNHglycan	714	717	PF01048	0.690
MOD_GlcNHglycan	793	798	PF01048	0.780
MOD_GlcNHglycan	802	805	PF01048	0.732
MOD_GlcNHglycan	862	865	PF01048	0.761
MOD_GSK3_1	141	148	PF00069	0.533
MOD_GSK3_1	254	261	PF00069	0.642
MOD_GSK3_1	298	305	PF00069	0.518
MOD_GSK3_1	3	10	PF00069	0.588
MOD_GSK3_1	315	322	PF00069	0.391
MOD_GSK3_1	335	342	PF00069	0.787
MOD_GSK3_1	683	690	PF00069	0.496
MOD_GSK3_1	793	800	PF00069	0.760
MOD_GSK3_1	828	835	PF00069	0.762
MOD_GSK3_1	843	850	PF00069	0.670
MOD_GSK3_1	856	863	PF00069	0.701
MOD_GSK3_1	865	872	PF00069	0.760
MOD_LATS_1	450	456	PF00433	0.450
MOD_N-GLC_1	531	536	PF02516	0.595
MOD_N-GLC_1	828	833	PF02516	0.823
MOD_N-GLC_2	390	392	PF02516	0.619
MOD_N-GLC_2	593	595	PF02516	0.414
MOD_NEK2_1	147	152	PF00069	0.604
MOD_NEK2_1	221	226	PF00069	0.617
MOD_NEK2_1	254	259	PF00069	0.662
MOD_NEK2_1	309	314	PF00069	0.567
MOD_NEK2_1	411	416	PF00069	0.409
MOD_NEK2_1	489	494	PF00069	0.500
MOD_NEK2_1	497	502	PF00069	0.430
MOD_NEK2_1	594	599	PF00069	0.540
MOD_NEK2_1	687	692	PF00069	0.549
MOD_NEK2_1	858	863	PF00069	0.657
MOD_NEK2_2	444	449	PF00069	0.655
MOD_PIKK_1	489	495	PF00454	0.625
MOD_PIKK_1	785	791	PF00454	0.602
MOD_PIKK_1	797	803	PF00454	0.781
MOD_PIKK_1	832	838	PF00454	0.601
MOD_PK_1	851	857	PF00069	0.575
MOD_PKA_1	315	321	PF00069	0.505
MOD_PKA_1	335	341	PF00069	0.768
MOD_PKA_1	866	872	PF00069	0.765
MOD_PKA_2	254	260	PF00069	0.662
MOD_PKA_2	315	321	PF00069	0.483
MOD_PKA_2	335	341	PF00069	0.751
MOD_PKA_2	487	493	PF00069	0.562
MOD_PKA_2	497	503	PF00069	0.562
MOD_PKA_2	747	753	PF00069	0.527
MOD_PKA_2	846	852	PF00069	0.826
MOD_PKA_2	866	872	PF00069	0.594
MOD_PKB_1	313	321	PF00069	0.378
MOD_PKB_1	335	343	PF00069	0.795
MOD_PKB_1	826	834	PF00069	0.597
MOD_Plk_1	160	166	PF00069	0.716
MOD_Plk_1	276	282	PF00069	0.603
MOD_Plk_1	302	308	PF00069	0.421
MOD_Plk_1	583	589	PF00069	0.657
MOD_Plk_1	626	632	PF00069	0.590
MOD_Plk_1	651	657	PF00069	0.533
MOD_Plk_1	762	768	PF00069	0.729
MOD_Plk_4	106	112	PF00069	0.718
MOD_Plk_4	254	260	PF00069	0.571
MOD_Plk_4	444	450	PF00069	0.637
MOD_Plk_4	497	503	PF00069	0.543
MOD_Plk_4	627	633	PF00069	0.605
MOD_Plk_4	645	651	PF00069	0.349
MOD_Plk_4	676	682	PF00069	0.401
MOD_Plk_4	747	753	PF00069	0.743
MOD_ProDKin_1	18	24	PF00069	0.558
MOD_ProDKin_1	258	264	PF00069	0.487
MOD_ProDKin_1	304	310	PF00069	0.506
MOD_ProDKin_1	339	345	PF00069	0.793
MOD_ProDKin_1	430	436	PF00069	0.574
MOD_ProDKin_1	688	694	PF00069	0.572
MOD_ProDKin_1	7	13	PF00069	0.595
MOD_ProDKin_1	841	847	PF00069	0.797
MOD_SUMO_rev_2	179	184	PF00179	0.539
MOD_SUMO_rev_2	417	426	PF00179	0.528
MOD_SUMO_rev_2	521	527	PF00179	0.484
TRG_DiLeu_BaEn_1	398	403	PF01217	0.532
TRG_DiLeu_BaEn_1	512	517	PF01217	0.585
TRG_DiLeu_BaEn_1	547	552	PF01217	0.400
TRG_DiLeu_BaEn_4	549	555	PF01217	0.526
TRG_ENDOCYTIC_2	123	126	PF00928	0.451
TRG_ENDOCYTIC_2	486	489	PF00928	0.618
TRG_ENDOCYTIC_2	596	599	PF00928	0.542
TRG_ENDOCYTIC_2	617	620	PF00928	0.576
TRG_ENDOCYTIC_2	682	685	PF00928	0.493
TRG_ENDOCYTIC_2	761	764	PF00928	0.686
TRG_ER_diArg_1	209	211	PF00400	0.463
TRG_ER_diArg_1	313	316	PF00400	0.553
TRG_ER_diArg_1	335	337	PF00400	0.783
TRG_ER_diLys_1	874	878	PF00400	0.585
TRG_NES_CRM1_1	419	432	PF08389	0.560
TRG_NLS_Bipartite_1	315	337	PF00514	0.704
TRG_NLS_MonoCore_2	332	337	PF00514	0.779
TRG_NLS_MonoExtC_3	332	337	PF00514	0.789
TRG_NLS_MonoExtN_4	333	338	PF00514	0.794
TRG_Pf-PMV_PEXEL_1	400	405	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD7	Leptomonas seymouri	66%	100%
A0A0N1ILZ8	Leptomonas seymouri	23%	94%
A0A1X0P8A9	Trypanosomatidae	36%	100%
A0A3S7X009	Leishmania donovani	69%	100%
A0A422N0G0	Trypanosoma rangeli	33%	100%
A0A422NQU4	Trypanosoma rangeli	23%	100%
A4I2C4	Leishmania infantum	69%	100%
C9ZX89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AYH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q8Z6	Leishmania major	67%	100%